Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Fang H et al. | Toxoplasma gondii-derived heat shock protein 70 induces lethal anaphylactic reaction through activation of cytosolic phospholipase A2 and platelet-activating factor via Toll-like receptor 4/myeloid differentiation factor 88. | 2008 | Microbiol. Immunol. | pmid:18667035 |
| Sánchez FA et al. | Internalization of eNOS via caveolae regulates PAF-induced inflammatory hyperpermeability to macromolecules. | 2008 | Am. J. Physiol. Heart Circ. Physiol. | pmid:18708444 |
| Si J et al. | STAT5 mediates PAF-induced NADPH oxidase NOX5-S expression in Barrett's esophageal adenocarcinoma cells. | 2008 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:17947454 |
| Zhang XP et al. | The pathogenic mechanism of severe acute pancreatitis complicated with renal injury: a review of current knowledge. | 2008 | Dig. Dis. Sci. | pmid:17597411 |
| Aomatsu K et al. | Toll-like receptor agonists stimulate human neutrophil migration via activation of mitogen-activated protein kinases. | 2008 | Immunology | pmid:17662043 |
| Smith JC et al. | Identification of lysophosphatidylcholine (LPC) and platelet activating factor (PAF) from PC12 cells and mouse cortex using liquid chromatography/multi-stage mass spectrometry (LC/MS3). | 2008 | Rapid Commun. Mass Spectrom. | pmid:18937225 |
| Yuhki K et al. | Prostaglandin I2 plays a key role in zymosan-induced mouse pleurisy. | 2008 | J. Pharmacol. Exp. Ther. | pmid:18256172 |
| Chia YC et al. | Antiplatelet aggregation coumarins from the leaves of Murraya omphalocarpa. | 2008 | Molecules | pmid:18259135 |
| Kasperska-Zajac A et al. | Platelet activating factor as a mediator and therapeutic approach in bronchial asthma. | 2008 | Inflammation | pmid:18193345 |
| Vadas P et al. | Platelet-activating factor, PAF acetylhydrolase, and severe anaphylaxis. | 2008 | N. Engl. J. Med. | pmid:18172172 |
| Burks AW | Factoring PAF in anaphylaxis. | 2008 | N. Engl. J. Med. | pmid:18172180 |
| Menzies-Gow NJ et al. | Roles of thromboxane A2 and 5-hydroxytryptamine in endotoxin-induced digital vasoconstriction in horses. | 2008 | Am. J. Vet. Res. | pmid:18241016 |
| Caprani A et al. | Preliminary study of pulsed-electromagnetic fields effects on endothelial (HUVEC) cell secretions--modulation of the thrombo-hemorrhagic balance. | 2008 | Electromagn Biol Med | pmid:19037787 |
| Satoh K | [Plasma platelet-activating factor acetylhydrolase (PAF-AH) deficiency as a risk factor for stroke]. | 2008 | Brain Nerve | pmid:19069165 |
| Hemetsberger R et al. | Association between the efficacy of dual antiplatelet therapy and the development of in-stent neointimal hyperplasia in porcine coronary arteries. | 2008 | Coron. Artery Dis. | pmid:19005299 |
| Frost BL et al. | The importance of pro-inflammatory signaling in neonatal necrotizing enterocolitis. | 2008 | Semin. Perinatol. | pmid:18346533 |
| Zhang Y et al. | Glycosides from the bark of Adina polycephala. | 2008 | J. Nat. Prod. | pmid:18303851 |
| Tsuchiya R et al. | Characterization of canine platelet activation induced by platelet activating factor (PAF). | 2008 | J. Vet. Med. Sci. | pmid:18319579 |
| Song W et al. | Pyridinium alkaloid-coupled secoiridoids from the flower buds of Lonicera japonica. | 2008 | J. Nat. Prod. | pmid:18321056 |
| Shiva D et al. | High dose of lipopolysaccharide pre-treatment prevents OVA-induced anaphylactic decreases in rectal temperature in the immunized mice. | 2008 | Immunol. Lett. | pmid:18433880 |
| Leary PJ et al. | A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation. | 2008 | Am. J. Physiol. Heart Circ. Physiol. | pmid:18441203 |
| Cooper D et al. | Novel insights into the inhibitory effects of Galectin-1 on neutrophil recruitment under flow. | 2008 | J. Leukoc. Biol. | pmid:18372340 |
| Bansal AS et al. | Platelet-activating factor, PAF acetylhydrolase, and anaphylaxis. | 2008 | N. Engl. J. Med. | pmid:18389523 |
| Okamoto H and Kamatani N | Platelet-activating factor, PAF acetylhydrolase, and anaphylaxis. | 2008 | N. Engl. J. Med. | pmid:18389524 |
| Sreevidya CS et al. | Inhibition of photocarcinogenesis by platelet-activating factor or serotonin receptor antagonists. | 2008 | Cancer Res. | pmid:18483284 |
| Landgraf RG et al. | Prostaglandins, leukotrienes and PAF selectively modulate lymphocyte subset and eosinophil infiltration into the airways in a murine model of asthma. | 2007 Oct-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17923399 |
