Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Respiratory Distress Syndrome, Adult D012128 15 associated lipids
Epilepsy D004827 35 associated lipids
Seizures D012640 87 associated lipids
Nerve Degeneration D009410 53 associated lipids
Birth Weight D001724 23 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Hypertension D006973 115 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Cerebrovascular Disorders D002561 25 associated lipids
Nasal Polyps D009298 26 associated lipids
Leukemia, Myeloid, Acute D015470 19 associated lipids
Ear Diseases D004427 7 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Respiratory Hypersensitivity D012130 18 associated lipids
Subarachnoid Hemorrhage D013345 17 associated lipids
Leukemia, Experimental D007942 42 associated lipids
Diabetic Angiopathies D003925 20 associated lipids
Agranulocytosis D000380 7 associated lipids
Shock D012769 11 associated lipids
Polycythemia Vera D011087 13 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Li SH et al. [Effect of an extract from the cauline of Piper kadsura ohwi on endotoxin-induced hypotension and lung injury in rats]. 1989 Zhongguo Zhong Yao Za Zhi pmid:2619897
Cheng NN and Ma YM [A hypotensive analog of platelet-activating factor (PAF) in pheretima]. 1993 Zhongguo Zhong Yao Za Zhi pmid:8011088
Chen ZN et al. [Anti-platelet activating factor constituents, 2,5-diaryltetrahydrofuran type lignans, from Piper futokadsura Sied. et Zucc]. 1993 Zhongguo Zhong Yao Za Zhi pmid:8216803
Wang WJ et al. [Effects of musk glucoprotein on PAF production and cytosolic Ca2+ level in rat polymorphonuclear leukocytes in vitro]. 2000 Zhongguo Zhong Yao Za Zhi pmid:12525061
Zang BX et al. [Inhibitory effect of kaempferol against binding of platelet activating factor to its receptor]. 2004 Zhongguo Zhong Yao Za Zhi pmid:15506296
Dong JC et al. [Ginkgolides antagonizing some effects of platelet-activating factor in vitro]. 1995 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:8704427
Dong JC et al. [Experimental study on antagonism of ginkgolides against effect of platelet-activating factor on lung strip of guinea pigs]. 1997 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:10322836
Chen WM et al. [Experimental study on inhibitory effect of rutin against platelet activation induced by platelet activating factor in rabbits]. 2002 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:12584792
Wang J et al. [Effect of Radix notoginseng saponins on platelet activating molecule expression and aggregation in patients with blood hyperviscosity syndrome]. 2004 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:15143716
Shao P et al. [Research on relationship of syndrome type and parameters of hemorheology and platelet activation in patients with acute gout arthritis of dampness-heat blockage type and stasis-heat accumulate type]. 2006 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:17186728