| MeSH term | MeSH ID | Detail |
|---|---|---|
| Burns, Inhalation | D002059 | 4 associated lipids |
| Shock, Traumatic | D012774 | 4 associated lipids |
| Hypertrophy, Right Ventricular | D017380 | 4 associated lipids |
| Hepatitis B, Chronic | D019694 | 4 associated lipids |
| Lymphoma, T-Cell, Cutaneous | D016410 | 4 associated lipids |
| Liver Failure | D017093 | 5 associated lipids |
| Neoplastic Cells, Circulating | D009360 | 5 associated lipids |
| Hepatitis, Alcoholic | D006519 | 5 associated lipids |
| Granulomatosis with Polyangiitis | D014890 | 5 associated lipids |
| Spasm | D013035 | 5 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mayerle J et al. | [Conservative treatment of acute pancreatitis]. | 2003 | Med. Klin. (Munich) | pmid:14685675 |
| Tellis C et al. | Localization of an alkyl-acetyl-glycerol-CDP-choline: cholinephosphotransferase activity in submitochondrial fractions of Tetrahymena pyriformis. | 2003 | Eur. J. Cell Biol. | pmid:14703014 |
| Stafforini DM et al. | Platelet-activating factor, a pleiotrophic mediator of physiological and pathological processes. | 2003 | Crit Rev Clin Lab Sci | pmid:14708958 |
| Narahara H et al. | Platelet-activating factor inhibits the secretion of platelet-activating factor acetylhydrolase by human decidual macrophages. | 2003 | J. Clin. Endocrinol. Metab. | pmid:14671207 |
| Gálvez J et al. | The intestinal anti-inflammatory activity of UR-12746S on reactivated experimental colitis is mediated through downregulation of cytokine production. | 2003 | Inflamm. Bowel Dis. | pmid:14671485 |
| Ishizuka S et al. | Effects of rhinovirus infection on the adherence of Streptococcus pneumoniae to cultured human airway epithelial cells. | 2003 | J. Infect. Dis. | pmid:14673774 |
| Koyama N | Platelet activating factor in surfactant-TA is inhibited by coexisting inhibitors. | 2003 | Lung | pmid:14692561 |
| Russo S et al. | Platelet-activating factor mediates CD40-dependent angiogenesis and endothelial-smooth muscle cell interaction. | 2003 | J. Immunol. | pmid:14607955 |
| Slomiany BL and Slomiany A | Biphasic role of platelet-activating factor in oral mucosal ulcer healing. | 2003 | IUBMB Life | pmid:14609204 |
| Yang Y et al. | Kupffer cells are a major source of increased platelet activating factor in the CCl4-induced cirrhotic rat liver. | 2003 | J. Hepatol. | pmid:12873816 |
| Biffl WL et al. | Clinically relevant hypertonicity prevents stored blood- and lipid-mediated delayed neutrophil apoptosis independent of p38 MAPK or caspase-3 activation. | 2003 | Surgery | pmid:12874587 |
| Akisu M et al. | Selective head cooling with hypothermia suppresses the generation of platelet-activating factor in cerebrospinal fluid of newborn infants with perinatal asphyxia. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12878450 |
| Zhu X et al. | Structural determinants of blockade of eosinophil activation, adhesion and secretion by synthetic analogs of phomactin. | 2003 | Life Sci. | pmid:14519449 |
| Møller CH and Steinbrüchel DA | Platelet function after coronary artery bypass grafting: is there a procoagulant activity after off-pump compared with on-pump surgery? | 2003 | Scand. Cardiovasc. J. | pmid:12881156 |
| Guarino MP et al. | PAF-like lipids- and PAF-induced gallbladder muscle contraction is mediated by different pathways in guinea pigs. | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12936911 |
| Curry FE et al. | Thrombin increases permeability only in venules exposed to inflammatory conditions. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12893636 |
