Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
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What lipids are associated with Platelet activating factor?
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mueller HW et al. | 1-O-alkyl-linked glycerophospholipids of human neutrophils: distribution of arachidonate and other acyl residues in the ether-linked and diacyl species. | 1984 | J. Lipid Res. | pmid:6427378 |
| Wasserman SI | The human lung mast cell. | 1984 | Environ. Health Perspect. | pmid:6428878 |
| O'Flaherty JT et al. | Diacylglycerols enhance human neutrophil degranulation responses: relevancy to a multiple mediator hypothesis of cell function. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6433920 |
| Mendlovic F et al. | Possible involvement of cyclooxygenase products in the actions of platelet-activating factor and of lipoxygenase products in the vascular effects of epinephrine in perfused rat liver. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6435614 |
| Fouque F and Vargaftig BB | Triggering by Paf-acether and adrenaline of cyclo-oxygenase-independent platelet aggregation. | 1984 | Br. J. Pharmacol. | pmid:6439269 |
| Karlsson G and Pipkorn U | Effect of disodium chromoglycate on changes in nasal airway resistance induced by platelet activating factor. | 1984 | Eur. J. Clin. Pharmacol. | pmid:6439565 |
| Sänze JU et al. | On the nature of the vasoreactivity depressing factor (VDF) in inflammation and anaphylaxis in the rat and mouse. | 1984 | Biomed. Biochim. Acta | pmid:6440544 |
| Handley DA et al. | Effect of platelet activating factor on endothelial permeability to plasma macromolecules. | 1984 | Immunopharmacology | pmid:6083990 |
| Camussi G et al. | Effect of platelet activating factor on guinea-pig papillary muscle. | 1984 | Experientia | pmid:6086382 |
| Sills RH | Thrombotic thrombocytopenic purpura. I. Pathophysiology and clinical manifestations. | 1984 | Am J Pediatr Hematol Oncol | pmid:6442830 |
| Lartigue-Mattei C et al. | Pharmacokinetic study of 3H-labelled PAF-acether II. Comparison with 3H-labelled lyso-PAF-acether after intravenous administration in the rabbit and protein binding. | 1984 | Agents Actions | pmid:6532184 |
| Kulikov VI et al. | [Incorporation of 1-0-alkyl-2-acetyl-sn-glycerol-3-phosphocholine into human plasma lipoproteins in vitro. Effect of the lecithin:cholesterol acyltransferase activity of plasma]. | 1984 | Biokhimiia | pmid:6542803 |
| Nagata K et al. | [Thrombotic thrombocytopenic purpura (TTP) with a remission following splenectomy after the failure of antiplatelet therapy and plasmapheresis]. | 1984 | Rinsho Ketsueki | pmid:6542941 |
| Pirotzky E et al. | PAF-acether-induced plasma exudation in rat skin is independent of platelets and neutrophils. | 1984 | Microcirc Endothelium Lymphatics | pmid:6546141 |
| Smith RJ et al. | Stimulation of the human neutrophil superoxide anion-generating system with 1-O-hexadecyl/octadecyl-2-acetyl-sn-glyceryl-3- phosphorylcholine. | 1984 | Biochem. Pharmacol. | pmid:6324816 |
| Buxton DB et al. | Stimulation of hepatic glycogenolysis by acetylglyceryl ether phosphorylcholine. | 1984 | J. Biol. Chem. | pmid:6693418 |
| Sakamoto H et al. | Stimulation of leukocyte phagocytic activity by the platelet release reaction. | 1984 | Pathology | pmid:6462776 |
| Shukla SD and Hanahan DJ | Acetylglyceryl ether phosphorylcholine (AGEPC; platelet-activating factor)-induced stimulation of rabbit platelets: correlation between phosphatidic acid level, 45Ca2+ uptake, and [3H]serotonin secretion. | 1984 | Arch. Biochem. Biophys. | pmid:6465886 |
| Doebber TW et al. | Platelet activating factor intravenous infusion in rats stimulates vascular lysosomal hydrolase secretion independent of blood neutrophils. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6517949 |
| Heinrich J and Zimmermann RE | Compound 48/80 is a potent inhibitor of human platelet aggregation antagonizing the calmodulin-dependent platelet reaction in vitro. | 1984 | Thromb. Res. | pmid:6523451 |
| Oxholm P et al. | Lack of evidence for human lymphokines with thrombocyte aggregating activity. An in vitro study. | 1984 | Allergy | pmid:6528957 |
| Hwang SB et al. | Effects of nonsteroid antiinflammatory drugs on the specific binding of platelet activating factor to membrane preparations of rabbit platelets. | 1984 | Thromb. Res. | pmid:6429890 |
| Colditz IG and Movat HZ | Kinetics of neutrophil accumulation in acute inflammatory lesions induced by chemotaxins and chemotaxinigens. | 1984 | J. Immunol. | pmid:6470487 |
