| MeSH term | MeSH ID | Detail |
|---|---|---|
| AIDS Dementia Complex | D015526 | 4 associated lipids |
| Neoplasms, Germ Cell and Embryonal | D009373 | 4 associated lipids |
| Burns, Inhalation | D002059 | 4 associated lipids |
| Shock, Traumatic | D012774 | 4 associated lipids |
| Hypertrophy, Right Ventricular | D017380 | 4 associated lipids |
| Strongylida Infections | D017206 | 5 associated lipids |
| Liver Failure | D017093 | 5 associated lipids |
| Neoplastic Cells, Circulating | D009360 | 5 associated lipids |
| Hepatitis, Alcoholic | D006519 | 5 associated lipids |
| Granulomatosis with Polyangiitis | D014890 | 5 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yamanaka S et al. | Putative mechanism of hypotensive action of platelet-activating factor in dogs. | 1992 | Circ. Res. | pmid:1568300 |
| Shimada T et al. | Platelet-activating factor acts on cortisol secretion by perfused guinea-pig adrenals via calcium-/phospholipid-dependent mechanisms. | 2005 | J. Endocrinol. | pmid:15684346 |
| Yasu T et al. | Activated leukocytes and endothelial cells enhance retention of ultrasound contrast microspheres containing perfluoropropane in inflamed venules. | 2005 | Int. J. Cardiol. | pmid:15686774 |
| Koch E | Inhibition of platelet activating factor (PAF)-induced aggregation of human thrombocytes by ginkgolides: considerations on possible bleeding complications after oral intake of Ginkgo biloba extracts. | 2005 | Phytomedicine | pmid:15693702 |
| Jantan I et al. | Platelet-activating factor (PAF) receptor-binding antagonist activity of Malaysian medicinal plants. | 2005 | Phytomedicine | pmid:15693713 |
| Kawata H et al. | Evidence for the role of neutrophils in reperfusion injury after cold cardioplegic ischemia in neonatal lambs. | 1992 | J. Thorac. Cardiovasc. Surg. | pmid:1569774 |
| Grimminger F et al. | Ligand-operated synthesis of 4-series and 5-series leukotrienes in human neutrophils: critical dependence on exogenous free fatty acid supply. | 1992 | Mol. Pharmacol. | pmid:1569925 |
| Fell JM | Neonatal inflammatory intestinal diseases: necrotising enterocolitis and allergic colitis. | 2005 | Early Hum. Dev. | pmid:15707723 |
| Schaloske RH et al. | Molecular characterization of the lipopolysaccharide/platelet activating factor- and zymosan-induced pathways leading to prostaglandin production in P388D1 macrophages. | 2005 | Biochim. Biophys. Acta | pmid:15708354 |
| El-Medany A et al. | Attenuation of bleomycin-induced lung fibrosis in rats by mesna. | 2005 | Eur. J. Pharmacol. | pmid:15713430 |
| Fujimura K et al. | Role of endogenous platelet-activating factor in caerulein-induced acute pancreatitis in rats: protective effects of a PAF-antagonist. | 1992 Mar-Apr | J. Gastroenterol. Hepatol. | pmid:1571504 |
| Ninio E | Phospholipid mediators in the vessel wall: involvement in atherosclerosis. | 2005 | Curr Opin Clin Nutr Metab Care | pmid:15716789 |
| Leong LL et al. | Effect of WEB 2086 on myocardial infarct size and regional blood flow in the dog. | 1992 | Cardiovasc. Res. | pmid:1571932 |
| Tippins JR et al. | WEB 2086 inhibits neutrophil dependent increases in coronary resistance in blood perfused rabbit heart. | 1992 | Cardiovasc. Res. | pmid:1571936 |
| Evans L et al. | A pharmacokinetic/pharmacodynamic model for a platelet activating factor antagonist based on data arising from Phase I studies. | 2005 | J. Pharm. Pharmacol. | pmid:15720781 |
| Lin P et al. | Lysophosphatidylcholine modulates neutrophil oxidant production through elevation of cyclic AMP. | 2005 | J. Immunol. | pmid:15728511 |
| Vardar S et al. | Therapeutic versus prophylactic plus therapeutic administration of omega-3 fatty acid on endotoxin-induced periodontitis in rats. | 2004 | J. Periodontol. | pmid:15732866 |
