| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypertrophy, Right Ventricular | D017380 | 4 associated lipids |
| Hepatitis B, Chronic | D019694 | 4 associated lipids |
| Lymphoma, T-Cell, Cutaneous | D016410 | 4 associated lipids |
| Milk Hypersensitivity | D016269 | 4 associated lipids |
| Brain Injuries | D001930 | 4 associated lipids |
| Liver Failure | D017093 | 5 associated lipids |
| Neoplastic Cells, Circulating | D009360 | 5 associated lipids |
| Hepatitis, Alcoholic | D006519 | 5 associated lipids |
| Granulomatosis with Polyangiitis | D014890 | 5 associated lipids |
| Spasm | D013035 | 5 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ulrich CD | Lexipafant in severe acute pancreatitis: the final word? | 2001 | Curr Gastroenterol Rep | pmid:11276374 |
| Ishizuka S et al. | Acid exposure stimulates the adherence of Streptococcus pneumoniae to cultured human airway epithelial cells: effects on platelet-activating factor receptor expression. | 2001 | Am. J. Respir. Cell Mol. Biol. | pmid:11306440 |
| Lukashova V et al. | G-protein-independent activation of Tyk2 by the platelet-activating factor receptor. | 2001 | J. Biol. Chem. | pmid:11309383 |
| Grassi S and Pettorossi VE | Synaptic plasticity in the medial vestibular nuclei: role of glutamate receptors and retrograde messengers in rat brainstem slices. | 2001 | Prog. Neurobiol. | pmid:11311461 |
| Marcano H et al. | Effect of dopamine on platelet activating factor induced-pulmonary edema in isolated and perfused rabbit lungs. | 2001 | Respir Physiol | pmid:11348642 |
| Wild MD and Roudebush WE | Platelet-activating factor improves intrauterine insemination outcome. | 2001 | Am. J. Obstet. Gynecol. | pmid:11349157 |
| Wu C et al. | Evidence for the autocrine induction of capacitation of mammalian spermatozoa. | 2001 | J. Biol. Chem. | pmid:11350972 |
| Taylor R et al. | Platelet-activating factor antagonism and streptokinase-induced hypotension in clinical acute myocardial infarction. | 2001 | Clin. Sci. | pmid:11352774 |
| Hayashi J et al. | Platelet-activating factor antagonist, SM-12502, attenuates experimental glomerular thrombosis in rats. | 2001 | Nephron | pmid:11287764 |
| Choi JH et al. | Platelet-activating factor-induced early activation of NF-kappa B plays a crucial role for organ clearance of Candida albicans. | 2001 | J. Immunol. | pmid:11290796 |
| Marathe GK et al. | Identification of platelet-activating factor as the inflammatory lipid mediator in CCl4-metabolizing rat liver. | 2001 | J. Lipid Res. | pmid:11290831 |
| Kato M et al. | Platelet activating factor degradation in tear fluid from guinea pigs with allergic conjunctivitis. | 2001 | J Ocul Pharmacol Ther | pmid:11327052 |
| Wang H et al. | Platelet-activating factor and endotoxin activate CCAAT/enhancer binding protein in rat small intestine. | 2001 | Br. J. Pharmacol. | pmid:11429396 |
| Miguel BG et al. | Increase of phosphoinositide hydrolysis and diacylglycerol production by PAF in isolated rat liver nuclei. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11444588 |
| Hirashima Y et al. | Effect of a platelet-activating factor receptor antagonist, E5880, on cerebral vasospasm after aneurysmal subarachnoid hemorrhage--open clinical trial to investigate efficacy and safety. | 2001 | Neurol. Med. Chir. (Tokyo) | pmid:11381675 |
| Liu XH et al. | Platelet-activating factor antagonist BN 50730 attenuates hypoxic-ischemic brain injury in neonatal rats. | 2001 | Pediatr. Res. | pmid:11385142 |
| Mi B and Maleczka RE | A Nozaki-Hiyama-Kishi Ni(II)/Cr(II) coupling approach to the phomactins. | 2001 | Org. Lett. | pmid:11388849 |
