| MeSH term | MeSH ID | Detail |
|---|---|---|
| Leukemia, Experimental | D007942 | 42 associated lipids |
| Hypotension | D007022 | 41 associated lipids |
| Leukemia, Erythroblastic, Acute | D004915 | 41 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
| Zellweger Syndrome | D015211 | 39 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Peritonitis | D010538 | 38 associated lipids |
| Nervous System Diseases | D009422 | 37 associated lipids |
| Lung Diseases | D008171 | 37 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ulrich CD | Lexipafant in severe acute pancreatitis: the final word? | 2001 | Curr Gastroenterol Rep | pmid:11276374 |
| Ishizuka S et al. | Acid exposure stimulates the adherence of Streptococcus pneumoniae to cultured human airway epithelial cells: effects on platelet-activating factor receptor expression. | 2001 | Am. J. Respir. Cell Mol. Biol. | pmid:11306440 |
| Miguel BG et al. | Increase of phosphoinositide hydrolysis and diacylglycerol production by PAF in isolated rat liver nuclei. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11444588 |
| Hirashima Y et al. | Effect of a platelet-activating factor receptor antagonist, E5880, on cerebral vasospasm after aneurysmal subarachnoid hemorrhage--open clinical trial to investigate efficacy and safety. | 2001 | Neurol. Med. Chir. (Tokyo) | pmid:11381675 |
| Liu XH et al. | Platelet-activating factor antagonist BN 50730 attenuates hypoxic-ischemic brain injury in neonatal rats. | 2001 | Pediatr. Res. | pmid:11385142 |
| Mi B and Maleczka RE | A Nozaki-Hiyama-Kishi Ni(II)/Cr(II) coupling approach to the phomactins. | 2001 | Org. Lett. | pmid:11388849 |
| Elzi DJ et al. | Ionomycin causes activation of p38 and p42/44 mitogen-activated protein kinases in human neutrophils. | 2001 | Am. J. Physiol., Cell Physiol. | pmid:11401859 |
| Tiemann U et al. | Platelet-activating factor (PAF)-like activity, localization of PAF receptor (PAF-R) and PAF-acetylhydrolase (PAF-AH) activity in bovine endometrium at different stages of the estrous cycle and early pregnancy. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11403499 |
| Tong N et al. | Activation of glycogen synthase kinase 3 beta (GSK-3beta) by platelet activating factor mediates migration and cell death in cerebellar granule neurons. | 2001 | Eur. J. Neurosci. | pmid:11403684 |
| Rodrigo L et al. | Hydrolysis of platelet-activating factor by human serum paraoxonase. | 2001 | Biochem. J. | pmid:11171072 |
| Del Sorbo L et al. | Tat-induced platelet-activating factor synthesis contributes to the angiogenic effect of HIV-1 Tat. | 2001 | Eur. J. Immunol. | pmid:11180101 |
| Rabinowitz SS et al. | Platelet-activating factor in infants at risk for necrotizing enterocolitis. | 2001 | J. Pediatr. | pmid:11148517 |
| Gandhi CR et al. | A23187 causes release of inositol phosphates from cultured rat Kupffer cells. | 2001 | Eur. J. Pharmacol. | pmid:11245846 |
| Denis MA et al. | Increased response of blood eosinophils to various chemotactic agents in quiescent Crohn disease. | 2001 | Scand. J. Gastroenterol. | pmid:11252412 |
| Storey RF et al. | Effects of P2Y(1) and P2Y(12) receptor antagonists on platelet aggregation induced by different agonists in human whole blood. | 2001 | Platelets | pmid:11674863 |
| Camici M and Sagripanti A | Plasma platelet activating factor in nephrotic syndrome. | 2001 | Minerva Med. | pmid:11675576 |
| Kohno S and Nabe T | [Inflammatory mediators (leukotrienes, thromboxane A2, tachykinins and others)]. | 2001 | Nippon Rinsho | pmid:11676130 |
| Pettorossi VE and Grassi S | Different contributions of platelet-activating factor and nitric oxide in long-term potentiation of the rat medial vestibular nuclei. | 2001 | Acta Otolaryngol Suppl | pmid:11677732 |
| Rosa MS et al. | Platelet-activating factor (PAF) modulates peritoneal mouse macrophage infection by Leishmania amazonensis. | 2001 | Curr. Microbiol. | pmid:11375661 |
