| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemorrhage | D006470 | 15 associated lipids |
| Gastrointestinal Hemorrhage | D006471 | 27 associated lipids |
| Hemorrhagic Fever, American | D006478 | 2 associated lipids |
| Hepatitis, Alcoholic | D006519 | 5 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Hyperalgesia | D006930 | 42 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Hyperlipoproteinemia Type II | D006938 | 22 associated lipids |
| Hyperinsulinism | D006946 | 27 associated lipids |
| Hypersensitivity | D006967 | 22 associated lipids |
| Hypersensitivity, Delayed | D006968 | 43 associated lipids |
| Hypersensitivity, Immediate | D006969 | 14 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Hypertension, Portal | D006975 | 12 associated lipids |
| Hypertension, Pulmonary | D006976 | 32 associated lipids |
| Hypotension | D007022 | 41 associated lipids |
| Ileal Diseases | D007077 | 3 associated lipids |
| Ileitis | D007079 | 2 associated lipids |
| Immune Complex Diseases | D007105 | 9 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Borin ML et al. | [Relation between the changes in Na+/H+-exchange and cytoplasmic Ca levels in platelet activation]. | 1988 | Biull Eksp Biol Med | pmid:2844320 |
| Joseph R et al. | Cytosolic ionized calcium homeostasis in platelets: an abnormal sensitivity to PAF-activation in migraine. | 1988 | Headache | pmid:2844693 |
| Criscuoli M and Subissi A | Catecholamines released from the adrenal medulla exert a compensatory, protective effect at beta 2-adrenoceptors against Paf-induced death in mice. | 1988 | Br. J. Pharmacol. | pmid:2894872 |
| Bekker AY et al. | Dose-response relationships between platelet activating factor and permeability--surface area product of FITC-dextran 150 in the hamster cheek pouch. | 1988 | Microcirc Endothelium Lymphatics | pmid:2475751 |
| Vivier E et al. | Immunoregulatory functions of paf-acether. II. Decrease of CD2 and CD3 antigen expression. | 1988 | Eur. J. Immunol. | pmid:2895712 |
| Elstad MR et al. | Synthesis and release of platelet-activating factor by stimulated human mononuclear phagocytes. | 1988 | J. Immunol. | pmid:3126231 |
| Hanss M and Dechavanne M | 48740 RP, an antagonist of PAF, does not affect human plasma fibrinolysis before and after venous occlusion. | 1988 | Thromb. Res. | pmid:3126559 |
| Dulioust A et al. | Immunoregulatory functions of paf-acether. I. Effect of paf-acether on CD4+ cell proliferation. | 1988 | J. Immunol. | pmid:2961808 |
| Acker G et al. | Role of platelet-activating factor (PAF) in the ovoimplantation in the rat: effect of the specific PAF-acether antagonist, BN 52021. | 1988 | Prostaglandins | pmid:3129758 |
| Bochner BS et al. | Adherence of human basophils to cultured umbilical vein endothelial cells. | 1988 | J. Clin. Invest. | pmid:3130394 |
| Lerner R et al. | Platelet activating factor and leukotriene B4 induce hyperpolarization of human endothelial cells but depolarization of neutrophils. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2838025 |
| Trovati M et al. | Insulin directly reduces platelet sensitivity to aggregating agents. Studies in vitro and in vivo. | 1988 | Diabetes | pmid:2838353 |
| Crouch MF and Lapetina EG | No direct correlation between Ca2+ mobilization and dissociation of Gi during platelet phospholipase A2 activation. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3132162 |
| Russell JA et al. | Changes in the levels of bioactive components of cotton bracts accompanying senescence. | 1988 | Lung | pmid:3132575 |
| Lefort J et al. | Pharmacological profile of 48740 R.P., a PAF-acether antagonist. | 1988 | Eur. J. Pharmacol. | pmid:2843382 |
