| MeSH term | MeSH ID | Detail |
|---|---|---|
| Respiratory Distress Syndrome, Adult | D012128 | 15 associated lipids |
| Epilepsy | D004827 | 35 associated lipids |
| Seizures | D012640 | 87 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Birth Weight | D001724 | 23 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Ischemic Attack, Transient | D002546 | 42 associated lipids |
| Cerebrovascular Disorders | D002561 | 25 associated lipids |
| Nasal Polyps | D009298 | 26 associated lipids |
| Leukemia, Myeloid, Acute | D015470 | 19 associated lipids |
| Ear Diseases | D004427 | 7 associated lipids |
| Hypersensitivity, Immediate | D006969 | 14 associated lipids |
| Respiratory Hypersensitivity | D012130 | 18 associated lipids |
| Subarachnoid Hemorrhage | D013345 | 17 associated lipids |
| Leukemia, Experimental | D007942 | 42 associated lipids |
| Diabetic Angiopathies | D003925 | 20 associated lipids |
| Agranulocytosis | D000380 | 7 associated lipids |
| Shock | D012769 | 11 associated lipids |
| Polycythemia Vera | D011087 | 13 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Izaki S et al. | Platelet-activating factor and arachidonic acid metabolites in psoriatic inflammation. | 1996 | Br. J. Dermatol. | pmid:8763425 |
| Xiao J et al. | [Effects of platelet activating factor and platelet activating factor receptor antagonist on spinal cord blood flow after spinal cord injury]. | 1995 | Zhonghua Wai Ke Za Zhi | pmid:8762548 |
| Nahas N et al. | Tyrosine phosphorylation and activation of a new mitogen-activated protein (MAP)-kinase cascade in human neutrophils stimulated with various agonists. | 1996 | Biochem. J. | pmid:8761479 |
| Trapali M et al. | PAF-acetylhydrolase activity and PAF levels in pancreas and plasma of well-fed, diabetic and fasted rat. | 1996 | Life Sci. | pmid:8761318 |
| Woolley DS et al. | Platelet activating factor mediates cardiopulmonary dysfunction during graded bacteremic shock. | 1996 | J Trauma | pmid:8760539 |
| Ding Z et al. | Inhibitory effects of isoproterenol on PAF-induced endothelial cell permeability and morphological changes. | 1996 | Sci. China, C, Life Sci. | pmid:8760474 |
| Soldi R et al. | Platelet-activating factor (PAF) induces the early tyrosine phosphorylation of focal adhesion kinase (p125FAK) in human endothelial cells. | 1996 | Oncogene | pmid:8760293 |
| Macari DM et al. | Priming of eosinophil recruitment in vivo by LPS pretreatment. | 1996 | J. Immunol. | pmid:8759756 |
| Zhu Z et al. | Platelet activating factor inhibits fluid transport by corneal endothelium. | 1996 | Invest. Ophthalmol. Vis. Sci. | pmid:8759360 |
| Xiao J et al. | [Effect of platelet activating factor receptor at spinal cord neurocyte membrane on secondary damage after spinal cord injury]. | 1996 | Zhonghua Yi Xue Za Zhi | pmid:8758444 |
| Masclans JR et al. | Salbutamol reduces pulmonary neutrophil sequestration of platelet-activating factor in humans. | 1996 | Am. J. Respir. Crit. Care Med. | pmid:8756833 |
| Radhika V et al. | Granulocytes from chronic myeloid leukemia (CML) patients show differential response to different chemoattractants. | 1996 | Am. J. Hematol. | pmid:8756080 |
| Asano K et al. | Distribution of platelet activating factor receptor mRNA along the rat nephron segments. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8753768 |
| Travers JB et al. | Platelet-activating factor biosynthesis induced by various stimuli in human HaCaT keratinocytes. | 1996 | J. Invest. Dermatol. | pmid:8752845 |
| Kawata E et al. | Effect of benzodiazepine on antigen-induced eosinophil infiltration into guinea pig conjunctiva. | 1996 | Arerugi | pmid:8752723 |
| Serhan CN et al. | Lipid mediator networks in cell signaling: update and impact of cytokines. | 1996 | FASEB J. | pmid:8751717 |
