| MeSH term | MeSH ID | Detail |
|---|---|---|
| Respiratory Distress Syndrome, Adult | D012128 | 15 associated lipids |
| Epilepsy | D004827 | 35 associated lipids |
| Seizures | D012640 | 87 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Birth Weight | D001724 | 23 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Ischemic Attack, Transient | D002546 | 42 associated lipids |
| Cerebrovascular Disorders | D002561 | 25 associated lipids |
| Nasal Polyps | D009298 | 26 associated lipids |
| Leukemia, Myeloid, Acute | D015470 | 19 associated lipids |
| Ear Diseases | D004427 | 7 associated lipids |
| Hypersensitivity, Immediate | D006969 | 14 associated lipids |
| Respiratory Hypersensitivity | D012130 | 18 associated lipids |
| Subarachnoid Hemorrhage | D013345 | 17 associated lipids |
| Leukemia, Experimental | D007942 | 42 associated lipids |
| Diabetic Angiopathies | D003925 | 20 associated lipids |
| Agranulocytosis | D000380 | 7 associated lipids |
| Shock | D012769 | 11 associated lipids |
| Polycythemia Vera | D011087 | 13 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Am. J. Physiol., Cell Physiol. (2)
- Arterioscler. Thromb. Vasc. Biol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Naraba H et al. | Enhanced production of platelet-activating factor in stimulated rat leukocytes caused by the blockade of lysophospholipid acylation. | 1993 | Jpn. J. Pharmacol. | pmid:8459648 |
| Lachapelle MH et al. | Effect of lysoplatelet-activating factor on human sperm fertilizing ability. | 1993 | Fertil. Steril. | pmid:8458509 |
| Hatmi M et al. | Carrageenan-induced activation of human platelets is dependent on the phospholipase C pathway. | 1993 | Br. J. Haematol. | pmid:8457475 |
| Damas J et al. | Platelet-activating factor and the vascular effects of zymosan in rats. | 1993 | Eur. J. Pharmacol. | pmid:8453979 |
| Matsuda Y et al. | Role of sympathetic nervous system in hypotension induced by platelet-activating factor in anesthetized dogs. | 1993 | Circ. Shock | pmid:8453742 |
| Newman GE et al. | Utilization by human amniocytes for prostaglandin synthesis of [1-14C]arachidonate derived from 2-[1-14C]arachidonylphosphatidylcholine associated with human fetal pulmonary surfactant. | 1993 | Biochim. Biophys. Acta | pmid:8452866 |
| Pretolani M and Vargaftig BB | From lung hypersensitivity to bronchial hyperreactivity. What can we learn from studies on animal models? | 1993 | Biochem. Pharmacol. | pmid:8452553 |
| Church DJ et al. | Protein kinase C-mediated phospholipase A2 activation, platelet-activating factor generation and prostacyclin release in spontaneously beating rat cardiomyocytes. | 1993 | Biochem. J. | pmid:8452537 |
| Minami T et al. | Regional blood flow volume in the eustachian tube. | 1993 | Acta Otolaryngol Suppl | pmid:8452027 |
| Green PG et al. | Neurogenic and non-neurogenic mechanisms of plasma extravasation in the rat. | 1993 | Neuroscience | pmid:8450970 |
| Mounier C et al. | Competitive inhibition of phospholipase A2 activity by the platelet-activating factor antagonist Ro 19-3704 and evidence for a novel suppressive effect on platelet activation. | 1993 | J. Pharmacol. Exp. Ther. | pmid:8450479 |
| Hirashima Y et al. | Platelet-activating factor and cerebral vasospasm following subarachnoid hemorrhage. | 1993 | J. Neurosurg. | pmid:8450333 |
| Hirata Y et al. | Roles of platelet-activating factor, thromboxane A2, ADP and thrombin in thrombogenesis in the guinea pig. | 1993 | Eur. J. Pharmacol. | pmid:8449234 |
| Arreto CD et al. | Pharmacological differentiation by pertussis toxin of the in vivo acute responses to fMLP and PAF in guinea-pig lungs. | 1993 | Br. J. Pharmacol. | pmid:8448592 |
