| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cluster Headache | D003027 | 4 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Colonic Diseases | D003108 | 5 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Conjunctivitis | D003231 | 7 associated lipids |
| Constriction, Pathologic | D003251 | 8 associated lipids |
| Contracture | D003286 | 3 associated lipids |
| Coronary Artery Disease | D003324 | 47 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Christman BW et al. | Prostaglandin E2 limits arachidonic acid availability and inhibits leukotriene B4 synthesis in rat alveolar macrophages by a nonphospholipase A2 mechanism. | 1993 | J. Immunol. | pmid:8393898 |
| Kester M | Platelet-activating factor stimulates phosphatidic acid formation in cultured rat mesangial cells: roles of phospholipase D, diglyceride kinase, and de novo phospholipid synthesis. | 1993 | J. Cell. Physiol. | pmid:8393878 |
| Lerner R et al. | Lipoxin A4 induces hyperadhesiveness in human endothelial cells for neutrophils. | 1993 | Blood | pmid:8393356 |
| Kuruvilla A et al. | Tyrosine phosphorylation of phospholipase C concomitant with its activation by platelet-activating factor in a human B cell line. | 1993 | J. Immunol. | pmid:8393037 |
| Barnes PJ | Effect of nedocromil sodium on platelet-activating factor-induced airway responses. | 1993 | J. Allergy Clin. Immunol. | pmid:8393026 |
| Abraham WM | Effect of nedocromil sodium on specific mediator- and antigen-induced airway responses in allergic sheep. | 1993 | J. Allergy Clin. Immunol. | pmid:8393023 |
| Bennett SA et al. | Platelet activating factor, an endogenous mediator of inflammation, induces phenotypic transformation of rat embryo cells. | 1993 | Carcinogenesis | pmid:8392443 |
| Götz E et al. | Meningocortical lesion increases expression of the cholecystokinin gene in rat cerebral cortex: evidence for the involvement of platelet-activating factor (PAF). | 1993 | Brain Res. Mol. Brain Res. | pmid:8392132 |
| Fonteh AN et al. | Influence of isoproterenol and phosphodiesterase inhibitors on platelet-activating factor biosynthesis in the human neutrophil. | 1993 | J. Immunol. | pmid:8392098 |
| O'Flaherty JT and Rossi AG | 5-hydroxyicosatetraenoate stimulates neutrophils by a stereospecific, G protein-linked mechanism. | 1993 | J. Biol. Chem. | pmid:8392058 |
| Tufano MA et al. | Outer-membrane porins from gram-negative bacteria stimulate platelet-activating-factor biosynthesis by cultured human endothelial cells. | 1993 | Eur. J. Biochem. | pmid:8391435 |
| Chao W and Olson MS | Platelet-activating factor: receptors and signal transduction. | 1993 | Biochem. J. | pmid:8391253 |
| Tsukagoshi H and Kurosawa M | [Effect of Asthremedin on bronchial hyperresponsiveness (BHR) to histamine induced by intravenous administration of platelet activating factor (PAF) in guinea pigs]. | 1993 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:8391092 |
| Zweiman B et al. | Comparison of cytosolic calcium shifts, superoxide generation, and lactoferrin secretion in the neutrophils of atopics and nonatopics. | 1993 | J. Leukoc. Biol. | pmid:8391056 |
| Tao W et al. | Recombinant bovine GM-CSF primes superoxide production but not degranulation induced by recombinant bovine interleukin-1 beta in bovine neutrophils. | 1993 | J. Leukoc. Biol. | pmid:8391055 |
| Gay JC | Mechanism and regulation of neutrophil priming by platelet-activating factor. | 1993 | J. Cell. Physiol. | pmid:8391006 |
| Zimmermann A and Keller H | Shape changes and chemokinesis of Walker carcinosarcoma cells: effects of protein kinase inhibitors (HA-1004, polymyxin B, sangivamycin and tamoxifen) and an inhibitor of diacylglycerol kinase (R 59022). | 1993 Mar-Apr | Anticancer Res. | pmid:8390801 |
