Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Leukemia, Experimental D007942 42 associated lipids
Hypotension D007022 41 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Arthritis D001168 41 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Peritonitis D010538 38 associated lipids
Nervous System Diseases D009422 37 associated lipids
Lung Diseases D008171 37 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Authors Title Published Journal PubMed Link
Shi B et al. [Influence of intensive insulin therapy on the intestinal microcirculatory dysfunction in rats with sepsis]. 2009 Zhongguo Wei Zhong Bing Ji Jiu Yi Xue pmid:19695175
Hao J et al. [Dynamic changes of platelet number in early multiple injury and it is effect on prognosis]. 2003 Zhongguo Wei Zhong Bing Ji Jiu Yi Xue pmid:14552687
Ding DD et al. [Changes of platelet α-particle membrane protein, platelet activating factor and platelet parameters in patients with hyperuricemia]. 2012 Zhongguo Shi Yan Xue Ye Xue Za Zhi pmid:22541106
Guo NJ et al. [Activation of platelet-neutrophil mediated by platelet-activating factor]. 2005 Zhongguo Shi Yan Xue Ye Xue Za Zhi pmid:15972139
Bao GQ and Ju AZ [Signal pathways of eryptosis-review]. 2009 Zhongguo Shi Yan Xue Ye Xue Za Zhi pmid:19698269
Wang LJ et al. [Role of platelet activating factor in the injury of intestinal immuno-barrier function in young rats]. 2006 Zhongguo Dang Dai Er Ke Za Zhi pmid:16522243
Xu CL et al. [Inhibitory effect of TBN on platelet aggregation in rabbit]. 2010 Zhong Yao Cai pmid:21243778
Zhang XT et al. [Study on the pharmacokinetics of ginkgolide B for injection in rats]. 2012 Zhong Yao Cai pmid:22876684
Zhang XT et al. [Study on pharmacokinetics of ginkgolide B injection in Beagle dogs]. 2012 Zhong Yao Cai pmid:23213741
Huang GD et al. [Observation on the expression of PS2 and platelet activating factor affected by Jianwei Yuyang granules and study its potential mechanisim against peptic ulcer]. 2007 Zhong Yao Cai pmid:18422199