Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mollinedo F et al. | Selective induction of apoptosis in cancer cells by the ether lipid ET-18-OCH3 (Edelfosine): molecular structure requirements, cellular uptake, and protection by Bcl-2 and Bcl-X(L). | 1997 | Cancer Res. | pmid:9102220 |
| Denizot Y et al. | Presence and metabolism of lyso platelet-activating factor in human bone marrow. | 1997 | J Lipid Mediat Cell Signal | pmid:9101422 |
| Kudolo GB et al. | Chronic hyperinsulinemia inhibits platelet-activating factor (PAF) biosynthesis in the rat kidney. | 1997 | J Lipid Mediat Cell Signal | pmid:9101420 |
| Rocha FA et al. | PAF modulates eicosanoids and TNF release in immune-complex arthritis in rats. | 1997 | J Lipid Mediat Cell Signal | pmid:9101418 |
| Matsubara T et al. | Platelet-activating factor (PAF) and PAF acetylhydrolase activity in rat uterus and placenta during the late stages of pregnancy. | 1997 | Biol. Reprod. | pmid:9096869 |
| Byrum RS et al. | Role of the 5-lipoxygenase-activating protein (FLAP) in murine acute inflammatory responses. | 1997 | J. Exp. Med. | pmid:9091580 |
| Yatsu T et al. | Renal effect of YM435, a new dopamine D1 receptor agonist, in anesthetized dogs. | 1997 | Eur. J. Pharmacol. | pmid:9088869 |
| Lin CC and Lin CY | Bronchoconstriction and eosinophil recruitment in guinea pig lungs after platelet activating factor administration. | 1997 | J Asthma | pmid:9088302 |
| Kurose I et al. | Oxidative stress during platelet-activating factor-induced microvascular dysfunction. | 1996 | Microcirculation | pmid:9086452 |
| Kume K et al. | [Study of platelet activating factor by using mouse ontogenic technology]. | 1996 | Nihon Rinsho Meneki Gakkai Kaishi | pmid:9081720 |
| Mori TA et al. | Interactions between dietary fat, fish, and fish oils and their effects on platelet function in men at risk of cardiovascular disease. | 1997 | Arterioscler. Thromb. Vasc. Biol. | pmid:9081682 |
| Mineshita M et al. | Whole-blood incubation method to study neutrophil cytoskeletal dynamics. | 1997 | J. Immunol. Methods | pmid:9075772 |
| Tamura T et al. | Effects of platelet-activating factor on left ventricular performance in dogs. | 1997 | Jpn. Circ. J. | pmid:9070974 |
| Gomez R et al. | Pathogenesis of preterm labor and preterm premature rupture of membranes associated with intraamniotic infection. | 1997 | Infect. Dis. Clin. North Am. | pmid:9067790 |
| Kagoshima M et al. | Effects of Y-24180, a long-acting and potent antagonist to platelet-activating factor, on immediate asthmatic response in guinea pigs. | 1997 | Pharmacology | pmid:9065955 |
| Wang H et al. | Regulation of platelet-activating factor receptor gene expression in vivo by endotoxin, platelet-activating factor and endogenous tumour necrosis factor. | 1997 | Biochem. J. | pmid:9065783 |
| Bauldry SA and Wooten RE | Induction of cytosolic phospholipase A2 activity by phosphatidic acid and diglycerides in permeabilized human neutrophils: interrelationship between phospholipases D and A2. | 1997 | Biochem. J. | pmid:9065750 |
| Odawara M et al. | Ginkgo biloba. | 1997 | Neurology | pmid:9065574 |
| Ishii I et al. | Alanine exchanges of polar amino acids in the transmembrane domains of a platelet-activating factor receptor generate both constitutively active and inactive mutants. | 1997 | J. Biol. Chem. | pmid:9065450 |
| Becker BF et al. | [Interaction of adenosine with leukocytes and thrombocytes]. | 1996 | Z Kardiol | pmid:9064961 |