| Elzi DJ et al. | Ionomycin causes activation of p38 and p42/44 mitogen-activated protein kinases in human neutrophils. | 2001 | Am. J. Physiol., Cell Physiol. | pmid:11401859 |
| Tiemann U et al. | Platelet-activating factor (PAF)-like activity, localization of PAF receptor (PAF-R) and PAF-acetylhydrolase (PAF-AH) activity in bovine endometrium at different stages of the estrous cycle and early pregnancy. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11403499 |
| Tong N et al. | Activation of glycogen synthase kinase 3 beta (GSK-3beta) by platelet activating factor mediates migration and cell death in cerebellar granule neurons. | 2001 | Eur. J. Neurosci. | pmid:11403684 |
| Roudebush WE | Role of platelet-activating factor in reproduction: sperm function. | 2001 | Asian J. Androl. | pmid:11404790 |
| Briton-Jones C et al. | The effects of follicular fluid and platelet-activating factor on motion characteristics of poor-quality cryopreserved human sperm. | 2001 | J. Assist. Reprod. Genet. | pmid:11411433 |
| Mizuno S et al. | Role of PAF in acute liver injury after extended hepatectomy: overexpression of PAF receptor mRNA in Kupffer cells. | 2001 | Dig. Dis. Sci. | pmid:11414308 |
| Tsoukatos DC et al. | Platelet-activating factor acetylhydrolase and transacetylase activities in human plasma low-density lipoprotein. | 2001 | Biochem. J. | pmid:11439095 |
| Roudebush WE and Diehl JR | Platelet-activating factor content in boar spermatozoa correlates with fertility. | 2001 | Theriogenology | pmid:11396471 |
| Bassi F et al. | Detection of platelet-activating factor in gingival tissue surrounding failed dental implants. | 2001 | J. Periodontol. | pmid:11210074 |
| Ferland C et al. | Eotaxin promotes eosinophil transmigration via the activation of the plasminogen-plasmin system. | 2001 | J. Leukoc. Biol. | pmid:11358986 |
| de Meis L | Role of the sarcoplasmic reticulum Ca2+-ATPase on heat production and thermogenesis. | 2001 | Biosci. Rep. | pmid:11725862 |
| Rodrigo L et al. | Hydrolysis of platelet-activating factor by human serum paraoxonase. | 2001 | Biochem. J. | pmid:11171072 |
| Del Sorbo L et al. | Tat-induced platelet-activating factor synthesis contributes to the angiogenic effect of HIV-1 Tat. | 2001 | Eur. J. Immunol. | pmid:11180101 |
| Karasawa K | [Physiological role of novel metabolic pathway of platelet-activating factor(PAF): PAF-dependent transacetylation]. | 2001 | Tanpakushitsu Kakusan Koso | pmid:11193332 |
| Urasaki T et al. | Pivotal role of 5-lipoxygenase in the activation of human eosinophils: platelet-activating factor and interleukin-5 induce CD69 on eosinophils through the 5-lipoxygenase pathway. | 2001 | J. Leukoc. Biol. | pmid:11200053 |
| Petty HR and Kindzelskii AL | Dissipative metabolic patterns respond during neutrophil transmembrane signaling. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11248046 |
| Hauser CJ et al. | PAF-mediated Ca2+ influx in human neutrophils occurs via store-operated mechanisms. | 2001 | J. Leukoc. Biol. | pmid:11200069 |
| Jeon SY et al. | Nitric oxide mediates platelet activating factor-induced microvascular leakage in rat airways. | 2001 | Ann. Otol. Rhinol. Laryngol. | pmid:11201815 |
| Wittwer T et al. | Impact of PAF antagonist BN 52021 (Ginkolide B) on post-ischemic graft function in clinical lung transplantation. | 2001 | J. Heart Lung Transplant. | pmid:11257563 |
| Clavijo LC et al. | PAF increases vascular permeability without increasing pulmonary arterial pressure in the rat. | 2001 | J. Appl. Physiol. | pmid:11133918 |
| Zhang J et al. | Effect of buyang huanwu decoction on platelet activating factor content in arterial blood pre- and post-arterial thrombosis in rats. | 2001 | J Tradit Chin Med | pmid:12014136 |