| Matthews JS and Jones RL | Potentiation of aggregation and inhibition of adenylate cyclase in human platelets by prostaglandin E analogues. | 1993 | Br. J. Pharmacol. | pmid:8448586 |
| Filep JG et al. | Nitric oxide modulates vascular permeability in the rat coronary circulation. | 1993 | Br. J. Pharmacol. | pmid:8448583 |
| Wang F et al. | A new protein kinase C, nPKC eta', and nPKC theta are expressed in human platelets: involvement of nPKC eta' and nPKC theta in signal transduction stimulated by PAF. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8447826 |
| Mózes T et al. | Protective effect of diclofenac sodium against endotoxic shock in anaesthetized pigs. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8446657 |
| Huang YC et al. | Protection against platelet-activating factor-induced injury by interferon inducer in perfused rabbit lung. | 1993 | J. Appl. Physiol. | pmid:8444700 |
| Tsuruta S et al. | Effects of adenosine and its analogues on actin polymerization in human polymorphonuclear leucocytes. | 1993 | Clin. Exp. Pharmacol. Physiol. | pmid:8443979 |
| Tanaka T et al. | Formation of platelet-activating factor-like phospholipids by Fe2+/ascorbate/EDTA-induced lipid peroxidation. | 1993 | Biochim. Biophys. Acta | pmid:8443246 |
| Wucherpfennig AL et al. | Platelet activating factor increases intracellular calcium in isolated osteoclasts but does not modify bone resorption. | 1993 | Bone | pmid:8442997 |
| Noris M et al. | Urinary excretion of platelet activating factor in patients with immune-mediated glomerulonephritis. | 1993 | Kidney Int. | pmid:8441238 |
| Garcia C et al. | Biosynthesis of platelet-activating factor (PAF) induced by chemotactic peptide is modulated at the lyso-PAF:acetyl-CoA acetyltransferase level by calcium transient and phosphatidic acid. | 1993 | J. Biol. Chem. | pmid:8440692 |
| Muguruma K et al. | Platelet-activating factor (PAF) in male reproductive organs of guinea pigs and rats: effect of androgen on PAF in seminal vesicles. | 1993 | Biol. Reprod. | pmid:8439628 |
| Chen JJ and Liew CC | Phosphorylation of an acid-soluble nuclear protein in response to catecholamine in cultured rat cardiocytes. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8439325 |
| Cheng JB et al. | Antigen-mediated pulmonary eosinophilia in immunoglobulin G1-sensitized guinea pigs: eosinophil peroxidase as a simple specific marker for detecting eosinophils in bronchoalveolar lavage fluid. | 1993 | J. Pharmacol. Exp. Ther. | pmid:8437132 |
| Hsieh KH and Ng CK | Increased plasma platelet-activating factor in children with acute asthmatic attacks and decreased in vivo and in vitro production of platelet-activating factor after immunotherapy. | 1993 | J. Allergy Clin. Immunol. | pmid:8436778 |
| Valone F | Quantifying platelet-activating factor in biologic systems. | 1993 | J. Allergy Clin. Immunol. | pmid:8436770 |
| Hashemi S et al. | Platelet-activating factor secreted by DDAVP-treated monocytes mediates von Willebrand factor release from endothelial cells. | 1993 | J. Cell. Physiol. | pmid:8436598 |
| Lin CN et al. | Antiplatelet activity of some prenylflavonoids. | 1993 | Biochem. Pharmacol. | pmid:8435100 |
| Montrucchio G et al. | Role of platelet-activating factor in polymorphonuclear neutrophil recruitment in reperfused ischemic rabbit heart. | 1993 | Am. J. Pathol. | pmid:8434642 |
| Harris MC et al. | Diminished actin polymerization by neutrophils from newborn infants. | 1993 | Pediatr. Res. | pmid:8433856 |
| ten Cate H et al. | [Current viewpoints and hypotheses concerning in vivo blood coagulation]. | 1993 | Ned Tijdschr Geneeskd | pmid:8433772 |
| Naruse T | [Hemolytic uremic syndrome (HUS): pathophysiology--with reference to the differentiation between HUS and thrombotic thrombocytopenic purpura]. | 1993 | Nippon Rinsho | pmid:8433517 |
