Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Respiratory Distress Syndrome, Adult D012128 15 associated lipids
Epilepsy D004827 35 associated lipids
Seizures D012640 87 associated lipids
Nerve Degeneration D009410 53 associated lipids
Birth Weight D001724 23 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Hypertension D006973 115 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Cerebrovascular Disorders D002561 25 associated lipids
Nasal Polyps D009298 26 associated lipids
Leukemia, Myeloid, Acute D015470 19 associated lipids
Ear Diseases D004427 7 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Respiratory Hypersensitivity D012130 18 associated lipids
Subarachnoid Hemorrhage D013345 17 associated lipids
Leukemia, Experimental D007942 42 associated lipids
Diabetic Angiopathies D003925 20 associated lipids
Agranulocytosis D000380 7 associated lipids
Shock D012769 11 associated lipids
Polycythemia Vera D011087 13 associated lipids
Per page 10 20 50 100 | Total 288

PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with Platelet activating factor

Download all related citations
Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Landgraf RG et al. Prostaglandins, leukotrienes and PAF selectively modulate lymphocyte subset and eosinophil infiltration into the airways in a murine model of asthma. 2007 Oct-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:17923399
Kono N et al. Protection against oxidative stress-induced hepatic injury by intracellular type II platelet-activating factor acetylhydrolase by metabolism of oxidized phospholipids in vivo. 2008 J. Biol. Chem. pmid:18024956
Steel HC et al. Comparison of the anti-inflammatory activities of imidazole antimycotics in relation to molecular structure. 2008 Chem Biol Drug Des pmid:18924285
Schaefer MB et al. Peroxisome proliferator-activated receptor-alpha reduces inflammation and vascular leakage in a murine model of acute lung injury. 2008 Eur. Respir. J. pmid:18653653
Samanta U and Bahnson BJ Crystal structure of human plasma platelet-activating factor acetylhydrolase: structural implication to lipoprotein binding and catalysis. 2008 J. Biol. Chem. pmid:18784071
Beuk RJ et al. Leucocyte and platelet adhesion in different layers of the small bowel during experimental total warm ischaemia and reperfusion. 2008 Br J Surg pmid:18720462
Konger RL et al. Oxidized glycerophosphocholines as biologically active mediators for ultraviolet radiation-mediated effects. 2008 Prostaglandins Other Lipid Mediat. pmid:18555720
Fang H et al. Toxoplasma gondii-derived heat shock protein 70 induces lethal anaphylactic reaction through activation of cytosolic phospholipase A2 and platelet-activating factor via Toll-like receptor 4/myeloid differentiation factor 88. 2008 Microbiol. Immunol. pmid:18667035
Sánchez FA et al. Internalization of eNOS via caveolae regulates PAF-induced inflammatory hyperpermeability to macromolecules. 2008 Am. J. Physiol. Heart Circ. Physiol. pmid:18708444
Shibamoto T et al. PAF, rather than histamine, participates in mouse anaphylactic hypotension. 2008 Pharmacology pmid:18583921
Penna C et al. The platelet activating factor triggers preconditioning-like cardioprotective effect via mitochondrial K-ATP channels and redox-sensible signaling. 2008 J. Physiol. Pharmacol. pmid:18441387
Bang UC et al. Pharmacological approach to acute pancreatitis. 2008 World J. Gastroenterol. pmid:18494044
Kuliszkiewicz-Janus M et al. Platelet-activating factor changes in phospholipid extracts from the plasma, peripheral blood mononuclear cells and bone marrow mononuclear cells of patients with acute leukemia--a 31P MRS in vitro study. 2008 Cell. Mol. Biol. Lett. pmid:17952375
