| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Leukemia, Erythroblastic, Acute | D004915 | 41 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
| Hypotension | D007022 | 41 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Zellweger Syndrome | D015211 | 39 associated lipids |
| Peritonitis | D010538 | 38 associated lipids |
| Nervous System Diseases | D009422 | 37 associated lipids |
| Lung Diseases | D008171 | 37 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hoffman DR et al. | Synthesis of platelet activating factor by cholinephosphotransferase in developing fetal rabbit lung. | 1988 | Lipids | pmid:2897059 |
| Leff AR | Neurohumoral regulation of airway contractile responses. | 1988 | Chest | pmid:2897271 |
| Junier MP et al. | Inhibitory effect of platelet-activating factor (PAF) on luteinizing hormone-releasing hormone and somatostatin release from rat median eminence in vitro correlated with the characterization of specific PAF receptor sites in rat hypothalamus. | 1988 | Endocrinology | pmid:2898362 |
| Guinot P et al. | Treatment of adult systemic mastocytosis with a PAF-acether antagonist BN52063. | 1988 | Lancet | pmid:2898694 |
| Peers SH | Dexamethasone inhibits platelet activating factor-induced inflammation in the paw but not the pleural cavity of rats. | 1988 | Eur. J. Pharmacol. | pmid:3136026 |
| Mangold HK | Synthesis of biologically active ether lipids. | 1988 | Prog Biochem Pharmacol | pmid:3136454 |
| Anderson GP et al. | Increased airways responsiveness to histamine induced by platelet activating factor in the guinea-pig: possible role of lipoxygenase metabolites. | 1988 | Agents Actions | pmid:3136622 |
| Fernandez-Gallardo S et al. | Role of paf-acether in the mediation of pathophysiological responses to aggregated immunoglobulins. Studies with the platelet-activating factor receptor antagonist BN 52021. | 1988 | Int. J. Immunopharmacol. | pmid:3139574 |
| Winkler JD et al. | Leukotriene B4-induced homologous desensitization of calcium mobilization and phosphoinositide metabolism in U-937 cells. | 1988 | J. Pharmacol. Exp. Ther. | pmid:2839662 |
| Berti F et al. | New pharmacological data on the bronchospasmolytic activity of bamifylline. | 1988 | Arzneimittelforschung | pmid:3365275 |
| Sun XM and Hsueh W | Bowel necrosis induced by tumor necrosis factor in rats is mediated by platelet-activating factor. | 1988 | J. Clin. Invest. | pmid:3366898 |
| Calignano A et al. | Isolation and identification of platelet-activating factor in UV-irradiated guinea pig skin. | 1988 | J Pharmacol Methods | pmid:3367652 |
| Nolte D | [Bronchial hyperreactivity: pingpong between cells, nerves and mediators]. | 1988 | Med. Klin. (Munich) | pmid:3367876 |
| Jouquey S et al. | Comparison of the effects of the ace inhibitors trandolapril and enalapril on phlogogen induced foot pad oedema in the rat. | 1988 | Agents Actions | pmid:2459935 |
| Spinks NR and O'Neill C | Antagonists of embryo-derived platelet-activating factor prevent implantation of mouse embryos. | 1988 | J. Reprod. Fertil. | pmid:2460623 |
| Dorsch W et al. | Anti-asthmatic effects of onions. Alk(en)ylsulfinothioic acid alk(en)yl-esters inhibit histamine release, leukotriene and thromboxane biosynthesis in vitro and counteract PAF and allergen-induced bronchial obstruction in vivo. | 1988 | Biochem. Pharmacol. | pmid:2462422 |
| Wallace JL and MacNaughton WK | Gastrointestinal damage induced by platelet-activating factor: role of leukotrienes. | 1988 | Eur. J. Pharmacol. | pmid:2843390 |
| Lagente V et al. | Interference of the Paf antagonist Ro 19-3704 with Paf and antigen-induced bronchoconstriction in the guinea-pig. | 1988 | Br. J. Pharmacol. | pmid:3401641 |