| Zinchuk O et al. | Direct action of platelet activating factor (PAF) induces eosinophil accumulation and enhances expression of PAF receptors in conjunctivitis. | 2005 | Mol. Vis. | pmid:15735601 |
| Phenekos C et al. | Effect of gliclazide on platelet-activating factor-induced platelet aggregation in patients with non-insulin-dependent diabetes mellitus. | 1992 | Metab. Clin. Exp. | pmid:1574012 |
| Lang PA et al. | Stimulation of erythrocyte ceramide formation by platelet-activating factor. | 2005 | J. Cell. Sci. | pmid:15741229 |
| Jantan I et al. | Inhibitory effects of compounds from Zingiberaceae species on platelet activating factor receptor binding. | 2004 | Phytother Res | pmid:15742349 |
| Grigoriou O et al. | Effect of sperm treatment with exogenous platelet-activating factor on the outcome of intrauterine insemination. | 2005 | Fertil. Steril. | pmid:15749490 |
| Nathan N et al. | Variations in blood platelet-activating-factor levels after protamine reversal of heparin in humans. | 1992 | Acta Anaesthesiol Scand | pmid:1574976 |
| Satoh K et al. | Increased levels of blood platelet-activating factor (PAF) and PAF-like lipids in patients with ischemic stroke. | 1992 | Acta Neurol. Scand. | pmid:1574985 |
| Sanwick JM et al. | Human spermatozoa produce C16-platelet-activating factor. | 1992 | Arch. Biochem. Biophys. | pmid:1575513 |
| Cabré F et al. | Differential hydrolysis of 1-alkyl-2-acyl and diacylglycerophosphocholines by human and non-human phospholipases A2. | 1992 | Biochim. Biophys. Acta | pmid:1576169 |
| Kumar S and Sharma A | Platelet activating factor improves the in vitro penetration of zona free hamster eggs by buffalo (Bubalus bubalis) spermatozoa. | 2005 | Theriogenology | pmid:15763101 |
| Tsuri T et al. | A novel class of platelet activating factor (PAF) antagonists. II. Modification of the 2-position of the glycerol backbone of PAF-sulfonamide isosteres. | 1992 | Chem. Pharm. Bull. | pmid:1576692 |
| Yatomi Y et al. | Phosphorylation of the inhibitory guanine-nucleotide-binding protein as a possible mechanism of inhibition by protein kinase C of agonist-induced Ca2+ mobilization in human platelet. | 1992 | Eur. J. Biochem. | pmid:1576985 |
| Klementsson H and Andersson M | Eosinophil chemotactic activity of topical PAF on the human nasal mucosa. | 1992 | Eur. J. Clin. Pharmacol. | pmid:1577048 |
| Nacken W et al. | S100A9 deficiency alters adenosine-5'-triphosphate induced calcium signalling but does not generally interfere with calcium and zinc homeostasis in murine neutrophils. | 2005 | Int. J. Biochem. Cell Biol. | pmid:15778088 |
| Minnear FL et al. | Sphingosine 1-phosphate prevents platelet-activating factor-induced increase in hydraulic conductivity in rat mesenteric venules: pertussis toxin sensitive. | 2005 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15778280 |
| Perry SW et al. | HIV-1 transactivator of transcription protein induces mitochondrial hyperpolarization and synaptic stress leading to apoptosis. | 2005 | J. Immunol. | pmid:15778398 |
| Bazan HE | Cellular and molecular events in corneal wound healing: significance of lipid signalling. | 2005 | Exp. Eye Res. | pmid:15781273 |
| Cassatella MA et al. | IL-8 production by human polymorphonuclear leukocytes. The chemoattractant formyl-methionyl-leucyl-phenylalanine induces the gene expression and release of IL-8 through a pertussis toxin-sensitive pathway. | 1992 | J. Immunol. | pmid:1578146 |
| Wissner A et al. | Analogues of platelet activating factor. 6. Mono- and bis-aryl phosphate antagonists of platelet activating factor. | 1992 | J. Med. Chem. | pmid:1578493 |
| Ishiura Y et al. | In vivo PAF-induced airway eosinophil accumulation reduces bronchial responsiveness to inhaled histamine. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:15789611 |