Bélanger C et al. Involvement of endogenous leukotriene B4 and platelet-activating factor in polymorphonuclear leucocyte recruitment to dermal inflammatory sites in rats. 2008 Immunology pmid:18217950
Leong HS et al. Vimentin autoantibodies induce platelet activation and formation of platelet-leukocyte conjugates via platelet-activating factor. 2008 J. Leukoc. Biol. pmid:17974709
Kostopanagiotou G et al. Acute lung injury in a rat model of intestinal ischemia-reperfusion: the potential time depended role of phospholipases A(2). 2008 J. Surg. Res. pmid:17981297
Si J et al. STAT5 mediates PAF-induced NADPH oxidase NOX5-S expression in Barrett's esophageal adenocarcinoma cells. 2008 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:17947454
Zhang XP et al. The pathogenic mechanism of severe acute pancreatitis complicated with renal injury: a review of current knowledge. 2008 Dig. Dis. Sci. pmid:17597411
Zheng HL et al. [Role of platelet-activating factor in progesterone synthesis and vascular endothelial growth factor expression in rat luteal cells]. 2008 Sheng Li Xue Bao pmid:18425318
Di Y et al. [Effect of ginkgolide B on plasma levels of interleukin-12 and PAF in severe acute pancreatitis in rats]. 2008 Zhongguo Ying Yong Sheng Li Xue Za Zhi pmid:21141514
Aomatsu K et al. Toll-like receptor agonists stimulate human neutrophil migration via activation of mitogen-activated protein kinases. 2008 Immunology pmid:17662043
Ogura M et al. Platelet-activating factor (PAF) induced cytokine production and otitis media with effusion (OME) in the rat middle ear. 2008 Auris Nasus Larynx pmid:17997066
Figueiredo MB et al. Blockades of phospholipase A(2) and platelet-activating factor receptors reduce the hemocyte phagocytosis in Rhodnius prolixus: in vitro experiments. 2008 J. Insect Physiol. pmid:18036540
Smith JC et al. Identification of lysophosphatidylcholine (LPC) and platelet activating factor (PAF) from PC12 cells and mouse cortex using liquid chromatography/multi-stage mass spectrometry (LC/MS3). 2008 Rapid Commun. Mass Spectrom. pmid:18937225
Kihara Y et al. Platelet-activating factor production in the spinal cord of experimental allergic encephalomyelitis mice via the group IVA cytosolic phospholipase A2-lyso-PAFAT axis. 2008 J. Immunol. pmid:18802104
Wislet-Gendebien S et al. Differential regulation of wild-type and mutant alpha-synuclein binding to synaptic membranes by cytosolic factors. 2008 BMC Neurosci pmid:18808659
Adamson RH et al. Epac/Rap1 pathway regulates microvascular hyperpermeability induced by PAF in rat mesentery. 2008 Am. J. Physiol. Heart Circ. Physiol. pmid:18178724
Zheng M et al. (3S)-N-(L-Aminoacyl)-1,2,3,4-tetrahydroisoquinolines, a class of novel antithrombotic agents: synthesis, bioassay, 3D QSAR, and ADME analysis. 2008 Bioorg. Med. Chem. pmid:18835178
Gountopoulou A et al. TNFalpha is a potent inducer of platelet-activating factor synthesis in adipocytes but not in preadipocytes. Differential regulation by PI3K. 2008 Cytokine pmid:18180165
Kwasniewski FH et al. Small bowel injury associated to allergy is triggered by platelet-activating factor, mast cells, neutrophils and protected by nitric oxide. 2008 Int. Immunopharmacol. pmid:18182253
Chen Y et al. Hepatic stellate cells may be potential effectors of platelet activating factor induced portal hypertension. 2008 World J. Gastroenterol. pmid:18186558
Rastogi P et al. Tryptase activates calcium-independent phospholipase A2 and releases PGE2 in airway epithelial cells. 2008 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:18790994