| Ko TC et al. | Synthesis of 4-alkoxy-2-phenylquinoline derivatives as potent antiplatelet agents. | 2001 | Bioorg. Med. Chem. Lett. | pmid:11212091 |
| McManus LM et al. | Agonist-dependent failure of neutrophil function in diabetes correlates with extent of hyperglycemia. | 2001 | J. Leukoc. Biol. | pmid:11527989 |
| Qian C et al. | Anti-inflammatory activities of LDP-392, a dual PAF receptor antagonist and 5-lipoxygenase inhibitor. | 2001 | Pharmacol. Res. | pmid:11529688 |
| Jerkić M et al. | The mechanism of increased renal susceptibility to toxic substances in the elderly. Part I. The role of increased vasoconstriction. | 2001 | Int Urol Nephrol | pmid:11989542 |
| Arese M et al. | HIV-1 Tat protein stimulates in vivo vascular permeability and lymphomononuclear cell recruitment. | 2001 | J. Immunol. | pmid:11145723 |
| Rabinowitz SS et al. | Platelet-activating factor in infants at risk for necrotizing enterocolitis. | 2001 | J. Pediatr. | pmid:11148517 |
| Gandhi CR et al. | A23187 causes release of inositol phosphates from cultured rat Kupffer cells. | 2001 | Eur. J. Pharmacol. | pmid:11245846 |
| Kawaguchi A et al. | Preventive effect of platelet-activating factor antagonist, Y-24180, against cyclosporine-induced acute nephrotoxicity. | 2001 | Life Sci. | pmid:11228102 |
| Denis MA et al. | Increased response of blood eosinophils to various chemotactic agents in quiescent Crohn disease. | 2001 | Scand. J. Gastroenterol. | pmid:11252412 |
| Storey RF et al. | Effects of P2Y(1) and P2Y(12) receptor antagonists on platelet aggregation induced by different agonists in human whole blood. | 2001 | Platelets | pmid:11674863 |
| Camici M and Sagripanti A | Plasma platelet activating factor in nephrotic syndrome. | 2001 | Minerva Med. | pmid:11675576 |
| Kohno S and Nabe T | [Inflammatory mediators (leukotrienes, thromboxane A2, tachykinins and others)]. | 2001 | Nippon Rinsho | pmid:11676130 |
| Pettorossi VE and Grassi S | Different contributions of platelet-activating factor and nitric oxide in long-term potentiation of the rat medial vestibular nuclei. | 2001 | Acta Otolaryngol Suppl | pmid:11677732 |
| Wielockx B et al. | Involvement of a serine protease, but not of neutrophil elastase, in tumor necrosis factor-induced lethal hepatitis and induction of platelet-activating factor. | 2001 | J. Hepatol. | pmid:11682033 |
| Dutra PM et al. | Platelet-activating factor modulates a secreted phosphatase activity of the trypanosomatid parasite Herpetomonas muscarum muscarum. | 2001 | Curr. Microbiol. | pmid:11683365 |
| Mathison R et al. | Regulation of leukocyte adhesion to heart by the tripeptides feG and feG(NH2). | 2001 | Can. J. Physiol. Pharmacol. | pmid:11599779 |
| Havt A et al. | The renal effects of Bothrops jararacussu venom and the role of PLA(2) and PAF blockers. | 2001 | Toxicon | pmid:11600146 |
| Claman P | Platelet activating factor does not improve intrauterine insemination outcome. | 2001 | Am. J. Obstet. Gynecol. | pmid:11717679 |
| Caplan MS and Jilling T | The role of polyunsaturated fatty acid supplementation in intestinal inflammation and neonatal necrotizing enterocolitis. | 2001 | Lipids | pmid:11724457 |
| Kaul DK et al. | Ameliorating effects of fluorocarbon emulsion on sickle red blood cell-induced obstruction in an ex vivo vasculature. | 2001 | Blood | pmid:11698300 |
| Casao MA et al. | Promotion of platelet aggregation by sera from brucellosis patients with antiphosphatidylcholine antibodies. | 2001 | J. Med. Microbiol. | pmid:11699593 |
| Lendvai B et al. | Platelet-activating factor evokes Ca2+ transients after the blockade of ryanodine receptor by dantrolene in RAW 264.7 macrophages. | 2001 | Neurochem. Res. | pmid:11699928 |