| Groscurth P et al. | Effects of platelet activating factor (PAF) on human citrated whole blood. | 1988 | Eur. J. Haematol. | pmid:3402585 |
| Rylander R et al. | Modulation of pulmonary inflammation after endotoxin inhalation with a platelet-activating factor antagonist (48740 RP). | 1988 | Int. Arch. Allergy Appl. Immunol. | pmid:3403044 |
| Satoh K et al. | [Endothelial injury as an initiating factor: vascular endothelial cell injury and biosynthesis of PAF]. | 1988 | Nippon Rinsho | pmid:3404682 |
| Roberts NM et al. | Effect of a PAF antagonist, BN52063, on antigen-induced, acute, and late-onset cutaneous responses in atopic subjects. | 1988 | J. Allergy Clin. Immunol. | pmid:3403863 |
| Cueva JP and Hsueh W | Role of oxygen derived free radicals in platelet activating factor induced bowel necrosis. | 1988 | Gut | pmid:3197995 |
| Bass DA et al. | Selective priming of rate and duration of the respiratory burst of neutrophils by 1,2-diacyl and 1-O-alkyl-2-acyl diglycerides. Possible relation to effects on protein kinase C. | 1988 | J. Biol. Chem. | pmid:3198643 |
| Lewis MS et al. | Hydrogen peroxide stimulates the synthesis of platelet-activating factor by endothelium and induces endothelial cell-dependent neutrophil adhesion. | 1988 | J. Clin. Invest. | pmid:3198764 |
| Misawa M and Takata T | Effects of platelet-activating factor on rat airways. | 1988 | Jpn. J. Pharmacol. | pmid:3199608 |
| Keery RJ and Lumley P | AH6809, a prostaglandin DP-receptor blocking drug on human platelets. | 1988 | Br. J. Pharmacol. | pmid:2460179 |
| Willuweit B and Aktories K | Heparin and heparinoids impair adrenaline and platelet-activating factor but not thrombin-induced inhibition of adenylate cyclase and stimulation of GTP hydrolysis in human platelet membranes. | 1988 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:2969081 |
| Jancar S et al. | Immune complex induced pancreatitis: effect of BN 52021, a selective antagonist of platelet-activating factor. | 1988 | Prostaglandins | pmid:2969600 |
| Tkhostov EB et al. | [Calcium metabolism in arterial hypertension. I. Myocardial hypertrophy and hormone-dependent increase in Ca2+ levels in the thrombocytes of patients with arterial hypertension]. | 1988 | Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR | pmid:2969736 |
| Leprevost C et al. | Inhibition of eosinophil chemotaxis by a new antiallergic compound (cetirizine). | 1988 | Int. Arch. Allergy Appl. Immunol. | pmid:2971624 |
| Popovich KJ et al. | Role of platelets in contraction of canine tracheal muscle elicited by PAF in vitro. | 1988 | J. Appl. Physiol. | pmid:3170437 |
| Moriyama T et al. | Elevation of cytosolic free Ca2+ is directly evoked by thromboxane A2 in human platelets during activation with collagen. | 1988 | J. Biochem. | pmid:3170519 |
| Lagente V et al. | PAF-acether and endotoxin display similar effects on rat mesenteric microvessels: inhibition by specific antagonists. | 1988 | J. Pharmacol. Exp. Ther. | pmid:3171975 |
| Danko G et al. | Effect of the PAF antagonists, CV-3988 and L-652,731 on the pulmonary and hematological responses to guinea pig anaphylaxis. | 1988 | Pharmacol Res Commun | pmid:3174804 |
| Tilley JW et al. | Pyrido[2,1-b]quinazolinecarboxamide derivatives as platelet activating factor antagonists. | 1988 | J. Med. Chem. | pmid:3339617 |
| Ferguson MK et al. | Lymphatic smooth muscle responses to leukotrienes, histamine and platelet activating factor. | 1988 | J. Surg. Res. | pmid:3339877 |
| Kelefiotis D et al. | Study of digoxin as inhibitor of the in vivo effects of acetyl glyceryl ether phosphorylcholine (AGEPC) in mice. | 1988 | Life Sci. | pmid:3339951 |
