Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

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Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
AIDS Dementia Complex D015526 4 associated lipids
Neoplasms, Germ Cell and Embryonal D009373 4 associated lipids
Burns, Inhalation D002059 4 associated lipids
Shock, Traumatic D012774 4 associated lipids
Hypertrophy, Right Ventricular D017380 4 associated lipids
Strongylida Infections D017206 5 associated lipids
Neoplastic Cells, Circulating D009360 5 associated lipids
Liver Failure D017093 5 associated lipids
Hepatitis, Alcoholic D006519 5 associated lipids
Granulomatosis with Polyangiitis D014890 5 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

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What functions are associated with Platelet activating factor?


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What lipids are associated with Platelet activating factor?

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What genes are associated with Platelet activating factor?

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What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Authors Title Published Journal PubMed Link
Rezaul K et al. Platelet-activating factor stimulates calcium-dependent activation of protein-tyrosine kinase Syk in a human B cell line. 1997 Biochem. Biophys. Res. Commun. pmid:9345263
Iwamoto S et al. The release mechanism of platelet-activating factor during shear-stress induced platelet aggregation. 1997 Biochem. Biophys. Res. Commun. pmid:9345277
Palmblad J et al. Leukotriene B4 induced hyperadhesiveness of endothelial cells for neutrophils. 1990 Biochem. Biophys. Res. Commun. pmid:2154222
Agrawal DK and Townley RG Effect of platelet-activating factor on beta-adrenoceptors in human lung. 1987 Biochem. Biophys. Res. Commun. pmid:3030311
Hwang SB Competitive inhibition of tritium-labeled platelet-activating factor binding to rabbit platelet membranes by amiloride and amiloride analogs. 1989 Biochem. Biophys. Res. Commun. pmid:2549986
Kuruvilla A et al. High-level expression of functional platelet-activating factor receptors on a human B lymphoblastoid cell line. 1991 Biochem. Biophys. Res. Commun. pmid:1659411
Catalán RE et al. Nitric oxide mediates the PAF-stimulated cyclic GMP production in hippocampal slices. 1996 Biochem. Biophys. Res. Commun. pmid:8806587
Lee TC et al. Renal necrosis and the involvement of a single enzyme of the de novo pathway for the biosynthesis of platelet-activating factor in the rat kidney inner medulla. 1989 Biochem. Biophys. Res. Commun. pmid:2551264
Tysnes OB et al. Neomycin inhibits agonist-stimulated polyphosphoinositide metabolism and responses in human platelets. 1987 Biochem. Biophys. Res. Commun. pmid:3034251
Hirata F et al. IL-1 beta regulates the expression of the Gi2 alpha gene via lipid mediators in guinea pig tracheal muscle. 1994 Biochem. Biophys. Res. Commun. pmid:7945342
Wang F et al. A new protein kinase C, nPKC eta', and nPKC theta are expressed in human platelets: involvement of nPKC eta' and nPKC theta in signal transduction stimulated by PAF. 1993 Biochem. Biophys. Res. Commun. pmid:8447826
Chesney CM et al. Triazolobenzodiazepines competitively inhibit the binding of platelet activating factor (PAF) to human platelets. 1987 Biochem. Biophys. Res. Commun. pmid:3579913
O'Flaherty JT et al. 5-L-hydroxy-6,8,11,14-eicosatetraenoate potentiates the human neutrophil degranulating action of platelet-activating factor. 1983 Biochem. Biophys. Res. Commun. pmid:6403011
Smith RJ et al. Effects of an anion channel blocker, 4, 4'-diisothiocyano-2,2'-disulfonic acid stilbene (DIDS), on human neutrophil function. 1984 Biochem. Biophys. Res. Commun. pmid:6329191
Dillon AM and Heath MF The effects of tyrphostins B42 and B46 on equine platelet function and protein tyrosine phosphorylation. 1995 Biochem. Biophys. Res. Commun. pmid:7542881