| Winkler JD et al. | Leukotriene B4-induced homologous desensitization of calcium mobilization and phosphoinositide metabolism in U-937 cells. | 1988 | J. Pharmacol. Exp. Ther. | pmid:2839662 |
| Valone FH and Epstein LB | Biphasic platelet-activating factor synthesis by human monocytes stimulated with IL-1-beta, tumor necrosis factor, or IFN-gamma. | 1988 | J. Immunol. | pmid:3141509 |
| O'Flaherty JT et al. | Mechanism involved in the mobilization of neutrophil calcium by 5-hydroxyeicosatetraenoate. | 1988 | J. Immunol. | pmid:2836511 |
| Rydzewska G and Gabryelewicz A | [Platelet activating factor (PAF) and its inhibitors]. | 1988 | Pol. Arch. Med. Wewn. | pmid:2482481 |
| Demopoulos CA et al. | Abnormal platelet response to PAF and ADP in beta-thalassaemia. | 1988 | Int. J. Biochem. | pmid:3391336 |
| Lichterfeld A et al. | [Platelet activating factor and its possible role in bronchial asthma]. | 1988 | Prax Klin Pneumol | pmid:3041401 |
| Christman BW et al. | Role of circulating platelets and granulocytes in PAF-induced pulmonary dysfunction in awake sheep. | 1988 | J. Appl. Physiol. | pmid:3391901 |
| Barnes PJ | Inflammatory mechanisms and nocturnal asthma. | 1988 | Am. J. Med. | pmid:3041827 |
| Greenberg S et al. | Extracellular nucleotides mediate Ca2+ fluxes in J774 macrophages by two distinct mechanisms. | 1988 | J. Biol. Chem. | pmid:3392016 |
| Camussi G and Salvidio G | Platelet-activating factor in graft rejection. | 1988 | Prog Biochem Pharmacol | pmid:3043426 |
| Wallace JL and MacNaughton WK | Gastrointestinal damage induced by platelet-activating factor: role of leukotrienes. | 1988 | Eur. J. Pharmacol. | pmid:2843390 |
| Hénocq E | PAF-acether and eosinophils. | 1988 | Prog Biochem Pharmacol | pmid:3043428 |
| Etienne A et al. | Possible involvement of platelet-activating factor in endotoxin-induced abortion. | 1988 | Prog. Clin. Biol. Res. | pmid:3393560 |
| Kok PT et al. | Arachidonic acid can induce leukotriene C4 formation by purified human eosinophils in the absence of other stimuli. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3132917 |
| Lazanas M et al. | PAF of biological fluids in disease: IV. Levels in blood in allergic reactions induced by drugs. | 1988 | Arch. Dermatol. Res. | pmid:3395143 |
| Satoh K et al. | Activity of platelet-activating factor (PAF) acetylhydrolase in plasma from patients with ischemic cerebrovascular disease. | 1988 | Prostaglandins | pmid:3399678 |
| There is a case for PAF-acether antagonists. Abstracts of the conference. Paris, France, May 25-27, 1988. | 1988 | Prostaglandins | pmid:3399682 | |
| Valone FH | Platelet-activating factor binding and metabolism during human platelet aggregation. | 1988 | Thromb. Res. | pmid:3400077 |
| Bratton DL et al. | Effects of platelet activating factor on calcium-lipid interactions and lateral phase separations in phospholipid vesicles. | 1988 | Biochim. Biophys. Acta | pmid:3401478 |
| Roberts NM et al. | Effect of a PAF antagonist, BN52063, on antigen-induced, acute, and late-onset cutaneous responses in atopic subjects. | 1988 | J. Allergy Clin. Immunol. | pmid:3403863 |
| Koenderman L et al. | An improved method for the isolation of eosinophilic granulocytes from peripheral blood of normal individuals. | 1988 | J. Leukoc. Biol. | pmid:3404069 |
| Anderson GP and Fennessy MR | Lipoxygenase metabolites as mediators of platelet activating factor-induced increased airways responsiveness to histamine in the guinea-pig. | 1988 | Agents Actions Suppl. | pmid:3140616 |