| Soybel DI et al. | Effects of platelet-activating factor on canine gastric mucosal blood flow and permeability to luminal acid. | 1988 | Am. J. Surg. | pmid:3341532 |
| Page CP and Robertson DN | The role of PAF in altered airway responsiveness. | 1988 | Prog. Clin. Biol. Res. | pmid:3289016 |
| Arnout J et al. | Effectiveness and tolerability of CV-3988, a selective PAF antagonist, after intravenous administration to man. | 1988 | Br J Clin Pharmacol | pmid:3289599 |
| O'Donnell SR and Barnett CJ | pA2 values for antagonists of platelet activating factor on aggregation of rabbit platelets. | 1988 | Br. J. Pharmacol. | pmid:3293683 |
| Giovannini L et al. | N-acetyl-beta-glucosaminidase (NAG) and alpha-glycosidase released by PAF in isolated perfused rat kidney. | 1988 | Int J Tissue React | pmid:3294206 |
| Nakayama R et al. | 1-O-hexadec-1'-enyl-2-acetyl-sn-glycero-3-phosphocholine and its biological activity. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3355555 |
| Kramer RM et al. | Hydrolysis of 1-alkyl-2-arachidonoyl-sn-glycero-3-phosphocholine, a common precursor of platelet-activating factor and eicosanoids, by human platelet phospholipase A2. | 1988 | Biochim. Biophys. Acta | pmid:3355850 |
| McGowan HM et al. | Increased levels of platelet-activating factor (1-O-alkyl-2-acetylglycerophosphocholine) in blood after reversal of renal clip hypertension in the rat. | 1988 | Clin. Sci. | pmid:3356112 |
| Quinn MT et al. | Lysophosphatidylcholine: a chemotactic factor for human monocytes and its potential role in atherogenesis. | 1988 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3357891 |
| Blank ML et al. | Stimulation of the de novo pathway for the biosynthesis of platelet-activating factor (PAF) via cytidylyltransferase activation in cells with minimal endogenous PAF production. | 1988 | J. Biol. Chem. | pmid:2833508 |
| Rola-Pleszczynski M et al. | Immune regulation by platelet-activating factor. I. Induction of suppressor cell activity in human monocytes and CD8+ T cells and of helper cell activity in CD4+ T cells. | 1988 | J. Immunol. | pmid:2834440 |
| Worthen GS et al. | The priming of neutrophils by lipopolysaccharide for production of intracellular platelet-activating factor. Potential role in mediation of enhanced superoxide secretion. | 1988 | J. Immunol. | pmid:2834441 |
| Errasfa M et al. | Inhibition of phospholipase A2 activity of guinea-pig alveolar macrophages by lipocortin-like proteins purified from mice lung. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2968795 |
| Parnham MJ | PAF receptors. | 1988 | Prog Biochem Pharmacol | pmid:2841664 |
| Shkhvatsabaia IK et al. | [Receptor-dependent regulation of the concentration of Ca2+ in the cytoplasm of thrombocytes in hypertensive patients]. | 1988 | Kardiologiia | pmid:2842537 |
| Tahraoui L et al. | High affinity specific binding sites for tritiated platelet-activating factor in canine platelet membranes: counterparts of platelet-activating factor receptors mediating platelet aggregation. | 1988 | Mol. Pharmacol. | pmid:2842653 |
| Garcia JG et al. | Effect of platelet activating factor on leukocyte-endothelial cell interactions. | 1988 | Thromb. Res. | pmid:2842887 |
| Ontell SJ et al. | Improved hepatic function in the 24-hour preserved rat liver with UW-lactobionate solution and SRI 63-441. | 1988 | Gastroenterology | pmid:3263295 |
| Breviario F et al. | IL-1-induced adhesion of polymorphonuclear leukocytes to cultured human endothelial cells. Role of platelet-activating factor. | 1988 | J. Immunol. | pmid:3263425 |
| Page CP | The role of platelet-activating factor in asthma. | 1988 | J. Allergy Clin. Immunol. | pmid:3276759 |
