| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypertrophy, Right Ventricular | D017380 | 4 associated lipids |
| Brain Injuries | D001930 | 4 associated lipids |
| Hepatitis B, Chronic | D019694 | 4 associated lipids |
| Lymphoma, T-Cell, Cutaneous | D016410 | 4 associated lipids |
| Milk Hypersensitivity | D016269 | 4 associated lipids |
| Liver Failure | D017093 | 5 associated lipids |
| Neoplastic Cells, Circulating | D009360 | 5 associated lipids |
| Hepatitis, Alcoholic | D006519 | 5 associated lipids |
| Granulomatosis with Polyangiitis | D014890 | 5 associated lipids |
| Osteonecrosis | D010020 | 5 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Am. J. Physiol., Cell Physiol. (2)
- Arterioscler. Thromb. Vasc. Biol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kerek M et al. | Effects of recombinant platelet activating factor acetylhydrolase in obstructive jaundice. | 2003 Jul-Aug | Hepatogastroenterology | pmid:12845989 |
| Nomikos TN et al. | Acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyltransferase (lyso-PAF AT) activity in cortical and medullary human renal tissue. | 2003 | Eur. J. Biochem. | pmid:12846832 |
| Suzuki M et al. | Actin assembly is a crucial factor for superoxide anion generation from adherent human eosinophils. | 2003 | J. Allergy Clin. Immunol. | pmid:12847489 |
| Talvani A et al. | Experimental Trypanosoma cruzi infection in platelet-activating factor receptor-deficient mice. | 2003 | Microbes Infect. | pmid:12850205 |
| Desquand S et al. | Interference of BN 52021, an antagonist of PAF, with different forms of active anaphylaxis in the guinea-pig: importance of the booster injection. | 1991 | Br. J. Pharmacol. | pmid:1285397 |
| Taggart DP et al. | Neuroprotection during cardiac surgery: a randomised trial of a platelet activating factor antagonist. | 2003 | Heart | pmid:12860868 |
| Takafuji S et al. | Matrix metalloproteinase-9 release from human leukocytes. | 2003 | J Investig Allergol Clin Immunol | pmid:12861851 |
| Bar-Or D et al. | Copper stimulates the synthesis and release of interleukin-8 in human endothelial cells: a possible early role in systemic inflammatory responses. | 2003 | Shock | pmid:12865660 |
| Kujiraoka T et al. | Altered distribution of plasma PAF-AH between HDLs and other lipoproteins in hyperlipidemia and diabetes mellitus. | 2003 | J. Lipid Res. | pmid:12867534 |
| D'Andrea D et al. | Induction of tissue factor in the arterial wall during recurrent thrombus formation. | 2003 | Arterioscler. Thromb. Vasc. Biol. | pmid:12869352 |
| Lupia E et al. | The membrane attack complex of complement contributes to plasmin-induced synthesis of platelet-activating factor by endothelial cells and neutrophils. | 2003 | Immunology | pmid:12871223 |
| Kuo RY et al. | Antiplatelet activity of benzylisoquinoline derivatives oxidized by cerium(IV) ammonium nitrate. | 2003 | Bioorg. Med. Chem. Lett. | pmid:12873516 |
| Yang Y et al. | Kupffer cells are a major source of increased platelet activating factor in the CCl4-induced cirrhotic rat liver. | 2003 | J. Hepatol. | pmid:12873816 |
| Biffl WL et al. | Clinically relevant hypertonicity prevents stored blood- and lipid-mediated delayed neutrophil apoptosis independent of p38 MAPK or caspase-3 activation. | 2003 | Surgery | pmid:12874587 |
| Fukuoka T et al. | [Experimental study on platelet activating factor and systemic circulatory failure caused by ischemic liver]. | 1992 | Nihon Geka Gakkai Zasshi | pmid:1287460 |
| Vernadakis A et al. | Role of astrocytes in aging: late passage primary mouse brain astrocytes and C-6 glial cells as models. | 1992 | Prog. Brain Res. | pmid:1287725 |
| Akisu M et al. | Selective head cooling with hypothermia suppresses the generation of platelet-activating factor in cerebrospinal fluid of newborn infants with perinatal asphyxia. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12878450 |