| Houghton TJ et al. | Efficient assembly of the phomactin core via two different macrocyclization protocols. | 2001 | Org. Lett. | pmid:11700095 |
| Rosa MS et al. | Platelet-activating factor (PAF) modulates peritoneal mouse macrophage infection by Leishmania amazonensis. | 2001 | Curr. Microbiol. | pmid:11375661 |
| Adams JM et al. | Entry of gut lymph into the circulation primes rat neutrophil respiratory burst in hemorrhagic shock. | 2001 | Crit. Care Med. | pmid:11700422 |
| Zhao L et al. | Effects of combining three different antiplatelet agents on platelets and leukocytes in whole blood in vitro. | 2001 | Br. J. Pharmacol. | pmid:11564653 |
| Bhatia M et al. | Inflammatory mediators as therapeutic targets in acute pancreatitis. | 2001 | Curr Opin Investig Drugs | pmid:11566005 |
| Emingil G et al. | Levels of platelet-activating factor in gingival crevicular fluid and gingival tissue in specific periodontal diseases. | 2001 | J. Periodontol. | pmid:11525434 |
| Thomet OA et al. | Differential inhibition of inflammatory effector functions by petasin, isopetasin and neopetasin in human eosinophils. | 2001 | Clin. Exp. Allergy | pmid:11529903 |
| Watanabe S et al. | Suppression of platelet-activating factor generation and modulation of arachidonate metabolism by dietary enrichment with (n-9) eicosatrienoic acid or docosahexaenoic acid in mouse peritoneal cells. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11534547 |
| Stafforini DM | PAF acetylhydrolase gene polymorphisms and asthma severity. | 2001 | Pharmacogenomics | pmid:11535107 |
| Steer ML | Relationship between pancreatitis and lung diseases. | 2001 | Respir Physiol | pmid:11535257 |
| Tokutomi T et al. | Production of platelet-activating factor by neuronal cells in the rat brain with cold injury. | 2001 | Neurol. Res. | pmid:11547929 |
| Chemler SR et al. | Enantioselective synthesis of the oxadecalin core of phomactin A via a highly stereoselective Diels-Alder reaction. | 2001 | Org. Lett. | pmid:11554815 |
| Kavakli K et al. | Intraleucocyte platelet-activating factor levels in desmopressin-treated patients with haemophilia A and von Willebrand disease. | 2001 | Haemophilia | pmid:11554936 |
| Rozenfeld RA et al. | Role of gut flora on intestinal group II phospholipase A2 activity and intestinal injury in shock. | 2001 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11557516 |
| Stoddart NR et al. | Exogenous platelet-activating factor stimulates cell proliferation in mouse pre-implantation embryos prior to the fourth cell cycle and shows isoform-specific stimulatory effects. | 2001 | Zygote | pmid:11510473 |
| Feldman C et al. | Vitamin E attenuates the injurious effects of bioactive phospholipids on human ciliated epithelium in vitro. | 2001 | Eur. Respir. J. | pmid:11510782 |
| Mooren FC et al. | Decoupling of intracellular calcium signaling in granulocytes after exhaustive exercise. | 2001 | Int J Sports Med | pmid:11510867 |
| Hermoso M et al. | Platelet activating factor increases ciliary activity in the hamster oviduct through epithelial production of prostaglandin E2. | 2001 | Pflugers Arch. | pmid:11484763 |
| Sachais BS | Platelet-endothelial interactions in atherosclerosis. | 2001 | Curr Atheroscler Rep | pmid:11487452 |
| Jantan I et al. | Inhibition of platelet-activating factor receptor binding by aporphine and phenanthrenoid alkaloids from Aromadendron elegans. | 2001 | Planta Med. | pmid:11488464 |
| Thomet OA et al. | Role of petasin in the potential anti-inflammatory activity of a plant extract of petasites hybridus. | 2001 | Biochem. Pharmacol. | pmid:11286996 |
