| MeSH term | MeSH ID | Detail |
|---|---|---|
| Pulmonary Edema | D011654 | 23 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Intestinal Obstruction | D007415 | 6 associated lipids |
| Pancreatitis | D010195 | 10 associated lipids |
| Liver Cirrhosis, Experimental | D008106 | 36 associated lipids |
| Hypersensitivity | D006967 | 22 associated lipids |
| Osteosarcoma | D012516 | 50 associated lipids |
| Rhinitis | D012220 | 10 associated lipids |
| Arterial Occlusive Diseases | D001157 | 12 associated lipids |
| Leukemia, Erythroblastic, Acute | D004915 | 41 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Bailey SR et al. | Actions and interactions of ADP, 5- HT, histamine and PAF on equine platelets. | 2000 | Res. Vet. Sci. | pmid:10756136 |
| Cijevschi I and Cijevschi D | [Ocular immunopathological characteristics and the involvement of the platelet-aggregation factor and the anti-PAF at the level of the eye]. | 1999 Jan-Jun | Rev Med Chir Soc Med Nat Iasi | pmid:10756889 |
| Liao CH et al. | Antiplatelet effect of marchantinquinone, isolated from Reboulia hemisphaerica, in rabbit washed platelets. | 2000 | J. Pharm. Pharmacol. | pmid:10757426 |
| Kalia N et al. | Mechanisms of Helicobacter pylori-induced rat gastric mucosal microcirculatory disturbances in vivo. | 2000 | Dig. Dis. Sci. | pmid:10759248 |
| Triggiani M et al. | Metabolism of lipid mediators in human eosinophils. | 2000 | Chem. Immunol. | pmid:10761306 |
| Emerson M et al. | Characterization and functional significance of calcium transients in the 2-cell mouse embryo induced by an autocrine growth factor. | 2000 | J. Biol. Chem. | pmid:10764773 |
| Munakata M et al. | Nafamostat mesilate modulates the release of platelet-activating factor during left ventricular assistance with hemofiltration in canine heart failure. | 2000 | Jpn. J. Thorac. Cardiovasc. Surg. | pmid:10769990 |
| Connolly AB and Vernon DR | Manipulations of the metabolic response for management of patients with severe surgical illness: review. | 2000 | World J Surg | pmid:10773122 |
| Bastos da Silva M et al. | In vitro inhibitory effect of SR 27417, a potent platelet-activating factor (PAF) receptor antagonist, on the PAF-induced bovine platelet aggregation. | 2000 Mar-Apr | Vet. Res. | pmid:10779205 |
| Lagente V et al. | Effects of the platelet activating factor antagonists BN 52021 and BN 50730 on antigen-induced bronchial hyperresponsiveness and eosinophil infiltration in lung from sensitized guinea-pigs. | 1993 | Clin. Exp. Allergy | pmid:10779293 |
| Sehmi R et al. | Interleukin-8 is a chemo-attractant for eosinophils purified from subjects with a blood eosinophilia but not from normal healthy subjects. | 1993 | Clin. Exp. Allergy | pmid:10779297 |
| Shute J | Signal transduction mechanisms in human eosinophils. | 1993 | Clin. Exp. Allergy | pmid:10779300 |
| Hauser CJ et al. | Major trauma enhances store-operated calcium influx in human neutrophils. | 2000 | J Trauma | pmid:10780589 |
| Yamada Y et al. | Correlations between plasma platelet-activating factor acetylhydrolase (PAF-AH) activity and PAF-AH genotype, age, and atherosclerosis in a Japanese population. | 2000 | Atherosclerosis | pmid:10781653 |
| Smith J et al. | Differences in gene density on chicken macrochromosomes and microchromosomes. | 2000 | Anim. Genet. | pmid:10782207 |
| Friedman E et al. | Effect of hydrocortisone on platelet activating factor induced lung edema in isolated rabbit lungs. | 2000 | Respir Physiol | pmid:10786645 |
| Asai Y et al. | A temperature study on critical micellization concentration of the novel platelet-activating factor receptor antagonist E5880 in water by electric conductivity measurements. | 2000 | Drug Dev Ind Pharm | pmid:10789068 |