| Bourgain RH et al. | PAF-acether induced arterial thrombosis and the effect of specific antagonists. | 1992 | Adv. Exp. Med. Biol. | pmid:1288104 |
| Møller CH and Steinbrüchel DA | Platelet function after coronary artery bypass grafting: is there a procoagulant activity after off-pump compared with on-pump surgery? | 2003 | Scand. Cardiovasc. J. | pmid:12881156 |
| Lupia E et al. | Intra-plaque production of platelet-activating factor correlates with neoangiogenesis in human carotid atherosclerotic lesions. | 2003 | Int. J. Mol. Med. | pmid:12883648 |
| Handa RK et al. | Role of Nitric oxide in the renal and systemic vasodilatory responses to platelet-activating factor in the rat, in vivo. | 2003 | Kidney Blood Press. Res. | pmid:12886044 |
| Curry FE et al. | Thrombin increases permeability only in venules exposed to inflammatory conditions. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12893636 |
| Mayer K et al. | Omega-3 vs. omega-6 lipid emulsions exert differential influence on neutrophils in septic shock patients: impact on plasma fatty acids and lipid mediator generation. | 2003 | Intensive Care Med | pmid:12897994 |
| Shen Z et al. | Effects of plumbagin on platelet aggregation and platelet-neutrophil interactions. | 2003 | Planta Med. | pmid:12898414 |
| de Assis EF et al. | Synergism between platelet-activating factor-like phospholipids and peroxisome proliferator-activated receptor gamma agonists generated during low density lipoprotein oxidation that induces lipid body formation in leukocytes. | 2003 | J. Immunol. | pmid:12902515 |
| Hu H et al. | Glycoprotein IIb/IIIa inhibition attenuates platelet-activating factor-induced platelet activation by reducing protein kinase C activity. | 2003 | J. Thromb. Haemost. | pmid:12911597 |
| Kalia N and Bardhan KD | Of blood and guts: association between Helicobacter pylori and the gastric microcirculation. | 2003 | J. Gastroenterol. Hepatol. | pmid:12911655 |
| Tokuoka SM et al. | Involvement of platelet-activating factor and LIS1 in neuronal migration. | 2003 | Eur. J. Neurosci. | pmid:12911752 |
| Lie WJ et al. | Regulation and kinetics of platelet-activating factor and leukotriene C4 synthesis by activated human basophils. | 2003 | Clin. Exp. Allergy | pmid:12911788 |
| Nakatsuka M et al. | Platelet activating factor in culture media as an indicator of human embryonic development after in-vitro fertilization. | 1992 | Hum. Reprod. | pmid:1291573 |
| Mano T et al. | Novel imidazole compounds as a new series of potent, orally active inhibitors of 5-lipoxygenase. | 2003 | Bioorg. Med. Chem. | pmid:12927848 |
| Kald B et al. | Platelet-activating factor (PAF-acether) formation in neonatal intestinal mucosa and in cultured intestinal epithelial cells. | 1992 | Eur Surg Res | pmid:1292936 |
| Abete P et al. | Age-related effects of platelet activating factor (PAF) in the isolated perfused rat heart. | 1992 | J. Mol. Cell. Cardiol. | pmid:1293314 |
| Guarino MP et al. | PAF-like lipids- and PAF-induced gallbladder muscle contraction is mediated by different pathways in guinea pigs. | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12936911 |
| Tomaszewska R et al. | Platelet activating factor (PAF) inhibitor (TCV-309) reduces caerulein- and PAF-induced pancreatitis. A morphologic and functional study in the rat. | 1992 | J. Physiol. Pharmacol. | pmid:1294265 |
| Izquierdo I et al. | Rupatadine: a new selective histamine H1 receptor and platelet-activating factor (PAF) antagonist. A review of pharmacological profile and clinical management of allergic rhinitis. | 2003 | Drugs Today | pmid:12944997 |
| Zhu L et al. | Internalization of caveolin-1 scaffolding domain facilitated by Antennapedia homeodomain attenuates PAF-induced increase in microvessel permeability. | 2004 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12946927 |
