Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Burns, Inhalation D002059 4 associated lipids
AIDS Dementia Complex D015526 4 associated lipids
Neoplasms, Germ Cell and Embryonal D009373 4 associated lipids
Shock, Traumatic D012774 4 associated lipids
Hypertrophy, Right Ventricular D017380 4 associated lipids
Neoplastic Cells, Circulating D009360 5 associated lipids
Liver Failure D017093 5 associated lipids
Hepatitis, Alcoholic D006519 5 associated lipids
Granulomatosis with Polyangiitis D014890 5 associated lipids
Spasm D013035 5 associated lipids
Per page 10 20 50 100 | Total 288

PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with Platelet activating factor

Download all related citations
Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Böhm R and Giessler AJ [Thrombocyte aggregation inhibitors. A new class of active substances]. 1986 Pharmazie pmid:3515372
Vieweg H et al. [Synthesis of N-(2-carboxy-thieno(2,3-b)pyridin-3-yl)-amidines by the reaction with 4-oxo-4H-pyrido(3',2':4,5)-thieno(3,2-d)-1,3-oxazines with secondary cycloaliphatic amines]. 1992 Pharmazie pmid:1492113
Kertscher HP and Ostermann G [Synthesis and thrombocyte aggregating action of stereoisomers of PAF-acether]. 1986 Pharmazie pmid:3786385
Kertscher HP and Ostermann G [PAF-antagonists with phospholipid structure. 2. Phospholipids with heteroarene head groups and variations of the phosphorus-nitrogen distance; synthesis, characterization and structure-activity relationships]. 1991 Pharmazie pmid:1803385
Kertscher HP et al. [Synthesis and thrombocyte-aggregating action of a structural analog of platelet activating factor with a modified head group]. 1988 Pharmazie pmid:3380866
Kertscher HP et al. [PAF-antagonists with phospholipid structure. 4. Alkylcarbamoylphospholipids with heteroarene and heterocyclase head groups and variation of the P-N-distance; synthesis, characterization and structure-activity relationship]. 1992 Pharmazie pmid:1615020
Kertscher HP et al. [PAF-antagonists with a phospholipid structure. 1. Phospholipids with hetero-arene head groups: synthesis, characterization and determination of the action of structural elements]. 1991 Pharmazie pmid:1798710
Kertscher HP et al. [PAF-antagonists with a phospholipid structure. 5. Propanediol phospholipids with various substituted pyridinium and quinuclidinium head groups and variations of the phosphorus-nitrogen distance;synthesis, characterization and structure activity relationship]. 1993 Pharmazie pmid:8460172
Ostermann G et al. [Platelet activating factor--a biologically active phospholipid]. 1990 Pharmazie pmid:2236190
Kertscher HP and Ostermann G [Synthesis and platelet aggregating activity of structural analogs of platelet-activating factor with a heterocyclic head group]. 1987 Pharmazie pmid:3438334
Chatterjee SS et al. Structure-activity studies with Ginkgo biloba extract constituents as receptor-gated chloride channel blockers and modulators. 2003 Pharmacopsychiatry pmid:13130392
Ueno M et al. Antiallergic action of betotastine besilate (TAU-284) in animal models: A comparison with ketotifen. 1998 Pharmacology pmid:9730778
Shibamoto T et al. PAF, rather than histamine, participates in mouse anaphylactic hypotension. 2008 Pharmacology pmid:18583921
Kagoshima M et al. Effects of Y-24180, a long-acting and potent antagonist to platelet-activating factor, on immediate asthmatic response in guinea pigs. 1997 Pharmacology pmid:9065955
Singh N et al. Possible mechanism of alprazolam-induced amnesia in mice. 1998 Pharmacology pmid:9467187
Merlos M et al. Comparative study of the effect of CV-6209, a specific PAF-antagonist, on rat paw edema caused by different phlogogen agents. 1990 Pharmacology pmid:1697076
Kagoshima M et al. Effect of Y-24180, a long-acting antagonist to platelet-activating factor (PAF), on PAF-induced reactions: a relationship between the partial structure of the compound and its duration of the action. 1997 Pharmacology pmid:9380772
Achterrath-Tuckermann U et al. Azelastine, a new antiallergic/antiasthmatic agent, inhibits PAF-acether-induced platelet aggregation, paw edema and bronchoconstriction. 1988 Pharmacology pmid:3380879