| Rotllan E et al. | [Effect of PAF (platelet-activating factor) on hemostasis. Studies on endothelial cells and platelets]. | 1993 | Sangre (Barc) | pmid:8390724 |
| Müller E et al. | Identification and functional characterization of platelet-activating factor receptors in human leukocyte populations using polyclonal anti-peptide antibody. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8390683 |
| Montero M et al. | Transient inhibition by chemotactic peptide of a store-operated Ca2+ entry pathway in human neutrophils. | 1993 | J. Biol. Chem. | pmid:8390453 |
| Catalán RE et al. | PAF and thrombin actions in platelets are selectively affected by a new 1,4-dihydropyridine derivative. | 1993 | J. Biochem. | pmid:8390447 |
| Laffi G et al. | Impaired superoxide anion, platelet-activating factor, and leukotriene B4 synthesis by neutrophils in cirrhosis. | 1993 | Gastroenterology | pmid:8390378 |
| Shiono S et al. | Neurotransmitter release from lysophosphatidic acid stimulated PC12 cells: involvement of lysophosphatidic acid receptors. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8390248 |
| Nishinaka Y et al. | A new sensitive chemiluminescence probe, L-012, for measuring the production of superoxide anion by cells. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8390246 |
| Venable ME et al. | Platelet-activating factor: a phospholipid autacoid with diverse actions. | 1993 | J. Lipid Res. | pmid:8389794 |
| Roth M et al. | Inhibition of receptor-mediated platelet activation by nedocromil sodium. | 1993 | J. Allergy Clin. Immunol. | pmid:8389778 |
| Mori M et al. | Energy-dependent export of leukotriene B4 in Xenopus oocytes. | 1993 | Biochim. Biophys. Acta | pmid:8389202 |
| Nieuwland R et al. | Effect of epinephrine on the regulation of Na+/H+ exchange in human platelets. | 1993 | Biochim. Biophys. Acta | pmid:8389195 |
| Brunton VG and Workman P | In vitro antitumour activity of the novel imidazoisoquinoline SDZ 62-434. | 1993 | Br. J. Cancer | pmid:8388233 |
| Tomioka H and Kagami M | [Clinical relevance on the inhibition of eosinophil functions--a review with special reference to eosinophilopietic cytokines]. | 1993 | Nippon Rinsho | pmid:8388064 |
| Takizawa H | [Eosinophils in immediate allergic reactions]. | 1993 | Nippon Rinsho | pmid:8388063 |
| Arndt H et al. | Leukocyte-endothelial cell adhesion in spontaneously hypertensive and normotensive rats. | 1993 | Hypertension | pmid:8387961 |
| Winkler JD et al. | Influence of arachidonic acid on indices of phospholipase A2 activity in the human neutrophil. | 1993 | Biochem. J. | pmid:8387780 |
| Rosenthal MD et al. | 1,3-Dioctanoylglycerol modulates arachidonate mobilization in human neutrophils and its inhibition by PGBx: evidence of a protein-kinase-C-independent role for diacylglycerols in signal transduction. | 1993 | Biochim. Biophys. Acta | pmid:8387343 |
| Daniels RH et al. | Differential regulation of early phase and late phase responses in human neutrophils by cAMP. | 1993 | Biochem. Pharmacol. | pmid:8387301 |
| Dent G and Barnes PJ | Platelet activating factor stimulates a receptor-coupled membrane GTPase in guinea pig eosinophils. | 1993 | Life Sci. | pmid:8387140 |
| Levistre R et al. | Stimulatory and inhibitory guanine-nucleotide-binding regulatory protein involvement in stimulation of arachidonic-acid release by N-formyl-methionyl-leucyl-phenylalanine and platelet-activating factor from guinea-pig alveolar macrophages. Differential receptor/G-protein interaction assessed by pertussis and cholera toxins. | 1993 | Eur. J. Biochem. | pmid:8386624 |