O'Flaherty JT et al. 1-O-alkyl-2-N-methylcarbamyl-glycerophosphocholine: a biologically potent, non-metabolizable analog of platelet-activating factor. 1987 Biochem. Biophys. Res. Commun. pmid:2820395
Wymann MP et al. Oscillatory motion in human neutrophils responding to chemotactic stimuli. 1987 Biochem. Biophys. Res. Commun. pmid:2820398
Sozzani S et al. Synergism between platelet activating factor and C-C chemokines for arachidonate release in human monocytes. 1994 Biochem. Biophys. Res. Commun. pmid:7510961
Rengan R and Omann GM Regulation of oscillations in filamentous actin content in polymorphonuclear leukocytes stimulated with leukotriene B(4) and platelet-activating factor. 1999 Biochem. Biophys. Res. Commun. pmid:10462500
Yasuda K et al. Platelet-activating factor in normal rat uterus. 1986 Biochem. Biophys. Res. Commun. pmid:3753495
Jamil KM et al. Expression of platelet activating factor receptor in renal tubular cell line (LLC-PK1). 1992 Biochem. Biophys. Res. Commun. pmid:1326956
Steiner M et al. Biological activity of platelet activating factor-amidophosphonate (PAF-AP), a novel phosphonolipid selective inhibitor of platelet activating factor (PAF). 1985 Biochem. Biophys. Res. Commun. pmid:3936503
Yeo YK et al. The effect of long-term consumption of fish oil on platelet-activating factor synthesis in rat renal microsomes. 1989 Biochem. Biophys. Res. Commun. pmid:2543394
Wirthmueller U et al. Studies on the mechanism of platelet-activating factor production in GM-CSF primed neutrophils: involvement of protein synthesis and phospholipase A2 activation. 1990 Biochem. Biophys. Res. Commun. pmid:2166499
Chiang CF and Hauser G Effects of bradykinin, GTP gamma S, R59022 and N-ethylmaleimide on inositol phosphate production in NG108-15 cells. 1989 Biochem. Biophys. Res. Commun. pmid:2686644
Levy JV Spasmogenic effect of platelet activating factor (PAF) on isolated rat stomach fundus strip. 1987 Biochem. Biophys. Res. Commun. pmid:3619905
Lachachi H et al. Inhibition of transmembrane movement and metabolism of platelet activating factor (PAF-acether) by a specific antagonist, BN 52021. 1985 Biochem. Biophys. Res. Commun. pmid:2998370
Clay KL et al. Structure elucidation of platelet activating factor derived from human neutrophils. 1984 Biochem. Biophys. Res. Commun. pmid:6430285
Alexandre A et al. Inhibition by antioxidants of agonist evoked cytosolic Ca++ increase, ATP secretion and aggregation of aspirinated human platelets. 1986 Biochem. Biophys. Res. Commun. pmid:3094518
Lanara E et al. Response of mice and mouse platelets to acetyl glyceryl ether phosphorylcholine. 1982 Biochem. Biophys. Res. Commun. pmid:7168759
O'Flaherty JT et al. Diacylglycerols enhance human neutrophil degranulation responses: relevancy to a multiple mediator hypothesis of cell function. 1984 Biochem. Biophys. Res. Commun. pmid:6433920
Mendlovic F et al. Possible involvement of cyclooxygenase products in the actions of platelet-activating factor and of lipoxygenase products in the vascular effects of epinephrine in perfused rat liver. 1984 Biochem. Biophys. Res. Commun. pmid:6435614
Rola-Pleszczynski M et al. Inhibition of human lymphocyte proliferation and interleukin 2 production by platelet activating factor (PAF-acether): reversal by a specific antagonist, BN 52021. 1987 Biochem. Biophys. Res. Commun. pmid:3493773
Sha'afi RI and Molski TF Signalling for increased cytoskeletal actin in neutrophils. 1987 Biochem. Biophys. Res. Commun. pmid:3036146
Domingo MT et al. Characterization of specific binding sites for PAF in the iris and ciliary body of rabbit. 1989 Biochem. Biophys. Res. Commun. pmid:2540746
Griffin K et al. The benzodiazepine receptor ligands RO 5-4864 and RO 15-1788 do not block the inhibition of PAF-induced platelet aggregation seen with the hetrazepine WEB2086. 1989 Biochem. Biophys. Res. Commun. pmid:2540748