Suzuki S et al. Effect of a platelet-activating factor antagonist, WEB 2086, on inhibition of active oxygen generation in human polymorphonuclear leukocytes. 1994 Pharmacology pmid:8134402
Capasso F et al. Effect of senna is not mediated by platelet-activating factor. 1993 Pharmacology pmid:8234442
Cheng HH et al. Defect in regulation of Ca2+ movement in platelets from patients with systemic lupus erythematosus. 2005 Pharmacology pmid:15591819
Pei HX et al. Ginkgolide B Reduces the Degradation of Membrane Phospholipids to Prevent Ischemia/Reperfusion Myocardial Injury in Rats. 2015 Pharmacology pmid:26382046
Bannenberg G et al. Hydrogen peroxide-induced broncho- and vasoconstriction in the isolated perfused and ventilated guinea pig lung. 1993 Apr-May Pharmacol. Toxicol. pmid:8372054
Cakici I et al. Effects of platelet-activating factor antagonists WEB 2086 and BN 50730 on digoxin-induced arrhythmias. 1995 Pharmacol. Toxicol. pmid:7479573
Chen SF and Ruan YJ 1 alpha,25-Dihydroxyvitamin D3 decreases scalding- and platelet-activating factor-induced high vascular permeability and tissue oedema. 1995 Pharmacol. Toxicol. pmid:7479576
Moilanen E and Kankaanranta H Tolfenamic acid and leukotriene synthesis inhibition. 1994 Pharmacol. Toxicol. pmid:7816785
Abu-Zidan FM et al. BB-882 is a potent antagonist of the haemodynamic changes induced by platelet-activating factor in pigs. 1996 Pharmacol. Toxicol. pmid:8685082
Monteiro HS et al. Glomerular effects of cholera toxin in isolated perfused rat kidney: a potential role for platelet activating factor. 1999 Pharmacol. Toxicol. pmid:10522748
Morley J et al. Platelet activating factor and airway smooth muscle. 1989 Pharmacol. Ther. pmid:2646651
Williams FM Neutrophils and myocardial reperfusion injury. 1996 Pharmacol. Ther. pmid:8981567
Braquet P et al. Perspectives in platelet-activating factor research. 1987 Pharmacol. Rev. pmid:3303066
Saeed SA et al. Anti-thrombotic and anti-inflammatory activities of protopine. 1997 Pharmacol. Res. pmid:9368908
Caruso A et al. Protective effect of propionyl-L-carnitine against PAF-induced rat paw oedema. 1995 Pharmacol. Res. pmid:7784308
SariahmetoÄŸlu M et al. Effects of WEB 2086 on the protective role of preconditioning against arrhythmias in rats. 1998 Pharmacol. Res. pmid:9782066
Qian C et al. Anti-inflammatory activities of LDP-392, a dual PAF receptor antagonist and 5-lipoxygenase inhibitor. 2001 Pharmacol. Res. pmid:11529688
Mest HJ et al. WEB 2086, a novel specific PAF antagonist, prevents PAF induced arrhythmogenicity. 1990 Jul-Aug Pharmacol. Res. pmid:2402478
Lagente V et al. Protective effect of a specific platelet-activating factor antagonist, BN 52021, on bupivacaine-induced cardiovascular impairments in rats. 1989 Sep-Oct Pharmacol. Res. pmid:2594614
Mest HJ et al. Effect of BN 52256 and other mediator antagonists on ouabain-induced cardiac arrhythmia in a model of anaphylaxis in guinea-pigs. 1992 Feb-Mar Pharmacol. Res. pmid:1635894
Lograno MD et al. Effects of prostaglandins and PAF on the contractility of the bovine ciliary muscle. 1992 Feb-Mar Pharmacol. Res. pmid:1635897
Montesi L et al. Human platelet activation by PAF: receptor characterization. 1989 Nov-Dec Pharmacol. Res. pmid:2561199
Berti F et al. Cardiovascular and pulmonary activity of platelet-activating factor (PAF-acether) and its derivatives. 1986 Pharmacol Res Commun pmid:3749244
Foegh ML et al. The causal role of PAF and leukotrienes in acute cardiac allograft rejection in rats. 1986 Pharmacol Res Commun pmid:3534895
Brambilla A et al. WEB 2086. A potent PAF antagonist exerts protective effect toward PAF-induced gastric damage. 1987 Pharmacol Res Commun pmid:3588650
Baranes J et al. The effects of PAF-acether on the cardiovascular system and their inhibition by a new highly specific PAF-acether receptor antagonist BN 52021. 1986 Pharmacol Res Commun pmid:3763677
Danko G et al. Effect of the PAF antagonists, CV-3988 and L-652,731 on the pulmonary and hematological responses to guinea pig anaphylaxis. 1988 Pharmacol Res Commun pmid:3174804
