Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Pulmonary Edema D011654 23 associated lipids
Coronary Disease D003327 70 associated lipids
Intestinal Obstruction D007415 6 associated lipids
Pancreatitis D010195 10 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Hypersensitivity D006967 22 associated lipids
Osteosarcoma D012516 50 associated lipids
Rhinitis D012220 10 associated lipids
Arterial Occlusive Diseases D001157 12 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Authors Title Published Journal PubMed Link
Yamauchi A et al. Systematic single cell analysis of migration and morphological changes of human neutrophils over stimulus concentration gradients. 2014 J. Immunol. Methods pmid:24370750
Zebrowska A et al. Mediators of mast cells in bullous pemphigoid and dermatitis herpetiformis. 2014 Mediators Inflamm. pmid:25400334
Sahu RP et al. Chemotherapeutic agents subvert tumor immunity by generating agonists of platelet-activating factor. 2014 Cancer Res. pmid:25304264
Wu H et al. Lipoxin A4 and platelet activating factor are involved in E. coli or LPS-induced lung inflammation in CFTR-deficient mice. 2014 PLoS ONE pmid:24671173
Kaplanis M et al. Re(I) tricarbonyl complex of 1,10-phenanthroline-5,6-dione: DNA binding, cytotoxicity, anti-inflammatory and anti-coagulant effects towards platelet activating factor. 2014 J. Inorg. Biochem. pmid:24632342
Mallet de Lima CD et al. Central role of PAFR signalling in ExoU-induced NF-κB activation. 2014 Cell. Microbiol. pmid:24612488
Moschos MM et al. In vitro effects of vitamin supplements on platelet-activating factor and its metabolism in age-related macular degeneration. 2014 Cutan Ocul Toxicol pmid:24147947
Abdulnour RE et al. Maresin 1 biosynthesis during platelet-neutrophil interactions is organ-protective. 2014 Proc. Natl. Acad. Sci. U.S.A. pmid:25369934
Chou YI et al. Correlations of platelet-derived microparticles with thromboxane B2, platelet-activating factor, endothelin-1, and neutrophil to lymphocyte ratio in patients with coronary intermediate lesions. 2014 Biomarkers pmid:25391885
Rivera J et al. Platelet-activating factor contributes to Bacillus anthracis lethal toxin-associated damage. 2014 J. Biol. Chem. pmid:24478317
Kim KJ et al. Platelet-activating factor enhances tumour metastasis via the reactive oxygen species-dependent protein kinase casein kinase 2-mediated nuclear factor-κB activation. 2014 Immunology pmid:24628121
Frazer CA Heparin-induced thrombocytopenia. 2013 Nov-Dec Medsurg Nurs pmid:24600938
Muñoz-Cano R et al. Platelet-activating factor nasal challenge induces nasal congestion and reduces nasal volume in both healthy volunteers and allergic rhinitis patients. 2013 Mar-Apr Am J Rhinol Allergy pmid:23562190
Archer SL and Roudebush WE Enhancement of sperm motility using pentoxifylline and platelet-activating factor. 2013 Methods Mol. Biol. pmid:22992918
Flasiński M et al. Interactions between single-chained ether phospholipids and sphingomyelin in mixed monolayers at the air/water interface-Grazing incidence X-ray diffraction and Brewster angle microscopy studies. 2013 Colloids Surf B Biointerfaces pmid:23777791
Grotta MB et al. Obesity increases eosinophil activity in asthmatic children and adolescents. 2013 BMC Pulm Med pmid:23773659
Zhou Z et al. Chemical constituents of Callicarpa nudiflora and their anti-platelet aggregation activity. 2013 Fitoterapia pmid:23669034
Wang TM et al. Alkyl and phenolic glycosides from Saussurea stella. 2013 Fitoterapia pmid:23567860
Herndon B et al. Urease and Helicobacter spp. antigens in pulmonary granuloma. 2013 J. Comp. Pathol. pmid:22901429
Nasopoulou C et al. Hen egg yolk lipid fractions with antiatherogenic properties. 2013 Anim. Sci. J. pmid:23480708
Sato A et al. An endothelin-3-related synthetic biotinylated pentapeptide as a novel inhibitor of platelet-activating factor. 2013 Eur. J. Pharmacol. pmid:23792041
Ayaz G et al. The association of MDR1 C3435T and G2677T/A polymorphisms with plasma platelet-activating factor levels and coronary artery disease risk in Turkish population. 2013 Gene pmid:23816407
Yamazaki Y et al. A Penicillium sp. F33 metabolite and its synthetic derivatives inhibit acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyltransferase (a key enzyme in platelet-activating factor biosynthesis) and carrageenan-induced paw edema in mice. 2013 Biochem. Pharmacol. pmid:23817078
Hirayama F Current understanding of allergic transfusion reactions: incidence, pathogenesis, laboratory tests, prevention and treatment. 2013 Br. J. Haematol. pmid:23215650
