| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemorrhage | D006470 | 15 associated lipids |
| Gastrointestinal Hemorrhage | D006471 | 27 associated lipids |
| Hemorrhagic Fever, American | D006478 | 2 associated lipids |
| Hepatitis, Alcoholic | D006519 | 5 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Hyperalgesia | D006930 | 42 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Hyperlipoproteinemia Type II | D006938 | 22 associated lipids |
| Hyperinsulinism | D006946 | 27 associated lipids |
| Hypersensitivity | D006967 | 22 associated lipids |
| Hypersensitivity, Delayed | D006968 | 43 associated lipids |
| Hypersensitivity, Immediate | D006969 | 14 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Hypertension, Portal | D006975 | 12 associated lipids |
| Hypertension, Pulmonary | D006976 | 32 associated lipids |
| Hypotension | D007022 | 41 associated lipids |
| Ileal Diseases | D007077 | 3 associated lipids |
| Ileitis | D007079 | 2 associated lipids |
| Immune Complex Diseases | D007105 | 9 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Borin ML et al. | [Relation between the changes in Na+/H+-exchange and cytoplasmic Ca levels in platelet activation]. | 1988 | Biull Eksp Biol Med | pmid:2844320 |
| Joseph R et al. | Cytosolic ionized calcium homeostasis in platelets: an abnormal sensitivity to PAF-activation in migraine. | 1988 | Headache | pmid:2844693 |
| Michel L et al. | Inhibitory effect of oral cetirizine on in vivo antigen-induced histamine and PAF-acether release and eosinophil recruitment in human skin. | 1988 | J. Allergy Clin. Immunol. | pmid:2899102 |
| Michel L et al. | Release of PAF-acether and precursors during allergic cutaneous reactions. | 1988 | Lancet | pmid:2899817 |
| Frick KK et al. | Platelet-derived growth factor-induced c-myc RNA expression. Analysis of an inducible pathway independent of protein kinase C. | 1988 | J. Biol. Chem. | pmid:2449430 |
| Dillon PK and Durán WN | Effect of platelet-activating factor on microvascular permselectivity: dose-response relations and pathways of action in the hamster cheek pouch microcirculation. | 1988 | Circ. Res. | pmid:2450695 |
| Okuda Y et al. | Histamine release from human leukocytes by platelet-activating factor. | 1988 | Int. Arch. Allergy Appl. Immunol. | pmid:2450844 |
| Spicer BA et al. | Changes in leucocyte numbers without diapedesis in rats given platelet-activating factor (PAF-acether). | 1988 | Int. Arch. Allergy Appl. Immunol. | pmid:2450847 |
| Bachelet M et al. | Interaction between PAF-acether and drugs that stimulate cyclic AMP in guinea-pig alveolar macrophages. | 1988 | Eur. J. Pharmacol. | pmid:2840303 |
| Lerner R et al. | Platelet activating factor and leukotriene B4 induce hyperpolarization of human endothelial cells but depolarization of neutrophils. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2838025 |
| Trovati M et al. | Insulin directly reduces platelet sensitivity to aggregating agents. Studies in vitro and in vivo. | 1988 | Diabetes | pmid:2838353 |
| Slapke J et al. | [Test hierarchy for the development of new drug action principles with the action site in phospholipid metabolism for bronchial asthma and pulmonary hypertension]. | 1988 | Prax Klin Pneumol | pmid:3140230 |
| Lefort J et al. | Pharmacological profile of 48740 R.P., a PAF-acether antagonist. | 1988 | Eur. J. Pharmacol. | pmid:2843382 |
| Kuiper J et al. | The induction of glycogenolysis in the perfused liver by platelet activating factor is mediated by prostaglandin D2 from Kupffer cells. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3144970 |