| Coyle AJ et al. | The effect of the selective PAF antagonist BN 52021 on PAF- and antigen-induced bronchial hyper-reactivity and eosinophil accumulation. | 1988 | Eur. J. Pharmacol. | pmid:3383997 |
| Tokumura A et al. | Study of platelet activating factor and its antagonists on rat colon strip with a new method avoiding tachyphylaxis. | 1988 | Eur. J. Pharmacol. | pmid:3384001 |
| Pirotzky E and Braquet P | [The role of the platelet-activating factor (PAF-acether) in renal pathology]. | 1988 | Presse Med | pmid:2966954 |
| Cunha FQ et al. | Failure of PAF-acether to induce in vivo neutrophil migration. | 1988 | Agents Actions | pmid:3055873 |
| Kato T et al. | Augmentation of DNA synthesis in guinea pig bone marrow cells by platelet-activating factor (PAF). | 1988 | Biochem. Biophys. Res. Commun. | pmid:3202869 |
| Keery RJ and Lumley P | AH6809, a prostaglandin DP-receptor blocking drug on human platelets. | 1988 | Br. J. Pharmacol. | pmid:2460179 |
| Foegh ML | Eicosanoids and platelet activating factor mechanisms in organ rejection. | 1988 | Transplant. Proc. | pmid:3059615 |
| Roberts NM et al. | Effect of a PAF antagonist, BN52063, on PAF-induced bronchoconstriction in normal subjects. | 1988 | Br J Clin Pharmacol | pmid:3203062 |
| Lagarde M | Metabolism of fatty acids by platelets and the functions of various metabolites in mediating platelet function. | 1988 | Prog. Lipid Res. | pmid:3060881 |
| Freitas JC et al. | Inhibition of platelet aggregation by manoalide: preliminary results. | 1988 | Braz. J. Med. Biol. Res. | pmid:3203166 |
| Pai JK et al. | Phospholipase D catalyzes phospholipid metabolism in chemotactic peptide-stimulated HL-60 granulocytes. | 1988 | J. Biol. Chem. | pmid:3165977 |
| Collier M et al. | Biochemical and pharmacological characterization of human embryo-derived platelet activating factor. | 1988 | Hum. Reprod. | pmid:3204154 |
| Rosario-Jansen T et al. | Phospholipids chiral at phosphorus. Synthesis and stereospecificity of phosphorothioate analogues of platelet-activating factor. | 1988 | Biochemistry | pmid:3167004 |
| Prévost MC et al. | Possible origins of PAF-acether and lyso-PAF-acether in rat lung alveoli secondary to hypoxia. | 1988 | Biochim. Biophys. Acta | pmid:3167085 |
| Nagpurkar A et al. | Effect of rat phosphorylcholine-binding protein on platelet aggregation. | 1988 | Biochim. Biophys. Acta | pmid:3167098 |
| Wallace JL | Release of platelet-activating factor (PAF) and accelerated healing induced by a PAF antagonist in an animal model of chronic colitis. | 1988 | Can. J. Physiol. Pharmacol. | pmid:3167675 |
| Stenson WF | Platelet-activating factor and inflammatory bowel disease. | 1988 | Gastroenterology | pmid:3169505 |
| Armstead WM et al. | Platelet activating factor: a potent constrictor of cerebral arterioles in newborn pigs. | 1988 | Circ. Res. | pmid:3335052 |
| Bonventre JV et al. | PAF and PDGF increase cytosolic [Ca2+] and phospholipase activity in mesangial cells. | 1988 | Am. J. Physiol. | pmid:3337246 |
| Wallace JL and Whittle BJ | Gastrointestinal damage induced by platelet-activating factor. Inhibition by the corticoid, dexamethasone. | 1988 | Dig. Dis. Sci. | pmid:3338370 |
| Benveniste J et al. | Preformed PAF-acether and lyso PAF-acether are bound to blood lipoproteins. | 1988 | FEBS Lett. | pmid:3338565 |
| Lagente V et al. | Involvement of PAF-acether in anaphylactic bronchoconstriction induced in guinea pigs by aerosolized antigen. | 1988 | Int. Arch. Allergy Appl. Immunol. | pmid:3338855 |
| Imai T et al. | Pulmonary hypertension and edema induced by platelet-activating factor in isolated, perfused rat lungs are blocked by BN52021. | 1988 | J. Lab. Clin. Med. | pmid:3339274 |