| Mayer K et al. | Omega-3 vs. omega-6 lipid emulsions exert differential influence on neutrophils in septic shock patients: impact on plasma fatty acids and lipid mediator generation. | 2003 | Intensive Care Med | pmid:12897994 |
| Shen Z et al. | Effects of plumbagin on platelet aggregation and platelet-neutrophil interactions. | 2003 | Planta Med. | pmid:12898414 |
| de Assis EF et al. | Synergism between platelet-activating factor-like phospholipids and peroxisome proliferator-activated receptor gamma agonists generated during low density lipoprotein oxidation that induces lipid body formation in leukocytes. | 2003 | J. Immunol. | pmid:12902515 |
| Gabrijelcic J et al. | Neutrophil airway influx by platelet-activating factor in asthma: role of adhesion molecules and LTB4 expression. | 2003 | Eur. Respir. J. | pmid:12952263 |
| Hu H et al. | Glycoprotein IIb/IIIa inhibition attenuates platelet-activating factor-induced platelet activation by reducing protein kinase C activity. | 2003 | J. Thromb. Haemost. | pmid:12911597 |
| Kalia N and Bardhan KD | Of blood and guts: association between Helicobacter pylori and the gastric microcirculation. | 2003 | J. Gastroenterol. Hepatol. | pmid:12911655 |
| Tokuoka SM et al. | Involvement of platelet-activating factor and LIS1 in neuronal migration. | 2003 | Eur. J. Neurosci. | pmid:12911752 |
| Lupia E et al. | Intra-plaque production of platelet-activating factor correlates with neoangiogenesis in human carotid atherosclerotic lesions. | 2003 | Int. J. Mol. Med. | pmid:12883648 |
| Handa RK et al. | Role of Nitric oxide in the renal and systemic vasodilatory responses to platelet-activating factor in the rat, in vivo. | 2003 | Kidney Blood Press. Res. | pmid:12886044 |
| Taggart DP et al. | Neuroprotection during cardiac surgery: a randomised trial of a platelet activating factor antagonist. | 2003 | Heart | pmid:12860868 |
| Takafuji S et al. | Matrix metalloproteinase-9 release from human leukocytes. | 2003 | J Investig Allergol Clin Immunol | pmid:12861851 |
| Bar-Or D et al. | Copper stimulates the synthesis and release of interleukin-8 in human endothelial cells: a possible early role in systemic inflammatory responses. | 2003 | Shock | pmid:12865660 |
| Liu J et al. | Lipopolysaccharide induces anandamide synthesis in macrophages via CD14/MAPK/phosphoinositide 3-kinase/NF-kappaB independently of platelet-activating factor. | 2003 | J. Biol. Chem. | pmid:12949078 |
| Brandt EB et al. | Mast cells are required for experimental oral allergen-induced diarrhea. | 2003 | J. Clin. Invest. | pmid:14660743 |
| Rhee CK | Candidate's thesis: Platelet-activating factor-induced hearing loss: mediated by nitric oxide? | 2003 | Laryngoscope | pmid:14660903 |
| Diaper CM et al. | A total synthesis of (+/-)-phomactin A. | 2003 | Org. Biomol. Chem. | pmid:14664384 |
| Beck-Speier I et al. | Sulfur-related air pollutants induce the generation of platelet-activating factor, 5-lipoxygenase- and cyclooxygenase-products in canine alveolar macrophages via activation of phospholipases A2. | 2003 | Prostaglandins Other Lipid Mediat. | pmid:14518563 |
| Antonopoulou S et al. | Hydroxyl-platelet-activating factor exists in blood of healthy volunteers and periodontal patients. | 2003 | Mediators Inflamm. | pmid:14514473 |
| Gödecke A | PAF, PIP(3) and NO: emerging role in reperfusion injury. | 2003 | Cardiovasc. Res. | pmid:14613846 |
| Alloatti G et al. | Phosphoinositide 3-kinase gamma-deficient hearts are protected from the PAF-dependent depression of cardiac contractility. | 2003 | Cardiovasc. Res. | pmid:14613853 |
| Akisu M et al. | Supplementation with Saccharomyces boulardii ameliorates hypoxia/reoxygenation-induced necrotizing enterocolitis in young mice. | 2003 | Eur J Pediatr Surg | pmid:14618522 |
