| MeSH term | MeSH ID | Detail |
|---|---|---|
| Pulmonary Edema | D011654 | 23 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Intestinal Obstruction | D007415 | 6 associated lipids |
| Pancreatitis | D010195 | 10 associated lipids |
| Liver Cirrhosis, Experimental | D008106 | 36 associated lipids |
| Hypersensitivity | D006967 | 22 associated lipids |
| Osteosarcoma | D012516 | 50 associated lipids |
| Rhinitis | D012220 | 10 associated lipids |
| Arterial Occlusive Diseases | D001157 | 12 associated lipids |
| Leukemia, Erythroblastic, Acute | D004915 | 41 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Cruzado JM et al. | Effect of a platelet-activating factor (PAF) receptor antagonist on hyperacute xenograft rejection; evaluation in a pig kidney-human blood xenoperfusion model. | 1998 | Clin. Exp. Immunol. | pmid:9697996 |
| Eakes AT and Olson MS | Regulation of endothelin synthesis in hepatic endothelial cells. | 1998 | Am. J. Physiol. | pmid:9696707 |
| Karlsson H et al. | Heparin ameliorates pulmonary hypertension induced by platelet-activating factor in pigs. | 1998 | Thromb. Res. | pmid:9694244 |
| Napoli C | Familial hypercholesterolaemia and platelet-activating factor acetylhydrolase: difference between the homozygous and heterozygous form. | 1998 | Eur. J. Clin. Invest. | pmid:9693945 |
| Moro F et al. | The beta and gamma subunits of the human platelet-activating factor acetyl hydrolase isoform Ib (PAFAH1B2 and PAFAH1B3) map to chromosome 11q23 and 19q13.1, respectively. | 1998 | Genomics | pmid:9693049 |
| Li HP et al. | Effect of chinonin on acute hypoxic pulmonary vasoconstriction in Sprague-Dawley rats. | 1998 | Respirology | pmid:9692515 |
| Kaminskaia GO et al. | [Features of oxidative metabolism and level of platelet activating factor in pulmonary and circulating phagocytes of tuberculosis-resistant animals at stages of experimental infection]. | 1998 | Probl Tuberk | pmid:9691697 |
| Ribaldi E et al. | PAF levels in saliva are regulated by inflammatory cells. | 1998 | J. Periodont. Res. | pmid:9689619 |
| Stolarek R et al. | Effect of various agonists on nitric oxide generation by human polymorphonuclear leukocytes. | 1998 | Int. J. Clin. Lab. Res. | pmid:9689552 |
| Gozal D et al. | Platelet-activating factor modulates cardiorespiratory responses in the conscious rat. | 1998 | Am. J. Physiol. | pmid:9688699 |
| Bussolati B et al. | Platelet-activating factor synthesized by IL-12-stimulated polymorphonuclear neutrophils and NK cells mediates chemotaxis. | 1998 | J. Immunol. | pmid:9686616 |
| da Silva MB et al. | Protective effects of WEB 2086 (PAF antagonist) and ketoprofen (NSAID) on PAF-induced changes in the morphological ultrastructure of blood platelets in calves. | 1998 | Vet. Res. Commun. | pmid:9686442 |
| Peçanha EP et al. | Synthesis and pharmacological evaluation of a new class of bicyclic phospholipids, designed as platelet activating factor antagonists. | 1998 | Farmaco | pmid:9679282 |
| Barber LA et al. | Expression of the platelet-activating factor receptor results in enhanced ultraviolet B radiation-induced apoptosis in a human epidermal cell line. | 1998 | J. Biol. Chem. | pmid:9668065 |
| Tuder RM and Voelkel NF | Pulmonary hypertension and inflammation. | 1998 | J. Lab. Clin. Med. | pmid:9665367 |
| Manya H et al. | Switching of platelet-activating factor acetylhydrolase catalytic subunits in developing rat brain. | 1998 | J. Biol. Chem. | pmid:9660828 |
| Akisü M et al. | Effect of dietary n-3 fatty acids on hypoxia-induced necrotizing enterocolitis in young mice. n-3 fatty acids alter platelet-activating factor and leukotriene B4 production in the intestine. | 1998 | Biol. Neonate | pmid:9657667 |
| Ahmed A et al. | Localization, quantification, and activation of platelet-activating factor receptor in human endometrium during the menstrual cycle: PAF stimulates NO, VEGF, and FAKpp125. | 1998 | FASEB J. | pmid:9657523 |
| Rainger GE et al. | Neutrophils rolling on immobilised platelets migrate into homotypic aggregates after activation. | 1998 | Thromb. Haemost. | pmid:9657445 |
| Schwartz JD et al. | Cardiopulmonary bypass primes polymorphonuclear leukocytes. | 1998 | J. Surg. Res. | pmid:9655092 |