| Gaudreault E et al. | Involvement of leukotriene B4 receptor 1 signaling in platelet-activating factor-mediated neutrophil degranulation and chemotaxis. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:15789613 |
| Calcerrada MC et al. | Selective translocation of protein kinase c isozymes by PAF in rabbit platelets. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:15789614 |
| O'Neill C | The role of paf in embryo physiology. | 2005 May-Jun | Hum. Reprod. Update | pmid:15790601 |
| Hudry-Clergeon H et al. | Platelet-activating factor increases VE-cadherin tyrosine phosphorylation in mouse endothelial cells and its association with the PtdIns3'-kinase. | 2005 | FASEB J. | pmid:15791001 |
| Ersoy B et al. | The role of platelet-activating factor in pathogenesis of type 1 diabetes. | 2005 | Diabetes Care | pmid:15793212 |
| Asai Y | Formation of spherical micelles composed of the novel platelet activating factor receptor antagonist, E5880. | 2005 | Pharmazie | pmid:15801673 |
| Fulkerson PC et al. | CXCL9 inhibits eosinophil responses by a CCR3- and Rac2-dependent mechanism. | 2005 | Blood | pmid:15802529 |
| Adamson LM et al. | Release of anti-PAF activity from PAF-binding human ovarian cancer cells in culture. | 1992 Mar-Apr | Anticancer Res. | pmid:1580546 |
| Echazarreta AL et al. | Lack of systemic oxidative stress during PAF challenge in mild asthma. | 2005 | Respir Med | pmid:15823446 |
| Sheppard FR et al. | Clinically relevant osmolar stress inhibits priming-induced PMN NADPH oxidase subunit translocation. | 2005 | J Trauma | pmid:15824651 |
| Leveau P et al. | Severity of pancreatitis-associated gut barrier dysfunction is reduced following treatment with the PAF inhibitor lexipafant. | 2005 | Biochem. Pharmacol. | pmid:15826603 |
| Dorsch W et al. | Antiasthmatic effects of Galphimia glauca, gallic acid, and related compounds prevent allergen- and platelet-activating factor-induced bronchial obstruction as well as bronchial hyperreactivity in guinea pigs. | 1992 | Int. Arch. Allergy Immunol. | pmid:1582692 |
| Bates EJ et al. | Inhibition of neutrophil respiratory burst and degranulation responses to platelet-activating factor by antagonists WEB 2086, CV 6209 and CV 3988. | 1992 | Int. Arch. Allergy Immunol. | pmid:1582698 |
| Sipka S et al. | Histamine potentiates human platelet aggregation induced by platelet-activating factor. | 1992 | Int. Arch. Allergy Immunol. | pmid:1582704 |
| Iwama T et al. | Inhibitory effect of NZ-107 on anaphylactic bronchoconstriction in guinea pigs and rats. | 1992 | Int. Arch. Allergy Immunol. | pmid:1582710 |
| Vardar S et al. | Individual and combined effects of selective cyclooxygenase-2 inhibitor and omega-3 fatty acid on endotoxin-induced periodontitis in rats. | 2005 | J. Periodontol. | pmid:15830643 |
| Alloatti G et al. | Platelet-activating factor (PAF) induces platelet/neutrophil co-operation during myocardial reperfusion. | 1992 | J. Mol. Cell. Cardiol. | pmid:1583699 |
| Iida H et al. | Effects of the platelet-activating factor antagonists CV-6209 and CV-3988 on nephrotoxic serum nephritis in the rat. | 1992 | Nephron | pmid:1584324 |
| Furukawa M et al. | Evidence of platelet-activating factor in nasal polyps. | 1992 | ORL J. Otorhinolaryngol. Relat. Spec. | pmid:1584590 |
| Ko HM et al. | Involvement of matrix metalloproteinase-9 in platelet-activating factor-induced angiogenesis. | 2005 | FEBS Lett. | pmid:15848174 |
| Orevi M et al. | A potent inhibitor of platelet activating factor from the saliva of the leech Hirudo medicinalis. | 1992 | Prostaglandins | pmid:1584997 |
| O'Neill C et al. | Outcome of pregnancies resulting from a trial of supplementing human IVF culture media with platelet activating factor. | 1992 | Reprod. Fertil. Dev. | pmid:1585005 |
