Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

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Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Hemorrhage D006470 15 associated lipids
Gastrointestinal Hemorrhage D006471 27 associated lipids
Hemorrhagic Fever, American D006478 2 associated lipids
Hepatitis, Alcoholic D006519 5 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hyperalgesia D006930 42 associated lipids
Hypercalcemia D006934 13 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Hyperinsulinism D006946 27 associated lipids
Hypersensitivity D006967 22 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Hypertension D006973 115 associated lipids
Hypertension, Portal D006975 12 associated lipids
Hypertension, Pulmonary D006976 32 associated lipids
Hypotension D007022 41 associated lipids
Ileal Diseases D007077 3 associated lipids
Ileitis D007079 2 associated lipids
Immune Complex Diseases D007105 9 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Fujii E et al. Role of nitric oxide and prostaglandins in lipopolysaccharide-induced increase in vascular permeability in mouse skin. 1996 Eur. J. Pharmacol. pmid:8666058
Goudevenos J et al. Platelet aggregability to platelet activating factor at rest and after exercise in patients with coronary artery disease. 1995 Eur. Heart J. pmid:8665964
Nathan N et al. Effects of a paf-receptor antagonist on hemodynamics during and after cardiopulmonary bypass. 1995 J. Cardiothorac. Vasc. Anesth. pmid:8664454
Ettinger SL et al. Protein kinase C delta specifically associates with phosphatidylinositol 3-kinase following cytokine stimulation. 1996 J. Biol. Chem. pmid:8663229
Ferby IM et al. Wortmannin inhibits mitogen-activated protein kinase activation by platelet-activating factor through a mechanism independent of p85/p110-type phosphatidylinositol 3-kinase. 1996 J. Biol. Chem. pmid:8662643
Ganbo T et al. Effects of platelet activating factor on mucociliary clearance of the eustachian tube. 1996 Ann. Otol. Rhinol. Laryngol. pmid:8659935
Leont'ev VK and Kankanian AP [The local activation of leukocytes and thrombocytes in periodontal diseases: the role of thrombocyte-activating factor]. 1996 Stomatologiia (Mosk) pmid:8658569
Sheen WS et al. Indolopyridoquinazoline alkaloids with antiplatelet aggregation activity from Zanthoxylum integrifoliolum. 1996 Planta Med. pmid:8657756
Franciose RJ et al. Hypoxia/reoxygenation of human endothelium activates PMNs to detach endothelial cells via a PAF mechanism. 1996 J. Surg. Res. pmid:8656625
Zimmerman GA et al. Platelet-activating factor: antagonists, terminators, molecular mimics, and microbial opportunism. 1996 J. Intern. Med. pmid:8656138
Das AK and Hajra AK A simple chemical synthesis of the ether analog of lysophosphatidylcholine and platelet-activating factor. 1995 J. Lipid Res. pmid:8656084
Miadonna A et al. Nasal neutrophilia and release of myeloperoxidase induced by nasal challenge with platelet activating factor: different degrees of responsiveness in atopic and nonatopic subjects. 1996 J. Allergy Clin. Immunol. pmid:8655890
Iatrou C et al. The production of platelet-activating factor (PAF) during hemodialysis with cuprophane membrane. Does the calcium concentration in the dialysate play any role on it? 1995 Int J Artif Organs pmid:8655220
Im SY et al. Augmentation of tumor metastasis by platelet-activating factor. 1996 Cancer Res. pmid:8653713
Resink T et al. Involvement of protein kinase C in hypoxia-induced desensitization of the beta-adrenergic system in human endothelial cells. 1996 Biochem. Biophys. Res. Commun. pmid:8651917
Nikolelis DP and Siontorou CG Ammonium ion minisensors form self-assembled bilayer lipid membranes using gramicidin as an ionophore. Modulation of ammonium selectivity by platelet-activating factor. 1996 Anal. Chem. pmid:8651482