| Benelli R et al. | Neutrophils and angiogenesis: potential initiators of the angiogenic cascade. | 2003 | Chem Immunol Allergy | pmid:12947984 |
| Shinozaki K et al. | Species differences in platelet aggregation induced by platelet-activating factor (PAF). | 1992 | Methods Find Exp Clin Pharmacol | pmid:1294855 |
| Liu J et al. | Lipopolysaccharide induces anandamide synthesis in macrophages via CD14/MAPK/phosphoinositide 3-kinase/NF-kappaB independently of platelet-activating factor. | 2003 | J. Biol. Chem. | pmid:12949078 |
| Wierzbicki T et al. | IL-4 primes human endothelial cells for secondary responses to histamine. | 2003 | J. Leukoc. Biol. | pmid:12949246 |
| Gabrijelcic J et al. | Neutrophil airway influx by platelet-activating factor in asthma: role of adhesion molecules and LTB4 expression. | 2003 | Eur. Respir. J. | pmid:12952263 |
| Perales J et al. | Neutralization of the oedematogenic activity of Bothrops jararaca venom on the mouse paw by an antibothropic fraction isolated from opossum (Didelphis marsupialis) serum. | 1992 | Agents Actions | pmid:1295374 |
| McDonagh PF et al. | Chronic expression of platelet adhesion proteins is associated with severe ischemic heart disease in type 2 diabetic patients: Chronic platelet activation in diabetic heart patients. | 2003 Sep-Oct | J. Diabetes Complicat. | pmid:12954156 |
| Armenaka M and Rosenstreich DL | The pathophysiology of chronic urticaria. | 1992 | Clin Rev Allergy | pmid:1295690 |
| Krause S et al. | Defective function of blood granulocytes in patients with diabetes mellitus-associated marginal periodontitis. | 1992 | Folia Biol. (Praha) | pmid:1295773 |
| Bayar MA et al. | The effect of EGb-761 on morphologic vasospasm in canine basilar artery after subarachnoid hemorrhage. | 2003 | J. Cardiovasc. Pharmacol. | pmid:12960685 |
| Kato M et al. | The role of platelet activating factor and the efficacy of apafant ophthalmic solution in experimental allergic conjunctivitis. | 2003 | J Ocul Pharmacol Ther | pmid:12964956 |
| Ishiura Y et al. | Airway eosinophil accumulation on sensory neuropeptide release in a guinea pig model of distilled-water-induced bronchoconstriction. | 2003 | J Investig Allergol Clin Immunol | pmid:12968390 |
| Calabresi L et al. | Endothelial protection by high-density lipoproteins: from bench to bedside. | 2003 | Arterioscler. Thromb. Vasc. Biol. | pmid:12969988 |
| Zhao XY et al. | [Effects of BIO-1211 on eosinophil chemotaxis, recruitment and mediator release]. | 2003 | Zhejiang Da Xue Xue Bao Yi Xue Ban | pmid:12970925 |
| Lamparter E and Lunkenheimer CH | The automation of dissolution testing of solid oral dosage forms. | 1992 Oct-Dec | J Pharm Biomed Anal | pmid:1298375 |
| Cheng NN et al. | [The composition of phospholipid and biosynthesis of platelet-activating factor in earthworm (Eisenia foetida)]. | 1992 | Yao Xue Xue Bao | pmid:1299136 |
| Wong B et al. | Identification of a membrane-associated 1-0-alkyl-2-arachidonoyl-sn-glycero-3-phosphocholine hydrolyzing phospholipase A2 in guinea pig 1 epidermis. Implications in the cutaneous biosynthesis of platelet-activating factor. | 1992 | FEBS Lett. | pmid:1299618 |
| Wu QX | [Amplification and desensitization in platelet activation]. | 1992 | Sheng Li Ke Xue Jin Zhan | pmid:1299958 |
| Doly M et al. | Inhibition of vincristine-induced retinal impairments by a specific PAF antagonist. | 1992 | Lens Eye Toxic Res | pmid:1301801 |
| Nijkamp FP et al. | Reversal of the endotoxin-induced bronchial hyperreactivity to histamine by the platelet activating factor antagonist BN 52021. | 1992 | Pneumonol Alergol Pol | pmid:1305483 |
| Hirano T and Manabe T | "Cocktail" therapy for acute pancreatitis: combined therapy of protease inhibitor, xanthine oxidase inhibitor and platelet activating factor antagonist in rat caerulein-induced pancreatis. | 1992 | Nihon Geka Hokan | pmid:1306981 |