| Hirashima Y et al. | Platelet-activating factor (PAF) and the formation of chronic subdural haematoma. Measurement of plasma PAF levels and anti-PAF immunoglobulin titers. | 1995 | Acta Neurochir (Wien) | pmid:8748861 |
| Seeds EA et al. | Role of lipoxygenase metabolites in platelet-activating factor- and antigen-induced bronchial hyperresponsiveness and eosinophil infiltration. | 1995 | Eur. J. Pharmacol. | pmid:8748690 |
| Muñoz HR et al. | Platelet-activating factor (PAF) does not affect diastolic function in isolated rat hearts. | 1995 | Cardiovasc. Res. | pmid:8746220 |
| Arnould T et al. | Hypoxia induces PMN adherence to umbilical vein endothelium. | 1995 | Cardiovasc. Res. | pmid:8746218 |
| Liu Y and Kang GF | [Lipid mediators and liver injury]. | 1995 | Sheng Li Ke Xue Jin Zhan | pmid:8745570 |
| Psychoyos A et al. | The role of prostaglandins in blastocyst implantation. | 1995 | Hum. Reprod. | pmid:8745299 |
| Tellis C et al. | Isolation, chemical characterization, and subcellular distribution of 1-O-alkyl-2-acetyl-sn-glycerol in Tetrahymena pyriformis cells. | 1996 | J. Biochem. | pmid:8743588 |
| Clark GD et al. | Platelet-activating factor produces neuronal growth cone collapse. | 1995 | Neuroreport | pmid:8741765 |
| Clark GD et al. | Lipids as axon guidance molecules? | 1995 | Neuroreport | pmid:8741737 |
| Prescott SM et al. | Inflammation as an early component of atherosclerosis and vascular damage--a role for P-selectin and platelet-activating factor. | 1996 | Jpn. Circ. J. | pmid:8741238 |
| Whelan CJ | Inhibition of PAF-, LPS-, and cytokine-induced granulocyte accumulation in guinea pig lung by dexamethasone: evidence that inhibition of IL-5 release is responsible for the selective inhibition of eosinophilia by glucocorticoids in guinea-pigs. | 1996 | Inflamm. Res. | pmid:8741005 |
| Giudice A et al. | Prevention of platelet-activating factor-induced gastrointestinal lesions in rats by the new specific antagonist N-(2-dimethylaminoethyl)-N-(3-pyridinylmethyl)[4-(2,4,6-triisopropylphe nyl) thiazol-2yl]amine. | 1996 | Arzneimittelforschung | pmid:8740089 |
| Cardile V et al. | Effects of ether lipid 1-O-octadecyl-2-methoxy-rac-glycero- 3-phosphocholine and its analogs PAF and CPAF on the release of nitric oxide in primary cultures of rat astrocytes. | 1996 | Brain Res. | pmid:8739627 |
| Ackerman Z et al. | Renal vasoactive mediator generation in portal hypertensive and bile duct ligated rats. | 1996 | J. Hepatol. | pmid:8738735 |
| Mascolo N et al. | Relationship between nitric oxide and platelet-activating factor in castor-oil induced mucosal injury in the rat duodenum. | 1996 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:8738301 |
| Kahhak L et al. | Decrease of ciliary beat frequency by platelet activating factor: protective effect of ketotifen. | 1996 | Inflamm. Res. | pmid:8737746 |
| Stücker O et al. | Effects of Ginkgo biloba extract (EGb 761) on arteriolar spasm in a rat cremaster muscle preparation. | 1996 Mar-Apr | Int J Microcirc Clin Exp | pmid:8737713 |
| Sanderson HM et al. | Studies on the effects of agonists and antagonists on platelet shape change and platelet aggregation in whole blood. | 1996 | Blood Coagul. Fibrinolysis | pmid:8735830 |
| Nakonechnicov S et al. | Platelet aggregation in patients with primary pulmonary hypertension. | 1996 | Blood Coagul. Fibrinolysis | pmid:8735825 |
| Jarvis GE and Evans RJ | Platelet-activating factor and not thromboxane A2 is an important mediator of endotoxin-induced platelet aggregation in equine heparinised whole blood in vitro. | 1996 | Blood Coagul. Fibrinolysis | pmid:8735817 |
| Doly M and Oustrin J | [Suppression of platelet activating factor effects (PAF) on the retina by G-proteins inhibitors]. | 1996 | Ann Pharm Fr | pmid:8734330 |