| Fernandes LB and Goldie RG | The single mediator approach to asthma therapy: is it so unreasonable? | 2003 | Curr Opin Pharmacol | pmid:12810188 |
| Zhang X et al. | Age-related increase of plasma platelet-activating factor concentrations in Chinese. | 2003 | Clin. Chim. Acta | pmid:14568193 |
| Watanabe J et al. | Endotoxins stimulate neutrophil adhesion followed by synthesis and release of platelet-activating factor in microparticles. | 2003 | J. Biol. Chem. | pmid:12810708 |
| Toledo AA et al. | Fertilization potential of human sperm is correlated with endogenous platelet-activating factor content. | 2003 | J. Assist. Reprod. Genet. | pmid:12812462 |
| Souza DG et al. | Role of PAF receptors during intestinal ischemia and reperfusion injury. A comparative study between PAF receptor-deficient mice and PAF receptor antagonist treatment. | 2003 | Br. J. Pharmacol. | pmid:12812996 |
| Brown RA et al. | Effects of heparin and related molecules upon neutrophil aggregation and elastase release in vitro. | 2003 | Br. J. Pharmacol. | pmid:12813008 |
| Abu-Zidan FM | Comment on "Low-dose ethanol alters the cardiovascular, metabolic, and respiratory compensation for severe blood loss". | 2003 | J Trauma | pmid:12813357 |
| Toledo DP et al. | Microvascular reactivity in experimental diabetes: responses of male and female rats. | 2003 | Inflamm. Res. | pmid:12813623 |
| Tonks AJ et al. | Regulation of platelet-activating factor synthesis in human monocytes by dipalmitoyl phosphatidylcholine. | 2003 | J. Leukoc. Biol. | pmid:12832447 |
| Choi IW et al. | Platelet-activating factor-mediated NF-kappaB dependency of a late anaphylactic reaction. | 2003 | J. Exp. Med. | pmid:12835479 |
| Proudfoot JM et al. | Angiotensin II type 1 receptor antagonists inhibit basal as well as low-density lipoprotein and platelet-activating factor-stimulated human monocyte chemoattractant protein-1. | 2003 | J. Pharmacol. Exp. Ther. | pmid:12626661 |
| Fang HY et al. | Cyclooxygenase-2 in human non-small cell lung cancer. | 2003 | Eur J Surg Oncol | pmid:12633561 |
| Witko-Sarsat V et al. | AOPP-induced activation of human neutrophil and monocyte oxidative metabolism: a potential target for N-acetylcysteine treatment in dialysis patients. | 2003 | Kidney Int. | pmid:12787398 |
| Slomiany BL and Slomiany A | Platelet-activating factor modulates gastric mucosal inflammatory responses to Helicobacter pylori lipopolysaccharide. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12788098 |
| Schuster DP et al. | Recombinant platelet-activating factor acetylhydrolase to prevent acute respiratory distress syndrome and mortality in severe sepsis: Phase IIb, multicenter, randomized, placebo-controlled, clinical trial. | 2003 | Crit. Care Med. | pmid:12794395 |
| Rabinovici R | Platelet activating factor inhibition in sepsis: the end? | 2003 | Crit. Care Med. | pmid:12794432 |
| Bernatchez PN et al. | Sphingosine 1-phosphate effect on endothelial cell PAF synthesis: role in cellular migration. | 2003 | J. Cell. Biochem. | pmid:14587028 |
| Saraf MK et al. | Role of platelet activating factor in triazolobenzodiazepines-induced retrograde amnesia. | 2003 | Behav. Brain Res. | pmid:12798263 |
| Denizot Y et al. | Platelet-activating factor and normal or leukaemic haematopoiesis. | 2003 | Leuk. Lymphoma | pmid:12802913 |
| Li XG and Luo HM | [Progress in studies of chemical constituents and pharmacological activities of Kadsura]. | 2003 | Zhongguo Zhong Yao Za Zhi | pmid:15617488 |
| Zang BX et al. | [Antagonistic effect of myricetin on platelet activing factor]. | 2003 | Yao Xue Xue Bao | pmid:14991995 |