| Hattori A et al. | [Platelets-morphology, shape changing factor, and platelet agglutinating factor. TTP Research Group]. | 1993 | Nippon Rinsho | pmid:8433504 |
| Salgado J et al. | Effects of platelet-activating factor and related lipids on dielaidoylphosphatidylethanolamine by DSC, FTIR and NMR. | 1993 | Biochim. Biophys. Acta | pmid:8431461 |
| Wilson DV et al. | Cardiovascular responses to exogenous platelet-activating factor (PAF) in anesthetized ponies, and the effects of a PAF antagonist, WEB 2086. | 1993 | Am. J. Vet. Res. | pmid:8430938 |
| Zheng ZG et al. | Platelet-activating factor stimulates resorption by rabbit osteoclasts in vitro. | 1993 | Am. J. Physiol. | pmid:8430791 |
| Silver RK et al. | Acetylsalicylic acid inhibits anticardiolipin antibody-induced platelet-activating factor (PAF) synthesis. | 1993 | Prostaglandins | pmid:8430224 |
| Bruijnzeel PL et al. | Eosinophil migration in atopic dermatitis. I: Increased migratory responses to N-formyl-methionyl-leucyl-phenylalanine, neutrophil-activating factor, platelet-activating factor, and platelet factor 4. | 1993 | J. Invest. Dermatol. | pmid:8429236 |
| el Azzouzi B et al. | Immunoregulatory functions of paf-acether. IX. Modulation of apoptosis in an immature T cell line. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8427577 |
| Deigner HP and Dresel HA | Effect of platelet activating factor on the kinetics of LDL oxidation in vitro. | 1993 | FEBS Lett. | pmid:8425606 |
| Jager GV et al. | Antagonist of platelet-activating factor prevents prostaglandin E2 induced ocular hypertension in rabbits. | 1993 | Prostaglandins | pmid:8424134 |
| Galli C et al. | Modulation of lipid derived mediators by polyunsaturated fatty acids. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8424123 |
| Hemmings R et al. | Platelet-activating factor acetylhydrolase activity in peritoneal fluids of women with endometriosis. | 1993 | Obstet Gynecol | pmid:8423963 |
| McManus LM et al. | Radiation-induced increased platelet-activating factor activity in mixed saliva. | 1993 | Lab. Invest. | pmid:8423671 |
| Yamamoto H et al. | The evidence of platelet activation in bronchial asthma. | 1993 | J. Allergy Clin. Immunol. | pmid:8423274 |
| Ogata M et al. | An antagonist of platelet-activating factor suppresses endotoxin-induced tumor necrosis factor and mortality in mice pretreated with carrageenan. | 1993 | Infect. Immun. | pmid:8423096 |
| Kuitert LM et al. | Effect of the platelet-activating factor antagonist UK-74,505 on the early and late response to allergen. | 1993 | Am. Rev. Respir. Dis. | pmid:8420437 |
| Kidney JC et al. | Inhibition of platelet-activating factor-induced bronchoconstriction by the leukotriene D4 receptor antagonist ICI 204,219. | 1993 | Am. Rev. Respir. Dis. | pmid:8420421 |
| Morteau O et al. | Platelet-activating factor and interleukin 1 are involved in colonic dysmotility in experimental colitis in rats. | 1993 | Gastroenterology | pmid:8419261 |
| Amirkhanian JD and Taeusch HW | Reversible and irreversible inactivation of preformed pulmonary surfactant surface films by changes in subphase constituents. | 1993 | Biochim. Biophys. Acta | pmid:8418890 |
| Yoshida H et al. | Platelet-activating factor acetylhydrolase in red cell membranes. Does decreased activity impair erythrocyte deformability in ischemic stroke patients? | 1993 | Stroke | pmid:8418541 |
| Mangin EL et al. | Effects of lysolipids and oxidatively modified low density lipoprotein on endothelium-dependent relaxation of rabbit aorta. | 1993 | Circ. Res. | pmid:8417838 |
| Burgers JA et al. | Human platelets secrete chemotactic activity for eosinophils. | 1993 | Blood | pmid:8417801 |
| Wang KS et al. | Protective effect of platelet-activating factor antagonist on ischemia-induced liver injury in rats. | 1993 | Surgery | pmid:8417492 |