| Valone FH and Epstein LB | Biphasic platelet-activating factor synthesis by human monocytes stimulated with IL-1-beta, tumor necrosis factor, or IFN-gamma. | 1988 | J. Immunol. | pmid:3141509 |
| Bratton DL et al. | Effects of platelet activating factor and related lipids on phase transition of dipalmitoylphosphatidylcholine. | 1988 | Biochim. Biophys. Acta | pmid:3370214 |
| Wang J et al. | The effects of endotoxin on platelet-activating factor synthesis in cultured rat glomerular mesangial cells. | 1988 | Biochim. Biophys. Acta | pmid:3370222 |
| Grue-Sørensen G et al. | Derivatives of 2-methylenepropane-1,3-diol as new antagonists of platelet activating factor. | 1988 | J. Med. Chem. | pmid:3373485 |
| Pirotzky E et al. | Protection of platelet-activating factor-induced acute renal failure by BN 52021. | 1988 | Br J Exp Pathol | pmid:3377967 |
| Csatò M and Czarnetzki BM | Effect of BN 52021, a platelet activating factor antagonist, on experimental murine contact dermatitis. | 1988 | Br. J. Dermatol. | pmid:3377969 |
| O'Flaherty JT et al. | Mechanism involved in the mobilization of neutrophil calcium by 5-hydroxyeicosatetraenoate. | 1988 | J. Immunol. | pmid:2836511 |
| Hoffman DR et al. | Platelet-activating factor induces glycogen degradation in fetal rabbit lung in utero. | 1988 | J. Biol. Chem. | pmid:3379072 |
| Kertscher HP et al. | [Synthesis and thrombocyte-aggregating action of a structural analog of platelet activating factor with a modified head group]. | 1988 | Pharmazie | pmid:3380866 |
| Smith RJ et al. | Diacylglycerols modulate human polymorphonuclear neutrophil responsiveness: effects on intracellular calcium mobilization, granule exocytosis, and superoxide anion production. | 1988 | J. Leukoc. Biol. | pmid:2836539 |
| Achterrath-Tuckermann U et al. | Azelastine, a new antiallergic/antiasthmatic agent, inhibits PAF-acether-induced platelet aggregation, paw edema and bronchoconstriction. | 1988 | Pharmacology | pmid:3380879 |
| Kornecki E and Ehrlich YH | Neuroregulatory and neuropathological actions of the ether-phospholipid platelet-activating factor. | 1988 | Science | pmid:3381103 |
| Lichterfeld A et al. | [Platelet activating factor and its possible role in bronchial asthma]. | 1988 | Prax Klin Pneumol | pmid:3041401 |
| Barnes PJ | Inflammatory mechanisms and nocturnal asthma. | 1988 | Am. J. Med. | pmid:3041827 |
| Serio R and Daniel EE | Thromboxane effects on canine trachealis neuromuscular function. | 1988 | J. Appl. Physiol. | pmid:2839451 |
| Kok PT et al. | Arachidonic acid can induce leukotriene C4 formation by purified human eosinophils in the absence of other stimuli. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3132917 |
| Tomooka M et al. | [Azelastine inhibits bronchoconstriction induced by histamine and leukotriene C4]. | 1988 | Arerugi | pmid:2906534 |
| Iwama T et al. | Pharmacological modulation of platelet activating factor (PAF)-induced bronchoconstriction and hypertension in anaesthetized guinea-pigs. | 1988 | J. Pharm. Pharmacol. | pmid:2907007 |
| Nogami M et al. | [Effects of a PAF antagonist CV-3988 on the acute gastric erosions of rats by water-immersion stress]. | 1988 | Nihon Shokakibyo Gakkai Zasshi | pmid:3404759 |
| Biologically active ether lipids. | 1988 | Prog Biochem Pharmacol | pmid:3405995 | |
| Taira M et al. | Lack of involvement of leukotriene and platelet activating factor in passive cutaneous anaphylaxis in rats. | 1988 | Agents Actions | pmid:3407549 |
| Mollinedo F et al. | Intracellular localization of platelet-activating factor synthesis in human neutrophils. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3408495 |
| Koenderman L et al. | An improved method for the isolation of eosinophilic granulocytes from peripheral blood of normal individuals. | 1988 | J. Leukoc. Biol. | pmid:3404069 |
