Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
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What functions are associated with Platelet activating factor?
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What lipids are associated with Platelet activating factor?
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Michel L and Dubertret L | A simple method for studying chemotaxis, vascular permeability and histological modifications induced by mediators of inflammation in vivo in man. | 1985 | Br. J. Dermatol. | pmid:2990519 |
| Morris HG | Mechanisms of glucocorticoid action in pulmonary disease. | 1985 | Chest | pmid:2410202 |
| Doebber TW et al. | Platelet activating factor (PAF) involvement in endotoxin-induced hypotension in rats. Studies with PAF-receptor antagonist kadsurenone. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2985058 |
| Pfeilschifter J et al. | Inhibition of renin secretion by platelet activating factor (acetylglyceryl ether phosphorylcholine) in cultured rat renal juxtaglomerular cells. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2985064 |
| Hwang SB et al. | Specific binding sites for platelet activating factor in human lung tissues. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2986633 |
| Terashita Z et al. | Inhibition by CV-3988 of the binding of [3H]-platelet activating factor (PAF) to the platelet. | 1985 | Biochem. Pharmacol. | pmid:2986648 |
| Vanderwel M and Haslam RJ | Inhibition and subsequent enhancement of platelet responsiveness by prostacyclin in the rabbit. Relationship to platelet adenosine 3',5'-cyclic monophosphate. | 1985 | J. Clin. Invest. | pmid:2991338 |
| Iñarrea P et al. | Synthesis of PAF-acether and blood volume changes in gram-negative sepsis. | 1985 | Immunopharmacology | pmid:3886598 |
| Lellouch-Tubiana A et al. | Ultrastructural evidence for extravascular platelet recruitment in the lung upon intravenous injection of platelet-activating factor (PAF-acether) to guinea-pigs. | 1985 | Br J Exp Pathol | pmid:3890915 |
| Weber N and Mangold HK | Semi-synthetic preparation of 1-O-[1'-14C]hexadecyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor) using plant cell cultures. | 1985 | J. Lipid Res. | pmid:3891896 |
| Hanahan DJ and Weintraub ST | Platelet-activating factor isolation, identification, and assay. | 1985 | Methods Biochem Anal | pmid:3894881 |
| Maes L et al. | In vivo arterial platelet-vessel wall interaction and thrombosis: induction, on-line registration and ultrastructural control. | 1985 | Adv. Exp. Med. Biol. | pmid:3832867 |
| Tuffin DP et al. | Specific binding of [3H]-1-O-octadecyl Paf-acether to washed human platelets. | 1985 | Adv. Exp. Med. Biol. | pmid:3834789 |
| Parente L and Flower RJ | Hydrocortisone and 'macrocortin' inhibit the zymosan-induced release of lyso-PAF from rat peritoneal leucocytes. | 1985 | Life Sci. | pmid:3838566 |
| Kumar R et al. | Occurrence of glyceryl ethers in the phosphatidylcholine fraction of surfactant from dog lungs. | 1985 | Biochim. Biophys. Acta | pmid:3839684 |
| Lad PM et al. | Platelet-activating factor mediated effects on human neutrophil function are inhibited by pertussis toxin. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2990462 |
| Hayashi H et al. | Macrophage activation by PAF incorporated into dipalmitoylphosphatidylcholine-cholesterol liposomes. | 1985 | J. Biochem. | pmid:3839790 |
| Tokumura A et al. | Structural analogs of alkylacetylglycerophosphocholine inhibitory behavior on platelet activation. | 1985 | J. Biol. Chem. | pmid:3840169 |
| Sánchez-Crespo M et al. | Inhibition of the vascular actions of IgG aggregates by BN 52021, a highly specific antagonist of paf-acether. | 1985 | Immunopharmacology | pmid:3840779 |
| Billah MM et al. | Lipoxygenase products of arachidonic acid modulate biosynthesis of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) by human neutrophils via phospholipase A2. | 1985 | J. Biol. Chem. | pmid:3922982 |
| Tokumura A and Tsukatani H | [Antagonists of platelet activating factor]. | 1985 | Seikagaku | pmid:3009656 |
| MacIntyre DE et al. | Agonist-induced inositol phospholipid metabolism and Ca++ flux in human platelet activation. | 1985 | Adv. Exp. Med. Biol. | pmid:3010662 |
| Hallam TJ et al. | Control and interrelation of aggregation and secretion; the roles of Ca2+, diacylglycerol and thromboxane with particular reference to ADP stimulation. | 1985 | Adv. Exp. Med. Biol. | pmid:3010663 |
| Gerrard JM et al. | Platelet protein phosphorylation. | 1985 | Adv. Exp. Med. Biol. | pmid:3010667 |
| Haslam RJ et al. | Receptor-effector coupling in platelets: roles of guanine nucleotides. | 1985 | Adv. Exp. Med. Biol. | pmid:3010668 |