| Salva AM et al. | Hypoxia attenuates metabolism of platelet activating factor by fetal and newborn lamb lungs. | 1996 | J. Lipid Res. | pmid:8732778 |
| Cheng D and Chen W | [Effects of ginkgolide B on isobaric hypoxic pulmonary hypertension in rats]. | 1995 | Hua Xi Yi Ke Da Xue Xue Bao | pmid:8732057 |
| Shi H et al. | [Effects of a platelet-activating factor antagonist ONO-6240 on antigen induced eosinophil infiltration into the airways]. | 1995 | Zhonghua Nei Ke Za Zhi | pmid:8731847 |
| Anderson R et al. | Anti-inflammatory, membrane-stabilizing interactions of salmeterol with human neutrophils in vitro. | 1996 | Br. J. Pharmacol. | pmid:8730730 |
| Iatrou C et al. | Platelet-activating factor levels and PAF acetylhydrolase activities in patients with primary glomerulonephritis. | 1996 | Nephron | pmid:8730430 |
| Thyssen E et al. | Quantification of distinct molecular species of platelet activating factor in ulcerative colitis. | 1996 | Lipids | pmid:8729129 |
| Pastores SM et al. | Posttraumatic multiple-organ dysfunction syndrome: role of mediators in systemic inflammation and subsequent organ failure. | 1996 | Acad Emerg Med | pmid:8727633 |
| Evans DJ et al. | Priming of circulating human eosinophils following late response to allergen challenge. | 1996 | Eur. Respir. J. | pmid:8726934 |
| Ogura M et al. | Role of endogenous platelet-activating factor in the regulation of pancreatic blood flow during caerulein stimulation. | 1996 | J. Gastroenterol. | pmid:8726834 |
| Misra UK and Pizzo SV | Ligation of the alpha 2-macroglobulin signaling receptor on macrophages induces synthesis of platelet activating factor. | 1996 | J. Cell. Biochem. | pmid:8726354 |
| Muzia GI and Kulikov VI | [Effect of sn-2-acetylated analogs of phosphatidalic acid on release and aggregation of human platelets]. | 1996 | Biokhimiia | pmid:8724603 |
| Kulikov VI and Muzia GI | [Biological role of cellular metabolites--structural analogs of platelet activating factor]. | 1996 | Biokhimiia | pmid:8724598 |
| Zuberbier T et al. | Histamine releasability of basophils and skin mast cells in chronic urticaria. | 1996 | Allergy | pmid:8721524 |
| Kruse-Elliott KT et al. | Attenuation of endotoxin-induced pathophysiology by a new potent PAF receptor antagonist. | 1996 | Shock | pmid:8721386 |
| Suzuki H et al. | Enhanced levels of chemiluminescence and platelet activating factor in urease-positive gastric ulcers. | 1996 | Free Radic. Biol. Med. | pmid:8720917 |
| Keicher U et al. | Omega-3 fatty acids suppress the enhanced production of 5-lipoxygenase products from polymorph neutrophil granulocytes in cystic fibrosis. | 1995 | Eur. J. Clin. Invest. | pmid:8719931 |
| Nunoya K et al. | S-oxidation of (+)-cis-3,5-dimethyl-2-(3-pyridyl)-thiazolidin-4-one hydrochloride by rat hepatic flavin-containing monooxygenase 1 expressed in yeast. | 1995 | Xenobiotica | pmid:8719904 |
| De Kimpe SJ et al. | Role for intracellular platelet-activating factor in the circulatory failure in a model of gram-positive shock. | 1995 | Br. J. Pharmacol. | pmid:8719795 |
| Thorlacius H et al. | Microvascular mechanisms of histamine-induced potentiation of leukocyte adhesion evoked by chemoattractants. | 1995 | Br. J. Pharmacol. | pmid:8719793 |
| Ortiz JL et al. | Effects of selective phosphodiesterase inhibitors on platelet-activating factor- and antigen-induced airway hyperreactivity, eosinophil accumulation, and microvascular leakage in guinea pigs. | 1996 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:8717161 |
| Miao FJ et al. | Role of sympathetic postganglionic neurons in synovial plasma extravasation induced by bradykinin. | 1996 | J. Neurophysiol. | pmid:8714647 |