| Hirafuji M et al. | Transient increase of cytosolic free calcium in cultured human vascular endothelial cells by platelet-activating factor. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3408504 |
| Anderson GP and Fennessy MR | Lipoxygenase metabolites as mediators of platelet activating factor-induced increased airways responsiveness to histamine in the guinea-pig. | 1988 | Agents Actions Suppl. | pmid:3140616 |
| Stahl GL et al. | Salutary consequences of blockade of platelet activating factor in hemorrhagic shock. | 1988 | Eur. J. Pharmacol. | pmid:3409951 |
| Coyle AJ et al. | The effect of the selective PAF antagonist BN 52021 on PAF- and antigen-induced bronchial hyper-reactivity and eosinophil accumulation. | 1988 | Eur. J. Pharmacol. | pmid:3383997 |
| Kroegel C et al. | Platelet-activating factor induces eosinophil peroxidase release from purified human eosinophils. | 1988 | Immunology | pmid:3410498 |
| Tokumura A et al. | Study of platelet activating factor and its antagonists on rat colon strip with a new method avoiding tachyphylaxis. | 1988 | Eur. J. Pharmacol. | pmid:3384001 |
| Takizawa H et al. | Bronchoconstriction induced by platelet-activating factor in the guinea pig and its inhibition by CV-3988, a PAF antagonist: serial changes in findings of lung histology and bronchoalveolar lavage cell population. | 1988 | Int. Arch. Allergy Appl. Immunol. | pmid:3410557 |
| Misawa M and Takata T | Effects of platelet-activating factor on rat airways. | 1988 | Jpn. J. Pharmacol. | pmid:3199608 |
| Kato T et al. | Augmentation of DNA synthesis in guinea pig bone marrow cells by platelet-activating factor (PAF). | 1988 | Biochem. Biophys. Res. Commun. | pmid:3202869 |
| Roberts NM et al. | Effect of a PAF antagonist, BN52063, on PAF-induced bronchoconstriction in normal subjects. | 1988 | Br J Clin Pharmacol | pmid:3203062 |
| Freitas JC et al. | Inhibition of platelet aggregation by manoalide: preliminary results. | 1988 | Braz. J. Med. Biol. Res. | pmid:3203166 |
| Collier M et al. | Biochemical and pharmacological characterization of human embryo-derived platelet activating factor. | 1988 | Hum. Reprod. | pmid:3204154 |
| Ohmori K et al. | Antiinflammatory and antiallergic effects of a novel metabolite of Nocardiopsis sp. as a potent protein kinase C inhibitor from microbial origin. | 1988 | Arzneimittelforschung | pmid:2972291 |
| Masugi F et al. | Platelet-activating factor and anti-platelet-aggregating factor in acute reduction of blood pressure following percutaneous transluminal renal angioplasty in patients with renovascular hypertension. | 1988 | J Hum Hypertens | pmid:2977405 |
| Bussolino F et al. | Platelet activating factor induces dopamine release in PC-12 cell line. | 1988 | Am. J. Physiol. | pmid:3177629 |
| Gay JC and Stitt ES | Platelet-activating factor induces protein kinase activity in the particulate fraction of human neutrophils. | 1988 | Blood | pmid:2825844 |
| Hill CE et al. | Location of platelet activating factor binding in rat liver. | 1988 | Biochem. J. | pmid:3178735 |
| Crouch MF and Lapetina EG | Spacial isolation of protein kinase C activation in thrombin stimulated human platelets. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3178827 |
| Andersson M and Pipkorn U | The effect of platelet activating factor on nasal hypersensitivity. | 1988 | Eur. J. Clin. Pharmacol. | pmid:3181276 |
| Adamus WS et al. | Inhibitory effect of oral WEB 2086, a novel selective PAF-acether antagonist, on ex vivo platelet aggregation. | 1988 | Eur. J. Clin. Pharmacol. | pmid:3181277 |