| Arribas I et al. | Direct interactions between platelets and cultured rat mesangial cells. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8415809 |
| Saito M et al. | Role of leukotrienes and platelet activating factor in allergic bronchoconstriction and their interactions in guinea pig airway in vivo. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8415807 |
| Saito H and Tamura Y | [Antiatherogenic action of omega-3 polyunsaturated fatty acids]. | 1993 | Nippon Rinsho | pmid:8411664 |
| Katnik C and Nelson DJ | Platelet activating factor-induced increase in cytosolic calcium and transmembrane current in human macrophages. | 1993 | J. Membr. Biol. | pmid:8411123 |
| Carceller E et al. | Synthesis and structure-activity relationships of 1-acyl-4-((2-methyl-3-pyridyl)cyanomethyl)piperazines as PAF antagonists. | 1993 | J. Med. Chem. | pmid:8411016 |
| Angle MJ et al. | Effect of platelet-activating factor (PAF) on human spermatozoa-oocyte interactions. | 1993 | J. Reprod. Fertil. | pmid:8410823 |
| Lepage N et al. | Distribution of lysophospholipids and metabolism of platelet-activating factor in human follicular and peritoneal fluids. | 1993 | J. Reprod. Fertil. | pmid:8410799 |
| Ninio E et al. | Autocrine amplification of PAF-acether formation in immunologically activated murine macrophages. | 1993 | J. Leukoc. Biol. | pmid:8409751 |
| Tomioka K et al. | GM-CSF regulates human eosinophil responses to F-Met peptide and platelet activating factor. | 1993 | J. Immunol. | pmid:8409452 |
| Pires JG et al. | ICI 169,369, A 5-HT2/5-HT1C antagonist, that can evoke endothelium-dependent relaxation in rabbit aorta. | 1993 | J Auton Pharmacol | pmid:8408095 |
| Pellon MI et al. | Effect of immunological stimulation on the production of platelet-activating factor by rat peritoneal cells: its relevance to anaphylactic reactions. | 1993 Jul-Aug | Immunopharmacology | pmid:8407286 |
| Tremblay GM et al. | Murine hypersensitivity pneumonitis: evidences for the role of eicosanoids and platelet activating factor. | 1993 | Immunol. Invest. | pmid:8406624 |
| Tripathi YB et al. | Anti-platelet activating factor property of Rubia cordifolia Linn. | 1993 | Indian J. Exp. Biol. | pmid:8406601 |
| Wozniak A et al. | Interleukin-8 primes human neutrophils for enhanced superoxide anion production. | 1993 | Immunology | pmid:8406585 |
| Boichot E et al. | Bronchopulmonary responses to endothelin-1 in sensitized and challenged guinea-pigs: role of cyclooxygenase metabolites and platelet-activating factor. | 1993 | Fundam Clin Pharmacol | pmid:8406292 |
| Denizot Y and Nathan N | Platelet-activating factor antagonists and infected cirrhosis. | 1993 | Gastroenterology | pmid:8405881 |
| Wang R et al. | Platelet activating factor and pentoxifylline as human sperm cryoprotectants. | 1993 | Fertil. Steril. | pmid:8405531 |
| Mabuchi-Itoh K et al. | Aspirin induces non-enzymatic formation of platelet-activating factor from lyso platelet-activating factor. | 1993 | FEBS Lett. | pmid:8405463 |
| Ito Y et al. | Corneal PAF acetylhydrolase increases in anterior segment ischemia in rabbits. | 1993 | Exp. Eye Res. | pmid:8405166 |
| Colard O et al. | Biosynthesis of platelet-activating factor in cultured mast cells. Involvement of the CoA-independent transacylase demonstrated by analysis of the molecular species of platelet-activating factor. | 1993 | Eur. J. Biochem. | pmid:8404903 |
| Kuo RC et al. | A metabolic view of receptor activation in cultured cells following cryopreservation. | 1993 | Cryobiology | pmid:8403989 |
| Montrucchio G et al. | Streptokinase induces intravascular release of platelet-activating factor in patients with acute myocardial infarction and stimulates its synthesis by cultured human endothelial cells. | 1993 | Circulation | pmid:8403295 |