| Samiei M et al. | Activation of myelin basic protein and S6 peptide kinases in phorbol ester- and PAF-treated sheep platelets. | 1993 | Biochim. Biophys. Acta | pmid:8385998 |
| Burgers JA and Akkerman JW | Regulation of the receptor for platelet-activating factor on human platelets. | 1993 | Biochem. J. | pmid:8385926 |
| Croft KD and Beilin LJ | Platelet and neutrophil function and eicosanoid release in a subject with abetalipoproteinaemia. | 1993 | Thromb. Res. | pmid:8385810 |
| Becker K et al. | PAF-induced death in NMRI mice--a suitable shock model for testing new PAF receptor antagonists. Correlation with eicosanoid related substances. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8385779 |
| Carrick JB et al. | Administration of a receptor antagonist for platelet-activating factor during equine endotoxaemia. | 1993 | Equine Vet. J. | pmid:8385601 |
| Tsutsui H and Morisawa S | [Trend of molecular biological studies on the liver sinusoidal cells--Kupffer cells]. | 1993 | Nippon Rinsho | pmid:8385242 |
| Hashimoto K et al. | Comparison of the effects of intra-third ventricular administration of interleukin-1 or platelet activating factor on ACTH secretion and the sympathetic-adrenomedullary system in conscious rats. | 1993 | Acta Med. Okayama | pmid:8384777 |
| Kato M et al. | Platelet-activating factor-induced enhancement of superoxide anion generation in guinea-pigs. | 1993 | Eur. J. Pharmacol. | pmid:8384564 |
| Mulder K and Colditz IG | Migratory responses of ovine neutrophils to inflammatory mediators in vitro and in vivo. | 1993 | J. Leukoc. Biol. | pmid:8384237 |
| Sordano C et al. | Platelet activating factor modulates signal transduction in Dictyostelium. | 1993 | J. Cell. Sci. | pmid:8383695 |
| Chase PB et al. | Cloning of a human platelet-activating factor receptor gene: evidence for an intron in the 5'-untranslated region. | 1993 | Am. J. Respir. Cell Mol. Biol. | pmid:8383507 |
| Gardner CR et al. | Platelet-activating factor-induced calcium mobilization and oxidative metabolism in hepatic macrophages and endothelial cells. | 1993 | J. Leukoc. Biol. | pmid:8383168 |
| Rossi AG et al. | Stimulation of human polymorphonuclear leukocytes by leukotriene B4 and platelet-activating factor: an ultrastructural and pharmacological study. | 1993 | J. Leukoc. Biol. | pmid:8383164 |
| Ramos-Franco J et al. | Platelet-activating factor receptor-dependent activation of the muscarinic K+ current in bullfrog atrial myocytes. | 1993 | Circ. Res. | pmid:8383014 |
| Siafaka-Kapadai A and Hanahan D | An endogenous inhibitor of PAF-induced platelet aggregation, isolated from rat liver, has been identified as free fatty acid. | 1993 | Biochim. Biophys. Acta | pmid:8382959 |
| Stewart AG and Harris T | Adenosine inhibits platelet-activating factor, but not tumour necrosis factor-alpha-induced priming of human neutrophils. | 1993 | Immunology | pmid:8382188 |
| Alonso-Torre SR et al. | Control of Ca2+ entry into HL60 and U937 human leukaemia cells by the filling state of the intracellular Ca2+ stores. | 1993 | Biochem. J. | pmid:8382050 |
| Ito K | [Thrombotic thrombocytopenic purpura--recent development of TTP study]. | 1993 | Nippon Rinsho | pmid:8381882 |
| Bertrand C et al. | Role of neurogenic inflammation in antigen-induced vascular extravasation in guinea pig trachea. | 1993 | J. Immunol. | pmid:8381836 |
| Sperling RI et al. | Dietary omega-3 polyunsaturated fatty acids inhibit phosphoinositide formation and chemotaxis in neutrophils. | 1993 | J. Clin. Invest. | pmid:8381824 |
| Eliakim R et al. | Octreotide effectively decreases mucosal damage in experimental colitis. | 1993 | Gut | pmid:8381760 |