| Oshiro T et al. | Characterization of platelet-activating factor-induced cytosolic calcium mobilization in human eosinophils. | 2000 | Clin. Exp. Allergy | pmid:10792362 |
| Asai Y and Watanabe S | Characterization of the physicochemical properties of the micelles by the novel platelet activating factor receptor antagonist E5880. | 2000 | Eur J Pharm Biopharm | pmid:10799812 |
| Balsinde J et al. | Cellular regulation of cytosolic group IV phospholipase A2 by phosphatidylinositol bisphosphate levels. | 2000 | J. Immunol. | pmid:10799904 |
| Dearn S et al. | Activation of platelet-activating factor (PAF) receptor stimulates nitric oxide (NO) release via protein kinase C-alpha in HEC-1B human endometrial epithelial cell line. | 2000 | Mol. Med. | pmid:10803407 |
| Kosaka T et al. | Spectrophotometric assay for serum platelet-activating factor acetylhydrolase activity. | 2000 | Clin. Chim. Acta | pmid:10807978 |
| Kulikov VI and Muzya GI | Bioactive amide of prostaglandin E1 and ethanolamine plasmalogen analog of platelet-activating factor inhibits several pathways of human platelet aggregation. | 2000 | Biochemistry Mosc. | pmid:10810178 |
| Shindou H et al. | Roles of cytosolic phospholipase A(2) and platelet-activating factor receptor in the Ca-induced biosynthesis of PAF. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10814544 |
| Luu NT et al. | Differential ability of exogenous chemotactic agents to disrupt transendothelial migration of flowing neutrophils. | 2000 | J. Immunol. | pmid:10820279 |
| Sugatani J et al. | Inhibition of rabbit platelet aggregation by nucleoside 5'-alkylphosphates: correlation with inhibition of agonist-induced calcium influx. | 2000 | Biochem. Pharmacol. | pmid:10825464 |
| Ohishi S | [Evaluation of time course and inter-relationship of inflammatory mediators in experimental inflammatory reaction]. | 2000 | Yakugaku Zasshi | pmid:10825809 |
| Asai Y et al. | Characterization of the physicochemical properties of the micelles of platelet-activating factor (C18:0). | 2000 | Drug Dev Ind Pharm | pmid:10826115 |
| Tokumura A et al. | Structural identification of phosphatidylcholines having an oxidatively shortened linoleate residue generated through its oxygenation with soybean or rabbit reticulocyte lipoxygenase. | 2000 | J. Lipid Res. | pmid:10828088 |
| Mizutani Y et al. | Cloning and expression of rat neutral sphingomyelinase: enzymological characterization and identification of essential histidine residues. | 2000 | Biochim. Biophys. Acta | pmid:10832103 |
| Serradji N et al. | Structure-activity relationships in platelet-activating factor (PAF). 10. From PAF antagonism to inhibition of HIV-1 replication. | 2000 | J. Med. Chem. | pmid:10841793 |
| Ma X and Bazan HE | Increased platelet-activating factor receptor gene expression by corneal epithelial wound healing. | 2000 | Invest. Ophthalmol. Vis. Sci. | pmid:10845588 |
| Kobayashi N et al. | Transepithelial migration of activated eosinophils induces a decrease of E-cadherin expression in cultured human nasal epithelial cells. | 2000 | Clin. Exp. Allergy | pmid:10848899 |
| Poveshchenko AF and Kozlov VA | [The effect of platelet-activating factor and its antagonist--BN 52021--on immune reactions in vivo in mice and in vitro]. | 1999 Jul-Aug | Zh. Mikrobiol. Epidemiol. Immunobiol. | pmid:10852052 |
| Fukuyama S et al. | Effect of eotaxin and platelet-activating factor on airway inflammation and hyperresponsiveness in guinea pigs in vivo. | 2000 | Am. J. Respir. Crit. Care Med. | pmid:10852755 |
| Zhu X et al. | A surrogate method for assessment of beta(2)-integrin-dependent adhesion of human eosinophils to ICAM-1. | 2000 | J. Immunol. Methods | pmid:10854610 |