Aïssa J et al. Tissue levels of histamine, PAF-acether and lysopaf-acether in carrageenan-induced granuloma in rats. 1996 Int. Arch. Allergy Immunol. pmid:8645997
Korth RM Specific high affinity binding of platelet activating factor to intact human blood neutrophils and eosinophils. 1996 Int. Arch. Allergy Immunol. pmid:8645989
Ikemura T et al. KW-4679, an antiallergic drug, inhibits the production of inflammatory lipids in human polymorphonuclear leukocytes and guinea pig eosinophils. 1996 Int. Arch. Allergy Immunol. pmid:8645979
Genovese A et al. Role of mast cells, basophils and their mediators in adverse reactions to general anesthetics and radiocontrast media. 1996 Int. Arch. Allergy Immunol. pmid:8645973
Parent JL et al. Mutation of an aspartate at position 63 in the human platelet-activating factor receptor augments binding affinity but abolishes G-protein-coupling and inositol phosphate production. 1996 Biochem. Biophys. Res. Commun. pmid:8645288
Reddy DS and Singh M Antiperoxidative effects of platelet activating factor antagonists against iron-dependent lipid peroxidation in murine ventricular membranes. 1995 Jul-Aug Methods Find Exp Clin Pharmacol pmid:8642899
Mori M et al. Predominant expression of platelet-activating factor receptor in the rat brain microglia. 1996 J. Neurosci. pmid:8642404
Isogai E et al. Platelet-activating-factor-mediated pathogenesis in Lyme disease. 1996 Infect. Immun. pmid:8641753
Giannini S et al. Platelet-activating factor enhances production of insulin-like growth factor binding proteins in a human adenocarcinoma cell line (HEC-1A) 1996 Gynecol. Oncol. pmid:8641611
Watanabe M et al. Enhancement by cyclo-oxygenase inhibitors of platelet-activating factor production in thapsigargin-stimulated macrophages. 1995 Br. J. Pharmacol. pmid:8640357
Saito M et al. RANTES and platelet-activating factor open Ca2+-activated K+ channels in eosinophils. 1996 FASEB J. pmid:8635697
Niwa Y et al. Role of cytokines, tyrosine kinase, and protein kinase C on production of superoxide and induction of scavenging enzymes in human leukocytes. 1996 Clin. Immunol. Immunopathol. pmid:8635290
Francischi JN et al. Pharmacological characterization of Sephadex-induced oedema in rat paws: predominant role of serotonin and platelet-activating factor. 1996 Int. Arch. Allergy Immunol. pmid:8634526
Yin M et al. The PAF antagonist TCV-309 reduces graft PMN infiltration and enhances early function of 24-hour-preserved rat kidneys with long warm ischemia. 1996 Transplantation pmid:8633367
Alaei P et al. Inhibition of protein prenylation down-regulates signalling by inflammatory mediators in human keratinocytes. 1996 Biochem. Biophys. Res. Commun. pmid:8630058
Harris JG et al. Relative contribution of the selectins in the neutrophil recruitment caused by the chemokine cytokine-induced neutrophil chemoattractant (CINC). 1996 Biochem. Biophys. Res. Commun. pmid:8630023
Parent JL et al. Mutations of two adjacent amino acids generate inactive and constitutively active forms of the human platelet-activating factor receptor. 1996 J. Biol. Chem. pmid:8626474
Komatsu Y et al. Role of platelet-activating factor in pathogenesis of galactosamine-lipopolysaccharide-induced liver injury. 1996 Dig. Dis. Sci. pmid:8625746
Antonopoulou S et al. Blood cardiolipin in haemodialysis patients. Its implication in the biological action of platelet-activating factor. 1996 Int. J. Biochem. Cell Biol. pmid:8624843
Coceani F et al. Response of newborn and adult sheep to pyrogens: relation between fever and brain eicosanoid changes. 1995 Brain Res. pmid:8624710
Longphre M et al. PAF-induced airways hyperreactivity is modulated by mast cells in mice. 1996 Am. J. Respir. Cell Mol. Biol. pmid:8624251