| Nick JA et al. | Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and FMLP. | 1997 | J. Clin. Invest. | pmid:9062356 |
| Ohkuni H et al. | Purification and partial characterization of a novel human platelet aggregation factor in the extracellular products of Streptococcus mitis, strain Nm-65. | 1997 | FEMS Immunol. Med. Microbiol. | pmid:9061358 |
| Lee YP et al. | Analysis of human lecithin-cholesterol acyltransferase activity by carboxyl-terminal truncation. | 1997 | Biochim. Biophys. Acta | pmid:9059515 |
| Bussolino F et al. | Role of soluble mediators in angiogenesis. | 1996 | Eur. J. Cancer | pmid:9059328 |
| Yousefi S et al. | Platelet-activating factor and the production of human interferon-gamma. | 1997 | J. Interferon Cytokine Res. | pmid:9058317 |
| Abu-Zidan FM et al. | Role of platelet-activating factor on cardiovascular dysfunction in postischemic shock in pigs. | 1997 | Eur Surg Res | pmid:9058081 |
| Anderson MR and Blumer JL | Advances in the therapy for sepsis in children. | 1997 | Pediatr. Clin. North Am. | pmid:9057790 |
| Clinical studies of IL-11, new platelet growth factor, presented. | 1997 | Oncology (Williston Park, N.Y.) | pmid:9057177 | |
| Collins LC and Roberts AM | Effects of platelet-activating factor on arteriolar and venular tone in rat trachea. | 1997 | Microvasc. Res. | pmid:9056476 |
| Forde RC and Fitzgerald DJ | Reactive oxygen species and platelet activation in reperfusion injury. | 1997 | Circulation | pmid:9054729 |
| Rodriguez-Barbero A et al. | Involvement of platelet-activating factor in gentamicin nephrotoxicity in rats. | 1997 Jan-Feb | Exp. Nephrol. | pmid:9052848 |
| Gruska S et al. | Prevalence of increased intracellular signal transduction in immortalized lymphoblasts from patients with essential hypertension and normotensive subjects. | 1997 | J. Hypertens. | pmid:9050967 |
| Lin CH et al. | The effect of the selective PAF antagonist CIS-19 on PAF- and antigen-induced bronchoconstriction, microvascular leakage and bronchial hyperreactivity in guinea-pigs. | 1997 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:9050014 |
| Saitoh C et al. | Effect of YM934, a KATP channel opener, on airway hyperresponsiveness induced by platelet activating factor in guinea-pigs. | 1997 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:9050013 |
| Chang TW | Improvement of survival from hemorrhagic shock by enterectomy in rats: finding to implicate the role of the gut for irreversibility of hemorrhagic shock. | 1997 | J Trauma | pmid:9042872 |
| Bonaccorsi L et al. | Protein tyrosine kinase, mitogen-activated protein kinase and protein kinase C are involved in the mitogenic signaling of platelet-activating factor (PAF) in HEC-1A cells. | 1997 | Biochim. Biophys. Acta | pmid:9042336 |
| Dohi T et al. | Stimulation of platelet-activating factor synthesis by neurotransmitters in salivary glands. | 1997 | J. Dent. Res. | pmid:9042079 |
| Feuerstein G et al. | Platelet-activating factor and cardiac diseases: therapeutic potential for PAF inhibitors. | 1997 | J Lipid Mediat Cell Signal | pmid:9041476 |
| Izzo AA and Benveniste J | Presence of paf-acether in human blood after thin-layer chromatography, but not after high-performance liquid chromatography purification. | 1996 | J Pharmacol Toxicol Methods | pmid:9040113 |
| Brzustowicz LM et al. | Linkage analysis using platelet-activating factor Ca2+ response in transformed lymphoblasts. | 1997 | Hypertension | pmid:9039096 |
| Rainger GE et al. | Endothelial-borne platelet-activating factor and interleukin-8 rapidly immobilize rolling neutrophils. | 1997 | Am. J. Physiol. | pmid:9038929 |