| Caslake MJ et al. | Lipoprotein-associated phospholipase A(2), platelet-activating factor acetylhydrolase: a potential new risk factor for coronary artery disease. | 2000 | Atherosclerosis | pmid:10856534 |
| Nakajima T et al. | Phospholipase A2-mediated superoxide production of murine peritoneal macrophages induced by chrysotile stimulation. | 2000 | Int. J. Biochem. Cell Biol. | pmid:10856708 |
| Denizot Y et al. | Effect of cytokines and lipid mediators on the synthesis of interleukin 1 beta by human bone marrow stromal cells. | 2000 | Cytokine | pmid:10857767 |
| Huo LJ and Yang ZM | Effects of platelet activating factor on capacitation and acrosome reaction in mouse spermatozoa. | 2000 | Mol. Reprod. Dev. | pmid:10862011 |
| Cavallo-Perin P et al. | Increased blood levels of platelet-activating factor in insulin-dependent diabetic patients with microalbuminuria. | 2000 | Nephrol. Dial. Transplant. | pmid:10862637 |
| Bae K et al. | Platelet-activating factor (PAF)-dependent transacetylase and its relationship with PAF acetylhydrolases. | 2000 | J. Biol. Chem. | pmid:10867005 |
| Alappatt C et al. | Acute keratinocyte damage stimulates platelet-activating factor production. | 2000 | Arch. Dermatol. Res. | pmid:10867814 |
| Suzuki S et al. | The roles of platelet-activating factor and endothelin-1 in renal damage after total hepatic ischemia and reperfusion. | 2000 | Transplantation | pmid:10868624 |
| Xu H et al. | Platelet-activating factor acetylhydrolase gene mutation in Japanese children with Escherichia coli O157-associated hemolytic uremic syndrome. | 2000 | Am. J. Kidney Dis. | pmid:10873870 |
| Viswanath M et al. | Reduction of hypoxic-ischemic brain swelling in the neonatal rat with PAF antagonist WEB 2170: lack of long-term protection. | 2000 | Pediatr. Res. | pmid:10879808 |
| Kusuhara H et al. | Y-24180, an antagonist of platelet-activating factor, suppresses interleukin 5 production in cultured murine th(2)cells and human peripheral blood mononuclear cells. | 2000 | Cytokine | pmid:10880261 |
| Tektonidou MG et al. | Clinical importance of antibodies against platelet activating factor in antiphospholipid syndrome manifestations. | 2000 | Eur. J. Clin. Invest. | pmid:10886305 |
| Aihara M et al. | Interaction between neurone and microglia mediated by platelet-activating factor. | 2000 | Genes Cells | pmid:10886367 |
| Dent G et al. | Involvement of protein tyrosine kinases in activation of human eosinophils by platelet-activating factor. | 2000 | Immunology | pmid:10886400 |
| Folch E et al. | H(2)O(2) and PARS mediate lung P-selectin upregulation in acute pancreatitis. | 2000 | Free Radic. Biol. Med. | pmid:10889459 |
| Bailey SR et al. | Differential activation of platelets from normal and allergic ponies by PAF and ADP. | 2000 | Inflamm. Res. | pmid:10893045 |
| Lee YM et al. | Platelet-activating factor contributes to acute lung leak in rats given interleukin-1 intratracheally. | 2000 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:10893205 |
| Rose F et al. | E. coli hemolysin-induced lipid mediator metabolism in alveolar macrophages: impact of eicosapentaenoic acid. | 2000 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:10893208 |
| Hu L et al. | Alkyl and alkoxycarbonyl derivatives of ginkgolide B: synthesis and biological evaluation of PAF inhibitory activity. | 2000 | Bioorg. Med. Chem. | pmid:10896127 |
| Parkman HP et al. | The contractile action of platelet-activating factor on gallbladder smooth muscle. | 2000 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:10898747 |
| Clark GD et al. | Neuronal platelet-activating factor receptor signal transduction involves a pertussis toxin-sensitive G-protein. | 2000 | Neurochem. Res. | pmid:10905621 |