Nassif A et al. Role of cytokines and platelet-activating factor in inflammatory bowel disease. Implications for therapy. 1996 Dis. Colon Rectum pmid:8620791
Burns AR et al. Chemotactic factors stimulate CD18-dependent canine neutrophil adherence and motility on lung fibroblasts. 1996 J. Immunol. pmid:8617965
Dentan C et al. Phagocytic activation induces formation of platelet-activating factor in human monocyte-derived macrophages and in macrophage-derived foam cells. Relevance to the inflammatory reaction in atherogenesis. 1996 Eur. J. Biochem. pmid:8617285
Silva CL et al. Formation of a highly stable complex between BN 50730 [tetrahydro-4,7,8,10 methyl-1(chloro-2 phenyl)-6 (methoxy-4 phenyl-carbamoyl)-9 pyrido [4',3'-4,5] thieno [3,2-f] triazolo-1,2,4 [4,3-a] diazepine-1,4] and the platelet-activating factor receptor in rabbit platelet membranes. 1996 Biochem. Pharmacol. pmid:8615889
van Willigen G et al. Exposure of ligand-binding sites on platelet integrin alpha IIB/beta 3 by phosphorylation of the beta 3 subunit. 1996 Biochem. J. pmid:8615768
Svetlov SI et al. Interaction of platelet-activating factor with rat hepatocytes: uptake, translocation, metabolism, and effects on PAF-acetylhydrolase secretion and protein tyrosine phosphorylation. 1996 Arch. Biochem. Biophys. pmid:8615681
Bailie MB et al. Platelet activating factor receptor blockade alone or in combination with leukotriene synthesis inhibition does not ameliorate alpha-naphthylisothiocyanate-induced hepatotoxicity. 1996 Toxicol. Lett. pmid:8614909
Biffl WL et al. Interleukin-6 delays neutrophil apoptosis via a mechanism involving platelet-activating factor. 1996 J Trauma pmid:8614035
Biffl WL et al. Interleukin-6 stimulates neutrophil production of platelet-activating factor. 1996 J. Leukoc. Biol. pmid:8613706
Nishida K and Markey SP Platelet-activating factor in brain regions after transient ischemia in gerbils. 1996 Stroke pmid:8610322
Tan XD et al. Platelet activating factor and endotoxin increase the enzyme activity and gene expression of type II phospholipase A2 in the rat intestine. Role of polymorphonuclear leukocytes. 1996 J. Immunol. pmid:8609420
Gabbeta J et al. Abnormal inside-out signal transduction-dependent activation of glycoprotein IIb-IIIa in a patient with impaired pleckstrin phosphorylation. 1996 Blood pmid:8608226
Comminges C et al. Differential labelings suggest two specific phospholipid subclass hydrolysis promoted by PDGF-BB in vascular smooth muscle cells. 1996 Biochem. Biophys. Res. Commun. pmid:8607782
Satoh K et al. Production of platelet-activating factor by porcine brain microvascular endothelial cells in culture. 1995 Thromb. Haemost. pmid:8607119
Novo C et al. Factors associated with hyperdynamic or hypodynamic circulation and role of platelet-activating factor in hemodynamic alterations in bacterial peritonitis in conscious rats. 1995 J. Cardiovasc. Pharmacol. pmid:8606531
Ono S et al. A clinical study on the significance of platelet-activating factor in the pathophysiology of septic disseminated intravascular coagulation in surgery. 1996 Am. J. Surg. pmid:8604832
Schweizer RC et al. Mechanisms involved in eosinophil migration. Platelet-activating factor-induced chemotaxis and interleukin-5-induced chemokinesis are mediated by different signals. 1996 J. Leukoc. Biol. pmid:8604012
Pinckard RN and Prihoda TJ Alkyl-PAF and acyl-PAF human neutrophil priming for enhanced fMLP- and rC5a-induced superoxide anion production. 1996 J. Leukoc. Biol. pmid:8603994
Lombard MN et al. Liver and plasma concentrations in paf-acether and its precursors after partial hepatectomy. 1996 Cell Prolif. pmid:8603108