| Bhatia M et al. | Inflammatory mediators as therapeutic targets in acute pancreatitis. | 2001 | Curr Opin Investig Drugs | pmid:11566005 |
| Emingil G et al. | Levels of platelet-activating factor in gingival crevicular fluid and gingival tissue in specific periodontal diseases. | 2001 | J. Periodontol. | pmid:11525434 |
| Thomet OA et al. | Differential inhibition of inflammatory effector functions by petasin, isopetasin and neopetasin in human eosinophils. | 2001 | Clin. Exp. Allergy | pmid:11529903 |
| Watanabe S et al. | Suppression of platelet-activating factor generation and modulation of arachidonate metabolism by dietary enrichment with (n-9) eicosatrienoic acid or docosahexaenoic acid in mouse peritoneal cells. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11534547 |
| Stafforini DM | PAF acetylhydrolase gene polymorphisms and asthma severity. | 2001 | Pharmacogenomics | pmid:11535107 |
| Bernatchez PN et al. | VEGF stimulation of endothelial cell PAF synthesis is mediated by group V 14 kDa secretory phospholipase A2. | 2001 | Br. J. Pharmacol. | pmid:11522612 |
| Hourton D et al. | Oxidized low density lipoproteins downregulate LPS-induced platelet-activating factor receptor expression in human monocyte-derived macrophages: implications for LPS-induced nuclear factor-kappaB binding activity. | 2001 | Eur. J. Biochem. | pmid:11502209 |
| Velasquez LA et al. | PAF receptor and PAF acetylhydrolase expression in the endosalpinx of the human Fallopian tube: possible role of embryo-derived PAF in the control of embryo transport to the uterus. | 2001 | Hum. Reprod. | pmid:11473946 |
| Akisu M et al. | The role of recombinant human erythropoietin in lipid peroxidation and platelet-activating factor generation in a rat model of necrotizing enterocolitis. | 2001 | Eur J Pediatr Surg | pmid:11475112 |
| Hiran T et al. | Evidence for the involvement of the NADPH oxidase enzyme complex in the optimal accumulation of Platelet-activating factor in the human cell line PLB-985. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11785782 |
| Binisti C et al. | Structure-activity relationships in platelet-activating factor (PAF). 11-From PAF-antagonism to phospholipase A(2) inhibition: syntheses and structure-activity relationships in 1-arylsulfamido-2-alkylpiperazines. | 2001 | Eur J Med Chem | pmid:11738488 |
| Alam N et al. | Additional bioactive Lyso-PAF congeners from the sponge Spirastrella abata. | 2001 | J. Nat. Prod. | pmid:11325244 |
| Chłopicki S et al. | Residual pulmonary neutrophils are involved in vaso- and bronchoconstrictor responses to platelet activating factor in the isolated buffer-perfused rat lung. | 2000 May-Jun | Pol J Pharmacol | pmid:11055579 |
| Iglesias-De La Cruz MC et al. | Phenotypic modifications of human mesangial cells by extracellular matrix: the importance of matrix in the contractile response to reactive oxygen species. | 2000 Mar-Apr | Exp. Nephrol. | pmid:10729749 |
| Bastos da Silva M et al. | In vitro inhibitory effect of SR 27417, a potent platelet-activating factor (PAF) receptor antagonist, on the PAF-induced bovine platelet aggregation. | 2000 Mar-Apr | Vet. Res. | pmid:10779205 |
| Sibelius U et al. | Staphylococcal alpha-toxin provokes coronary vasoconstriction and loss in myocardial contractility in perfused rat hearts: role of thromboxane generation. | 2000 Jan 4-11 | Circulation | pmid:10618308 |
| Panayiotou A et al. | Lipid fractions with aggregatory and antiaggregatory activity toward platelets in fresh and fried cod (Gadus morhua): correlation with platelet-activating factor and atherogenesis. | 2000 | J. Agric. Food Chem. | pmid:11312810 |
| Vallee RB et al. | The role of cytoplasmic dynein in the human brain developmental disease lissencephaly. | 2000 | Biochim. Biophys. Acta | pmid:10722879 |