| Teng CM et al. | Action mechanism of the platelet aggregation inducer and inhibitor from Echis carinatus snake venom. | 1985 | Biochim. Biophys. Acta | pmid:3926005 |
| Satouchi K et al. | Evidence for production of 1-acyl-2-acetyl-sn-glyceryl-3-phosphorylcholine concomitantly with platelet-activating factor. | 1985 | Biochem. Biophys. Res. Commun. | pmid:4004866 |
| Detsouli A et al. | Histamine and leukotriene-independent guinea-pig anaphylactic shock unaccounted for by Paf-acether. | 1985 | Br. J. Pharmacol. | pmid:4005486 |
| Korth R et al. | Unsaturated 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholines (unsaturated platelet-activating factor): aggregation of human platelets after incubation with indomethacin, creatinephosphate/creatinephosphokinase, xylocain and hirudine, and serotonin release after incubation with indomethacin. | 1985 | Chem. Phys. Lipids | pmid:4006034 |
| Shigenobu K et al. | Platelet activating factor analogues: lack of correlation between their activities to produce hypotension and endothelium-mediated vasodilation. | 1985 | J. Pharmacobio-dyn. | pmid:4009403 |
| Apprill P et al. | Cyclic blood flow variations induced by platelet-activating factor in stenosed canine coronary arteries despite inhibition of thromboxane synthetase, serotonin receptors, and alpha-adrenergic receptors. | 1985 | Circulation | pmid:2988822 |
| Saeki S et al. | Effects of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor) on cardiac function in perfused guinea-pig heart. | 1985 | Life Sci. | pmid:4010479 |
| Nunn B et al. | Effect of temocillin and moxalactam on platelet responsiveness and bleeding time in normal volunteers. | 1985 | Antimicrob. Agents Chemother. | pmid:4015075 |
| Weintraub ST et al. | Fast atom bombardment-mass spectrometric identification of molecular species of platelet-activating factor produced by stimulated human polymorphonuclear leukocytes. | 1985 | Biochem. Biophys. Res. Commun. | pmid:4015656 |
| Yousufzai SY and Abdel-Latif AA | Effects of platelet-activating factor on the release of arachidonic acid and prostaglandins by rabbit iris smooth muscle. Inhibition by calcium channel antagonists. | 1985 | Biochem. J. | pmid:3927898 |
| Tokumura A et al. | Gas chromatographic-mass spectrometric analysis of biologically active phospholipids having an sn-2-acetyl group. | 1985 | J. Chromatogr. | pmid:4066848 |
| Meloni Bruneri LH and Barbieri D | [Platelet aggregation after the reduction of nitro-blue tetrazolium by eosinophils]. | 1985 | Sangre (Barc) | pmid:4071355 |
| Söling HD et al. | Regulation of protein kinases in exocrine secretory cells during agonist-induced exocytosis. | 1985 | Adv. Enzyme Regul. | pmid:4072796 |
| Mushayakarara EC and Mantsch HH | Thermotropic phase behavior of the platelet-activating factor: an infrared spectroscopic study. | 1985 | Can. J. Biochem. Cell Biol. | pmid:4075223 |
| Zimmerman GA et al. | Thrombin stimulates the adherence of neutrophils to human endothelial cells in vitro. | 1985 | J. Clin. Invest. | pmid:4077977 |
| Young JM et al. | Pharmacological investigation of the mechanisms of platelet-activating factor induced mortality in the mouse. | 1985 | Prostaglandins | pmid:4081060 |
| Is there a case for PAF-acether antagonists? Institut Pasteur, Paris, 21 June 1985. Abstracts. | 1985 | Prostaglandins | pmid:4081064 | |
| Morley J et al. | Platelets in asthma. | 1985 | Lancet | pmid:2863708 |
| Cox CP | Activation of washed chicken thrombocytes by 1-O-hexadecyl/octadecyl-2-acetyl-sn-glycero-3-phosphorylcholine (platelet-activating factor). | 1985 | Comp Biochem Physiol A Comp Physiol | pmid:2864195 |
| Snyder F | Chemical and biochemical aspects of platelet activating factor: a novel class of acetylated ether-linked choline-phospholipids. | 1985 Jan-Mar | Med Res Rev | pmid:2984489 |
| Kozubski W and Stańczyk L | [Platelet aggregation in patients with migraine during the pain attack and in the pain-free period]. | 1985 Jul-Aug | Neurol. Neurochir. Pol. | pmid:4094642 |
| Bette-Bobillo P et al. | Synthesis and characterization of a radioiodinated, photoreactive and physiologically active analogue of platelet activating factor. | 1985 Jun-Jul | Chem. Phys. Lipids | pmid:4042252 |
| Leprán I and Lefer AM | Ischemia aggravating effects of platelet-activating factor in acute myocardial ischemia. | 1985 Mar-Apr | Basic Res. Cardiol. | pmid:4039929 |
| Feuerstein G et al. | Thyrotropin-releasing hormone blocks the hypotensive effects of platelet-activating factor in the unanesthetized guinea pig. | 1985 Mar-Apr | J. Cardiovasc. Pharmacol. | pmid:2581089 |
| Masugi F et al. | Role of acetyl glyceryl ether phosphorylcholine in blood pressure regulation in rats. | 1985 Sep-Oct | Hypertension | pmid:4030044 |