| Barden A et al. | Neutrophil CD11B expression and neutrophil activation in pre-eclampsia. | 1997 | Clin. Sci. | pmid:9038589 |
| Le Gouill C et al. | Role of the Cys90, Cys95 and Cys173 residues in the structure and function of the human platelet-activating factor receptor. | 1997 | FEBS Lett. | pmid:9037196 |
| Morozova NG et al. | [Synthesis of cationic alkylglucosides]. | 1996 Oct-Nov | Bioorg. Khim. | pmid:9036840 |
| Massicot F et al. | Preventive effects of two PAF-antagonists, PMS 536 and PMS 549, on cyclosporin-induced LLC-PK1 oxidative injury. | 1997 | J Lipid Mediat Cell Signal | pmid:9034965 |
| Heymans F et al. | Design and modeling of new platelet-activating factor antagonists. 3. Relative importance of hydrophobicity and electronic distribution in piperazinic series. | 1997 | J Lipid Mediat Cell Signal | pmid:9034962 |
| Tavet F et al. | Design and modeling of new platelet-activating factor antagonists. 2. Synthesis and biological activity of 1,4-bis-(3',4',5'-trimethoxybenzoyl)-2-alkyl and 2-alkyloxymethylpiperazines. | 1997 | J Lipid Mediat Cell Signal | pmid:9034961 |
| Binisti C et al. | Structure-activity relationships in platelet activating factor. 9. From PAF-antagonism to PLA2 inhibition. | 1997 | J Lipid Mediat Cell Signal | pmid:9034960 |
| Herbert JM et al. | Effect of SR 27417, a novel PAF antagonist on antigen-induced hypotension in the rat. | 1997 | J Lipid Mediat Cell Signal | pmid:9034959 |
| Yoshikawa T et al. | Role of superoxide and nitric oxide in platelet-activating factor-induced acute lung injury, hypotension, and mortality in rats. | 1997 | Crit. Care Med. | pmid:9034266 |
| Herbertson MJ et al. | Platelet-activating factor antagonism improves ventricular contractility in endotoxemia. | 1997 | Crit. Care Med. | pmid:9034254 |
| Hotter G et al. | Free radical enhancement promotes leucocyte recruitment through a PAF and LTB4 dependent mechanism. | 1997 | Free Radic. Biol. Med. | pmid:9034233 |
| Koenderman L | Priming of circulating human eosinophils following late response to allergen challenge. | 1997 | Eur. Respir. J. | pmid:9032524 |
| Karpouza AP and Vakirtzi-Lemonias C | The platelet-activating factor acetylhydrolase of mouse platelets. | 1997 | Biochim. Biophys. Acta | pmid:9030208 |
| Comminges C et al. | Studies on ether-phospholipids of vascular smooth muscle cells. Identification of a rapid Ca(2+)-dependent hydrolysis of alkyl-phosphatidylethanolamine promoted by endothelin-l. | 1997 | Biochim. Biophys. Acta | pmid:9030203 |
| Packham MA et al. | Exogenous diacylglycerols synergize with PAF with human platelets, but inhibit PAF-induced responses of rabbit platelets. | 1996 | J Lipid Mediat Cell Signal | pmid:9029375 |
| Bleivik B et al. | Protein kinase C inhibitors and PAF stimulate phosphatidylserine synthesis in human leucocytes. | 1996 | J Lipid Mediat Cell Signal | pmid:9029372 |
| Denizot Y et al. | PAF and haematopoiesis: IX. Platelet-activating factor increases DNA synthesis in human bone marrow cells. | 1996 | J Lipid Mediat Cell Signal | pmid:9029369 |
| He J et al. | Micellar electrokinetic capillary chromatographic analysis of platelet activating factor in human blood by indirect ultraviolet detection. | 1996 | Ann. Ist. Super. Sanita | pmid:9028060 |
| Vlasova II et al. | [Effect of a micellar preparation of polyunsaturated phosphatidylcholine on platelet aggregation in vitro]. | 1996 | Biull Eksp Biol Med | pmid:9026131 |