| Lu Z and Wolf MB | Platelet activating factor-induced microvascular permeability increases in the cat hindlimb. | 1993 | Circ. Shock | pmid:8403248 |
| Noda N et al. | Isolation and characterization of seven lyso platelet-activating factors and two lyso phosphatidylcholines from the crude drug "suitetsu" (the leech, Hirudo nipponica). | 1993 | Chem. Pharm. Bull. | pmid:8403084 |
| Cheng DY and Chen WB | [The current status of the research on platelet activating factor and pulmonary hypertension]. | 1993 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:8403064 |
| Northover AM | An in vitro method for assessing the effects of pro-inflammatory and anti-inflammatory compounds on microvascular permeability in the rat small intestine. | 1993 | J Pharmacol Toxicol Methods | pmid:8400419 |
| Woodman RC et al. | Effects of human neutrophil elastase (HNE) on neutrophil function in vitro and in inflamed microvessels. | 1993 | Blood | pmid:8400269 |
| Aglietta M et al. | Interleukin-3 in vivo: kinetic of response of target cells. | 1993 | Blood | pmid:8400256 |
| Burgers JA et al. | Occupancy of platelet receptors for platelet-activating factor in asthmatic patients during an allergen-induced bronchoconstrictive reaction. | 1993 | J Lipid Mediat | pmid:8400115 |
| Hwang SB et al. | MK 287: a potent, specific, and orally active receptor antagonist of platelet-activating factor. | 1993 | J Lipid Mediat | pmid:8400114 |
| Mezzano S et al. | Detection of platelet-activating factor in plasma of patients with streptococcal nephritis. | 1993 | J. Am. Soc. Nephrol. | pmid:8400088 |
| Baker RR and Chang HY | The potential for platelet-activating factor synthesis in brain: properties of cholinephosphotransferase and 1-alkyl-sn-glycero-3-phosphate acetyltransferase in microsomal fractions of immature rabbit cerebral cortex. | 1993 | Biochim. Biophys. Acta | pmid:8399340 |
| Hogaboam CM et al. | Modulation of rat mast cell reactivity by IL-1 beta. Divergent effects on nitric oxide and platelet-activating factor release. | 1993 | J. Immunol. | pmid:8397260 |
| Pendino KJ et al. | Induction of functionally active platelet-activating factor receptors in rat alveolar macrophages. | 1993 | J. Biol. Chem. | pmid:8396125 |
| Pothoulakis C et al. | Ketotifen inhibits Clostridium difficile toxin A-induced enteritis in rat ileum. | 1993 | Gastroenterology | pmid:8395445 |
| Arndt H et al. | Mediators of leukocyte adhesion in rat mesenteric venules elicited by inhibition of nitric oxide synthesis. | 1993 | Gastroenterology | pmid:8395443 |
| Martins MA et al. | Interference of the PAF receptor antagonist, PCA 4248, with the rat pleurisy evoked by inflammatory mediators or allergen. | 1993 | Eur. J. Pharmacol. | pmid:8395390 |
| Herbert JM et al. | Effect of SR 27417 on the binding of [3H]PAF to rabbit and human platelets and human polymorphonuclear leukocytes. | 1993 | J Lipid Mediat | pmid:8395255 |
| Bito H et al. | Characterization of platelet-activating factor (PAF) receptor in the rat brain. | 1993 Mar-Apr | J Lipid Mediat | pmid:8395241 |
| Nakamura M et al. | Isolation and properties of platelet-activating factor receptor cDNAs. | 1993 Mar-Apr | J Lipid Mediat | pmid:8395240 |
| Moreno P et al. | Changes in peripheral blood levels of platelet-activating factor after orthotopic liver transplantation. | 1993 | Transplant. Proc. | pmid:8395105 |
| Thivierge M et al. | Transcriptional modulation of platelet-activating factor receptor gene expression by cyclic AMP. | 1993 | J. Biol. Chem. | pmid:8394344 |
| Stephens L et al. | Synthesis of phosphatidylinositol 3,4,5-trisphosphate in permeabilized neutrophils regulated by receptors and G-proteins. | 1993 | J. Biol. Chem. | pmid:8394332 |