Dupuis F et al. PAF and haematopoiesis. X. Macrophage colony-stimulating factor and granulocyte macrophage colony-stimulating factor enhance platelet-activating factor acetylhydrolase production by human blood-derived macrophages. 1996 Biochim. Biophys. Acta pmid:8603099
Carter MB et al. Platelet-activating factor mediates pulmonary macromolecular leak following intestinal ischemia-reperfusion. 1996 J. Surg. Res. pmid:8598677
Dentan C et al. Pefabloc, 4-[2-aminoethyl]benzenesulfonyl fluoride, is a new, potent nontoxic and irreversible inhibitor of PAF-degrading acetylhydrolase. 1996 Biochim. Biophys. Acta pmid:8597590
Klabunde RE and Calvello C Inhibition of endotoxin-induced microvascular leakage by a platelet-activating factor antagonist and 5-lipoxygenase inhibitor. 1995 Shock pmid:8595525
Bazan NG et al. Mediators of injury in neurotrauma: intracellular signal transduction and gene expression. 1995 J. Neurotrauma pmid:8594208
Zhou W et al. Evidence for altered cellular calcium in the pathogenetic mechanism of acute pancreatitis in rats. 1996 J. Surg. Res. pmid:8592406
Hurst JS and Bazan HE Activation of the phospholipase/cyclooxygenase cascade in the rabbit cornea by platelet-activating factor is challenged by PAF receptor antagonists. 1995 J Ocul Pharmacol Ther pmid:8590265
Pettigrew LC et al. Delayed elevation of platelet activating factor in ischemic hippocampus. 1995 Brain Res. pmid:8590061
Suzuki H et al. Evidence for the production of platelet-activating factor by murine embryos and its putative role in the maternal physiology. 1995 Biochem. Mol. Biol. Int. pmid:8589634
Calligerou M et al. Platelet activating factor and lyso-phosphatidylcholines from strawberry. 1996 Phytochemistry pmid:8588879
Myers SI et al. Platelet activating factor (PAF) stimulates release of PGI2 from inflamed rabbit gallbladder cell cultures. 1995 Prostaglandins pmid:8588069
Davis TM et al. The metabolism of platelet-activating factor in severe and cerebral malaria. 1995 J. Infect. pmid:8586836
Cheng D and Chen W [Distribution of platelet activating factor in the pulmonary tissues of normal rats]. 1995 Hua Xi Yi Ke Da Xue Xue Bao pmid:8586397
Tunón H et al. Evaluation of anti-inflammatory activity of some Swedish medicinal plants. Inhibition of prostaglandin biosynthesis and PAF-induced exocytosis. 1995 J Ethnopharmacol pmid:8583796
Komatsu H et al. Platelet-activating factor induces cell growth through tyrosine phosphorylation pathway in cultured rat mesangial cells. 1995 Nihon Jinzo Gakkai Shi pmid:8583698
Arthur JF et al. Paf antagonists block induction of nitric oxide synthase in cultured macrophages and vascular smooth muscle cells. 1995 Jun-Jul Clin. Exp. Pharmacol. Physiol. pmid:8582100
Morris J et al. Effects of garlic extract on platelet aggregation: a randomized placebo-controlled double-blind study. 1995 Jun-Jul Clin. Exp. Pharmacol. Physiol. pmid:8582091
Kuwahara M et al. Synthetic studies on condensed-azole derivatives. IV. Synthesis and anti-asthmatic activities of omega-sulfamoylalkyloxyimidazo[1,2-b]pyridazines. 1996 Chem. Pharm. Bull. pmid:8582031
Hilliquin P et al. Production of PAF-acether by synovial fluid neutrophils in rheumatoid arthritis. 1995 Inflamm. Res. pmid:8581516
Man RY and Kinnaird AA Similar coronary vascular effects in the rat perfused heart of platelet-activating factor structural analogues with agonist and antagonist properties. 1995 Br. J. Pharmacol. pmid:8581269
Iwamoto S et al. Platelet microparticles: a carrier of platelet-activating factor? 1996 Biochem. Biophys. Res. Commun. pmid:8579618
Diserbo M et al. Activation of large conductance Ca(2+)-activated K+ channels in N1E-115 neuroblastoma cells by platelet-activating factor. 1996 Biochem. Biophys. Res. Commun. pmid:8579584
Monthly prostaglandin bibliography prepared by the University of Sheffield Biomedical Information Service. 1995 Prostaglandins Leukot. Essent. Fatty Acids pmid:8577776