| Wang JH and Sun GY | Platelet activating factor (PAF) antagonists on cytokine induction of iNOS and sPLA2 in immortalized astrocytes (DITNC). | 2000 | Neurochem. Res. | pmid:10905622 |
| Baker RR | Lipid acetylation reactions and the metabolism of platelet-activating factor. | 2000 | Neurochem. Res. | pmid:10905630 |
| Francescangeli E et al. | Properties and regulation of microsomal PAF-synthesizing enzymes in rat brain cortex. | 2000 | Neurochem. Res. | pmid:10905633 |
| Parrish PR and Larson DF | Pharmacological effect of nitroprusside on platelet aggregation. | 1999 | J Extra Corpor Technol | pmid:10915472 |
| Unno N et al. | Plasma platelet-activating factor acetylhydrolase deficiency is associated with atherosclerotic occlusive disease in japan. | 2000 | J. Vasc. Surg. | pmid:10917985 |
| Hu GL and Guo HS | [Progress in platelet-activating factor receptor research]. | 1997 | Sheng Li Ke Xue Jin Zhan | pmid:10921090 |
| Choi JH et al. | Selective involvement of reactive oxygen intermediates in platelet-activating factor-mediated activation of NF-kappaB. | 2000 | Inflammation | pmid:10921504 |
| Smalley DM et al. | The local effect of PAF on leukocyte adherence to small bowel mesenteric venules following intra-abdominal contamination. | 2000 | Inflammation | pmid:10921505 |
| O'Brien JG et al. | Effects of tranexamic acid and aprotinin, two antifibrinolytic drugs, on PAF-induced plasma extravasation in unanesthetized rats. | 2000 | Inflammation | pmid:10921506 |
| Klyubin IV et al. | The role of reactive oxygen species in membrane potential changes in macrophages and astrocytes. | 2000 | Membr Cell Biol | pmid:10926373 |
| Roudebush WE and Purnell ET | Platelet-activating factor content in human spermatozoa and pregnancy outcome. | 2000 | Fertil. Steril. | pmid:10927041 |
| Matsunaga Y et al. | Regulation of lymphocyte proliferation by eosinophils via chymotrypsin-like protease activity and adhesion molecule interaction. | 2000 | Br. J. Pharmacol. | pmid:10928955 |
| Capasso R et al. | Preventive effect of eugenol on PAF and ethanol-induced gastric mucosal damage. | 2000 | Fitoterapia | pmid:10930724 |
| Henig NR et al. | Effect of recombinant human platelet-activating factor-acetylhydrolase on allergen-induced asthmatic responses. | 2000 | Am. J. Respir. Crit. Care Med. | pmid:10934081 |
| Haribabu B et al. | Targeted disruption of the leukotriene B(4) receptor in mice reveals its role in inflammation and platelet-activating factor-induced anaphylaxis. | 2000 | J. Exp. Med. | pmid:10934231 |
| Miyatake T et al. | Analysis of cardiac function during hyperacute rejection: effects of PAF antagonist, TXA(2) inhibitor/antagonists, and nitroglycerin. | 2000 | Transplant. Proc. | pmid:10936319 |
| Raible DG et al. | Hydrogen peroxide release from human eosinophils on fibronectin: scopoletin enhances eosinophil activation. | 2000 | Free Radic. Biol. Med. | pmid:10938462 |
| Baskova I et al. | Inhibition of induced and spontaneous platelet aggregation by destabilase from medicinal leech. | 2000 | Platelets | pmid:10938885 |
| Pávó I et al. | Interactions of pro-inflammatory and vasoactive mediators with nitric oxide in the regulation of rat vascular permeability during laparotomy. | 2000 | Eur. J. Pharmacol. | pmid:10940373 |
| Balestrieri ML and Lee T | Regulation of the biosynthesis of acyl analogs of platelet-activating factor by purinergic agonist in endothlial cells. | 2000 | FEBS Lett. | pmid:10940389 |
| Porta C et al. | Amifostine, a reactive oxigen species scavenger with radiation- and chemo-protective properties, inhibits in vitro platelet activation induced by ADP, collagen or PAF. | 2000 | Haematologica | pmid:10942928 |