| Li Q | [Effects of inhaled aerosol of platelet activating factor on pulmonary function and airway responsiveness in normal subjects]. | 1992 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:1307517 |
| Klöcking HP | Inhibition of PAF-induced tPA release by KO-286011. | 1992 | Ann. N. Y. Acad. Sci. | pmid:1309038 |
| Zoratti EM et al. | Platelet-activating factor primes human eosinophil generation of superoxide. | 1992 | Am. J. Respir. Cell Mol. Biol. | pmid:1309421 |
| van Willigen G and Akkerman JW | Regulation of glycoprotein IIB/IIIA exposure on platelets stimulated with alpha-thrombin. | 1992 | Blood | pmid:1309427 |
| Bratton DL et al. | The mechanism of internalization of platelet-activating factor in activated human neutrophils. Enhanced transbilayer movement across the plasma membrane. | 1992 | J. Immunol. | pmid:1309560 |
| Ono S and Voelkel NF | PAF receptor blockade inhibits lung vascular changes in the rat monocrotaline model. | 1992 | Lung | pmid:1310128 |
| Schwaner I et al. | Receptor-mediated increases in cytosolic Ca2+ in the human erythroleukaemia cell line involve pertussis toxin-sensitive and -insensitive pathways. | 1992 | Biochem. J. | pmid:1310589 |
| Gandhi CR et al. | A comparative study of endothelin- and platelet-activating-factor-mediated signal transduction and prostaglandin synthesis in rat Kupffer cells. | 1992 | Biochem. J. | pmid:1310601 |
| Jagels MA and Hugli TE | Neutrophil chemotactic factors promote leukocytosis. A common mechanism for cellular recruitment from bone marrow. | 1992 | J. Immunol. | pmid:1310708 |
| Földes-Filep E et al. | C-reactive protein inhibits intracellular calcium mobilization and superoxide production by guinea pig alveolar macrophages. | 1992 | J. Leukoc. Biol. | pmid:1311010 |
| Yue TL et al. | Platelet-activating factor stimulates phosphoinositide turnover in neurohybrid NCB-20 cells: involvement of pertussis toxin-sensitive guanine nucleotide-binding proteins and inhibition by protein kinase C. | 1992 | Mol. Pharmacol. | pmid:1311408 |
| Grandoni KM et al. | Trichothecene mycotoxins inhibit phosphoinositide hydrolysis in bovine platelets stimulated with platelet activating factor. | 1992 | Toxicology | pmid:1311467 |
| Wu T et al. | Endothelin-1 stimulates eicosanoid production in cultured human nasal mucosa. | 1992 | Am. J. Respir. Cell Mol. Biol. | pmid:1311593 |
| Catalán RE et al. | PAF-induced activation of polyphosphoinositide-hydrolyzing phospholipase C in cerebral cortex. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1311925 |
| Shukla SD | Platelet-activating factor receptor and signal transduction mechanisms. | 1992 | FASEB J. | pmid:1312046 |
| Aepfelbacher M et al. | Bacterial lipopolysaccharide up-regulates platelet-activating factor-stimulated Ca2+ mobilization and eicosanoid release in human Mono Mac 6 cells. | 1992 | J. Immunol. | pmid:1312103 |
| Henson PM et al. | NHLBI workshop summary. Platelet-activating factor: role in pulmonary injury and dysfunction and blood abnormalities. | 1992 | Am. Rev. Respir. Dis. | pmid:1312316 |
| Alonso MT et al. | Effects of the antithrombitic agent PCA 4230 on agonist-induced Ca2+ entry and Ca2+ release in human platelets. | 1992 | Biochim. Biophys. Acta | pmid:1312357 |
| Bazan NG | Synaptic lipid signaling: significance of polyunsaturated fatty acids and platelet-activating factor. | 2003 | J. Lipid Res. | pmid:13130128 |
| Chatterjee SS et al. | Structure-activity studies with Ginkgo biloba extract constituents as receptor-gated chloride channel blockers and modulators. | 2003 | Pharmacopsychiatry | pmid:13130392 |
| e Silva PM et al. | Nedocromil sodium prevents in vivo generation of the eosinophilotactic substance induced by PAF but fails to antagonize its effects. | 1992 | Br. J. Pharmacol. | pmid:1313729 |