Manning R et al. Lipid changes in HL-60 cells on differentiation into macrophages by treatment with a phorbol ester. 1995 Lipids pmid:8577224
Naz RK and Minhas BS Enhancement of sperm function for treatment of male infertility. 1995 Sep-Oct J. Androl. pmid:8575977
Fukumura D et al. Oxidative stress in gastric mucosal injury: role of platelet-activating factor-activated granulocytes. 1995 J. Gastroenterol. pmid:8574326
Samuelsson J Impaired activation of phospholipase D in polycythaemia vera-implications for the pathogenesis of the disease? 1995 Leuk. Lymphoma pmid:8574168
Muzia GI et al. [Inhibition of formation of superoxide radicals in leukocytes of hypercholesteremic patients under the effect of a lipid platelet activation factor antagonist]. 1995 Jul-Aug Vopr. Med. Khim. pmid:8571587
Kudolo GB et al. Differential metabolism of exogenous platelet-activating factor by glandular epithelial and stromal cells of rabbit endometrium. 1995 J. Reprod. Fertil. pmid:8568777
Lin CN et al. Synthesis and antiplatelet effects of omega-aminoalkoxylxanthones. 1995 J. Pharm. Pharmacol. pmid:8568627
Kyriacopoulos F et al. Role of PAF in the late airway microvascular leakage induced by antigen in IgE-sensitized rat. 1995 Fundam Clin Pharmacol pmid:8566934
Sasaki Y et al. [Effect of KW-4679, a novel antiallergic drug, on platelet-activating factor (PAF)-induced bronchoconstriction, airway hyperresponsiveness and pulmonary cell accumulation in guinea pigs]. 1995 Nippon Yakurigaku Zasshi pmid:8566911
Costuleanu M et al. Effects of liposome-entrapped platelet-activating factor in the isolated rat trachea. 1995 Eur. J. Pharmacol. pmid:8566122
Dillon AM and Heath MF Protein tyrosine phosphorylation in equine platelets: the effect of stimulation by thrombin and platelet-activating factor (PAF) 1995 Equine Vet. J. pmid:8565942
Yu P et al. [The roles of platelet activating factor in intestinal mucosal barrier injury after burn]. 1995 Zhonghua Wai Ke Za Zhi pmid:8565724
Wang C et al. [Inhalation of platelet-activating factor induced guinea pig airway hyperresponsiveness: role of eosinophils activation]. 1995 Zhonghua Jie He He Hu Xi Za Zhi pmid:8565083
Lorant DE et al. Platelet-activating factor mediates procoagulant activity on the surface of endothelial cells by promoting leukocyte adhesion. 1995 Semin. Cell Biol. pmid:8562922
Kaneko T et al. Elevated intracellular cyclic AMP inhibits chemotaxis in human eosinophils. 1995 Cell. Signal. pmid:8562314
van der Poll T et al. Interleukin 10 release during endotoxaemia in chimpanzees: role of platelet-activating factor and interleukin 6. 1996 Scand. J. Immunol. pmid:8560191
Tetta C et al. Adherence of human monocytes to haemodialysis membranes: LFA 1 (CD11a/CD18) CR1 (CD35) and CR3 (CD11b/CD18) triggering promotes the biosynthesis of platelet-activating factor and adherence. 1995 Nephrol. Dial. Transplant. pmid:8559489
Carceller E et al. Design, synthesis, and structure-activity relationship studies of novel 1-[(1-acyl-4-piperidyl)methyl]-1H-2- methylimidazo[4,5-c]pyridine derivatives as potent, orally active platelet-activating factor antagonists. 1996 J. Med. Chem. pmid:8558517
Endemann G et al. Novel anti-inflammatory compounds prevent CD11b/CD18, alpha M beta 2 (Mac-1)-dependent neutrophil adhesion without blocking activation-induced changes in Mac-1. 1996 J. Pharmacol. Exp. Ther. pmid:8558456
Kita H et al. Extracellular matrix proteins attenuate activation and degranulation of stimulated eosinophils. 1996 J. Immunol. pmid:8557995
Patke CL et al. Differential effects of interleukin-2 and interleukin-4 on immunomodulatory role of platelet-activating factor in human B cells. 1994 Clin. Diagn. Lab. Immunol. pmid:8556480