| Yanoshita R et al. | Hydrolysis of platelet activating factor and its methylated analogs by acetylhydrolases. | 1988 | J. Biochem. | pmid:3182751 |
| Lakin KM | [Problems of a pharmacologic search for inhibitors of platelet aggregation]. | 1988 | Kardiologiia | pmid:3066962 |
| Kawaguchi H et al. | [Effect of platelet-activating factor (PAF) on blood pressure, peripheral, coronary and renovascular system]. | 1988 | Kokyu To Junkan | pmid:3067285 |
| Kumar R et al. | Occurrence of platelet-activating factor in rabbit spermatozoa. | 1988 | Arch. Biochem. Biophys. | pmid:3341753 |
| Huo YN et al. | A preferential inhibition by Zn2+ on platelet activating factor- and thrombin-induced serotonin secretion from washed rabbit platelets. | 1988 | Arch. Biochem. Biophys. | pmid:3341767 |
| Whatley RE et al. | The regulation of synthesis of platelet-activating factor by endothelial cells. | 1988 | Chest | pmid:3342689 |
| Ukena D et al. | Radioligand binding of antagonists of platelet-activating factor to intact human platelets. | 1988 | FEBS Lett. | pmid:3342883 |
| Suzuki Y et al. | Release of acetylhydrolase from platelets on aggregation with platelet-activating factor. | 1988 | Eur. J. Biochem. | pmid:3345757 |
| Benveniste J and Leyravaud S | Retention of platelet activating factor by human neutrophils. | 1988 | J. Immunol. | pmid:3346547 |
| Immunomodulation: other approaches. | 1988 | Transplant. Proc. | pmid:3347955 | |
| Lang CH et al. | Platelet-activating factor-induced increases in glucose kinetics. | 1988 | Am. J. Physiol. | pmid:3348371 |
| Molski TF et al. | Intracellular calcium rise produced by platelet-activating factor is deactivated by fMet-Leu-Phe and this requires uninterrupted activation sequence: role of protein kinase C. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3348814 |
| Rees RS et al. | Plasma components are required for platelet activation by the toxin of Loxosceles reclusa. | 1988 | Toxicon | pmid:3245050 |
| Tatsumi N et al. | Neutrophil chemiluminescence induced by platelet activating factor and suppressed by C-reactive protein. | 1988 | Clin. Chim. Acta | pmid:3359655 |
| Mencia-Huerta JM et al. | [Effect of long-term administration of platelet activating factor on pulmonary response and morphology in the guinea pig]. | 1988 | Allerg Immunol (Paris) | pmid:3245884 |
| Hsueh W et al. | Sequential release of leukotrienes and norepinephrine in rat bowel after platelet-activating factor. A mechanistic study of platelet-activating factor-induced bowel necrosis. | 1988 | Gastroenterology | pmid:3360262 |
| Hasegawa T and Nakajima S | [Recent topics on platelet-activating-factor (PAF)]. | 1988 | Nippon Ika Daigaku Zasshi | pmid:3360909 |
| Touvay C et al. | Role of platelet-activating factor (PAF) in the bronchopulmonary alterations and beta-adrenoceptor function induced by endotoxin. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2835036 |
| Kimani G et al. | Stimulation of eosinophil adherence to human vascular endothelial cells in vitro by platelet-activating factor. | 1988 | J. Immunol. | pmid:3361129 |
| Robertson DA et al. | Negative inotropic effect of platelet-activating factor: association with a decrease in intracellular sodium activity. | 1988 | J. Pharmacol. Exp. Ther. | pmid:3361438 |
| 17th annual UCLA symposium. Abstracts: Cell activation and signal initiation: receptor and phospholipase control of inositol phosphate, PAF and eicosanoid production. | 1988 | J. Cell. Biochem. Suppl. | pmid:2835556 | |
| Paulson SK and Nicholson NS | A radioreceptor binding assay for measurement of platelet-activating factor synthesis by human neutrophils. | 1988 | J. Immunol. Methods | pmid:2837517 |