| Kimura I et al. | Release of endothelins and platelet-activating factor by a rat pleural mesothelial cell line. | 2000 | Eur. Respir. J. | pmid:10678641 |
| Orozco AS et al. | Mechanisms of the proinflammatory response of endothelial cells to Candida albicans infection. | 2000 | Infect. Immun. | pmid:10678917 |
| Ishihara Y et al. | Regulation of immunoglobulin G2 production by prostaglandin E(2) and platelet-activating factor. | 2000 | Infect. Immun. | pmid:10678975 |
| Fujimura M et al. | No involvement of lipid mediators in a guinea pig model of ultrasonically nebulized distilled water-induced bronchoconstriction. | 2000 | Prostaglandins Other Lipid Mediat. | pmid:10680775 |
| Sugano T et al. | Platelet-activating factor induces an imbalance between matrix metalloproteinase-1 and tissue inhibitor of metalloproteinases-1 expression in human uterine cervical fibroblasts. | 2000 | Biol. Reprod. | pmid:10684793 |
| Fukuda Y et al. | Effect of human plasma-type platelet-activating factor acetylhydrolase in two anaphylactic shock models. | 2000 | Eur. J. Pharmacol. | pmid:10708725 |
| Neuberger Y et al. | A lyso-platelet activating factor phospholipase C, originally suggested to be a neutral-sphingomyelinase, is located in the endoplasmic reticulum. | 2000 | FEBS Lett. | pmid:10708753 |
| Baker RR and Chang HY | The regulation of CoA-independent transacylation reactions in neuronal nuclei by lysophospholipid, free fatty acid, and lysophospholipase: the control of nuclear lyso platelet-activating factor metabolism. | 2000 | Mol. Cell. Biochem. | pmid:11204449 |
| Mannori G et al. | Interaction of tumor cells with vascular endothelia: role of platelet-activating factor. | 2000 | Clin. Exp. Metastasis | pmid:11206844 |
| Grimminger F et al. | PAF-induced synthesis of tetraenoic and pentaenoic leukotrienes in the isolated rabbit lung. | 2000 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:10666110 |
| Kaul DK et al. | Monoclonal antibodies to alphaVbeta3 (7E3 and LM609) inhibit sickle red blood cell-endothelium interactions induced by platelet-activating factor. | 2000 | Blood | pmid:10627437 |
| Franke B et al. | Sequential regulation of the small GTPase Rap1 in human platelets. | 2000 | Mol. Cell. Biol. | pmid:10629034 |
| Haines DD et al. | Cardioprotective effects of the calcineurin inhibitor FK506 and the PAF receptor antagonist and free radical scavenger, EGb 761, in isolated ischemic/reperfused rat hearts. | 2000 | J. Cardiovasc. Pharmacol. | pmid:10630731 |
| Fukuda S et al. | Mechanisms for regulation of fluid shear stress response in circulating leukocytes. | 2000 | Circ. Res. | pmid:10625314 |
| Kim DD et al. | Platelet-activating factor modulates microvascular dynamics through phospholipase C in the hamster cheek pouch. | 2000 | Microvasc. Res. | pmid:10625566 |
| Montrucchio G et al. | Platelet-activating factor enhances vascular endothelial growth factor-induced endothelial cell motility and neoangiogenesis in a murine matrigel model. | 2000 | Arterioscler. Thromb. Vasc. Biol. | pmid:10634803 |
| Kecskeméti V and Balogh I | The role of platelet-activating factor (PAF) antagonists and nitric oxide in cardiac actions of PAF. Electrophysiological and morphological study. | 2000 | J. Physiol. Pharmacol. | pmid:11192945 |
| Adams JM et al. | G-protein receptor responses in trauma neutrophils. | 2000 | J Trauma | pmid:11130495 |
| Asimakopoulos G et al. | Inhibition of neutrophil L-selectin shedding: a potential anti-inflammatory effect of aprotinin. | 2000 | Perfusion | pmid:11131212 |
| Burns AR et al. | Analysis of tight junctions during neutrophil transendothelial migration. | 2000 | J. Cell. Sci. | pmid:10591624 |
| Luu NT et al. | Differential ability of exogenous chemotactic agents to disrupt transendothelial migration of flowing neutrophils. | 2000 | J. Immunol. | pmid:10820279 |
