Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
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What lipids are associated with Platelet activating factor?
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Penna C et al. | Post-ischaemic activation of kinases in the pre-conditioning-like cardioprotective effect of the platelet-activating factor. | 2009 | Acta Physiol (Oxf) | pmid:19432589 |
| Lang F et al. | Osmotic shock-induced suicidal death of erythrocytes. | 2006 May-Jun | Acta Physiol (Oxf) | pmid:16734755 |
| Kecskemeti V | Electrophysiological effects of platelet-activating factor (PAF) in guinea-pig cardiac preparations. | 1990 | Acta Physiol Hung | pmid:2371852 |
| Balogh I et al. | Cytochemical effects of biologically active substances on the heart muscle. | 1990 | Acta Physiol Hung | pmid:2371866 |
| Alving K et al. | The possible role of prostaglandin D2 in the long-lasting airways vasodilatation induced by allergen in the sensitized pig. | 1991 | Acta Physiol. Scand. | pmid:1957709 |
| Arner M and Högestätt ED | Endothelium-dependent relaxation and effects of prostacyclin, endothelin and platelet-activating factor in human hand veins and arteries. | 1991 | Acta Physiol. Scand. | pmid:1715111 |
| Björk J et al. | Paf-acether (platelet-activating factor) increases microvascular permeability and affects endothelium-granulocyte interaction in microvascular beds. | 1983 | Acta Physiol. Scand. | pmid:6659994 |
| Karlström G et al. | Renal and circulatory effects of medullipin I, as studied in the in-vivo cross-circulated isolated kidney and intact Wistar-Kyoto (WKY) rat. | 1989 | Acta Physiol. Scand. | pmid:2603751 |
| Iversen VV et al. | Platelet activating factor (PAF) increases plasma protein extravasation and induces lowering of interstitial fluid pressure (P) in rat skin. | 2005 | Acta Physiol. Scand. | pmid:16128692 |
| Greiff L et al. | Effects of topical platelet activating factor on the guinea-pig tracheobronchial mucosa in vivo. | 1997 | Acta Physiol. Scand. | pmid:9338520 |
| Zia-ul-Haq M et al. | Platelet aggregation and anti-inflammatory effects of garden pea, Desi chickpea and Kabuli chickpea. | 2012 Jul-Aug | Acta Pol Pharm | pmid:22876614 |
| Rubio de Krömer MT et al. | Differences in eosinophil and neutrophil chemotactic responses in sowda and generalized form of onchocerciasis. | 1995 | Acta Trop. | pmid:8546035 |
| Konstantinov SM et al. | Efficacy of anticancer alkylphosphocholines in Trypanosoma brucei subspecies. | 1997 | Acta Trop. | pmid:9107362 |
| Dutra PM et al. | Stimulation of Leishmania tropica protein kinase CK2 activities by platelet-activating factor (PAF). | 2009 | Acta Trop. | pmid:19433049 |
| Bazan NG and Allan G | Platelet-activating factor is both a modulator of synaptic function and a mediator of cerebral injury and inflammation. | 1996 | Adv Neurol | pmid:8790822 |
| Söling HD et al. | Regulation of protein kinases in exocrine secretory cells during agonist-induced exocytosis. | 1985 | Adv. Enzyme Regul. | pmid:4072796 |
| Armant DR | Intracellular Ca2+ signaling and preimplantation development. | 2015 | Adv. Exp. Med. Biol. | pmid:25956298 |
| Proceedings of an International Symposium on Mechanisms of Platelet Activation and Control. London, United Kingdom, April 13-14, 1992. | 1993 | Adv. Exp. Med. Biol. | pmid:7911646 | |
| Shimizu T and Mutoh H | Structure and regulation of platelet activating factor receptor gene. | 1997 | Adv. Exp. Med. Biol. | pmid:9321953 |
| Mori M et al. | Localization of platelet-activating factor receptor in the rat brain. | 1997 | Adv. Exp. Med. Biol. | pmid:9321976 |
| Kornecki E et al. | Interactions of the alkyl-ether-phospholipid, platelet activating factor (PAF) with platelets, neural cells, and the psychotropic drugs triazolobenzodiazepines. | 1987 | Adv. Exp. Med. Biol. | pmid:2893525 |
| Erickson KL et al. | Alteration of platelet activating factor-induced macrophage tumoricidal response, IA expression, and signal transduction by N-3 fatty acids. | 1997 | Adv. Exp. Med. Biol. | pmid:9321978 |
| Muguruma K et al. | The central role of PAF in necrotizing enterocolitis development. | 1997 | Adv. Exp. Med. Biol. | pmid:9321979 |