| Barnes PJ | Platelet-activating factor and asthma. | 1988 | J. Allergy Clin. Immunol. | pmid:3276760 |
| Rouis M et al. | Platelet activating factor is a potent stimulant of the production of active oxygen species by human monocyte-derived macrophages. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2847729 |
| Doni MG et al. | Forskolin and prostacyclin inhibit fluoride induced platelet activation and protein kinase C dependent responses. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2847730 |
| Ghigo D et al. | Role of Na+/H+ exchange in thrombin-induced platelet-activating factor production by human endothelial cells. | 1988 | J. Biol. Chem. | pmid:2848827 |
| Mickelson JK et al. | Myocardial dysfunction and coronary vasoconstriction induced by platelet-activating factor in the post-infarcted rabbit isolated heart. | 1988 | J. Mol. Cell. Cardiol. | pmid:3216407 |
| Bussolino F | [Production of PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine) in the chick retina during embryogenesis]. | 1988 | Ann. Ist. Super. Sanita | pmid:3218801 |
| Dillon PK et al. | Effect of platelet-activating factor on leukocyte adhesion to microvascular endothelium. Time course and dose-response relationships. | 1988 | Inflammation | pmid:3220518 |
| Lohmann HF et al. | Idiopathic thrombocytopenia treated with Paf-acether antagonist WEB 2086. | 1988 | Lancet | pmid:2903365 |
| Martin J | Platelet-activating factor. | 1988 Dec 24-31 | Lancet | pmid:2904593 |
| Gebhardt BM et al. | Modulation of in vitro immune reactions by platelet activating factor and a platelet activating factor antagonist. | 1988 Jan-Feb | Immunopharmacology | pmid:2966135 |
| Santos OF et al. | [Platelet activating factor in nephrology: physiopathologic and therapeutic perspectives]. | 1988 Jul-Aug | Rev Paul Med | pmid:3076976 |
| Lakin KM et al. | [Effect of analogs and antagonists of the thrombocyte-activating factor (PAF) on blood platelet aggregation]. | 1988 Jul-Aug | Farmakol Toksikol | pmid:2847936 |
| Whatley RE et al. | Endothelium from diverse vascular sources synthesizes platelet-activating factor. | 1988 May-Jun | Arteriosclerosis | pmid:3130833 |
| Di Marzo V et al. | Neuropeptides and leukotriene biosynthesis: the effect of calcitonin, peptide histidine valine-42, helodermin, neuropeptide Y and galanin. | 1988 May-Jun | Neuropeptides | pmid:2458537 |
| Bellioni P et al. | [Histomorphological changes in nasal polyps in patients with glucose metabolism disorders]. | 1988 Nov-Dec | Acta Otorhinolaryngol Ital | pmid:3247845 |
| Labrakis-Lazanas K et al. | PAF of biological fluids in disease: blood levels in allergic rhinitis. | 1988 Sep-Oct | Haematologica | pmid:3143636 |
| Senn N and Garay RP | Regulation of Na+ and K+ contents in rat thymocytes. | 1989 | Am. J. Physiol. | pmid:2546433 |
| Dray F et al. | Prostaglandin E2, leukotriene C4, and platelet-activating factor receptor sites in the brain. Binding parameters and pharmacological studies. | 1989 | Ann. N. Y. Acad. Sci. | pmid:2549827 |
| Murphy S and Welk G | Arachidonic acid evokes inositol phospholipid hydrolysis in astrocytes. | 1989 | FEBS Lett. | pmid:2509246 |
| Prado-Franceschi J and Antunes E | Effect of metronidazole on platelet aggregation. | 1989 | Braz. J. Med. Biol. Res. | pmid:2641356 |
| Dembinska-Kiec A et al. | The effects of platelet-activating factor on flow rate and eicosanoid release in the isolated perfused rat gastric vascular bed. | 1989 | Prostaglandins | pmid:2717778 |
| Squinto SP et al. | Platelet-activating factor stimulates a fos/jun/AP-1 transcriptional signaling system in human neuroblastoma cells. | 1989 | J. Neurosci. Res. | pmid:2513416 |