| Riera M et al. | Neutrophils accentuate renal cold ischemia-reperfusion injury. Dose-dependent protective effect of a platelet-activating factor receptor antagonist. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9023292 |
| Lee DR et al. | Induction of acrosome reaction in human spermatozoa accelerates the time of pronucleus formation of hamster oocytes after intracytoplasmic sperm injection. | 1997 | Fertil. Steril. | pmid:9022609 |
| Fukuda AI and Breuel KF | Effect of platelet activating factor on embryonic development and implantation in the mouse. | 1996 | Hum. Reprod. | pmid:9021383 |
| Bazan NG et al. | Bioactive lipids in excitatory neurotransmission and neuronal plasticity. | 1997 | Neurochem. Int. | pmid:9017670 |
| Ohmori T et al. | In vitro hypoxia of cortical and hippocampal CA1 neurons: glutamate, nitric oxide, and platelet activating factor participate in the mechanism of selective neural death in CA1 neurons. | 1996 | Brain Res. | pmid:9017237 |
| Carlson SA et al. | Lack of constitutive activation or inactivation of the platelet-activating factor receptor by glutamate substitution of alanine 230. | 1996 | Recept Signal Transduct | pmid:9015866 |
| Maclennan KM et al. | Platelet-activating factor in the CNS. | 1996 | Prog. Neurobiol. | pmid:9015828 |
| Chakrabarti R et al. | Alteration of platelet-activating factor-induced signal transduction in macrophages by n-3 fatty acids. | 1997 | Cell. Immunol. | pmid:9015191 |
| Camussi G et al. | Angiogenesis induced in vivo by hepatocyte growth factor is mediated by platelet-activating factor synthesis from macrophages. | 1997 | J. Immunol. | pmid:9013973 |
| Ishii S et al. | Bronchial hyperreactivity, increased endotoxin lethality and melanocytic tumorigenesis in transgenic mice overexpressing platelet-activating factor receptor. | 1997 | EMBO J. | pmid:9009274 |
| Ohyama T et al. | Sensitive densitometry for the determination of platelet-activating factor and other phospholipids in human tears. | 1996 | Analyst | pmid:9008409 |
| Souza-Fiho MV et al. | Involvement of nitric oxide in the pathogenesis of cyclophosphamide-induced hemorrhagic cystitis. | 1997 | Am. J. Pathol. | pmid:9006340 |
| Vavilova GL et al. | [The role of the thrombocyte-activating factor in inhibiting Na+,K(+)-ATPase in different tissues after ischemia and reperfusion of the small intestine]. | 1996 Mar-Apr | Ukr. Biokhim. Zh. | pmid:9005660 |
| O'Neill C | Evidence for the requirement of autocrine growth factors for development of mouse preimplantation embryos in vitro. | 1997 | Biol. Reprod. | pmid:9002654 |
| Dagenais P et al. | Augmented expression of platelet-activating factor receptor gene by TNF-alpha through transcriptional activation in human monocytes. | 1997 | J. Leukoc. Biol. | pmid:9000543 |
| Sugatani J et al. | High-density lipoprotein inhibits the synthesis of platelet-activating factor in human vascular endothelial cells. | 1996 | J Lipid Mediat Cell Signal | pmid:8998599 |
| Merlos M et al. | Rupatadine, a new potent, orally active dual antagonist of histamine and platelet-activating factor (PAF). | 1997 | J. Pharmacol. Exp. Ther. | pmid:8996188 |
| Misra UK et al. | Up-regulation of the alpha2-macroglobulin signaling receptor on rheumatoid synovial fibroblasts. | 1997 | J. Biol. Chem. | pmid:8995289 |
| Tuomanen EI | Molecular and cellular mechanisms of pneumococcal meningitis. | 1996 | Ann. N. Y. Acad. Sci. | pmid:8993350 |
| Laniyonu AA et al. | Endotoxin-induced microvascular leakage is prevented by a PAF antagonist and NO synthase inhibitor. | 1997 | Shock | pmid:8989836 |
