Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Pulmonary Edema D011654 23 associated lipids
Coronary Disease D003327 70 associated lipids
Intestinal Obstruction D007415 6 associated lipids
Pancreatitis D010195 10 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Hypersensitivity D006967 22 associated lipids
Osteosarcoma D012516 50 associated lipids
Rhinitis D012220 10 associated lipids
Arterial Occlusive Diseases D001157 12 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Wang M et al. The Responses of Pulmonary and Systemic Circulation and Airway to Allergic Mediators in Anesthetized Rats. 2016 Biol. Pharm. Bull. pmid:27040628
Carretta MD et al. Butyric acid stimulates bovine neutrophil functions and potentiates the effect of platelet activating factor. 2016 Vet. Immunol. Immunopathol. pmid:27288853
Liu R et al. Pyruvate in oral rehydration salt improves hemodynamics, vasopermeability and survival after burns in dogs. 2016 Burns pmid:27130433
Grambow E et al. Differential effects of endogenous, phyto and synthetic cannabinoids on thrombogenesis and platelet activity. 2016 Biofactors pmid:27151562
Eleftheriou K et al. Comparative Experimental and Computational Study of Monoalkyl Chain Phosphatidylcholine-Containing Thermoresponsive Liposomes. 2016 J Phys Chem B pmid:27280363
Megson IL et al. Lipids and cardiovascular disease: where does dietary intervention sit alongside statin therapy? 2016 Food Funct pmid:27109548
Farbman KS and Michelson KA Anaphylaxis in children. 2016 Curr. Opin. Pediatr. pmid:26963947
Sahu RP et al. Radiation therapy generates platelet-activating factor agonists. 2016 Oncotarget pmid:26959112
Nel JG et al. Pneumolysin Mediates Platelet Activation In Vitro. 2016 Lung pmid:27192991
Silva-Herdade AS et al. Erythrocyte deformability - A partner of the inflammatory response. 2016 Microvasc. Res. pmid:27142964
Quinn RA et al. Metabolomics of reef benthic interactions reveals a bioactive lipid involved in coral defence. 2016 Proc. Biol. Sci. pmid:27122568
Lecewicz M et al. Effects of the platelet-activating factor (PAF) on selected quality parameters of cryopreserved bull semen (AI) with reduced sperm motility. 2016 Pol J Vet Sci pmid:27096799
Damiani E and Ullrich SE Understanding the connection between platelet-activating factor, a UV-induced lipid mediator of inflammation, immune suppression and skin cancer. 2016 Prog. Lipid Res. pmid:27073146
Jacob SP et al. Lipopolysaccharide Cross-Tolerance Delays Platelet-Activating Factor-Induced Sudden Death in Swiss Albino Mice: Involvement of Cyclooxygenase in Cross-Tolerance. 2016 PLoS ONE pmid:27064683
Eser A et al. Levels of thrombin-activatable fibrinolysis inhibitor and platelet-activating factor in recurrent pregnancy loss patients. 2016 Taiwan J Obstet Gynecol pmid:26927250
Guequén A et al. S-nitrosylation regulates VE-cadherin phosphorylation and internalization in microvascular permeability. 2016 Am. J. Physiol. Heart Circ. Physiol. pmid:26921435
Wang Y et al. Attenuated Reactive Gliosis and Enhanced Functional Recovery Following Spinal Cord Injury in Null Mutant Mice of Platelet-Activating Factor Receptor. 2016 Mol. Neurobiol. pmid:26084439
Yan W et al. BN52021 protects rat cardiomyocyte from doxorubicin induced cardiotoxicity. 2015 Int J Clin Exp Pathol pmid:25973059
Kim YH et al. SIRT1 attenuates PAF-induced MMP-2 production via down-regulation of PAF receptor expression in vascular smooth muscle cells. 2015 Vascul. Pharmacol. pmid:25967595
Armant DR Intracellular Ca2+ signaling and preimplantation development. 2015 Adv. Exp. Med. Biol. pmid:25956298
Puebla-Osorio N et al. Platelet-activating factor induces cell cycle arrest and disrupts the DNA damage response in mast cells. 2015 Cell Death Dis pmid:25950475
Sahu RP et al. Systemic chemotherapy is modulated by platelet-activating factor-receptor agonists. 2015 Mediators Inflamm. pmid:25922565
Shida-Sakazume T et al. Lysophosphatidylcholine acyltransferase1 overexpression promotes oral squamous cell carcinoma progression via enhanced biosynthesis of platelet-activating factor. 2015 PLoS ONE pmid:25803864
Lautenschläger I et al. Quinidine, but not eicosanoid antagonists or dexamethasone, protect the gut from platelet activating factor-induced vasoconstriction, edema and paralysis. 2015 PLoS ONE pmid:25793535