| Bonavida B et al. | The involvement of platelet-activating factor (PAF)-induced monocyte activation and tumor necrosis factor (TNF) production in shock. | 1989 | Prog. Clin. Biol. Res. | pmid:2780710 |
| Heuer H | Effect of a new and specific PAF-antagonist, WEB 2086, on PAF and endotoxin/tumor necrosis factor induced changes in mortality and intestinal transit velocity. | 1989 | Prog. Clin. Biol. Res. | pmid:2780739 |
| Lopez Diez F et al. | Occupancy of platelet receptors for platelet-activating factor in patients with septicemia. | 1989 | J. Clin. Invest. | pmid:2540221 |
| Wirthmueller U et al. | Platelet-activating factor production in human neutrophils by sequential stimulation with granulocyte-macrophage colony-stimulating factor and the chemotactic factors C5A or formyl-methionyl-leucyl-phenylalanine. | 1989 | J. Immunol. | pmid:2540238 |
| Burstein SH et al. | Antagonism to the actions of platelet activating factor by a nonpsychoactive cannabinoid. | 1989 | J. Pharmacol. Exp. Ther. | pmid:2553925 |
| Hsueh W and Sun XM | Tumor necrosis factor-induced bowel necrosis: the role of platelet-activating factor. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2526499 |
| Pignol B et al. | Effect of chronic administration of platelet-activating factor (PAF) in the guinea-pig and the rat. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2526500 |
| Cirino G and Wallace JL | A superfusion bioassay for platelet-activating factor. | 1989 | Can. J. Physiol. Pharmacol. | pmid:2713756 |
| Hemmendinger S et al. | Mitogenic activity on human arterial smooth muscle cells is increased in the plasma of patients undergoing hemodialysis with cuprophane membranes. | 1989 | Nephron | pmid:2812169 |
| Hermán F et al. | Decreased sensitivity of platelets to platelet-activating factor in migraine patients during the headache-free interval. | 1989 | Thromb. Haemost. | pmid:2814933 |
| Page CP and Coyle AJ | The interaction between PAF, platelets and eosinophils in bronchial asthma. | 1989 | Eur Respir J Suppl | pmid:2679601 |
| Konturek SJ et al. | Role of leukotrienes and platelet activating factor in acute gastric mucosal lesions in rats. | 1989 | Eur. J. Pharmacol. | pmid:2759176 |
| Koltai M et al. | Ginkgolide B protects isolated hearts against arrhythmias induced by ischemia but not reperfusion. | 1989 | Eur. J. Pharmacol. | pmid:2759177 |
| Damas J et al. | Endotoxin shock, kinin system and PAF-acether in the rat. | 1989 | Adv. Exp. Med. Biol. | pmid:2610092 |
| Bossant MJ et al. | Quantitation of paf-acether by release of endogenous platelet serotonin assessed by liquid chromatography with electrochemical detection. | 1989 | Anal. Biochem. | pmid:2610359 |
| Pirotzky E et al. | [Renal diseases and platelet activating factor]. | 1989 | Pediatrie | pmid:2740184 |
| Ng DS and Wong K | Effect of platelet-activating factor (PAF) on cytosolic free calcium in human peripheral blood mononuclear leukocytes. | 1989 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:2740622 |
| VornovitskiÄ EG et al. | [The blocking action of platelet-activating factor (PAF) on the calcium currents of the atrial fibers in the frog and guinea pig]. | 1989 | Biull Eksp Biol Med | pmid:2561348 |
| Hoshikawa-Fujimura AY et al. | PAF-acether, superoxide anion and beta-glucuronidase as parameters of polymorphonuclear cell activation associated with cardiac surgery and cardiopulmonary bypass. | 1989 | Braz. J. Med. Biol. Res. | pmid:2561459 |
| Yoshikawa T et al. | [Role of polymorphonuclear leukocytes and oxygen-derived free radicals in the formation of gastric mucosal lesions induced by platelet-activating factor]. | 1989 | Nihon Shokakibyo Gakkai Zasshi | pmid:2547098 |