| Segerer H et al. | Rapid tracheal infusion of surfactant versus bolus instillation in rabbits: effects on oxygenation, blood pressure and surfactant distribution. | 1996 | Biol. Neonate | pmid:8713657 |
| Grigg ME et al. | Characterization of a platelet-activating factor acetylhydrolase secreted by the nematode parasite Nippostrongylus brasiliensis. | 1996 | Biochem. J. | pmid:8713083 |
| Emil S et al. | Inhaled nitric oxide prevents experimental platelet activating factor-induced shock. | 1996 | Arch Surg | pmid:8712910 |
| Dodam JR et al. | Effect of pertussis toxin and B-oligomer on platelet-activating factor-induced generation of inositol phosphates in porcine alveolar macrophages. | 1996 | Am. J. Vet. Res. | pmid:8712527 |
| Gallego MJ et al. | Cyclosporine enhances leukocyte adhesion to vascular endothelium under physiologic flow conditions. | 1996 | Am. J. Kidney Dis. | pmid:8712218 |
| Shindo K et al. | Priming effect of platelet activating factor on leukotriene C4 from stimulated eosinophils of asthmatic patients. | 1996 | Thorax | pmid:8711647 |
| Agrawal DK et al. | Increased hypodense eosinophils after activation with PAF-acether and calcium ionophore in asthmatic subjects. | 1996 | J Asthma | pmid:8707776 |
| Dong JC et al. | [Ginkgolides antagonizing some effects of platelet-activating factor in vitro]. | 1995 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:8704427 |
| Denizot Y et al. | Platelet-activating factor and haematopoiesis. XI. Platelet-activating factor has no effect on the production of interleukin-6 and tumor necrosis factor-alpha by human bone marrow stromal cells. | 1996 Jan-Mar | Eur. Cytokine Netw. | pmid:8704099 |
| Biffl WL and Moore EE | Splanchnic ischaemia/reperfusion and multiple organ failure. | 1996 | Br J Anaesth | pmid:8703631 |
| Shen K et al. | Properties of circulating leukocytes in spontaneously hypertensive rats. | 1995 Jul-Aug | Biochem. Cell Biol. | pmid:8703419 |
| Tsai JJ et al. | The modulatory effect of antigen- and PAF-induced asthmatic reaction by aerosol administration of OKY-046 in guinea pigs. | 1995 | Asian Pac. J. Allergy Immunol. | pmid:8703249 |
| Camici M | [Progression of renal insufficiency and platelet activating factor (PAF)]. | 1996 | Minerva Med. | pmid:8700358 |
| Cypcar D et al. | Rat eosinophils: isolation and characterization of superoxide production. | 1996 | J. Leukoc. Biol. | pmid:8699113 |
| Anderson R et al. | Membrane stabilizing, anti-oxidative interactions of propranolol and dexpropranolol with neutrophils. | 1996 | Biochem. Pharmacol. | pmid:8694859 |
| Goldsmith JA et al. | Plasma potentiates the priming effects of endotoxin on platelet activating factor-induced pulmonary hypertension in the rabbit lung. | 1996 | Anesth. Analg. | pmid:8694300 |
| Mimura K et al. | Changes in glycerophospholipid profile in experimental nephrotic syndrome. | 1996 | Metab. Clin. Exp. | pmid:8692015 |
| Smith PF et al. | The neuroprotective properties of the Ginkgo biloba leaf: a review of the possible relationship to platelet-activating factor (PAF). | 1996 | J Ethnopharmacol | pmid:8691847 |
| Roth M et al. | Platelet-activating factor exerts mitogenic activity and stimulates expression of interleukin 6 and interleukin 8 in human lung fibroblasts via binding to its functional receptor. | 1996 | J. Exp. Med. | pmid:8691134 |
| Barnum D et al. | Identification of common functional configurations among molecules. | 1996 May-Jun | J Chem Inf Comput Sci | pmid:8690757 |
| Noda S et al. | Population of hepatic macrophages and response of perfused liver to platelet-activating factor during production of thioacetamide-induced cirrhosis in rats. | 1996 | Hepatology | pmid:8690413 |