Harleton E et al. Ability to induce atrial fibrillation in the peri-operative period is associated with phosphorylation-dependent inhibition of TWIK protein-related acid-sensitive potassium channel 1 (TASK-1). 2013 J. Biol. Chem. pmid:23229553
Detopoulou P et al. Platelet activating factor in heart failure: potential role in disease progression and novel target for therapy. 2013 Curr Heart Fail Rep pmid:23389700
Wang HL et al. Differential inhibitory effects of 2-azafluorenones on PI-PLC activation but not on PC-PLC- or PC-PLD-activation induced by histamine, PAF, PMA or A23187 in C6 glioma cells. 2013 Chin J Physiol pmid:23347011
Motoyama N et al. Pain-releasing action of platelet-activating factor (PAF) antagonists in neuropathic pain animal models and the mechanisms of action. 2013 Eur J Pain pmid:23355413
Tsoupras AB et al. Synthesis, biochemical evaluation and molecular modeling studies of novel rhodium complexes with nanomolar activity against Platelet Activating Factor. 2013 J. Inorg. Biochem. pmid:23318288
Krause K et al. Platelet-activating factor (PAF) induces wheal and flare skin reactions independent of mast cell degranulation. 2013 Allergy pmid:23320562
Vanstreels L and Merk HF [Value of in-vitro diagnostic tools after anaphylaxis]. 2013 Hautarzt pmid:23385619
Sato A and Ebina K Endothelin-3 at low concentrations attenuates inflammatory responses via the endothelin B2 receptor. 2013 Inflamm. Res. pmid:23370722
Singh P et al. Platelet-activating factor (PAF)-antagonists of natural origin. 2013 Fitoterapia pmid:23160091
Costa M et al. Derivation of endothelial cells from human embryonic stem cells in fully defined medium enables identification of lysophosphatidic acid and platelet activating factor as regulators of eNOS localization. 2013 Stem Cell Res pmid:23164599
Sirangelo I et al. Amyloid toxicity and platelet-activating factor signaling. 2013 J. Cell. Physiol. pmid:23169529
Xu B et al. Effects of platelet-activating factor and its differential regulation by androgens and steroid hormones in prostate cancers. 2013 Br. J. Cancer pmid:23949154
Alevizos M et al. Rupatadine inhibits inflammatory mediator release from human laboratory of allergic diseases 2 cultured mast cells stimulated by platelet-activating factor. 2013 Ann. Allergy Asthma Immunol. pmid:24267366
Cui H et al. Sphingosine-1-phosphate receptor 2 protects against anaphylactic shock through suppression of endothelial nitric oxide synthase in mice. 2013 J. Allergy Clin. Immunol. pmid:24021572
Flasiński M et al. Cholesterol as a factor regulating the influence of natural (PAF and lysoPAF) vs synthetic (ED) ether lipids on model lipid membranes. 2013 Biochim. Biophys. Acta pmid:23906729
Lv XX et al. Rupatadine protects against pulmonary fibrosis by attenuating PAF-mediated senescence in rodents. 2013 PLoS ONE pmid:23869224
Maziero AM et al. Inhibition of human platelet aggregation by eosinophils. 2013 Life Sci. pmid:23871985
Borthakur A et al. Lactobacillus acidophilus alleviates platelet-activating factor-induced inflammatory responses in human intestinal epithelial cells. 2013 PLoS ONE pmid:24130731
Predescu S et al. Platelet activating factor-induced ceramide micro-domains drive endothelial NOS activation and contribute to barrier dysfunction. 2013 PLoS ONE pmid:24086643
Sahu RP et al. Cigarette smoke exposure inhibits contact hypersensitivity via the generation of platelet-activating factor agonists. 2013 J. Immunol. pmid:23355733
Berman B and Cockerell CJ Pathobiology of actinic keratosis: ultraviolet-dependent keratinocyte proliferation. 2013 J. Am. Acad. Dermatol. pmid:23228301
Frost BL and Caplan MS Necrotizing enterocolitis: pathophysiology, platelet-activating factor, and probiotics. 2013 Semin. Pediatr. Surg. pmid:23611612
Renteria LS et al. RhoA-Rho kinase and platelet-activating factor stimulation of ovine foetal pulmonary vascular smooth muscle cell proliferation. 2013 Cell Prolif. pmid:24033386
Guerrero AT et al. The role of PAF/PAFR signaling in zymosan-induced articular inflammatory hyperalgesia. 2013 Naunyn Schmiedebergs Arch. Pharmacol. pmid:23187752
Shi YM et al. Lancolides, antiplatelet aggregation nortriterpenoids with tricyclo[6.3.0.0(2,11)]undecane-bridged system from Schisandra lancifolia. 2013 Org. Lett. pmid:24059675
Kang JW et al. Anti-platelet activity of erythro-(7S,8R)-7-acetoxy-3,4,3',5'-tetramethoxy-8-O-4'-neolignan from Myristica fragrans. 2013 Phytother Res pmid:23296979