Müller S and Nigam S Enhancement by staurosporine of platelet-activating factor formation in N-formyl peptide-challenged human neutrophils is mediated by intracellular platelet-activating factor binding sites. 1992 Biochem. Biophys. Res. Commun. pmid:1335246
Ashmore RC et al. Aggregating platelets increase intracellular calcium in endothelial cells through release of adenine nucleotides. 1990 Biochem. Biophys. Res. Commun. pmid:2302246
Sugimoto T et al. Molecular cloning and characterization of the platelet-activating factor receptor gene expressed in the human heart. 1992 Biochem. Biophys. Res. Commun. pmid:1281995
Francescangeli E and Goracci G The de novo biosynthesis of platelet-activating factor in rat brain. 1989 Biochem. Biophys. Res. Commun. pmid:2543404
Murphy CT et al. Evidence for the presence and location of annexins in human platelets. 1992 Biochem. Biophys. Res. Commun. pmid:1482379
Hussaini IM and Shen TY A specific, photolabile and irreversible antagonist (L662,025) of the PAF-receptor. 1989 Biochem. Biophys. Res. Commun. pmid:2543410
Shukla SD and Hanahan DJ AGEPC (platelet activating factor) induced stimulation of rabbit platelets: effects on phosphatidylinositol, di- and triphosphoinositides and phosphatidic acid metabolism. 1982 Biochem. Biophys. Res. Commun. pmid:6288030
Doebber TW et al. Platelet activating factor intravenous infusion in rats stimulates vascular lysosomal hydrolase secretion independent of blood neutrophils. 1984 Biochem. Biophys. Res. Commun. pmid:6517949
Mallet AI and Cunningham FM Structural identification of platelet activating factor in psoriatic scale. 1985 Biochem. Biophys. Res. Commun. pmid:3970690
Valone FH Inhibition of binding of the platelet-activating factor AGEPC to platelets by the AGEPC analog rac-3-(N-n-octadecylcarbamoyloxy)-2-methoxypropyl 2-thiazolioethyl phosphate (CV-3988). 1985 Biochem. Biophys. Res. Commun. pmid:3970703
Chesney CM et al. Desensitization of human platelets by platelet activating factor. 1985 Biochem. Biophys. Res. Commun. pmid:3977920
Nakayama R et al. Generation of acetyl glyceryl ether phosphorylcholine from the rat skin and muscle tissues stimulated by moxibustion. 1985 Biochem. Biophys. Res. Commun. pmid:3977939
Swendsen CL et al. 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine: a novel source of arachidonic acid in neutrophils stimulated by the calcium ionophore A23187. 1983 Biochem. Biophys. Res. Commun. pmid:6407484
Silva-Neto MA et al. Platelet-activating factor (PAF) activates casein kinase 2 in the protozoan parasite Herpetomonas muscarum muscarum. 2002 Biochem. Biophys. Res. Commun. pmid:12054663
Caramelo C et al. Presence of platelet-activating factor in blood from humans and experimental animals. Its absence in anephric individuals. 1984 Biochem. Biophys. Res. Commun. pmid:6732788
Lenihan DJ and Lee TC Regulation of platelet activating factor synthesis: modulation of 1-alkyl-2-lyso-sn-glycero-3-phosphocholine:acetyl-CoA acetyltransferase by phosphorylation and dephosphorylation in rat spleen microsomes. 1984 Biochem. Biophys. Res. Commun. pmid:6732789
Shindou H et al. Roles of cytosolic phospholipase A(2) and platelet-activating factor receptor in the Ca-induced biosynthesis of PAF. 2000 Biochem. Biophys. Res. Commun. pmid:10814544
Lagente V et al. Pharmacological modulation of the bronchopulmonary action of the vasoactive peptide, endothelin, administered by aerosol in the guinea-pig. 1989 Biochem. Biophys. Res. Commun. pmid:2645865
Mollinedo F et al. Intracellular localization of platelet-activating factor synthesis in human neutrophils. 1988 Biochem. Biophys. Res. Commun. pmid:3408495
Joseph R and Han E Amyloid beta-protein fragment 25-35 causes activation of cytoplasmic calcium in neurons. 1992 Biochem. Biophys. Res. Commun. pmid:1590803
Hirafuji M et al. Transient increase of cytosolic free calcium in cultured human vascular endothelial cells by platelet-activating factor. 1988 Biochem. Biophys. Res. Commun. pmid:3408504
Barr R et al. The effect of platelet activating factor on electron transport of spinach chloroplasts. 1988 Biochem. Biophys. Res. Commun. pmid:3048258