| Patterson R et al. | Airway responses to sequential challenges with platelet-activating factor and leukotriene D4 in rhesus monkeys. | 1984 | J. Lab. Clin. Med. | pmid:6470563 |
| Ludwig JC et al. | Modulation of platelet-activating factor (PAF) synthesis and release from human polymorphonuclear leukocytes (PMN): role of extracellular Ca2+. | 1984 | Arch. Biochem. Biophys. | pmid:6430234 |
| Pinckard RN et al. | Molecular heterogeneity of platelet-activating factor produced by stimulated human polymorphonuclear leukocytes. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6743335 |
| Feuerstein G et al. | Effect of platelet-activating factor on coronary circulation of the domestic pig. | 1984 | Am. J. Physiol. | pmid:6703081 |
| Pipkorn U et al. | Effect of platelet activating factor on the human nasal mucosa. | 1984 | Allergy | pmid:6703263 |
| Lüthje J and Ogilvie A | Diadenosine triphosphate (Ap3A) mediates human platelet aggregation by liberation of ADP. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6704102 |
| Clare KA and Scrutton MC | The role of Ca2+ uptake in the response of human platelets to adrenaline and to 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor). | 1984 | Eur. J. Biochem. | pmid:6705791 |
| Kumar R et al. | A facile route to semi-synthesis of acetyl glycerylether phosphoethanolamine and its choline analogue. | 1984 | J. Lipid Res. | pmid:6707528 |
| Archer CB et al. | Synergistic interaction between prostaglandins and PAF-acether in experimental animals and man. | 1984 | Prostaglandins | pmid:6203139 |
| Camussi G et al. | Platelet-activating factor-induced loss of glomerular anionic charges. | 1984 | Kidney Int. | pmid:6374251 |
| Schlondorff D et al. | Effect of platelet-activating factor and serum-treated zymosan on prostaglandin E2 synthesis, arachidonic acid release, and contraction of cultured rat mesangial cells. | 1984 | J. Clin. Invest. | pmid:6423667 |
| Vargaftig BB et al. | [Platelet aggregation and PAF-acether. Pharmacologic interference]. | 1984 | J Pharmacol | pmid:6374298 |
| Ito S et al. | Hyperacute renal allograft rejection in the rabbit. The role of platelet-activating factor and of cationic proteins derived from polymorphonuclear leukocytes and from platelets. | 1984 | Lab. Invest. | pmid:6379289 |
| Bult H et al. | Complement derived factors and prostacyclin formation by rabbit isolated peritoneum and cultured mesothelial cells. | 1984 | Agents Actions Suppl. | pmid:6382974 |
| Hechtman HB et al. | Role of humoral mediators in adult respiratory distress syndrome. | 1984 | Chest | pmid:6383742 |
| Kelton JG et al. | The detection of a platelet-agglutinating factor in thrombotic thrombocytopenic purpura. | 1984 | Ann. Intern. Med. | pmid:6333196 |
| Bussolino F et al. | Release of platelet-activating factor (PAF)-like material from human lymphoid cell lines. | 1984 | Exp. Hematol. | pmid:6333353 |
| Mojarad M et al. | Platelet-activating factor increases pulmonary microvascular permeability and induces pulmonary edema. A preliminary report. | 1983 May-Jun | Bull Eur Physiopathol Respir | pmid:6882949 |
| Pazzi A et al. | [Platelet activation in vivo. Electron microscopy study of a case of type II diabetes]. | 1983 Mar-Apr | G Clin Med | pmid:6884636 |
| Wasserman SI | Mediators of immediate hypersensitivity. | 1983 | J. Allergy Clin. Immunol. | pmid:6193157 |
| Shukla SD et al. | Acetylglyceryl ether phosphorylcholine. A potent activator of hepatic phosphoinositide metabolism and glycogenolysis. | 1983 | J. Biol. Chem. | pmid:6309795 |
| Myers A et al. | Glucocorticoid protection against PAF-acether toxicity in mice. | 1983 | Br. J. Pharmacol. | pmid:6652344 |
| Cervoni P et al. | Aortic vascular and atrial responses to (+/-)-1-O-octadecyl-2-acetyl-glyceryl-3-phosphorylcholine. | 1983 | Br. J. Pharmacol. | pmid:6652348 |
| Chilton FH et al. | Selective acylation of lyso platelet activating factor by arachidonate in human neutrophils. | 1983 | J. Biol. Chem. | pmid:6408071 |
| Lecrubier C et al. | Study of platelet aggregation induced by platelet activating factor (PAF) after administration of ticlopidine or aspirin. | 1983 | Agents Actions | pmid:6858789 |
| Camussi G et al. | Effect of prostacyclin (PGI2) on immune-complex-induced neutropenia. | 1983 | Immunology | pmid:6339375 |
| Billah MM and Lapetina EG | Platelet-activating factor stimulates metabolism of phosphoinositides in horse platelets: possible relationship to Ca2+ mobilization during stimulation. | 1983 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6341992 |