| Benelli R et al. | Neutrophils and angiogenesis: potential initiators of the angiogenic cascade. | 2003 | Chem Immunol Allergy | pmid:12947984 |
| Wierzbicki T et al. | IL-4 primes human endothelial cells for secondary responses to histamine. | 2003 | J. Leukoc. Biol. | pmid:12949246 |
| Khanna A et al. | Beneficial effects of intraluminal nitroglycerin in intestinal ischemia-reperfusion injury in rats. | 2003 | J. Surg. Res. | pmid:13678693 |
| Bazan NG | Synaptic lipid signaling: significance of polyunsaturated fatty acids and platelet-activating factor. | 2003 | J. Lipid Res. | pmid:13130128 |
| Chatterjee SS et al. | Structure-activity studies with Ginkgo biloba extract constituents as receptor-gated chloride channel blockers and modulators. | 2003 | Pharmacopsychiatry | pmid:13130392 |
| Mahgoub AA | Thymoquinone protects against experimental colitis in rats. | 2003 | Toxicol. Lett. | pmid:12749817 |
| Mariano F et al. | Platelet-activating factor synthesis by neutrophils, monocytes, and endothelial cells is modulated by nitric oxide production. | 2003 | Shock | pmid:12688545 |
| Thaete LG et al. | Infusion of exogenous platelet-activating factor produces intrauterine growth restriction in the rat. | 2003 | J. Soc. Gynecol. Investig. | pmid:12699876 |
| Simon HU et al. | Interleukin-2 primes eosinophil degranulation in hypereosinophilia and Wells' syndrome. | 2003 | Eur. J. Immunol. | pmid:12672048 |
| Teather LA and Wurtman RJ | Cyclooxygenase-2 mediates platelet-activating factor-induced prostaglandin E2 release from rat primary astrocytes. | 2003 | Neurosci. Lett. | pmid:12672535 |
| Kordan W et al. | Functions of platelet activating factor (PAF) in mammalian reproductive processes: a review. | 2003 | Pol J Vet Sci | pmid:12675470 |
| Loucks EB et al. | Role of platelet activating factor in cardiac dysfunction, apoptosis and nitric oxide synthase mRNA expression in the ischemic-reperfused rabbit heart. | 2003 | Can J Cardiol | pmid:12677282 |
| Ginesta MM et al. | Modulation of the pathology of late xenograft rejection by PAF-antagonist UR-12670 in the hamster-to-rat liver xenotransplant model. | 2003 | APMIS | pmid:12752216 |
| Peri A et al. | The effects of an autocrine loop mediated by platelet-activating factor (PAF) in HEC-1A cells are reverted by uteroglobin. | 2003 | Hum. Cell | pmid:15005239 |
| Wu B et al. | Platelet-activating factor promotes mucosal apoptosis via FasL-mediating caspase-9 active pathway in rat small intestine after ischemia-reperfusion. | 2003 | FASEB J. | pmid:12709415 |
| Ueda Y et al. | Effects on blood pressure decrease in response to PAF of Impatiens textori MIQ. | 2003 | Biol. Pharm. Bull. | pmid:14519965 |
| Akisu M et al. | The role of dietary supplementation with L-glutamine in inflammatory mediator release and intestinal injury in hypoxia/reoxygenation-induced experimental necrotizing enterocolitis. | 2003 | Ann. Nutr. Metab. | pmid:14520021 |
| Frostegård J et al. | Antibodies against platelet-activating factor and platelet-activating factor-like lipids are raised in women with primary recurrent abortion. | 2003 | Am. J. Obstet. Gynecol. | pmid:14520236 |
| Ahlemeyer B and Krieglstein J | Neuroprotective effects of Ginkgo biloba extract. | 2003 | Cell. Mol. Life Sci. | pmid:14523543 |
| Vogensen SB et al. | Preparation of 7-substituted ginkgolide derivatives: potent platelet activating factor (PAF) receptor antagonists. | 2003 | J. Med. Chem. | pmid:12570381 |
| Biancone L et al. | Platelet-activating factor inactivation by local expression of platelet-activating factor acetyl-hydrolase modifies tumor vascularization and growth. | 2003 | Clin. Cancer Res. | pmid:14519648 |