| Miyao Y et al. | Role of cytokines and adhesion molecules in ischemia and reperfusion in patients with acute myocardial infarction. | 1999 | Jpn. Circ. J. | pmid:10943615 |
| Kobayashi Y et al. | [Inhibitory effect of suplatast tosilate on eosinophil migration]. | 2000 | Arerugi | pmid:10944827 |
| Liu JK et al. | Paeonilide, a novel anti-PAF-active monoterpenoid-derived metabolite from Paeonia delavayi. | 2000 | Biosci. Biotechnol. Biochem. | pmid:10945272 |
| Ueda T et al. | Pancreatitis-associated ascitic fluid increases intracellular Ca(2+) concentration on hepatocytes. | 2000 | J. Surg. Res. | pmid:10945960 |
| Marathe GK et al. | Bioactive phospholipid oxidation products. | 2000 | Free Radic. Biol. Med. | pmid:10946218 |
| Zhuang Q et al. | Activation via multiple signaling pathways induces down-regulation of platelet-activating factor receptors on human B lymphocytes. | 2000 | J. Immunol. | pmid:10946267 |
| Davenpeck KL et al. | Activation of human leukocytes reduces surface P-selectin glycoprotein ligand-1 (PSGL-1, CD162) and adhesion to P-selectin in vitro. | 2000 | J. Immunol. | pmid:10946308 |
| Martin M et al. | [Antiretroviral ant anti-inflammatory properties of a novel platelet activation factor antagonist, PMS-601]. | 2000 | Pathol. Biol. | pmid:10949851 |
| Countryman NB et al. | Evidence for involvement of the epidermal platelet-activating factor receptor in ultraviolet-B-radiation-induced interleukin-8 production. | 2000 | J. Invest. Dermatol. | pmid:10951245 |
| Soeki T et al. | Plasma and platelet plasminogen activator inhibitor-1 in patients with acute myocardial infarction. | 2000 | Jpn. Circ. J. | pmid:10952148 |
| Gálvez J et al. | Intestinal anti-inflammatory activity of UR-12746, a novel 5-ASA conjugate, on acute and chronic experimental colitis in the rat. | 2000 | Br. J. Pharmacol. | pmid:10952687 |
| Maniscalco M et al. | The effect of platelet-activating factor (PAF) on nasal airway resistance in healthy subjects is not mediated by nitric oxide. | 2000 | Allergy | pmid:10955702 |
| Oktar BK et al. | Endothelin-1-induced PMN infiltration and mucosal dysfunction in the rat small intestine. | 2000 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:10960346 |
| Jeon SY et al. | Ultrastructural changes in platelet activating factor-induced epithelial damage in rabbit maxillary sinus mucosa. | 2000 | Ann. Otol. Rhinol. Laryngol. | pmid:10961804 |
| Toró A et al. | Transannular Diels-Alder studies on the asymmetric total synthesis of chatancin: the pyranophane approach. | 2000 | Org. Lett. | pmid:10964353 |
| Durán WN et al. | Stimulation of NO production and of eNOS phosphorylation in the microcirculation in vivo. | 2000 | Microvasc. Res. | pmid:10964584 |
| Wereszczynska-Siemiatkowska U et al. | Lysosomal activity of pulmonary alveolar macrophages in acute experimental pancreatitis in rats with reference to positive PAF-antagonist (BN 52021) effect. | 2000 | Exp. Toxicol. Pathol. | pmid:10965985 |
| Prescott SM et al. | Platelet-activating factor and related lipid mediators. | 2000 | Annu. Rev. Biochem. | pmid:10966465 |
| Kim JD et al. | Platelet activating factor acetylhydrolase decreases lung reperfusion injury. | 2000 | Ann. Thorac. Surg. | pmid:10969656 |
| Taguchi R et al. | Two-dimensional analysis of phospholipids by capillary liquid chromatography/electrospray ionization mass spectrometry. | 2000 | J Mass Spectrom | pmid:10972995 |
| Saito S et al. | Modulatory roles of RANTES in IL-4 production by human blood CD4(+)T cells. | 2000 | Cytokine | pmid:10975998 |
| Tanaka R et al. | Genetics of immunoglobulin A nephropathy. | 2000 | Ann. Acad. Med. Singap. | pmid:10976391 |