| Eliakim R et al. | Role of platelet-activating factor in ulcerative colitis. Enhanced production during active disease and inhibition by sulfasalazine and prednisolone. | 1988 | Gastroenterology | pmid:2901995 |
| Ng DS and Wong K | Specific binding of platelet-activating factor (PAF) by human peripheral blood mononuclear leukocytes. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2843182 |
| Browne PC et al. | Kinetics of the formation of thrombin-thrombospondin complexes: involvement of a 77-kDa intermediate. | 1988 | Arch. Biochem. Biophys. | pmid:2844122 |
| Royall JA and Levin DL | Adult respiratory distress syndrome in pediatric patients. I. Clinical aspects, pathophysiology, pathology, and mechanisms of lung injury. | 1988 | J. Pediatr. | pmid:3276861 |
| Vanhoutte PM | Platelets, endothelium and blood vessel wall. | 1988 | Experientia | pmid:3278917 |
| Lellouch-Tubiana A et al. | Eosinophil recruitment into guinea pig lungs after PAF-acether and allergen administration. Modulation by prostacyclin, platelet depletion, and selective antagonists. | 1988 | Am. Rev. Respir. Dis. | pmid:3281530 |
| Chung KF and Barnes PJ | PAF antagonists. Their potential therapeutic role in asthma. | 1988 | Drugs | pmid:3281823 |
| Plante GE et al. | Platelet activating factor antagonism with BN52021 protects the kidney against acute ischemic injury. | 1988 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:3231663 |
| Santos JC et al. | Effect of intrarenal infusion of synthetic PAF-acether in dogs. | 1988 | Rev. Esp. Fisiol. | pmid:3231880 |
| Ostermann G et al. | The degradation of platelet-activating factor in serum and its discriminative value in atherosclerotic patients. | 1988 | Thromb. Res. | pmid:3232123 |
| Avdonin PV et al. | Blocking of the receptor-stimulated calcium entry into human platelets by verapamil and nicardipine. | 1988 | Thromb. Res. | pmid:3232128 |
| Aratani H et al. | Effect of etizolam (Depas) on production of superoxide anion by platelet-activating factor and N-formyl-methionyl-leucyl-phenylalanine-stimulated guinea pig polymorphonuclear leukocytes. | 1988 | Jpn. J. Pharmacol. | pmid:2848961 |
| Robertson DN et al. | The effect of platelet-activating factor on histamine and muscarinic receptor function in guinea pig airways. | 1988 | Am. Rev. Respir. Dis. | pmid:2849329 |
| Stewart AG and Dusting GJ | Characterization of receptors for platelet-activating factor on platelets, polymorphonuclear leukocytes and macrophages. | 1988 | Br. J. Pharmacol. | pmid:2850058 |
| Korth R et al. | Comparison of three paf-acether receptor antagonist ginkgolides. | 1988 | Eur. J. Pharmacol. | pmid:2850196 |
| Valone FH | Interrelationships among platelet-activating factor binding and metabolism and induction of platelet activation. | 1988 | Prog. Clin. Biol. Res. | pmid:2850575 |
| Shukla SD and Morrison WJ | Platelet activating factor receptor occupancy in relation to activation and desensitization of phosphoinositide specific phospholipase C. | 1988 | Prog. Clin. Biol. Res. | pmid:2850576 |
| Chand N et al. | Effect of paf-acether on isoprenaline-induced relaxation in isolated tracheal segments of rats and guinea pigs. | 1988 | Eur. J. Pharmacol. | pmid:2851453 |
| Hayashi H et al. | A novel bioaction of PAF: induction of microbicidal activity in guinea pig bone marrow cells. | 1988 | Lipids | pmid:2852289 |
| Janero DR et al. | Radioligand competitive binding methodology for the evaluation of platelet-activating factor (PAF) and PAF-receptor antagonism using intact canine platelets. | 1988 | J Pharmacol Methods | pmid:2853256 |
| White HL and Faison LD | Inhibition of lyso-PAF: acetyl-CoA acetyltransferase by salicylates and other compounds. | 1988 | Prostaglandins | pmid:2903520 |