| Gabbianelli R et al. | A new method to evaluate spontaneous platelet aggregation in type 2 diabetes by Cellfacts. | 2003 | Clin. Chim. Acta | pmid:12589971 |
| D'Andrea G et al. | Platelet aggregation profiles in cluster headache. | 2003 | Headache | pmid:12603647 |
| Gruska S et al. | Sodium/lithium countertransport and intracellular calcium concentration in patients with essential hypertension and coronary heart disease. | 2003 | Clin. Sci. | pmid:12605593 |
| Lu DP et al. | Ligand-activated signal transduction in the 2-cell embryo. | 2003 | Biol. Reprod. | pmid:12606379 |
| Hu G et al. | Neutrophils pretreated with volatile anesthetics lose ability to cause cardiac dysfunction. | 2003 | Anesthesiology | pmid:12606916 |
| Corl CM et al. | Oxidant stress enhances Lyso-PAF-AcT activity by modifying phospholipase D and phosphatidic acid in aortic endothelial cells. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12615078 |
| Dinarello CA | The IL-1 family and inflammatory diseases. | 2002 Sep-Oct | Clin. Exp. Rheumatol. | pmid:14989423 |
| Chłopicki S et al. | Hypoxic pulmonary vasoconstriction in isolated blood-perfused rat lung; modulation by thromboxane A2, platelet-activating factor, cysteinyl leukotrienes and endothelin-1. | 2002 Sep-Oct | Pol J Pharmacol | pmid:12593530 |
| Klabunde RE and Anderson DE | Role of nitric oxide and reactive oxygen species in platelet-activating factor-induced microvascular leakage. | 2002 May-Jun | J. Vasc. Res. | pmid:12097822 |
| Huang JB et al. | Hexokinase translocation during neutrophil activation, chemotaxis, and phagocytosis: disruption by cytochalasin D, dexamethasone, and indomethacin. | 2002 Jul-Aug | Cell. Immunol. | pmid:12470617 |
| Levine AS et al. | A review of the effect of platelet-activating factor on male reproduction and sperm function. | 2002 Jul-Aug | J. Androl. | pmid:12065449 |
| Farbiszewski R et al. | [The role of platelet activating factor (PAF) in physiology and pathology of the central nervous system]. | 2002 Jul-Aug | Neurol. Neurochir. Pol. | pmid:12418143 |
| Leusch A et al. | Altered drug disposition of the platelet activating factor antagonist apafant in mdr1a knockout mice. | 2002 | Eur J Pharm Sci | pmid:12128165 |
| Megens AA et al. | Pharmacological profile of (2R-trans)-4-[1-[3,5-bis(trifluoromethyl)benzoyl]-2-(phenylmethyl)-4-piperidinyl]-N-(2,6-dimethylphenyl)-1-acetamide (S)-Hydroxybutanedioate (R116301), an orally and centrally active neurokinin-1 receptor antagonist. | 2002 | J. Pharmacol. Exp. Ther. | pmid:12130734 |
| Hostettler ME et al. | Platelet-activating factor induces cell death in cultured astrocytes and oligodendrocytes: involvement of caspase-3. | 2002 | Glia | pmid:11968060 |
| Acuña AA et al. | Fluticasone propionate attenuates platelet-activating factor-induced gas exchange defects in mild asthma. | 2002 | Eur. Respir. J. | pmid:12030727 |
| Steel HC et al. | Platelet-activating factor and lyso-PAF possess direct antimicrobial properties in vitro. | 2002 | APMIS | pmid:12064871 |
| Ibe BO et al. | Metabolism of platelet activating factor by intrapulmonary vascular smooth muscle cells. Effect of oxygen on phospholipase A2 protein expression and activities of acetyl-CoA acetyltransferase and cholinephosphotransferase. | 2002 | Mol. Genet. Metab. | pmid:12409272 |
| Klein A et al. | Platelet-activating factor drives eotaxin production in an allergic pleurisy in mice. | 2002 | Br. J. Pharmacol. | pmid:11877329 |
| Bulger EM et al. | The macrophage response to endotoxin requires platelet activating factor. | 2002 | Shock | pmid:11900334 |
| Furukawa M et al. | Presence of platelet-activating factor in nasal polyps and eosinophils. | 2002 | Acta Otolaryngol. | pmid:12542208 |