| Schaberg T et al. | Superoxide anion release induced by platelet-activating factor is increased in human alveolar macrophages from smokers. | 1992 | Eur. Respir. J. | pmid:1314191 |
| Zhu YP et al. | The presence of platelet-activating factor binding sites in human myometrium and their role in uterine contraction. | 1992 | Am. J. Obstet. Gynecol. | pmid:1314480 |
| Rabinovici R et al. | Platelet activating factor mediates interleukin-2-induced lung injury in the rat. | 1992 | J. Clin. Invest. | pmid:1314853 |
| Zarco P et al. | Involvement of platelet-activating factor and tumour necrosis factor in the pathogenesis of joint inflammation in rabbits. | 1992 | Clin. Exp. Immunol. | pmid:1315229 |
| Kuijpers TW et al. | Neutrophil migration across monolayers of cytokine-prestimulated endothelial cells: a role for platelet-activating factor and IL-8. | 1992 | J. Cell Biol. | pmid:1315317 |
| Carveth HJ et al. | Regulation of platelet-activating factor (PAF) synthesis and PAF-mediated neutrophil adhesion to endothelial cells activated by thrombin. | 1992 | Semin. Thromb. Hemost. | pmid:1315452 |
| Adler KB et al. | Platelet-activating factor provokes release of mucin-like glycoproteins from guinea pig respiratory epithelial cells via a lipoxygenase-dependent mechanism. | 1992 | Am. J. Respir. Cell Mol. Biol. | pmid:1316134 |
| Morland CM et al. | Selective eosinophil leukocyte recruitment by transendothelial migration and not by leukocyte-endothelial cell adhesion. | 1992 | Am. J. Respir. Cell Mol. Biol. | pmid:1316135 |
| Koltai M et al. | Role of PAF and cytokines in microvascular tissue injury. | 1992 | J. Lab. Clin. Med. | pmid:1316420 |
| Fukuchi Y et al. | Low ligand binding activities of two distinct types of Fc gamma receptor on guinea-pig peripheral blood polymorphonuclear leukocytes are differentially improved by proteolysis or platelet activating factor. | 1992 | Mol. Immunol. | pmid:1316550 |
| Sehmi R et al. | Interleukin-5 selectively enhances the chemotactic response of eosinophils obtained from normal but not eosinophilic subjects. | 1992 | Blood | pmid:1316789 |
| Pinckard RN et al. | Differential responsiveness of human neutrophils to the autocrine actions of 1-O-alkyl-homologs and 1-acyl analogs of platelet-activating factor. | 1992 | J. Immunol. | pmid:1316919 |
| Kimura K et al. | Different preparations of zymosan induce glycogenolysis independently in the perfused rat liver. Involvement of mannose receptors, peptide-leukotrienes and prostaglandins. | 1992 | Biochem. J. | pmid:1317164 |
| Joly F et al. | Biosynthesis of paf-acether in cultured-mouse mast cells: the role of calcium and G proteins. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1317174 |
| Moreira-Ludewig R and Healy CT | A rapid microtiter plate method for the detection of lysozyme release from human neutrophils. | 1992 | J Pharmacol Toxicol Methods | pmid:1317227 |
| Smith LJ | Bioactive mediators in asthma. | 1992 | Chest | pmid:1317278 |
| Graham RM et al. | Plasma platelet-activating factor degradation in patients with severe coronary artery disease. | 1992 | Clin. Sci. | pmid:1317763 |
| Guinn DE et al. | Synthesis and structure-activity relationships of a series of novel benzopyran-containing platelet activating factor antagonists. | 1992 | J. Med. Chem. | pmid:1317924 |
| Herbert JM | Characterization of specific binding sites of 3H-labelled platelet-activating factor ([3H]PAF) and a new antagonist, [3H]SR 27417, on guinea-pig tracheal epithelial cells. | 1992 | Biochem. J. | pmid:1318021 |
| Hidi R et al. | Formation of LTB4 by fMLP-stimulated alveolar macrophages accounts for eosinophil migration in vitro. | 1992 | J. Leukoc. Biol. | pmid:1318347 |
| Rediske JJ et al. | Platelet activating factor stimulates intracellular calcium transients in human neutrophils: involvement of endogenous 5-lipoxygenase products. | 1992 | J. Leukoc. Biol. | pmid:1318349 |