Catalán RE et al. PAF-induced activation of polyphosphoinositide-hydrolyzing phospholipase C in cerebral cortex. 1992 Biochem. Biophys. Res. Commun. pmid:1311925
Pai JK et al. Activation of phospholipase D by chemotactic peptide in HL-60 granulocytes. 1988 Biochem. Biophys. Res. Commun. pmid:3422154
Blank ML et al. A new class of antihypertensive neutral lipid: 1-alkyl-2-acetyl-sn-glycerols, a precursor of platelet activating factor. 1984 Biochem. Biophys. Res. Commun. pmid:6696762
Takano T et al. Demonstration of platelet activating factor receptor in guinea pig kidney. 1991 Biochem. Biophys. Res. Commun. pmid:1710454
Lüthje J and Ogilvie A Diadenosine triphosphate (Ap3A) mediates human platelet aggregation by liberation of ADP. 1984 Biochem. Biophys. Res. Commun. pmid:6704102
Patrignani P et al. Platelet-activating factor (PAF) receptor antagonists inhibit mitogen-induced human peripheral blood T-cell proliferation. 1987 Biochem. Biophys. Res. Commun. pmid:2825672
Földes-Filep E et al. Inhibition by BN 52021 (ginkgolide B) of the binding of [3H]-platelet-activating factor to human neutrophil granulocytes. 1987 Biochem. Biophys. Res. Commun. pmid:2825685
Lee TC et al. Activities of enzymes that metabolize platelet-activating factor (1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine) in neutrophils and eosinophils from humans and the effect of a calcium ionophore. 1982 Biochem. Biophys. Res. Commun. pmid:6808993
Di Marzo V et al. Platelet activating factor-mediated leukotriene biosynthesis in rat lungs: effect of prostaglandins E1 and F1 alpha. 1987 Biochem. Biophys. Res. Commun. pmid:2822041
Crouch MF and Lapetina EG Spacial isolation of protein kinase C activation in thrombin stimulated human platelets. 1988 Biochem. Biophys. Res. Commun. pmid:3178827
Rodrigues CO et al. Effect of platelet-activating factor on cell differentiation of Trypanosoma cruzi. 1996 Biochem. Biophys. Res. Commun. pmid:8687466
Panetta T et al. Effects of a platelet activating factor antagonist (BN 52021) on free fatty acids, diacylglycerols, polyphosphoinositides and blood flow in the gerbil brain: inhibition of ischemia-reperfusion induced cerebral injury. 1987 Biochem. Biophys. Res. Commun. pmid:2827647
Sugiura T et al. Transacylation of 1-O-alkyl-SN-glycero-3-phosphocholine (lyso platelet-activating factor) and 1-O-alkenyl-SN-glycero-3-phosphoethanolamine with docosahexaenoic acid (22:6 omega 3). 1985 Biochem. Biophys. Res. Commun. pmid:2935146
Bazan HE et al. The accumulation of platelet activating factor in the injured cornea may be interrelated with the synthesis of lipoxygenase products. 1987 Biochem. Biophys. Res. Commun. pmid:2827658
Tamura N et al. Effects of platelet activating factor on the chemotaxis of normodense eosinophils from normal subjects. 1987 Biochem. Biophys. Res. Commun. pmid:3030295
Molski TF et al. Intracellular calcium rise produced by platelet-activating factor is deactivated by fMet-Leu-Phe and this requires uninterrupted activation sequence: role of protein kinase C. 1988 Biochem. Biophys. Res. Commun. pmid:3348814
Nakayama R et al. 1-O-hexadec-1'-enyl-2-acetyl-sn-glycero-3-phosphocholine and its biological activity. 1988 Biochem. Biophys. Res. Commun. pmid:3355555
Beaubien BB et al. Platelet-activating factor stimulation of peptidoleukotriene release: inhibition by vasoactive polypeptide. 1984 Biochem. Biophys. Res. Commun. pmid:6594998
Billah MM and Johnston JM Identification of phospholipid platelet-activating factor (1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine) in human amniotic fluid and urine. 1983 Biochem. Biophys. Res. Commun. pmid:6407483
Smith CS et al. Cyclosporin A blocks induction of tumor necrosis factor-alpha in human B lymphocytes. 1994 Biochem. Biophys. Res. Commun. pmid:7524500
Hsu HC et al. Alpha-bulnesene, a novel PAF receptor antagonist isolated from Pogostemon cablin. 2006 Biochem. Biophys. Res. Commun. pmid:16712790