Bate C and Williams A α-Synuclein-induced synapse damage in cultured neurons is mediated by cholesterol-sensitive activation of cytoplasmic phospholipase A2. 2015 Biomolecules pmid:25761116
Sahu RP Expression of the platelet-activating factor receptor enhances benzyl isothiocyanate-induced apoptosis in murine and human melanoma cells. 2015 Mol Med Rep pmid:25695262
Reznichenko A and Korstanje R The role of platelet-activating factor in mesangial pathophysiology. 2015 Am. J. Pathol. pmid:25655028
Jeewandara C et al. Platelet activating factor contributes to vascular leak in acute dengue infection. 2015 PLoS Negl Trop Dis pmid:25646838
Valli A et al. Hypoxia induces a lipogenic cancer cell phenotype via HIF1α-dependent and -independent pathways. 2015 Oncotarget pmid:25605240
Yamaguchi M et al. A platelet-activating factor (PAF) receptor deficiency exacerbates diet-induced obesity but PAF/PAF receptor signaling does not contribute to the development of obesity-induced chronic inflammation. 2015 Biochem. Pharmacol. pmid:25577975
Johnson M et al. Levocetirizine and rupatadine in chronic idiopathic urticaria. 2015 Int. J. Dermatol. pmid:25521304
Kim H et al. Higher plasma platelet-activating factor levels are associated with increased risk of vertebral fracture and lower bone mineral density in postmenopausal women. 2015 J. Bone Miner. Metab. pmid:25501698
Mullol J et al. Update on rupatadine in the management of allergic disorders. 2015 Allergy pmid:25491409
Zhao YM and Maimone TJ Short, enantioselective total synthesis of chatancin. 2015 Angew. Chem. Int. Ed. Engl. pmid:25470723
Kattan JD and Sicherer SH Optimizing the diagnosis of food allergy. 2015 Immunol Allergy Clin North Am pmid:25459577
Huang JF et al. Protective effect of high concentration of BN52021 on retinal contusion in cat eyes. 2015 BMC Ophthalmol pmid:25956877
Sun L et al. PAF receptor antagonist Ginkgolide B inhibits tumourigenesis and angiogenesis in colitis-associated cancer. 2015 Int J Clin Exp Pathol pmid:25755731
Wang Y et al. Aqueous extract of Rabdosia rubescens leaves: forming nanoparticles, targeting P-selectin, and inhibiting thrombosis. 2015 Int J Nanomedicine pmid:26604756
Ohshima N et al. New members of the mammalian glycerophosphodiester phosphodiesterase family: GDE4 and GDE7 produce lysophosphatidic acid by lysophospholipase D activity. 2015 J. Biol. Chem. pmid:25528375
van Doorn R and de Gruijl F Chromatin Modifications and Mast Cell Migration in UV-Induced Immunosuppression, an Epigenetic Piece of The Puzzle. 2015 J. Invest. Dermatol. pmid:26569583
Pałgan K and Bartuzi Z Platelet activating factor in allergies. 2015 Int J Immunopathol Pharmacol pmid:26486136
Hergott CB et al. Bacterial exploitation of phosphorylcholine mimicry suppresses inflammation to promote airway infection. 2015 J. Clin. Invest. pmid:26426079
Speciani AF and Piuri G Measuring Biomarkers for an Innovative Personal Food Profile. 2015 J Am Coll Nutr pmid:26400432
Pei HX et al. Ginkgolide B Reduces the Degradation of Membrane Phospholipids to Prevent Ischemia/Reperfusion Myocardial Injury in Rats. 2015 Pharmacology pmid:26382046
Tiniakou I et al. Natural human apoA-I mutations L141RPisa and L159RFIN alter HDL structure and functionality and promote atherosclerosis development in mice. 2015 Atherosclerosis pmid:26363436
Vlachogianni IC et al. Platelet Activating Factor (PAF) biosynthesis is inhibited by phenolic compounds in U-937 cells under inflammatory conditions. 2015 Prostaglandins Other Lipid Mediat. pmid:26358846
Sato A et al. Angiotensin peptides attenuate platelet-activating factor-induced inflammatory activity in rats. 2015 Peptides pmid:26348270
Damiani E et al. Platelet-Activating Factor Induces Epigenetic Modifications in Human Mast Cells. 2015 J. Invest. Dermatol. pmid:26316070
Starossom SC et al. Platelets Play Differential Role During the Initiation and Progression of Autoimmune Neuroinflammation. 2015 Circ. Res. pmid:26294656
de Oliveira MC et al. Platelet-activating factor modulates fat storage in the liver induced by a high-refined carbohydrate-containing diet. 2015 J. Nutr. Biochem. pmid:26013469