Hikiji H et al. The roles of prostanoids, leukotrienes, and platelet-activating factor in bone metabolism and disease. 2008 Prog. Lipid Res. pmid:18187046
Belayev L et al. LAU-0901, a novel platelet-activating factor antagonist, is highly neuroprotective in cerebral ischemia. 2008 Exp. Neurol. pmid:18793637
Zhang Q et al. UVB radiation-mediated inhibition of contact hypersensitivity reactions is dependent on the platelet-activating factor system. 2008 J. Invest. Dermatol. pmid:18200048
Lu YY et al. Synthesis of platelet-activating factor and its receptor expression in Kupffer cells in rat carbon tetrachloride-induced cirrhosis. 2008 World J. Gastroenterol. pmid:18205269
Nomura DK et al. Dual roles of brain serine hydrolase KIAA1363 in ether lipid metabolism and organophosphate detoxification. 2008 Toxicol. Appl. Pharmacol. pmid:18164358
O' Meara CM et al. Relationship between in vitro sperm functional tests and in vivo fertility of rams following cervical artificial insemination of ewes with frozen-thawed semen. 2008 Theriogenology pmid:18248736
Sakellariou M et al. Intravenous infusion of PAF affects ovulation, fertilization and preimplantation embryonic development in NZB x NZW F1 hybrid mice. 2008 Prostaglandins Other Lipid Mediat. pmid:18248752
Yuhki K et al. Prostaglandin I2 plays a key role in zymosan-induced mouse pleurisy. 2008 J. Pharmacol. Exp. Ther. pmid:18256172
Chia YC et al. Antiplatelet aggregation coumarins from the leaves of Murraya omphalocarpa. 2008 Molecules pmid:18259135
Kasperska-Zajac A et al. Platelet activating factor as a mediator and therapeutic approach in bronchial asthma. 2008 Inflammation pmid:18193345
Vadas P et al. Platelet-activating factor, PAF acetylhydrolase, and severe anaphylaxis. 2008 N. Engl. J. Med. pmid:18172172
Burks AW Factoring PAF in anaphylaxis. 2008 N. Engl. J. Med. pmid:18172180
Menzies-Gow NJ et al. Roles of thromboxane A2 and 5-hydroxytryptamine in endotoxin-induced digital vasoconstriction in horses. 2008 Am. J. Vet. Res. pmid:18241016
Li J et al. PMS777, a bis-interacting ligand for PAF receptor antagonism and AChE inhibition, attenuates PAF-induced neurocytotoxicity in SH-SY5Y cells. 2008 Cell. Mol. Neurobiol. pmid:17712622
Caprani A et al. Preliminary study of pulsed-electromagnetic fields effects on endothelial (HUVEC) cell secretions--modulation of the thrombo-hemorrhagic balance. 2008 Electromagn Biol Med pmid:19037787
Satoh K [Plasma platelet-activating factor acetylhydrolase (PAF-AH) deficiency as a risk factor for stroke]. 2008 Brain Nerve pmid:19069165
Chu W et al. Flavonoids from Chinese Viscum coloratum produce cytoprotective effects against ischemic myocardial injuries: inhibitory effect of flavonoids on PAF-induced Ca2+ overload. 2008 Phytother Res pmid:17724771
Hemetsberger R et al. Association between the efficacy of dual antiplatelet therapy and the development of in-stent neointimal hyperplasia in porcine coronary arteries. 2008 Coron. Artery Dis. pmid:19005299
Morita K et al. Glycinergic mediation of tactile allodynia induced by platelet-activating factor (PAF) through glutamate-NO-cyclic GMP signalling in spinal cord in mice. 2008 Pain pmid:18353555
Simonenko VB et al. [Losartan for the correction of thrombocyte activity in patients suffering from arterial hypertension with metabolic syndrome]. 2008 Klin Med (Mosk) pmid:18326282
Harayama T et al. Identification of a novel noninflammatory biosynthetic pathway of platelet-activating factor. 2008 J. Biol. Chem. pmid:18285344
Mizutani T et al. Genuine functions of P-glycoprotein (ABCB1). 2008 Curr. Drug Metab. pmid:18288958
Kasperska-Zajac A et al. Platelet-activating factor (PAF): a review of its role in asthma and clinical efficacy of PAF antagonists in the disease therapy. 2008 Recent Pat Inflamm Allergy Drug Discov pmid:19075994