| Kato K | Modulation of long-term potentiation in the CA1 area of rat hippocampus by platelet-activating factor. | 1999 | Adv. Exp. Med. Biol. | pmid:10667334 |
| Goldman R et al. | Lipid mediators stimulate reactive oxygen species formation in immortalized human keratinocytes. | 1999 | Adv. Exp. Med. Biol. | pmid:10667361 |
| Muguruma K et al. | The prevention of necrotizing enterocolitis. The role of platelet-activating factor acetylhydrolase. | 1996 | Adv. Exp. Med. Biol. | pmid:9131138 |
| Baltas G et al. | Implication of PAF and acetylhydrolase (PAF-AH) activity in periodontal disease. | 1996 | Adv. Exp. Med. Biol. | pmid:9131139 |
| Ye RD et al. | Stimulation of NF-kappa B activation and gene expression by platelet-activating factor. | 1996 | Adv. Exp. Med. Biol. | pmid:9131140 |
| Shukla SD | Tyrosine kinase activation by PAF leads to downstream gene expression. | 1996 | Adv. Exp. Med. Biol. | pmid:9131141 |
| Morooka S and Natsume Y | Effect of SM-12502 on disseminated intravascular coagulation (DIC) in tumor-bearing rats. | 1996 | Adv. Exp. Med. Biol. | pmid:9131147 |
| Sanchez Crespo M et al. | Platelet-activating factor is an effector of rapid reactions and an inductor of late responses in immune-mediated injury. | 1996 | Adv. Exp. Med. Biol. | pmid:9131148 |
| Ohkuni H et al. | Purification and partial characterization of a novel human platelet aggregation factor in the extracellular products of Streptococcus mitis, strain Nm-65. | 1997 | Adv. Exp. Med. Biol. | pmid:9331745 |
| Saito K | PAF response to inflammatory and non-inflammatory stimuli. | 1996 | Adv. Exp. Med. Biol. | pmid:9131150 |
| Silver D et al. | Role of platelet-activating factor in skeletal muscle ischemia-reperfusion injury. | 1996 | Adv. Exp. Med. Biol. | pmid:9131151 |
| Lopes-Martins RA et al. | Platelet-activating factor. A possible role in the modulation of the vasomotor tone and blood pressure. | 1996 | Adv. Exp. Med. Biol. | pmid:9131152 |
| Camussi G et al. | Platelet-activating factor and angiogenesis. | 1996 | Adv. Exp. Med. Biol. | pmid:9131153 |
| Oh-Ishi S et al. | Role of synergistic action of PAF and kinin in bacterial endotoxin-induced hypotension in rats. | 1996 | Adv. Exp. Med. Biol. | pmid:9131154 |
| Bussolino F et al. | Role of platelet activating factor in the adhesion process of polymorphonuclear neutrophils to endothelial cells. | 1991 | Adv. Exp. Med. Biol. | pmid:1767755 |
| Maes L et al. | In vivo arterial platelet-vessel wall interaction and thrombosis: induction, on-line registration and ultrastructural control. | 1985 | Adv. Exp. Med. Biol. | pmid:3832867 |
| Tuffin DP et al. | Specific binding of [3H]-1-O-octadecyl Paf-acether to washed human platelets. | 1985 | Adv. Exp. Med. Biol. | pmid:3834789 |
| MacIntyre DE et al. | Agonist-induced inositol phospholipid metabolism and Ca++ flux in human platelet activation. | 1985 | Adv. Exp. Med. Biol. | pmid:3010662 |
| Hallam TJ et al. | Control and interrelation of aggregation and secretion; the roles of Ca2+, diacylglycerol and thromboxane with particular reference to ADP stimulation. | 1985 | Adv. Exp. Med. Biol. | pmid:3010663 |
| Gerrard JM et al. | Platelet protein phosphorylation. | 1985 | Adv. Exp. Med. Biol. | pmid:3010667 |
| Haslam RJ et al. | Receptor-effector coupling in platelets: roles of guanine nucleotides. | 1985 | Adv. Exp. Med. Biol. | pmid:3010668 |
| Kosar-Hashemi B et al. | Glyceryl ether monooxygenase [EC 1.14.16.5]: stoichiometry and inhibition. | 1993 | Adv. Exp. Med. Biol. | pmid:8304231 |
| Kochanek PM et al. | Platelet activating factor antagonists do not alter normal cerebral blood flow or cerebral oxygen consumption. | 1990 | Adv. Exp. Med. Biol. | pmid:2096640 |
| Camussi G et al. | Antiflammins inhibit synthesis of platelet-activating factor and intradermal inflammatory reactions. | 1990 | Adv. Exp. Med. Biol. | pmid:2096695 |
| Braquet P and Bourgain RH | Anti-anaphylactic properties of BN 52021: a potent platelet activating factor antagonist. | 1987 | Adv. Exp. Med. Biol. | pmid:3314403 |
| Winkler JD et al. | Inhibitors of arachidonate metabolism and effects on PAF production. | 1996 | Adv. Exp. Med. Biol. | pmid:9131119 |
| Vadas P and Pruzanski W | Phospholipase A2 activation is the pivotal step in the effector pathway of inflammation. | 1990 | Adv. Exp. Med. Biol. | pmid:2239447 |