| Bernatchez PN et al. | VEGF stimulation of endothelial cell PAF synthesis is mediated by group V 14 kDa secretory phospholipase A2. | 2001 | Br. J. Pharmacol. | pmid:11522612 |
| Hourton D et al. | Oxidized low density lipoproteins downregulate LPS-induced platelet-activating factor receptor expression in human monocyte-derived macrophages: implications for LPS-induced nuclear factor-kappaB binding activity. | 2001 | Eur. J. Biochem. | pmid:11502209 |
| Velasquez LA et al. | PAF receptor and PAF acetylhydrolase expression in the endosalpinx of the human Fallopian tube: possible role of embryo-derived PAF in the control of embryo transport to the uterus. | 2001 | Hum. Reprod. | pmid:11473946 |
| Akisu M et al. | The role of recombinant human erythropoietin in lipid peroxidation and platelet-activating factor generation in a rat model of necrotizing enterocolitis. | 2001 | Eur J Pediatr Surg | pmid:11475112 |
| Chang PY et al. | Oxidized low-density lipoprotein downregulates endothelial basic fibroblast growth factor through a pertussis toxin-sensitive G-protein pathway: mediator role of platelet-activating factor-like phospholipids. | 2001 | Circulation | pmid:11479258 |
| Küçükhüseyin C et al. | Renovascular actions of adenosine in the isolated perfused rat kidney: possible underlying mechanisms. | 2001 | J Basic Clin Physiol Pharmacol | pmid:11868905 |
| Tibiriçá E | Cardiovascular properties of yangambin, a lignan isolated from Brazilian plants. | 2001 | Cardiovasc Drug Rev | pmid:11830750 |
| Burke JR et al. | BMS-229724 is a tight-binding inhibitor of cytosolic phospholipase A2 that acts at the lipid/water interface and possesses anti-inflammatory activity in skin inflammation models. | 2001 | J. Pharmacol. Exp. Ther. | pmid:11408565 |
| Closa D et al. | Absorption and effects of 3-(N-phenylamino)-1,2-propanediol esters in relation to toxic oil syndrome. | 2001 | Lipids | pmid:11768157 |
| Hiran T et al. | Evidence for the involvement of the NADPH oxidase enzyme complex in the optimal accumulation of Platelet-activating factor in the human cell line PLB-985. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11785782 |
| Binisti C et al. | Structure-activity relationships in platelet-activating factor (PAF). 11-From PAF-antagonism to phospholipase A(2) inhibition: syntheses and structure-activity relationships in 1-arylsulfamido-2-alkylpiperazines. | 2001 | Eur J Med Chem | pmid:11738488 |
| Ribeiro JM and Francischetti IM | Platelet-activating-factor-hydrolyzing phospholipase C in the salivary glands and saliva of the mosquito Culex quinquefasciatus. | 2001 | J. Exp. Biol. | pmid:11807106 |
| Shah BH et al. | Molecular mechanisms involved in human platelet aggregation by synergistic interaction of platelet-activating factor and 5-hydroxytryptamine. | 2001 | Exp. Mol. Med. | pmid:11795484 |
| Cao YZ et al. | Selenium modulates 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) biosynthesis in bovine aortic endothelial cells. | 2001 | Antioxid. Redox Signal. | pmid:11813988 |
| den Dekker E et al. | Biogenesis of G-protein mediated calcium signaling in human megakaryocytes. | 2001 | Thromb. Haemost. | pmid:11686331 |
| Jin Y et al. | [The effect of autocrine factors on development of early embryos of mouse]. | 2001 | Shi Yan Sheng Wu Xue Bao | pmid:12549014 |
| Hattar K et al. | Cell density regulates neutrophil IL-8 synthesis: role of IL-1 receptor antagonist and soluble TNF receptors. | 2001 | J. Immunol. | pmid:11342652 |
| Berdyshev EV et al. | Activation of PAF receptors results in enhanced synthesis of 2-arachidonoylglycerol (2-AG) in immune cells. | 2001 | FASEB J. | pmid:11641243 |
| Alam N et al. | Additional bioactive Lyso-PAF congeners from the sponge Spirastrella abata. | 2001 | J. Nat. Prod. | pmid:11325244 |