Bussolino F et al. Interleukin 1 stimulates platelet activating factor production in cultured human endothelial cells. 1986 Pharmacol Res Commun pmid:3490673
Riedel A et al. The effect of the specific PAF antagonist BN 52021 and the calcium blocker diltiazem on PAF induced arrhythmogenicity. 1987 Pharmacol Res Commun pmid:3441484
Godfroid JJ et al. Synthesis of ether phospholipids. 1986 Pharmacol Res Commun pmid:3774838
PAF and leukotrienes '85. Proceedings of the meeting. Paris, September 27th 1985. 1986 Pharmacol Res Commun pmid:3774839
Vilain B et al. Pharmacological control of the in vivo passive anaphylactic shock by the PAF-acether antagonist compound BN 52021. 1986 Pharmacol Res Commun pmid:3774840
Bessin P PAF-acether and leukotriene participation in acute circulatory shock. 1986 Pharmacol Res Commun pmid:3774841
Goldstein RE et al. Coronary and pulmonary vascular effects of leukotrienes and PAF-acether. 1986 Pharmacol Res Commun pmid:3774842
Plante GE et al. Hemodynamic effects of PAF-acether. 1986 Pharmacol Res Commun pmid:3774843
Sanchez Crespo M et al. Evidence of a role for PAF-acether in the pathophysiology of the shock state. 1986 Pharmacol Res Commun pmid:3774844
Adnot S et al. Interference of BN 52021, a PAF-acether antagonist, with endotoxin-induced hypotension in the guinea-pig. 1986 Pharmacol Res Commun pmid:3774845
Rainsford KD Relative roles of leukotrienes and platelet activating factor in experimentally-induced gastric ulceration. 1986 Pharmacol Res Commun pmid:3774846
Page CP and Morley J Evidence favouring PAF rather than leukotrienes in the pathogenesis of asthma. 1986 Pharmacol Res Commun pmid:3774847
Haye-Legrand I et al. Production of PAF-acether and leukotrienes by cultured mouse macrophages. 1986 Pharmacol Res Commun pmid:3774848
Dupont L et al. Crystal and molecular structure of BN 52021, a PAF-acether antagonist. Comparison with the conformation of Kadsurenone and related compounds. 1986 Pharmacol Res Commun pmid:3774849
Bruynzeel PL et al. Platelet-activating factor (PAF-acether) induced leukotriene C4 formation and luminol dependent chemiluminescence by human eosinophils. 1986 Pharmacol Res Commun pmid:3774850
Etienne A et al. The relative role of PAF-acether and icosanoids in septic shock. 1986 Pharmacol Res Commun pmid:3774851
Maes L et al. Endogenic PAF-acether production by guinea pig endothelial cells in experimental arterial thrombosis. 1986 Pharmacol Res Commun pmid:3774852
Uhlig S et al. Mechanisms of platelet-activating factor (PAF)-mediated responses in the lung. 2005 Pharmacol Rep pmid:16415501
Stafforini DM PAF acetylhydrolase gene polymorphisms and asthma severity. 2001 Pharmacogenomics pmid:11535107
Semini G et al. Impact of alkylphospholipids on the gene expression profile of HaCaT cells. 2011 Pharmacogenet. Genomics pmid:21681147
Weber N [A platelet-activating factor--a physiologically active ether lipid]. 1986 Pharm Unserer Zeit pmid:3749211
Nordin N et al. Platelet-activating factor (PAF) receptor binding activity of the roots of Enicosanthellum pulchrum. 2012 Pharm Biol pmid:22103812
Alonso-Torre SR and Trautmann A Rapid refilling of Ca2+ stores in macrophages stimulated by ATP involves the sequential activation of phospholipase D and protein kinase C. 1995 Pflugers Arch. pmid:7675633
Randriamampita C et al. Cyclic-GMP-dependent refilling of calcium stores in macrophages. 1991 Pflugers Arch. pmid:1647519
Kester M et al. The potentiation of arterial contraction with platelet activating factor. 1984 Pflugers Arch. pmid:6718228
Hermoso M et al. Platelet activating factor increases ciliary activity in the hamster oviduct through epithelial production of prostaglandin E2. 2001 Pflugers Arch. pmid:11484763
Asimakopoulos G et al. Inhibition of neutrophil L-selectin shedding: a potential anti-inflammatory effect of aprotinin. 2000 Perfusion pmid:11131212
Quigley RL et al. Cardiopulmonary bypass with adequate flow and perfusion pressures prevents endotoxaemia and pathologic cytokine production. 1995 Perfusion pmid:7795310
Sung CP et al. CGRP stimulates the adhesion of leukocytes to vascular endothelial cells. 1992 May-Jun Peptides pmid:1326102
