Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Ding DD et al. | [Changes of platelet α-particle membrane protein, platelet activating factor and platelet parameters in patients with hyperuricemia]. | 2012 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:22541106 |
Camuesco D et al. | The intestinal anti-inflammatory effect of dersalazine sodium is related to a down-regulation in IL-17 production in experimental models of rodent colitis. | 2012 | Br. J. Pharmacol. | pmid:21790535 |
Sahu RP et al. | The environmental stressor ultraviolet B radiation inhibits murine antitumor immunity through its ability to generate platelet-activating factor agonists. | 2012 | Carcinogenesis | pmid:22542595 |
Sato A et al. | Synthetic biotinylated peptide compounds derived from Asp-hemolysin: novel potent inhibitors of platelet-activating factor. | 2012 | Eur. J. Pharmacol. | pmid:22542654 |
Bachi AL et al. | Apoptotic cells contribute to melanoma progression and this effect is partially mediated by the platelet-activating factor receptor. | 2012 | Mediators Inflamm. | pmid:22577252 |
Neerhof MG et al. | The significance of endothelin in platelet-activating factor-induced fetal growth restriction. | 2012 | Reprod Sci | pmid:22534337 |
Muehlmann LA et al. | PAF increases phagocytic capacity and superoxide anion production in equine alveolar macrophages and blood neutrophils. | 2012 | Res. Vet. Sci. | pmid:21820686 |
Kim HA et al. | Glutamine inhibits platelet-activating factor-mediated pulmonary tumour metastasis. | 2012 | Eur. J. Cancer | pmid:21889331 |
Conejeros I et al. | 2-Aminoethoxydiphenyl borate (2-APB) reduces respiratory burst, MMP-9 release and CD11b expression, and increases l-selectin shedding in bovine neutrophils. | 2012 | Res. Vet. Sci. | pmid:21071047 |
Park J et al. | Females with angina pectoris have altered lipoprotein metabolism with elevated cholesteryl ester transfer protein activity and impaired high-density lipoproteins-associated antioxidant enzymes. | 2012 | Int. J. Mol. Med. | pmid:22211242 |
Bae R et al. | Albuterol isomers modulate platelet-activating factor synthesis and receptor signaling in human bronchial smooth muscle cells. | 2012 | Int. Arch. Allergy Immunol. | pmid:22212397 |
Widgerow AD and Kalaria S | Pain mediators and wound healing--establishing the connection. | 2012 | Burns | pmid:22738827 |
Altomare A et al. | Platelet-activating factor and distinct chemokines are elevated in mucosal biopsies of erosive compared with non-erosive reflux disease patients and controls. | 2012 | Neurogastroenterol. Motil. | pmid:22734465 |
Akbarshahi H et al. | Acute lung injury in acute pancreatitis--awaiting the big leap. | 2012 | Respir Med | pmid:22749752 |
Kolovou V et al. | Platelet activating factor levels and metabolism in Tangier disease: a case study. | 2012 | Lipids Health Dis | pmid:22769014 |
Senbagavalli P et al. | Immune complexes isolated from patients with pulmonary tuberculosis modulate the activation and function of normal granulocytes. | 2012 | Clin. Vaccine Immunol. | pmid:23100480 |
Zhang J et al. | Traumatic brain injury-associated coagulopathy. | 2012 | J. Neurotrauma | pmid:23020190 |
Zia-Ul-Haq M et al. | Report: Platelet aggregation inhibition activity of selected legumes of Pakistan. | 2012 | Pak J Pharm Sci | pmid:23010006 |
Petho G and Reeh PW | Sensory and signaling mechanisms of bradykinin, eicosanoids, platelet-activating factor, and nitric oxide in peripheral nociceptors. | 2012 | Physiol. Rev. | pmid:23073630 |
Tsoupras AB et al. | Platelet-activating factor and its basic metabolic enzymes in blood of naive HIV-infected patients. | 2012 | Angiology | pmid:21948973 |