| Vadnais ML et al. | Current concepts of molecular events during bovine and porcine spermatozoa capacitation. | 2007 May-Jun | Arch. Androl. | pmid:17612869 |
| Rosenwasser L | New insights into the pathophysiology of allergic rhinitis. | 2007 Jan-Feb | Allergy Asthma Proc | pmid:17390750 |
| Kulkarni S et al. | Conversion of platelets from a proaggregatory to a proinflammatory adhesive phenotype: role of PAF in spatially regulating neutrophil adhesion and spreading. | 2007 | Blood | pmid:17548580 |
| Zhang LL et al. | [Protective effect of rupatadine against oleic acid-induced acute lung injury in rabbits]. | 2007 | Yao Xue Xue Bao | pmid:17520822 |
| Witzenrath M et al. | Role of platelet-activating factor in pneumolysin-induced acute lung injury. | 2007 | Crit. Care Med. | pmid:17522574 |
| Keles GC et al. | Levels of gingival tissue platelet activating factor after conventional and regenerative periodontal surgery. | 2007 | Clin Oral Investig | pmid:17522901 |
| Simonenko VB et al. | [Comparative evaluation of the influence of sulfhydryl and phosphate ACE inhibitors on thrombocyte aggregation in patients suffering from atrerial hypertension with metabolic syndrome]. | 2007 | Klin Med (Mosk) | pmid:17564032 |
| Li Y et al. | Autocrine activation of ion currents in the two-cell mouse embryo. | 2007 | Exp. Cell Res. | pmid:17583695 |
| Martin J et al. | The dialogue between endothelial cells and monocytes/macrophages in vascular syndromes. | 2007 | Curr. Pharm. Des. | pmid:17584105 |
| Zhao W et al. | [Effect of PAF on the expression of PACAP mRNA in the granulosa cells of rat ovary]. | 2007 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21180114 |
| Orr Y et al. | Conformational activation of CD11b without shedding of L-selectin on circulating human neutrophils. | 2007 | J. Leukoc. Biol. | pmid:17675559 |
| Bozlu G et al. | Platelet-activating factor antagonist (ABT-491) decreases neuronal apoptosis in neonatal rat model of hypoxic ischemic brain injury. | 2007 | Brain Res. | pmid:17320823 |
| Zhou W et al. | Platelet-activating factor induces ovine fetal pulmonary venous smooth muscle cell proliferation: role of epidermal growth factor receptor transactivation. | 2007 | Am. J. Physiol. Heart Circ. Physiol. | pmid:17322418 |
| Tsutsumi T et al. | Movement of monoglyceride derived from hydrolysis of fluorescence-labeled lyso platelet-activating factor by lysophospholipase C through plasma membranes of porcine kidney epithelial cell line LLC-PK1. | 2007 | Prostaglandins Other Lipid Mediat. | pmid:17259070 |
| Viergutz T and Löhrke B | Role of the platelet-activating factor and its receptor in the proliferative regulation of bovine ovarian granulosa cells. | 2007 | Cell Prolif. | pmid:18021181 |
| Chen Q et al. | The yeast acylglycerol acyltransferase LCA1 is a key component of Lands cycle for phosphatidylcholine turnover. | 2007 | FEBS Lett. | pmid:17996202 |
| Ezoulin MJ et al. | A new acetylcholinesterase inhibitor with anti-PAF activity modulates oxidative stress and pro-inflammatory mediators release in stimulated RAW 264.7 macrophage cells. Comparison with tacrine. | 2007 | Int. Immunopharmacol. | pmid:17996678 |
| Li J et al. | Pharmacological profile of PMS777, a new AChE inhibitor with PAF antagonistic activity. | 2007 | Int. J. Neuropsychopharmacol. | pmid:16426477 |
| Ryan SD et al. | Platelet activating factor-induced neuronal apoptosis is initiated independently of its G-protein coupled PAF receptor and is inhibited by the benzoate orsellinic acid. | 2007 | J. Neurochem. | pmid:17877634 |
| Madsen NJ et al. | Influence of preparative procedures on assay of platelet function and apparent effects of antiplatelet agents. | 2007 | Am. J. Cardiol. | pmid:17697836 |
| Tsoupras AB et al. | Characterization of the de novo biosynthetic enzyme of platelet activating factor, DDT-insensitive cholinephosphotransferase, of human mesangial cells. | 2007 | Mediators Inflamm. | pmid:17710109 |
| Melnikova V and Bar-Eli M | Inflammation and melanoma growth and metastasis: the role of platelet-activating factor (PAF) and its receptor. | 2007 | Cancer Metastasis Rev. | pmid:17721743 |
| Lo GK et al. | What is the potential for overdiagnosis of heparin-induced thrombocytopenia? | 2007 | Am. J. Hematol. | pmid:17722079 |
| Kuckleburg CJ et al. | Expression of phosphorylcholine by Histophilus somni induces bovine platelet aggregation. | 2007 | Infect. Immun. | pmid:17118985 |