Waga I et al. Two distinct signal transduction pathways for the activation of guinea-pig macrophages and neutrophils by endotoxin. 1993 Biochem. Biophys. Res. Commun. pmid:8267581
Hasegawa A et al. Influence of glucocorticoids on time-of-day-dependent variations in IgE-, histamine-, and platelet-activating factor-mediated systemic anaphylaxis in different mouse strains. 2018 Biochem. Biophys. Res. Commun. pmid:29269296
Levi R et al. Alkyl chain homologs of platelet-activating factor and their effects on the mammalian heart. 1989 Biochem. Biophys. Res. Commun. pmid:2742592
Touvay C et al. Role of platelet-activating factor (PAF) in the bronchopulmonary alterations and beta-adrenoceptor function induced by endotoxin. 1988 Biochem. Biophys. Res. Commun. pmid:2835036
Chignard M et al. Paf-acether formation and arachidonic acid freeing from platelet ether-linked glyceryl-phosphorylcholine. 1984 Biochem. Biophys. Res. Commun. pmid:6437404
Yang JP and Tashjian AH Platelet-activating factor affects cytosolic free calcium concentration and prolactin secretion in GH4C1 rat pituitary cells. 1991 Biochem. Biophys. Res. Commun. pmid:1847044
Mueller HW et al. Synthesis of 1-acyl-2-[3H]acetyl-SN-glycero-3-phosphocholine, a structural analog of platelet activating factor, by vascular endothelial cells. 1991 Biochem. Biophys. Res. Commun. pmid:2039529
Ng DS and Wong K Specific binding of platelet-activating factor (PAF) by human peripheral blood mononuclear leukocytes. 1988 Biochem. Biophys. Res. Commun. pmid:2843182
Harris JG et al. Relative contribution of the selectins in the neutrophil recruitment caused by the chemokine cytokine-induced neutrophil chemoattractant (CINC). 1996 Biochem. Biophys. Res. Commun. pmid:8630023
Sugiura T and Waku K CoA-independent transfer of arachidonic acid from 1,2-diacyl-sn-glycero-3-phosphocholine to 1-O-alkyl-sn-glycero-3-phosphocholine (lyso platelet-activating factor) by macrophage microsomes. 1985 Biochem. Biophys. Res. Commun. pmid:3919727
Alaei P et al. Inhibition of protein prenylation down-regulates signalling by inflammatory mediators in human keratinocytes. 1996 Biochem. Biophys. Res. Commun. pmid:8630058
Parent JL et al. Mutation of an aspartate at position 63 in the human platelet-activating factor receptor augments binding affinity but abolishes G-protein-coupling and inositol phosphate production. 1996 Biochem. Biophys. Res. Commun. pmid:8645288
Naoki K et al. PAF responsiveness in Japanese subjects with plasma PAF acetylhydrolase deficiency. 2004 Biochem. Biophys. Res. Commun. pmid:15047169
Rigat B et al. The GM2 activator protein, a novel inhibitor of platelet-activating factor. 1999 Biochem. Biophys. Res. Commun. pmid:10329374
Lumb RH et al. PAF-acether transfer activity in HL-60 cells is induced during differentiation. 1990 Biochem. Biophys. Res. Commun. pmid:2169726
Müller E et al. Human PAF receptor gene expression: induction during HL-60 cell differentiation. 1991 Biochem. Biophys. Res. Commun. pmid:1722407
Tou J Platelet-activating factor promotes arachidonate incorporation into phosphatidylinositol and phosphatidylcholine in neutrophils. 1985 Biochem. Biophys. Res. Commun. pmid:3921017
Pannocchia A and Hardisty RM Cyclic AMP inhibits platelet activation independently of its effect on cytosolic free calcium. 1985 Biochem. Biophys. Res. Commun. pmid:2983714
Parent JL and Stankova J Transforming growth factor-beta up-regulates the gene expression of the human platelet-activating factor receptor in monocytic and B cell lines. 1993 Biochem. Biophys. Res. Commun. pmid:8280163
Holtzman MJ et al. Synthesis of the 1-O-hexadecyl molecular species of platelet-activating factor by airway epithelial and vascular endothelial cells. 1991 Biochem. Biophys. Res. Commun. pmid:2043121
Tokumura A et al. Identification of sn-2-omega-hydroxycarboxylate-containing phospholipids in a lipid extract from bovine brain. 1991 Biochem. Biophys. Res. Commun. pmid:2043133