| Hwang SB | Identification of a second putative receptor of platelet-activating factor from human polymorphonuclear leukocytes. | 1988 | J. Biol. Chem. | pmid:2830276 |
| Marquis O et al. | [3H]52770 RP, a platelet-activating factor receptor antagonist, and tritiated platelet-activating factor label a common specific binding site in human polymorphonuclear leukocytes. | 1988 | J. Pharmacol. Exp. Ther. | pmid:2831350 |
| Domingo MT et al. | Presence of specific binding sites for platelet-activating factor (PAF) in brain. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2831903 |
| Dillon PK et al. | Vasoconstrictor effects of platelet-activating factor in the hamster cheek pouch microcirculation: dose-related relations and pathways of action. | 1988 | Circ. Res. | pmid:2832096 |
| Ma YH and Dunham EW | Antagonism of the vasodilator effects of a platelet activating factor precursor in anesthetized spontaneously hypertensive rats. | 1988 | Eur. J. Pharmacol. | pmid:2832188 |
| Hellegouarch A et al. | Lack of effect of atrial natriuretic factor on the tone induced in rat portal vein by platelet-activating factor. | 1988 | Eur. J. Pharmacol. | pmid:2832190 |
| Valone FH | Identification of platelet-activating factor receptors in P388D1 murine macrophages. | 1988 | J. Immunol. | pmid:2832476 |
| Homma H and Hanahan DJ | Attenuation of platelet activating factor (PAF)-induced stimulation of rabbit platelet GTPase by phorbol ester, dibutyryl cAMP, and desensitization: concomitant effects on PAF receptor binding characteristics. | 1988 | Arch. Biochem. Biophys. | pmid:2833174 |
| Huang SJ et al. | Platelet-activating factor-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate stimulates the production of reactive oxygen intermediates in macrophages. | 1988 | Biochem. J. | pmid:2833227 |
| Rees RS et al. | Plasma components are required for platelet activation by the toxin of Loxosceles reclusa. | 1988 | Toxicon | pmid:3245050 |
| Tatsumi N et al. | Neutrophil chemiluminescence induced by platelet activating factor and suppressed by C-reactive protein. | 1988 | Clin. Chim. Acta | pmid:3359655 |
| Mencia-Huerta JM et al. | [Effect of long-term administration of platelet activating factor on pulmonary response and morphology in the guinea pig]. | 1988 | Allerg Immunol (Paris) | pmid:3245884 |
| Hsueh W et al. | Sequential release of leukotrienes and norepinephrine in rat bowel after platelet-activating factor. A mechanistic study of platelet-activating factor-induced bowel necrosis. | 1988 | Gastroenterology | pmid:3360262 |
| Takeuchi N et al. | The antagonist effects of compounds derived from khellactone on platelet-activating factor. | 1988 | Chem. Pharm. Bull. | pmid:3245999 |
| Hasegawa T and Nakajima S | [Recent topics on platelet-activating-factor (PAF)]. | 1988 | Nippon Ika Daigaku Zasshi | pmid:3360909 |
| Chau LY and Jii YJ | Characterization of 3H-labelled platelet activating factor receptor complex solubilized from rabbit platelet membranes. | 1988 | Biochim. Biophys. Acta | pmid:2838093 |
| Kimani G et al. | Stimulation of eosinophil adherence to human vascular endothelial cells in vitro by platelet-activating factor. | 1988 | J. Immunol. | pmid:3361129 |
| Robertson DA et al. | Negative inotropic effect of platelet-activating factor: association with a decrease in intracellular sodium activity. | 1988 | J. Pharmacol. Exp. Ther. | pmid:3361438 |
| Thelen M et al. | Activation of monocytes by interferon-gamma has no effect on the level or affinity of the nicotinamide adenine dinucleotide-phosphate oxidase and on agonist-dependent superoxide formation. | 1988 | J. Clin. Invest. | pmid:2838524 |