| Sugatani J et al. | Inhibition of rabbit platelet aggregation by nucleoside 5'-alkylphosphates: correlation with inhibition of agonist-induced calcium influx. | 2000 | Biochem. Pharmacol. | pmid:10825464 |
| Ohishi S | [Evaluation of time course and inter-relationship of inflammatory mediators in experimental inflammatory reaction]. | 2000 | Yakugaku Zasshi | pmid:10825809 |
| Asai Y et al. | Characterization of the physicochemical properties of the micelles of platelet-activating factor (C18:0). | 2000 | Drug Dev Ind Pharm | pmid:10826115 |
| Desplat V et al. | Metabolism and effect of platelet-activating factor on the growth of human myeloma cell lines. | 2000 | Cancer Lett. | pmid:10737702 |
| Boccellino M et al. | Effect of platelet-activating factor receptor expression on CHO cell motility. | 2000 | J. Cell. Physiol. | pmid:10737901 |
| Hagi A et al. | Activation of G-protein coupled fMLP or PAF receptor directly triggers glucose transporter type 1 (GLUT1) translocation in Chinese hamster ovary (CHO) cells stably expressing fMLP or PAF receptor. | 2000 | J. Med. Invest. | pmid:10740976 |
| Logan JE and Roudebush WE | Platelet-activating factor increases intracellular calcium levels in preimplantation stage embryos. | 2000 | Early Pregnancy | pmid:11719820 |
| Lendvai N et al. | Mechanism for the isotype dependence of antibody-mediated toxicity in Cryptococcus neoformans-infected mice. | 2000 | J. Immunol. | pmid:10754337 |
| Gu M et al. | Pharmacologic graft protection without donor pretreatment in liver transplantation from non-heart-beating donors. | 2000 | Transplantation | pmid:11045637 |
| Poeze M et al. | Decreased organ failure in patients with severe SIRS and septic shock treated with the platelet-activating factor antagonist TCV-309: a prospective, multicenter, double-blind, randomized phase II trial. TCV-309 Septic Shock Study Group. | 2000 | Shock | pmid:11049104 |
| Karlstad MD et al. | Platelet-activating factor (PAF)-induced decreases in whole-body and skeletal muscle protein synthesis. | 2000 | Shock | pmid:11049115 |
| James JH and Fischer JE | Are the effects of platelet-activating factor on muscle metabolism of carbohydrates, amino acids and proteins attributable mainly to epinephrine? | 2000 | Shock | pmid:11049116 |
| Dichmann S et al. | Downregulation of platelet-activating factor responsiveness during maturation of human dendritic cells. | 2000 | J. Cell. Physiol. | pmid:11056009 |
| Grassi S and Pettorossi VE | Role of nitric oxide in long-term potentiation of the rat medial vestibular nuclei. | 2000 | Neuroscience | pmid:11068144 |
| Bussolati B et al. | PAF produced by human breast cancer cells promotes migration and proliferation of tumor cells and neo-angiogenesis. | 2000 | Am. J. Pathol. | pmid:11073830 |
| Wechsung E and Houvenaghel A | Involvement of platelet activating factor in the endotoxin-induced effects on gastrointestinal electrical activity and some haematological parameters in the conscious miniature pig. | 2000 | J. Vet. Pharmacol. Ther. | pmid:11107007 |
| Lonardoni MV et al. | Essential role of platelet-activating factor in control of Leishmania (Leishmania) amazonensis infection. | 2000 | Infect. Immun. | pmid:11035745 |
| Mul FP et al. | Sequential migration of neutrophils across monolayers of endothelial and epithelial cells. | 2000 | J. Leukoc. Biol. | pmid:11037975 |
| Peri A et al. | Uteroglobin reverts the transformed phenotype in the endometrial adenocarcinoma cell line HEC-1A by disrupting the metabolic pathways generating platelet-activating factor. | 2000 | Int. J. Cancer | pmid:11058867 |
| Tiano L et al. | Oxidative response and membrane modification of diabetic platelets challenged with PAF. | 2000 | Prostaglandins Other Lipid Mediat. | pmid:11060899 |