| Montrucchio G et al. | Role of platelet-activating factor in hypotension and platelet activation induced by infusion of thrombolytic agents in rabbits. | 1993 | Circ. Res. | pmid:8381725 |
| Ring PC et al. | Pharmacological characterization of a receptor for platelet-activating factor on guinea pig peritoneal macrophages using [3H]apafant, a selective and competitive platelet-activating factor antagonist: evidence that the noncompetitive behavior of apafant in functional studies relates to slow kinetics of dissociation. | 1993 | Mol. Pharmacol. | pmid:8381515 |
| Christy IJ et al. | Mediators of the hypotensive response to increased renal perfusion in rabbits. | 1993 | Hypertension | pmid:8381391 |
| Weg VB et al. | A monoclonal antibody recognizing very late activation antigen-4 inhibits eosinophil accumulation in vivo. | 1993 | J. Exp. Med. | pmid:8381157 |
| Martins MA et al. | Role of PAF in the allergic pleurisy caused by ovalbumin in actively sensitized rats. | 1993 | J. Leukoc. Biol. | pmid:8381149 |
| Herbert JM et al. | Binding of [3H]SR 27417, a novel platelet-activating factor (PAF) receptor antagonist, to rabbit and human platelets and polymorphonuclear leukocytes. | 1993 | Biochem. Pharmacol. | pmid:8381007 |
| Hatzelmann A et al. | Mode of action of the new selective leukotriene synthesis inhibitor BAY X 1005 ((R)-2-[4-(quinolin-2-yl-methoxy)phenyl]-2-cyclopentyl acetic acid) and structurally related compounds. | 1993 | Biochem. Pharmacol. | pmid:8381000 |
| Slama H et al. | Metabolism of arachidonic acid by caruncular and allantochorionic tissues in cows with retained fetal membranes (RFM). | 1993 | Prostaglandins | pmid:8380936 |
| Chilton FH et al. | Dietary n-3 fatty acid effects on neutrophil lipid composition and mediator production. Influence of duration and dosage. | 1993 | J. Clin. Invest. | pmid:8380809 |
| Svetlov S and Nigam S | Evidence for the presence of specific high affinity cytosolic binding sites for platelet-activating factor in human neutrophils. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8380690 |
| Asako H et al. | Leukocyte adherence in rat mesenteric venules: effects of adenosine and methotrexate. | 1993 | Gastroenterology | pmid:8380395 |
| Ko FN et al. | CIS-19, a novel platelet activating factor receptor antagonist: in vitro and in vivo studies. | 1993 | Biochim. Biophys. Acta | pmid:8380343 |
| Casale TB et al. | Platelet-activating factor-induced human eosinophil transendothelial migration: evidence for a dynamic role of the endothelium. | 1993 | Am. J. Respir. Cell Mol. Biol. | pmid:8380250 |
| Bazan HE et al. | Platelet-activating factor induces collagenase expression in corneal epithelial cells. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8378347 |
| Weber C et al. | Platelet activating factor enhances receptor-operated Ca(++)-influx and subsequent prostacyclin synthesis in human endothelial cells. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8373423 |
| Narahara H and Johnston JM | Effects of endotoxins and cytokines on the secretion of platelet-activating factor-acetylhydrolase by human decidual macrophages. | 1993 | Am. J. Obstet. Gynecol. | pmid:8372856 |
| Bannenberg G et al. | Hydrogen peroxide-induced broncho- and vasoconstriction in the isolated perfused and ventilated guinea pig lung. | 1993 Apr-May | Pharmacol. Toxicol. | pmid:8372054 |
| Norris LA et al. | Whole blood platelet aggregation in moderate and severe pre-eclampsia. | 1993 | Br J Obstet Gynaecol | pmid:8369255 |
| Smith LJ et al. | Effect of leukotriene D4 and platelet-activating factor on human alveolar macrophage eicosanoid and PAF synthesis. | 1993 | Am. Rev. Respir. Dis. | pmid:8368641 |