Cox CP et al. VIP elevates platelet cyclic AMP (cAMP) levels and inhibits in vitro platelet activation induced by platelet-activating factor (PAF). 1984 Mar-Apr Peptides pmid:6206481
Sato A et al. Angiotensin peptides attenuate platelet-activating factor-induced inflammatory activity in rats. 2015 Peptides pmid:26348270
Pirotzky E et al. [Renal diseases and platelet activating factor]. 1989 Pediatrie pmid:2740184
Ozturk H et al. PAF antagonist BN-52021 reduces intercellular adhesion molecule-1 expression and oxidative stress in rats with reperfusion damage due to unilateral testicular torsion. 2006 Pediatr. Surg. Int. pmid:16369775
McFall TL et al. Effect of group B streptococcal type-specific antigen on polymorphonuclear leukocyte function and polymorphonuclear leukocyte-endothelial cell interaction. 1987 Pediatr. Res. pmid:3037472
Caplan MS et al. Effect of polyunsaturated fatty acid (PUFA) supplementation on intestinal inflammation and necrotizing enterocolitis (NEC) in a neonatal rat model. 2001 Pediatr. Res. pmid:11328947
Wang H et al. Platelet-activating factor (PAF) up-regulates plasma and tissue PAF-acetylhydrolase activity in the rat: effect of cycloheximide. 1997 Pediatr. Res. pmid:9357930
Liu XH et al. Platelet-activating factor antagonist BN 50730 attenuates hypoxic-ischemic brain injury in neonatal rats. 2001 Pediatr. Res. pmid:11385142
Claud EC et al. Platelet-activating factor regulates chloride transport in colonic epithelial cell monolayers. 2002 Pediatr. Res. pmid:12149490
Brus F et al. Activation of circulating polymorphonuclear leukocytes in preterm infants with severe idiopathic respiratory distress syndrome. 1996 Pediatr. Res. pmid:8929866
Liu XH et al. The platelet-activating factor antagonist BN 52021 attenuates hypoxic-ischemic brain injury in the immature rat. 1996 Pediatr. Res. pmid:8947953
Stambouly JJ et al. Sustained effects of platelet-activating factor infusion in piglets. 1991 Pediatr. Res. pmid:1945566
Kikawa Y et al. Leukotriene B4 biosynthesis in polymorphonuclear leukocytes from blood of umbilical cord, infants, children, and adults. 1986 Pediatr. Res. pmid:3012451
Harris MC et al. Diminished actin polymerization by neutrophils from newborn infants. 1993 Pediatr. Res. pmid:8433856
Tan ND and Davidson D Comparative differences and combined effects of interleukin-8, leukotriene B4, and platelet-activating factor on neutrophil chemotaxis of the newborn. 1995 Pediatr. Res. pmid:7478787
MacKendrick W et al. Endogenous nitric oxide protects against platelet-activating factor-induced bowel injury in the rat. 1993 Pediatr. Res. pmid:8233729
Furukawa M et al. Platelet-activating factor-induced ischemic bowel necrosis: the effect of platelet-activating factor acetylhydrolase. 1993 Pediatr. Res. pmid:8233731
Bradley LM et al. Influence of thromboxane A2 receptor antagonism on pulmonary vasoconstrictor responses. 1989 Pediatr. Res. pmid:2587116
Lu J et al. Dual roles of endogenous platelet-activating factor acetylhydrolase in a murine model of necrotizing enterocolitis. 2010 Pediatr. Res. pmid:20531249
Viswanath M et al. Reduction of hypoxic-ischemic brain swelling in the neonatal rat with PAF antagonist WEB 2170: lack of long-term protection. 2000 Pediatr. Res. pmid:10879808
Caplan MS et al. Endotoxin and hypoxia-induced intestinal necrosis in rats: the role of platelet activating factor. 1992 Pediatr. Res. pmid:1603619
Abraham WM and Wanner A Inflammatory mediators of asthma. 1988 Pediatr. Pulmonol. pmid:2455882
Smith JM et al. Platelet-activating factor and Escherichia coliO157:H7 infections. 2002 Pediatr. Nephrol. pmid:12478356
Svetlov SI et al. Decreased intraplatelet Ca2+ release and ATP secretion in pediatric nephrotic syndrome. 1999 Pediatr. Nephrol. pmid:10353406
Hsueh W et al. Neonatal necrotizing enterocolitis: clinical considerations and pathogenetic concepts. 2003 Jan-Feb Pediatr. Dev. Pathol. pmid:12424605
Hsueh W et al. Necrotizing enterocolitis of the newborn: pathogenetic concepts in perspective. 1998 Jan-Feb Pediatr. Dev. Pathol. pmid:10463267