| Bracco E et al. | Cell-cell signaling and adhesion in phagocytosis and early development of Dictyostelium. | 2000 | Int. J. Dev. Biol. | pmid:11061438 |
| Biancone L et al. | Role of platelet-activating factor in functional alterations induced by xenoreactive antibodies in porcine endothelial cells. | 2000 | Transplantation | pmid:11063341 |
| Okunuki H et al. | Induction of active systemic anaphylaxis by oral sensitization with ovalbumin in mast-cell-deficient mice. | 2000 | Immunol. Lett. | pmid:11064108 |
| Toró A et al. | Transannular Diels-Alder studies on the asymmetric total synthesis of chatancin: the pyranophane approach. | 2000 | Org. Lett. | pmid:10964353 |
| Baskova I et al. | Inhibition of induced and spontaneous platelet aggregation by destabilase from medicinal leech. | 2000 | Platelets | pmid:10938885 |
| Pávó I et al. | Interactions of pro-inflammatory and vasoactive mediators with nitric oxide in the regulation of rat vascular permeability during laparotomy. | 2000 | Eur. J. Pharmacol. | pmid:10940373 |
| Balestrieri ML and Lee T | Regulation of the biosynthesis of acyl analogs of platelet-activating factor by purinergic agonist in endothlial cells. | 2000 | FEBS Lett. | pmid:10940389 |
| Gálvez J et al. | Intestinal anti-inflammatory activity of UR-12746, a novel 5-ASA conjugate, on acute and chronic experimental colitis in the rat. | 2000 | Br. J. Pharmacol. | pmid:10952687 |
| Maniscalco M et al. | The effect of platelet-activating factor (PAF) on nasal airway resistance in healthy subjects is not mediated by nitric oxide. | 2000 | Allergy | pmid:10955702 |
| Oktar BK et al. | Endothelin-1-induced PMN infiltration and mucosal dysfunction in the rat small intestine. | 2000 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:10960346 |
| Jeon SY et al. | Ultrastructural changes in platelet activating factor-induced epithelial damage in rabbit maxillary sinus mucosa. | 2000 | Ann. Otol. Rhinol. Laryngol. | pmid:10961804 |
| Saito S et al. | Modulatory roles of RANTES in IL-4 production by human blood CD4(+)T cells. | 2000 | Cytokine | pmid:10975998 |
| Tanaka R et al. | Genetics of immunoglobulin A nephropathy. | 2000 | Ann. Acad. Med. Singap. | pmid:10976391 |
| Emingil G et al. | Levels of leukotriene B4 and platelet activating factor in gingival crevicular fluid in renal transplant patients receiving cyclosporine A. | 2000 | J. Periodontol. | pmid:10695938 |
| Burgermeister E et al. | Inhibition of cytosolic phospholipase A(2) attenuates activation of mitogen-activated protein kinases in human monocytic cells. | 2000 | Eur. J. Pharmacol. | pmid:10675727 |
| Suzuki S et al. | The roles of platelet-activating factor and endothelin-1 in renal damage after total hepatic ischemia and reperfusion. | 2000 | Transplantation | pmid:10868624 |
| Serradji N et al. | Structure-activity relationships in platelet-activating factor (PAF). 10. From PAF antagonism to inhibition of HIV-1 replication. | 2000 | J. Med. Chem. | pmid:10841793 |
| Ma X and Bazan HE | Increased platelet-activating factor receptor gene expression by corneal epithelial wound healing. | 2000 | Invest. Ophthalmol. Vis. Sci. | pmid:10845588 |
| Kobayashi N et al. | Transepithelial migration of activated eosinophils induces a decrease of E-cadherin expression in cultured human nasal epithelial cells. | 2000 | Clin. Exp. Allergy | pmid:10848899 |
| Choi JH et al. | Selective involvement of reactive oxygen intermediates in platelet-activating factor-mediated activation of NF-kappaB. | 2000 | Inflammation | pmid:10921504 |
| Smalley DM et al. | The local effect of PAF on leukocyte adherence to small bowel mesenteric venules following intra-abdominal contamination. | 2000 | Inflammation | pmid:10921505 |
| O'Brien JG et al. | Effects of tranexamic acid and aprotinin, two antifibrinolytic drugs, on PAF-induced plasma extravasation in unanesthetized rats. | 2000 | Inflammation | pmid:10921506 |