| Ma Y et al. | [Studies on PAF antagonistic bicyclo(3,2,1) octanoid neolignans from Piper kadsura]. | 1993 | Yao Xue Xue Bao | pmid:8368081 |
| Rayner TE et al. | Prostaglandin F2 alpha mediates platelet-activating factor-stimulated atrial natriuretic factor release from the isolated rat heart. | 1993 | Endocrinology | pmid:8365356 |
| Louis R et al. | No increase in plasma histamine during PAF-induced airway obstruction in allergic asthmatics. | 1993 | Chest | pmid:8365293 |
| Wierenga EA et al. | Relative contributions of human types 1 and 2 T-helper cell-derived eosinophilotrophic cytokines to development of eosinophilia. | 1993 | Blood | pmid:8364199 |
| Nakamura T et al. | Effects of saiboku-to (TJ-96) on the production of platelet-activating factor in human neutrophils. | 1993 | Ann. N. Y. Acad. Sci. | pmid:8363265 |
| Kald B et al. | Release of platelet-activating factor in acute experimental pancreatitis. | 1993 | Pancreas | pmid:8361963 |
| Maki N et al. | [Analysis of platelet-activating factor and its effect on the lung]. | 1993 | Rinsho Byori | pmid:8361018 |
| Kawatake H and Kawakami Y | [Pulmonary thromboembolism and IgE]. | 1993 | Nippon Naika Gakkai Zasshi | pmid:8360566 |
| Kitajima T et al. | Role of endothelin and platelet-activating factor in indomethacin-induced gastric mucosal injury in rats. | 1993 | Digestion | pmid:8359557 |
| Hirafuji M and Shinoda H | Roles of prostacyclin, EDRF and active oxygens in leukocyte-dependent platelet adhesion to endothelial cells induced by platelet-activating factor in vitro. | 1993 | Br. J. Pharmacol. | pmid:8358552 |
| Defaux JP et al. | Involvement of platelet-activating factor (PAF) in endotoxin- or ischaemia-induced intestinal hyperpermeability in the rat. | 1993 | J Lipid Mediat | pmid:8358021 |
| Castro-Faria-Neto HC et al. | Pharmacological profile of epiyangambin: a furofuran lignan with PAF antagonist activity. | 1993 | J Lipid Mediat | pmid:8358020 |
| Yee GM et al. | Lipid mediators of implantation and decidualization. | 1993 Mar-Apr | J Lipid Mediat | pmid:8358012 |
| Koltai M et al. | PAF-induced amplification of mediator release in septic shock: prevention or downregulation by PAF antagonists. | 1993 Mar-Apr | J Lipid Mediat | pmid:8357981 |
| Borobia FG et al. | Platelet-activating factor antagonist BN52021 improves survival in normothermic liver ischemia in rats. | 1993 | Transplant. Proc. | pmid:8356661 |
| Golino P et al. | Short-term and long-term role of platelet activating factor as a mediator of in vivo platelet aggregation. | 1993 | Circulation | pmid:8353882 |
| Rhee CK et al. | Experimental otitis media with effusion induced by platelet activating factor. | 1993 | Ann. Otol. Rhinol. Laryngol. | pmid:8352483 |
| Hall AV et al. | Abrogation of MRL/lpr lupus nephritis by dietary flaxseed. | 1993 | Am. J. Kidney Dis. | pmid:8352261 |
| Thibodeaux JK et al. | Stimulation of development of in vitro-matured and in vitro-fertilized bovine embryos by platelets. | 1993 | J. Anim. Sci. | pmid:8349520 |
| Torras J et al. | Protective effect of the PAF antagonist BN 52021 in an experimental renal warm ischemia model. | 1993 | Transpl. Int. | pmid:8347271 |
| Kooistra T et al. | Triazolobenzodiazepines: a new class of stimulators of tissue-type plasminogen activator synthesis in human endothelial cells. | 1993 | Biochem. Pharmacol. | pmid:8347138 |
| Sugatani J et al. | Modulation by drugs acting on the autonomic nervous system of platelet-activating factor in the stomach of rats. | 1993 | Biochem. Pharmacol. | pmid:8347135 |
| Ihara Y et al. | Hormonal regulation of platelet-activating factor-acetyltransferase activity in rat tissues. | 1993 | Arch. Biochem. Biophys. | pmid:8346925 |