| Hardy P et al. | New insights into the retinal circulation: inflammatory lipid mediators in ischemic retinopathy. | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15850712 |
| Schram MT et al. | Advanced glycation end products are associated with pulse pressure in type 1 diabetes: the EURODIAB Prospective Complications Study. | 2005 | Hypertension | pmid:15851628 |
| Boccellino M et al. | Platelet-activating factor regulates cadherin-catenin adhesion system expression and beta-catenin phosphorylation during Kaposi's sarcoma cell motility. | 2005 | Am. J. Pathol. | pmid:15855650 |
| Owen JS et al. | Stress-induced platelet-activating factor synthesis in human neutrophils. | 2005 | Biochim. Biophys. Acta | pmid:15863359 |
| Göggel R and Uhlig S | The inositol trisphosphate pathway mediates platelet-activating-factor-induced pulmonary oedema. | 2005 | Eur. Respir. J. | pmid:15863642 |
| MartÃnez-Cócera C et al. | Rupatadine 10 mg and cetirizine 10 mg in seasonal allergic rhinitis: a randomised, double-blind parallel study. | 2005 | J Investig Allergol Clin Immunol | pmid:15864879 |
| Tool AT et al. | Release of platelet-activating factor is important for the respiratory burst induced in human eosinophils by opsonized particles. | 1992 | Blood | pmid:1586719 |
| Okada C et al. | Effect of terfenadine on neutrophil and eosinophil chemotactic activities after inhalation of platelet-activating factor in vivo and on neutrophil chemotaxis in vitro. | 1992 | Int. Arch. Allergy Immunol. | pmid:1587633 |
| Suda H et al. | Effects of NZ-107 on bronchoconstriction in guinea pigs. | 1992 | Int. Arch. Allergy Immunol. | pmid:1587634 |
| Chand N et al. | Inhibition of aeroallergen-induced bronchial eosinophilia by azelastine in guinea pigs. | 1992 | Int. Arch. Allergy Immunol. | pmid:1587636 |
| Yeh JH et al. | 2-O-methyl PAF as a Ca2+ mobilizer in Madin Darby canine kidney cells. | 2005 | Life Sci. | pmid:15878360 |
| Raible DG et al. | Mast cell mediators prostaglandin-D2 and histamine activate human eosinophils. | 1992 | J. Immunol. | pmid:1588043 |
| Medvedev IN and GromnatsiÄ NI | [The influence of nebivolol on thrombocyte aggregation in patients with arterial hypertension with metabolic sydrome]. | 2005 | Klin Med (Mosk) | pmid:15881638 |
| Rastelli VM et al. | Influence of insulin on the microvascular response to inflammatory mediators in neonatal streptozotocin diabetic rats. | 2005 | Inflamm. Res. | pmid:15883740 |
| Cheng L et al. | Platelet-activating factor and prostaglandin E2 impair esophageal ACh release in experimental esophagitis. | 2005 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:15890711 |
| Qu XW et al. | Tetrahydrobiopterin prevents platelet-activating factor-induced intestinal hypoperfusion and necrosis: Role of neuronal nitric oxide synthase. | 2005 | Crit. Care Med. | pmid:15891335 |
| Dunoyer-Geindre S et al. | PAF acether release on antigenic challenge. A method for the investigation of drug allergic reactions. | 1992 | Allergy | pmid:1590567 |
| Joseph R and Han E | Amyloid beta-protein fragment 25-35 causes activation of cytoplasmic calcium in neurons. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1590803 |
| Gilli UO et al. | Human polymorphonuclear neutrophils are recruited by porcine chemokines acting on CXC chemokine receptor 2, and platelet-activating factor. | 2005 | Transplantation | pmid:15912099 |
| Kasamo M et al. | In vitro prostaglandin release from and platelet-activating factor accumulation in isolated endometrial cells from pregnant and pseudopregnant rabbits. | 1992 | Biol. Reprod. | pmid:1591338 |
| Biancone L et al. | Platelet-activating factor biosynthesis by cultured mesangial cells is modulated by proteinase inhibitors. | 1992 | J. Am. Soc. Nephrol. | pmid:1591364 |
