Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Hepatitis C, Chronic D019698 12 associated lipids
Coronary Stenosis D023921 6 associated lipids
Aggressive Periodontitis D010520 8 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
Arteriosclerosis Obliterans D001162 8 associated lipids
Encephalitis D004660 15 associated lipids
Thyroiditis, Autoimmune D013967 9 associated lipids
Cholestasis, Intrahepatic D002780 4 associated lipids
Contracture D003286 3 associated lipids
Stomatitis D013280 14 associated lipids
Weight Loss D015431 56 associated lipids
Endotoxemia D019446 27 associated lipids
Blister D001768 16 associated lipids
Memory Disorders D008569 33 associated lipids
Acute Lung Injury D055371 33 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Granulomatosis with Polyangiitis D014890 5 associated lipids
Lupus Nephritis D008181 8 associated lipids
Pancreatitis, Acute Necrotizing D019283 18 associated lipids
Ileal Diseases D007077 3 associated lipids
Ventricular Remodeling D020257 28 associated lipids
Gliosis D005911 6 associated lipids
Neuralgia D009437 28 associated lipids
Pneumonia, Bacterial D018410 16 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Amnesia D000647 12 associated lipids
Tachycardia, Ventricular D017180 9 associated lipids
Hypoxia-Ischemia, Brain D020925 22 associated lipids
Sneezing D012912 6 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Malaria, Falciparum D016778 22 associated lipids
Liver Failure D017093 5 associated lipids
Hepatitis, Alcoholic D006519 5 associated lipids
Helicobacter Infections D016481 21 associated lipids
Gastroesophageal Reflux D005764 10 associated lipids
Mucositis D052016 7 associated lipids
Ileitis D007079 2 associated lipids
Carcinoma, Embryonal D018236 8 associated lipids
Postoperative Hemorrhage D019106 7 associated lipids
Neoplastic Cells, Circulating D009360 5 associated lipids
Corneal Neovascularization D016510 8 associated lipids
Xeroderma Pigmentosum D014983 6 associated lipids
Shock, Cardiogenic D012770 5 associated lipids
Hypertrophy, Right Ventricular D017380 4 associated lipids
Strongylida Infections D017206 5 associated lipids
Enterocolitis, Necrotizing D020345 3 associated lipids
Milk Hypersensitivity D016269 4 associated lipids
Hematoma, Subdural D006408 3 associated lipids
Venous Thrombosis D020246 11 associated lipids
Blood Loss, Surgical D016063 6 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Wang LJ et al. [Role of platelet activating factor in the injury of intestinal immuno-barrier function in young rats]. 2006 Zhongguo Dang Dai Er Ke Za Zhi pmid:16522243
Ding DD et al. [Changes of platelet α-particle membrane protein, platelet activating factor and platelet parameters in patients with hyperuricemia]. 2012 Zhongguo Shi Yan Xue Ye Xue Za Zhi pmid:22541106
Guo NJ et al. [Activation of platelet-neutrophil mediated by platelet-activating factor]. 2005 Zhongguo Shi Yan Xue Ye Xue Za Zhi pmid:15972139
Bao GQ and Ju AZ [Signal pathways of eryptosis-review]. 2009 Zhongguo Shi Yan Xue Ye Xue Za Zhi pmid:19698269
Jia XQ et al. [Changes in coagulation and fibrinolysis in the patients with coronary heart disease in acute period and effect of drug intervention]. 2012 Zhongguo Wei Zhong Bing Ji Jiu Yi Xue pmid:22464576
Shi B et al. [Influence of intensive insulin therapy on the intestinal microcirculatory dysfunction in rats with sepsis]. 2009 Zhongguo Wei Zhong Bing Ji Jiu Yi Xue pmid:19695175
Chen S et al. [Induction effect of platelet-activating factor on Src-suppressed C kinase substrate gene expression in rat pulmonary microvascular endothelial cells]. 2010 Zhongguo Wei Zhong Bing Ji Jiu Yi Xue pmid:20367900
Hao J et al. [Dynamic changes of platelet number in early multiple injury and it is effect on prognosis]. 2003 Zhongguo Wei Zhong Bing Ji Jiu Yi Xue pmid:14552687
Shen ZQ et al. Effect of protopine on cytosolic Ca2+ in rabbit platelets. 1999 Zhongguo Yao Li Xue Bao pmid:10452120
Li SH et al. Effects of platelet-activating factor on rat mesenteric microcirculation. 1990 Zhongguo Yao Li Xue Bao pmid:2104488
Zeng GQ and Rui YC [Inhibitory effect of dauricine on platelet activating factor released from calcimycin-induced mouse peritoneal macrophages]. 1990 Zhongguo Yao Li Xue Bao pmid:2104489
Fu Y and Hu YM Prophylactic effects of tetramethyl pyrazine on mice with endotoxemia and its relationship with platelet-activating factor. 1999 Zhongguo Yao Li Xue Bao pmid:10678147
Yi FX and Guo ZG Platelet-released ADP stabilizes PAF-induced rabbit platelet aggregation by stabilizing intracellular calcium. 1998 Zhongguo Yao Li Xue Bao pmid:10375790
Li SH et al. Pentoxifylline attenuates platelet activating factor-induced permeable edema in isolated perfused guinea pig lungs. 1994 Zhongguo Yao Li Xue Bao pmid:7976374
Zhang M et al. Effects of tetrandrine on rabbit platelet aggregation and platelet activating factor generation. 1995 Zhongguo Yao Li Xue Bao pmid:7660812
Ju DW et al. Inhibitory effects of triazolodiazepine on mouse splenocytes and peritoneal macrophages in vitro. 1994 Zhongguo Yao Li Xue Bao pmid:8010089
Hong JL et al. [Effects of tetrandrine on cytoplasmic free calcium in rat neutrophils]. 1989 Zhongguo Yao Li Xue Bao pmid:2561935
Zeng S and Guo ZG Mepyramine inhibits platelet activating factor-induced rabbit platelet aggregation: role of intracellular histamine. 1997 Zhongguo Yao Li Xue Bao pmid:10072970
Zeng GQ et al. Dauricine and anisodamine inhibited leukotrienes- and platelet activating factor-induced DNA synthesis and proliferation of bovine cerebral microvascular smooth muscle cells in culture. 1993 Zhongguo Yao Li Xue Bao pmid:8249627
Sun DX et al. Platelet activating factor production in bovine cerebral microvascular endothelial cells and its drug inhibition. 1993 Zhongguo Yao Li Xue Bao pmid:8503282