Fukunaga A et al. Dermal dendritic cells, and not Langerhans cells, play an essential role in inducing an immune response. 2008 J. Immunol. pmid:18292528
XUE M et al. Relationship between platelet activation related factors and polymorphism of related genes in patients with coronary heart disease of blood-stasis syndrome. 2008 Chin J Integr Med pmid:19082798
van Zoelen MA et al. Platelet-activating factor receptor contributes to host defense against Pseudomonas aeruginosa pneumonia but is not essential for the accompanying inflammatory and procoagulant response. 2008 J. Immunol. pmid:18292561
Knapp S et al. Lipoteichoic acid-induced lung inflammation depends on TLR2 and the concerted action of TLR4 and the platelet-activating factor receptor. 2008 J. Immunol. pmid:18292574
Mullol J et al. Rupatadine in allergic rhinitis and chronic urticaria. 2008 Allergy pmid:18339040
Claud EC et al. Platelet-activating factor-induced chloride channel activation is associated with intracellular acidosis and apoptosis of intestinal epithelial cells. 2008 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:18339705
Kudriavtseva IuA et al. [Sorption and contact-activating properties of the <biograft-artery> anastomosis zone: effect of suture material (communication II)]. 2008 Angiol Sosud Khir pmid:19156039
Shindou H [Lysophospholipid acyltransferase and platelet-activating factor (PAF) biosynthetic enzyme]. 2008 Seikagaku pmid:18341030
Tsujimura Y et al. Basophils play a pivotal role in immunoglobulin-G-mediated but not immunoglobulin-E-mediated systemic anaphylaxis. 2008 Immunity pmid:18342553
Patel MI et al. The arachidonic acid pathway and its role in prostate cancer development and progression. 2008 J. Urol. pmid:18343442
Frost BL et al. The importance of pro-inflammatory signaling in neonatal necrotizing enterocolitis. 2008 Semin. Perinatol. pmid:18346533
Zhang Y et al. Glycosides from the bark of Adina polycephala. 2008 J. Nat. Prod. pmid:18303851
Tsuchiya R et al. Characterization of canine platelet activation induced by platelet activating factor (PAF). 2008 J. Vet. Med. Sci. pmid:18319579
Song W et al. Pyridinium alkaloid-coupled secoiridoids from the flower buds of Lonicera japonica. 2008 J. Nat. Prod. pmid:18321056
Shiva D et al. High dose of lipopolysaccharide pre-treatment prevents OVA-induced anaphylactic decreases in rectal temperature in the immunized mice. 2008 Immunol. Lett. pmid:18433880
Leary PJ et al. A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation. 2008 Am. J. Physiol. Heart Circ. Physiol. pmid:18441203
Cooper D et al. Novel insights into the inhibitory effects of Galectin-1 on neutrophil recruitment under flow. 2008 J. Leukoc. Biol. pmid:18372340
Bansal AS et al. Platelet-activating factor, PAF acetylhydrolase, and anaphylaxis. 2008 N. Engl. J. Med. pmid:18389523
Okamoto H and Kamatani N Platelet-activating factor, PAF acetylhydrolase, and anaphylaxis. 2008 N. Engl. J. Med. pmid:18389524
Torres MI and Rios A Current view of the immunopathogenesis in inflammatory bowel disease and its implications for therapy. 2008 World J. Gastroenterol. pmid:18395894
Kim HA et al. Nitric oxide plays a key role in the platelet-activating factor-induced enhancement of resistance against systemic candidiasis. 2008 Immunology pmid:18397269
Galli SJ and Franco CB Basophils are back! 2008 Immunity pmid:18400194
Berry KA et al. Effects of acrolein on leukotriene biosynthesis in human neutrophils. 2008 Chem. Res. Toxicol. pmid:19548361
Levy JH Platelet-activating factor, PAF acetylhydrolase, and anaphylaxis. 2008 N. Engl. J. Med. pmid:18385504