| Lai CK and Holgate ST | Stimulation of human airway epithelial cells by platelet activating factor (PAF) and arachidonic acid produces 15-hydroxyeicosatetraenoic acid (15-HETE) capable of contracting bronchial smooth muscle. | 1992 | Pulm Pharmacol | pmid:1591466 |
| Park EJ et al. | Dietary ganglioside decreases cholesterol content, caveolin expression and inflammatory mediators in rat intestinal microdomains. | 2005 | Glycobiology | pmid:15917432 |
| Chen LW et al. | Different pathways leading to activation of extracellular signal-regulated kinase and p38 MAP kinase by formyl-methionyl-leucyl-phenylalanine or platelet activating factor in human neutrophils. | 2005 | J. Biomed. Sci. | pmid:15917990 |
| Goldring WP et al. | Novel phomactin analogues as PAF receptor ligands. | 2005 | Bioorg. Med. Chem. Lett. | pmid:15922596 |
| Ding Z et al. | Mechanisms of endothelial cell-dependent leukocyte adhesion stimulated by platelet-activating factor. | 1992 | Inflammation | pmid:1592489 |
| Tombul T et al. | Hemostatic markers and platelet aggregation factors as predictive markers for type of stroke and neurological disability following cerebral infarction. | 2005 | J Clin Neurosci | pmid:15925775 |
| Mansour E et al. | Attenuation of platelet-activating factor-induced airway responses with methylprednisolone succinate in sheep. | 1992 | J. Appl. Physiol. | pmid:1592746 |
| Vinson SM et al. | Neutrophil adherence to bladder microvascular endothelial cells following platelet-activating factor acetylhydrolase inhibition. | 2005 | J. Pharmacol. Exp. Ther. | pmid:15937147 |
| Estellés R et al. | Effect of boldine, secoboldine, and boldine methine on angiotensin II-induced neutrophil recruitment in vivo. | 2005 | J. Leukoc. Biol. | pmid:15944212 |
| Zhao T and Bokoch GM | Critical role of proline-rich tyrosine kinase 2 in reversion of the adhesion-mediated suppression of reactive oxygen species generation by human neutrophils. | 2005 | J. Immunol. | pmid:15944312 |
| Nagata M et al. | Effect of the cysteinyl leukotriene antagonist pranlukast on transendothelial migration of eosinophils. | 2005 | Int. Arch. Allergy Immunol. | pmid:15947477 |
| McLarnon JG et al. | Perturbations in calcium-mediated signal transduction in microglia from Alzheimer's disease patients. | 2005 | J. Neurosci. Res. | pmid:15948178 |
| Lang KS et al. | Mechanisms of suicidal erythrocyte death. | 2005 | Cell. Physiol. Biochem. | pmid:15956782 |
| Kita Y et al. | A multiplex quantitation method for eicosanoids and platelet-activating factor using column-switching reversed-phase liquid chromatography-tandem mass spectrometry. | 2005 | Anal. Biochem. | pmid:15958190 |
| Fang YH et al. | [Relationship between serum vWF and PAF in type 2 diabetic patients and diabetic nephropathy]. | 2005 | Di Yi Jun Yi Da Xue Xue Bao | pmid:15958323 |
| Souza DG and Teixeira MM | The balance between the production of tumor necrosis factor-alpha and interleukin-10 determines tissue injury and lethality during intestinal ischemia and reperfusion. | 2005 | Mem. Inst. Oswaldo Cruz | pmid:15962100 |
| Castro Faria Neto HC et al. | Regulating inflammation through the anti-inflammatory enzyme platelet-activating factor-acetylhydrolase. | 2005 | Mem. Inst. Oswaldo Cruz | pmid:15962103 |
| White DC et al. | Feasibility of assessment of regulatory lipids in breath condensate as potential presymptomatic harbingers of pulmonary pathobiology. | 2005 | J. Microbiol. Methods | pmid:15963585 |
| Joly F et al. | Heterogeneity of arachidonate and paf-acether precursor pools in mast cells. | 1992 | Biochim. Biophys. Acta | pmid:1596519 |
| Jeon SY et al. | Rat model of platelet-activating factor-induced rhinosinusitis. | 2005 | Ann. Otol. Rhinol. Laryngol. | pmid:15966528 |