Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Greenberg SS et al. | Ethanol suppresses endotoxin but not platelet activating factor-induced hypotension and nitric oxide. | 1996 | Alcohol. Clin. Exp. Res. | pmid:8904980 |
Baker RC et al. | Effects of ethanol on human platelets stimulated with platelet-activating factor, a biologically active ether phospholipid. | 1989 | Alcohol. Clin. Exp. Res. | pmid:2557776 |
Lands WE | Cellular signals in alcohol-induced liver injury: a review. | 1995 | Alcohol. Clin. Exp. Res. | pmid:7485841 |
Ligumsky M et al. | The role of platelet activating factor [correction of actor] in acute gastric injury and its protection by sucralfate. | 1990 | Aliment. Pharmacol. Ther. | pmid:2129638 |
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Mencia-Huerta JM et al. | [Effect of long-term administration of platelet activating factor on pulmonary response and morphology in the guinea pig]. | 1988 | Allerg Immunol (Paris) | pmid:3245884 |
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Oxholm P and Winther K | Thrombocyte involvement in immune inflammatory reactions. | 1986 | Allergy | pmid:3515999 |
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Mullol J et al. | Update on rupatadine in the management of allergic disorders. | 2015 | Allergy | pmid:25491409 |
Schauer U et al. | Enhanced production of platelet activating factor by peripheral granulocytes from children with asthma. | 1992 | Allergy | pmid:1514664 |
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Krause K et al. | Platelet-activating factor (PAF) induces wheal and flare skin reactions independent of mast cell degranulation. | 2013 | Allergy | pmid:23320562 |
Bachert C | Decongestant efficacy of desloratadine in patients with seasonal allergic rhinitis. | 2001 | Allergy | pmid:11243500 |
Oxholm P et al. | Lack of evidence for human lymphokines with thrombocyte aggregating activity. An in vitro study. | 1984 | Allergy | pmid:6528957 |
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Mullol J et al. | Rupatadine in allergic rhinitis and chronic urticaria. | 2008 | Allergy | pmid:18339040 |
Juhlin L | A comparison of the pharmacodynamics of H1-receptor antagonists as assessed by the induced wheal-and-flare model. | 1995 | Allergy | pmid:7645678 |
Meltzer EO | The use of anti-H1 drugs in mild asthma. | 1995 | Allergy | pmid:7645681 |
Pipkorn U et al. | Effect of platelet activating factor on the human nasal mucosa. | 1984 | Allergy | pmid:6703263 |
Takafuji S et al. | Effects of interleukin (IL)-3 and IL-5 on human eosinophil degranulation induced by complement components C3a and C5a. | 1996 | Allergy | pmid:8874660 |
Di Leo E et al. | Treatment of acquired cold urticaria with rupatadine. | 2009 | Allergy | pmid:19392988 |
Soyombo O et al. | Effects of lipoxin A4 on chemotaxis and degranulation of human eosinophils stimulated by platelet-activating factor and N-formyl-L-methionyl-L-leucyl-L-phenylalanine. | 1994 | Allergy | pmid:8037356 |
Takafuji S et al. | Release of granule proteins from human eosinophils stimulated with mast-cell mediators. | 1998 | Allergy | pmid:9821474 |
Maniscalco M et al. | The effect of platelet-activating factor (PAF) on nasal airway resistance in healthy subjects is not mediated by nitric oxide. | 2000 | Allergy | pmid:10955702 |
Leggieri E et al. | Study of the effects of paf-acether on human nasal airways. | 1991 | Allergy | pmid:1720286 |
Rosenwasser L | New insights into the pathophysiology of allergic rhinitis. | 2007 Jan-Feb | Allergy Asthma Proc | pmid:17390750 |
Klettke U et al. | Platelet-activating factor inhibits ciliary beat frequency of human bronchial epithelial cells. | 1999 Mar-Apr | Allergy Asthma Proc | pmid:10209689 |
Babayigit A et al. | Effects of Ginkgo biloba on airway histology in a mouse model of chronic asthma. | 2009 Mar-Apr | Allergy Asthma Proc | pmid:19118503 |
Gleich GJ and Abu-Ghazaleh R | Update on eosinophils. | 1989 Jan-Feb | Allergy Proc | pmid:2925087 |
Chung KF et al. | Platelet activating factor: effects on bronchomotor tone and bronchial responsiveness in human beings. | 1989 Sep-Oct | Allergy Proc | pmid:2684754 |
Nabe M et al. | The effect of ketotifen on eosinophils as measured at LTC4 release and by chemotaxis. | 1991 Jul-Aug | Allergy Proc | pmid:1936977 |
Coleus forskohlii. Monograph. | 2006 | Altern Med Rev | pmid:16597194 | |
McKenna DJ et al. | Efficacy, safety, and use of ginkgo biloba in clinical and preclinical applications. | 2001 Sep-Oct | Altern Ther Health Med | pmid:11565403 |
Sills RH | Thrombotic thrombocytopenic purpura. I. Pathophysiology and clinical manifestations. | 1984 | Am J Pediatr Hematol Oncol | pmid:6442830 |
Müllers SM et al. | Altered Platelet Function in Intrauterine Growth Restriction: A Cause or a Consequence of Uteroplacental Disease? | 2016 | Am J Perinatol | pmid:26906182 |
Adamson LM et al. | Mechanistic studies of early pregnancy associated thrombocytopenia (EPAT) in the mouse. | 1987 | Am J Reprod Immunol Microbiol | pmid:3605486 |
Cingi C et al. | The histopathological effect of thymoquinone on experimentally induced rhinosinusitis in rats. | 2011 Nov-Dec | Am J Rhinol Allergy | pmid:22185737 |
Muñoz-Cano R et al. | Platelet-activating factor nasal challenge induces nasal congestion and reduces nasal volume in both healthy volunteers and allergic rhinitis patients. | 2013 Mar-Apr | Am J Rhinol Allergy | pmid:23562190 |
Liu Q et al. | The effect of lexipafant on bacterial translocation in acute necrotizing pancreatitis in rats. | 1999 | Am Surg | pmid:10399968 |
Hebra A et al. | Systemic and mesenteric vascular effects of platelet-activating factor and cocaine. In vivo effects on a neonatal swine model. | 1993 | Am Surg | pmid:8480932 |