| Ohtani N and Asano G | [Purification and partial characterization of a novel human platelet aggregation factor in the extracellular products of Streptococcus mitis, strain Nm-65]. | 1996 | Nippon Ika Daigaku Zasshi | pmid:8987363 |
| Ferreira MG and Fonteles MC | Different classes of PAF-antagonists block norepinephrine-induced vascular escape and tachyphylaxis in the isolated rabbit kidney. | 1996 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:8987112 |
| de Boissieu D et al. | Effect of BN 50727 on pathological findings and tissue platelet activating factor levels during ileal ischemia in newborn piglets. | 1996 | J. Pediatr. Surg. | pmid:8986985 |
| Michibayashi T | [Vascular responsiveness of platelet activating factor--with special reference to its action in the presence of platelets]. | 1996 | J Smooth Muscle Res | pmid:8985919 |
| MonteseirÃn J et al. | Formation of lipids, peptides and cytokines. | 1996 Sep-Oct | Allergol Immunopathol (Madr) | pmid:8985477 |
| Ho YS et al. | Brain acetylhydrolase that inactivates platelet-activating factor is a G-protein-like trimer. | 1997 | Nature | pmid:8985254 |
| Dentener MA et al. | Bactericidal/permeability-increasing protein release in whole blood ex vivo: strong induction by lipopolysaccharide and tumor necrosis factor-alpha. | 1997 | J. Infect. Dis. | pmid:8985203 |
| Williams FM | Neutrophils and myocardial reperfusion injury. | 1996 | Pharmacol. Ther. | pmid:8981567 |
| Anderson R et al. | Membrane-stabilizing, anti-inflammatory interactions of macrolides with human neutrophils. | 1996 | Inflammation | pmid:8979156 |
| Sugano M et al. | Structure-activity relationships of phomactin derivatives as platelet activating factor antagonists. | 1996 | J. Med. Chem. | pmid:8978857 |
| Bkaily G et al. | Modulation of cardiac cell Ca2+ currents by PAF. | 1996 | Blood Press Suppl | pmid:8973773 |
| Terada N et al. | The effect of anti-VLA-4 monoclonal antibody on eosinophil accumulation and leukotriene production in nasal mucosa. | 1996 | Acta Otolaryngol. | pmid:8973726 |
| Tokumura A et al. | Lipid peroxidation in low density lipoproteins from human plasma and egg yolk promotes accumulation of 1-acyl analogues of platelet-activating factor-like lipids. | 1996 | Lipids | pmid:8972457 |
| Liu L et al. | Transmigration of human neutrophils across airway epithelial cell monolayers is preferentially in the physiologic basolateral-to-apical direction. | 1996 | Am. J. Respir. Cell Mol. Biol. | pmid:8969272 |
| West RR et al. | ZG-1494 alpha, a novel platelet-activating factor acetyltransferase inhibitor from Penicillium rubrum, isolation, structure elucidation andbiological activity. | 1996 | J. Antibiot. | pmid:8968388 |
| Despotis GJ et al. | Evaluation of a new point-of-care test that measures PAF-mediated acceleration of coagulation in cardiac surgical patients. | 1996 | Anesthesiology | pmid:8968178 |
| Sagara H et al. | Theophylline at therapeutic concentration suppresses PAF-induced upregulation of Mac-1 on human eosinophils. | 1996 | Clin. Exp. Allergy | pmid:8963871 |
| Roudebush WE et al. | Effect of platelet-activating factor (PAF) on preimplantation mouse B6D2F1/J embryo formation. | 1996 | Am. J. Reprod. Immunol. | pmid:8962660 |
| Minhas BS et al. | Platelet activating factor and conception. | 1996 | Am. J. Reprod. Immunol. | pmid:8962659 |
| Izzo AA | PAF and the digestive tract. A review. | 1996 | J. Pharm. Pharmacol. | pmid:8961155 |