| Terashita Z et al. | Protective action of prostaglandin E1 (PGE1) against constrictor mediators in isolated rat heart and lung. | 1988 | Biochem. Pharmacol. | pmid:2839198 |
| Prpic V et al. | Biochemical and functional responses stimulated by platelet-activating factor in murine peritoneal macrophages. | 1988 | J. Cell Biol. | pmid:2839520 |
| Kroegel C | The potential pathophysiological role of platelet-activating factor in human diseases. | 1988 | Klin. Wochenschr. | pmid:2839728 |
| Errasfa M et al. | Inhibition of phospholipase A2 activity of guinea-pig alveolar macrophages by lipocortin-like proteins purified from mice lung. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2968795 |
| Hammerschmidt DE et al. | Pentoxifylline inhibits granulocyte and platelet function, including granulocyte priming by platelet activating factor. | 1988 | J. Lab. Clin. Med. | pmid:2840477 |
| Eliakim R et al. | Role of platelet-activating factor in ulcerative colitis. Enhanced production during active disease and inhibition by sulfasalazine and prednisolone. | 1988 | Gastroenterology | pmid:2901995 |
| Royall JA and Levin DL | Adult respiratory distress syndrome in pediatric patients. I. Clinical aspects, pathophysiology, pathology, and mechanisms of lung injury. | 1988 | J. Pediatr. | pmid:3276861 |
| Vanhoutte PM | Platelets, endothelium and blood vessel wall. | 1988 | Experientia | pmid:3278917 |
| Lellouch-Tubiana A et al. | Eosinophil recruitment into guinea pig lungs after PAF-acether and allergen administration. Modulation by prostacyclin, platelet depletion, and selective antagonists. | 1988 | Am. Rev. Respir. Dis. | pmid:3281530 |
| Chung KF and Barnes PJ | PAF antagonists. Their potential therapeutic role in asthma. | 1988 | Drugs | pmid:3281823 |
| Plante GE et al. | Platelet activating factor antagonism with BN52021 protects the kidney against acute ischemic injury. | 1988 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:3231663 |
| Stephens LR et al. | Synthesis of myo-inositol 1,3,4,5,6-pentakisphosphate from inositol phosphates generated by receptor activation. | 1988 | Biochem. J. | pmid:2845930 |
| Santos JC et al. | Effect of intrarenal infusion of synthetic PAF-acether in dogs. | 1988 | Rev. Esp. Fisiol. | pmid:3231880 |
| Ukena D and Sybrecht GW | [Function of platelet activating factor in asthma]. | 1988 | Dtsch. Med. Wochenschr. | pmid:2846251 |
| Ostermann G et al. | The degradation of platelet-activating factor in serum and its discriminative value in atherosclerotic patients. | 1988 | Thromb. Res. | pmid:3232123 |
| Ng DS and Wong K | Effect of sulfhydryl reagents on PAF binding to human neutrophils and platelets. | 1988 | Eur. J. Pharmacol. | pmid:2846326 |
| Avdonin PV et al. | Blocking of the receptor-stimulated calcium entry into human platelets by verapamil and nicardipine. | 1988 | Thromb. Res. | pmid:3232128 |
| Storch J et al. | Influence of platelet activating factor and a nonmetabolizable analogue on superoxide production by bone marrow derived macrophages. | 1988 | J. Leukoc. Biol. | pmid:2846728 |
| Kiktev VG et al. | [Calcium metabolism of the thrombocytes in ischemic heart disease]. | 1988 | Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR | pmid:3233156 |
| Bussolino F et al. | Acetylcholine and dopamine promote the production of platelet activating factor in immature cells of chick embryonic retina. | 1988 | J. Neurochem. | pmid:2846783 |
| White HL and Faison LD | Inhibition of lyso-PAF: acetyl-CoA acetyltransferase by salicylates and other compounds. | 1988 | Prostaglandins | pmid:2903520 |