| Sansom JE et al. | Effects of H1- and H2-antihistamines on platelet-activating factor and bradykinin-induced inflammatory responses in human skin. | 1996 | Clin. Exp. Dermatol. | pmid:8689766 |
| González-Fajardo JA et al. | Protective effect of a platelet-activating factor antagonist (WEB-2086) in postischemic renal failure. | 1996 | Ann Vasc Surg | pmid:8688291 |
| Glaser KB et al. | Cellular and topical in vivo inflammatory murine models in the evaluation of inhibitors of phospholipase A2. | 1995 | Skin Pharmacol. | pmid:8688196 |
| Rodrigues CO et al. | Effect of platelet-activating factor on cell differentiation of Trypanosoma cruzi. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8687466 |
| Abu-Zidan FM et al. | BB-882 is a potent antagonist of the haemodynamic changes induced by platelet-activating factor in pigs. | 1996 | Pharmacol. Toxicol. | pmid:8685082 |
| Kuenemann-Migeot C et al. | Urinary promutagens of smokers: comparison of concentration methods and relation to cigarette consumption. | 1996 | Mutat. Res. | pmid:8684404 |
| Nakatsuji T | Alpha 1 antitrypsin defective Lewis rats injected with heparin: comparison of the glomerular changes with those of Lewis rats produced anti BSA antibody. | 1996 | Keio J Med | pmid:8683900 |
| Sobhani I et al. | Regulation of platelet-activating factor production in gastric epithelial cells. | 1996 | Eur. J. Clin. Invest. | pmid:8682156 |
| Nixon AB et al. | Comparison of acceptor and donor substrates in the CoA-independent transacylase reaction in human neutrophils. | 1996 | Biochim. Biophys. Acta | pmid:8679683 |
| Shibata K et al. | Ca2+ entry induced by calcium influx factor and its regulation by protein kinase C in rabbit neutrophils. | 1996 | Biochem. Pharmacol. | pmid:8678902 |
| Oda Y et al. | Quantitation of platelet-activating factor in biological samples using liquid chromatography/mass spectrometry with column-switching technique. | 1995 | Anal. Biochem. | pmid:8678293 |
| Nadel JA | Genetics reveals importance of platelet activating factor in asthma and possibly other inflammatory states. | 1996 | J. Clin. Invest. | pmid:8675676 |
| Serizawa A et al. | Involvement of platelet-activating factor in cytokine production and neutrophil activation after hepatic ischemia-reperfusion. | 1996 | Hepatology | pmid:8675190 |
| Mustafa SB et al. | Platelet-activating factor augments lipopolysaccharide-induced nitric oxide formation by rat Kupffer cells. | 1996 | Hepatology | pmid:8675186 |
| Wardle TD et al. | Platelet activating factor: release from colonic mucosa in patients with ulcerative colitis and its effect on colonic secretion. | 1996 | Gut | pmid:8675086 |
| Bagnis C et al. | Prevention of cyclosporin nephrotoxicity with a platelet-activating factor (PAF) antagonist. | 1996 | Nephrol. Dial. Transplant. | pmid:8671822 |
| Bustos C et al. | Urinary excretion of platelet-activating factor in human and experimental nephrosis. | 1996 | Nephrol. Dial. Transplant. | pmid:8671780 |
| Yamada M et al. | Platelet-activating factor production in stimulated macrophages is down-regulated by concurrently produced prostaglandin E2. | 1996 | J. Pharmacol. Exp. Ther. | pmid:8667229 |
| Albert DH et al. | Properties of ABT-299, a prodrug of A-85783, a highly potent platelet activating factor receptor antagonist. | 1996 | J. Pharmacol. Exp. Ther. | pmid:8667228 |
| Handa RK and Strandhoy JW | Nitric oxide mediates the inhibitory action of platelet-activating factor on angiotensin II-induced renal vasoconstriction, in vivo. | 1996 | J. Pharmacol. Exp. Ther. | pmid:8667214 |
| Bozza PT et al. | Mechanisms of platelet-activating factor-induced lipid body formation: requisite roles for 5-lipoxygenase and de novo protein synthesis in the compartmentalization of neutrophil lipids. | 1996 | J. Exp. Med. | pmid:8666909 |