Ibe BO et al. Mechanisms by which S-albuterol induces human bronchial smooth muscle cell proliferation. 2008 Int. Arch. Allergy Immunol. pmid:18362475
Tiemann U The role of platelet-activating factor in the mammalian female reproductive tract. 2008 Reprod. Domest. Anim. pmid:18363604
Ibe BO et al. Platelet-activating factor stimulates ovine foetal pulmonary vascular smooth muscle cell proliferation: role of nuclear factor-kappa B and cyclin-dependent kinases. 2008 Cell Prolif. pmid:18336468
Lu J et al. Polyunsaturated fatty acids block platelet-activating factor-induced phosphatidylinositol 3 kinase/Akt-mediated apoptosis in intestinal epithelial cells. 2008 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:18356536
Sreevidya CS et al. Inhibition of photocarcinogenesis by platelet-activating factor or serotonin receptor antagonists. 2008 Cancer Res. pmid:18483284
Burks AW Peanut allergy. 2008 Lancet pmid:18456104
Huang GD et al. Effect of volatile oil of amomum on expressions of platelet activating factor and mastocarcinoma-related peptide in the gastric membrane of chronic gastritis patients with helicobacter-pylori infection. 2008 Chin J Integr Med pmid:18568325
Egea L et al. Increased production of the ether-lipid platelet-activating factor in intestinal epithelial cells infected by Salmonella enteritidis. 2008 Biochim. Biophys. Acta pmid:18442488
Tsoukatos DC et al. Platelet-activating factor acetylhydrolase and transacetylase activities in human aorta and mammary artery. 2008 J. Lipid Res. pmid:18587071
Ryan SD et al. Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons. 2008 J. Lipid Res. pmid:18550892
Jiang Y et al. Three-dimensional localization and quantification of PAF-induced gap formation in intact venular microvessels. 2008 Am. J. Physiol. Heart Circ. Physiol. pmid:18515648
LeBlanc CJ et al. Effects of dietary supplementation with fish oil on in vivo production of inflammatory mediators in clinically normal dogs. 2008 Am. J. Vet. Res. pmid:18380580
Su J et al. Natural antibodies against phosphorylcholine as potential protective factors in SLE. 2008 Rheumatology (Oxford) pmid:18522961
McLaughlin NJ et al. Platelet-activating factor-mediated endosome formation causes membrane translocation of p67phox and p40phox that requires recruitment and activation of p38 MAPK, Rab5a, and phosphatidylinositol 3-kinase in human neutrophils. 2008 J. Immunol. pmid:18523285
Felfernig M et al. Molecular weight of hydroxyethyl starch molecules influences coagulation profile measured by thrombelastography. 2008 J R Nav Med Serv pmid:18524134
Tsoupras AB et al. Anti-platelet-activating factor effects of highly active antiretroviral therapy (HAART): a new insight in the drug therapy of HIV infection? 2008 AIDS Res. Hum. Retroviruses pmid:18620493
Corl CM et al. Platelet activating factor production and proinflammatory gene expression in endotoxin-challenged bovine mammary endothelial cells. 2008 J. Dairy Sci. pmid:18650283
Kikuchi M et al. Platelet-activating factor (PAF) increases NO production in human endothelial cells-real-time monitoring by DAR-4M AM. 2008 Apr-May Prostaglandins Leukot. Essent. Fatty Acids pmid:18502110
Chamogeorgakis TP et al. Effect of N-acetyl-L-cysteine on lung ischaemia reperfusion injury in a porcine experimental model. 2008 Jan-Feb ANZ J Surg pmid:18199211
Kurdiumov IN et al. [Cerebrovascular and antiaggregative effects of GABA-docosahexaenoyldopamine conjugate]. 2008 Jul-Aug Eksp Klin Farmakol pmid:18819437
Guo CJ et al. The synthesis and biological evaluation of 10-O-dialkylaminoethyl ginkgolide B as platelet-activating factor antagonist. 2008 Sep-Oct J Asian Nat Prod Res pmid:19003620