Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Czarnetzki BM | [Mediators and the bronchial system. Pathophysiologic and biochemical aspects of mediators of the bronchial system]. | 1987 | Wien Med Wochenschr Suppl | pmid:3078398 |
Keck M et al. | Pathophysiology of burns. | 2009 | Wien Med Wochenschr | pmid:19652939 |
Chmiel B | [The influence of select pathophysiologic factors of acute pancreatitis on erythrocytes' deformability examined in vitro]. | 2002 | Wiad. Lek. | pmid:12715347 |
Guan Z et al. | [Role of interleukin-6 and platelet-activating factor in delaying neutrophil apoptosis]. | 2000 | Wei Sheng Yan Jiu | pmid:12725051 |
Robeva R et al. | [Changes in blood coagulation in glomerulonephritis]. | 1982 | Vutr Boles | pmid:6219496 |
Denizot Y and Nathan N | Platelet-activating factor in operative salvaged blood. | 1994 | Vox Sang. | pmid:7801619 |
Silliman CC et al. | Stored blood components contain agents that prime the neutrophil NADPH oxidase through the platelet-activating-factor receptor. | 1992 | Vox Sang. | pmid:1332255 |
Sieunarine K et al. | Plasma levels of the lipid mediators, leukotriene B4 and lyso platelet-activating factor, in intraoperative salvaged blood. | 1992 | Vox Sang. | pmid:1333134 |
DaÄkhin EI et al. | [Clinical significance of studies of platelet activating factor (review of the literature)]. | 1989 Mar-Apr | Vopr. Med. Khim. | pmid:2662595 |
Shebzukhov IuV and Mysiakin EB | [Platelet activating factor--role in regulating the functional activity of the mononuclear phagocyte system]. | 1996 Oct-Dec | Vopr. Med. Khim. | pmid:9254510 |
Muzia GI et al. | [Inhibition of formation of superoxide radicals in leukocytes of hypercholesteremic patients under the effect of a lipid platelet activation factor antagonist]. | 1995 Jul-Aug | Vopr. Med. Khim. | pmid:8571587 |
Bastos da Silva MB et al. | The effect of intravenous administration of WEB 2086 on PAF-induced platelet aggregation in healthy Friesian calves. | 1997 | Vet. Res. Commun. | pmid:9345719 |
da Silva MB et al. | Protective effects of WEB 2086 (PAF antagonist) and ketoprofen (NSAID) on PAF-induced changes in the morphological ultrastructure of blood platelets in calves. | 1998 | Vet. Res. Commun. | pmid:9686442 |
Dawson J et al. | Platelet activating factor as a mediator of equine cell locomotion. | 1988 | Vet. Res. Commun. | pmid:3188378 |
Venugopalan CS et al. | Responses of guinea-pig lung parenchymal strips to tracheobronchial lavage fluid from horses affected with summer pasture-associated obstructive pulmonary disease. | 1998 | Vet. Res. Commun. | pmid:9868763 |
Bastos da Silva M et al. | Morphological alterations of blood platelets induced by platelet activating factor (PAF) and partial inhibition by ketoprofen in calves. | 1997 Sep-Oct | Vet. Res. | pmid:9342825 |
Lallès JP et al. | Small intestinal motility disorders in preruminant calves chronically fed a diet based on antigenic soya: characterization and possible mediators. | 1998 Jan-Feb | Vet. Res. | pmid:9559521 |
Bastos da Silva M et al. | In vitro inhibitory effect of SR 27417, a potent platelet-activating factor (PAF) receptor antagonist, on the PAF-induced bovine platelet aggregation. | 2000 Mar-Apr | Vet. Res. | pmid:10779205 |
Diez-Fraile A et al. | Analysis of selective mobilization of L-selectin and Mac-1 reservoirs in bovine neutrophils and eosinophils. | 2003 Jan-Feb | Vet. Res. | pmid:12588684 |
Van de Weerdt ML et al. | Effect of platelet-activating factor on bovine pulmonary function. | 1997 | Vet. Rec. | pmid:9290195 |
Slauson DO and Sanchez-Vizcaino JM | Leukocyte-dependent platelet vasoactive amine release and immune complex deposition in African swine fever. | 1981 | Vet. Pathol. | pmid:6170156 |
Wimberly HC et al. | Functional and biochemical characterization of immunologically derived equine platelet-activating factor. | 1985 | Vet. Pathol. | pmid:4035942 |
Van de Weerdt ML et al. | Ketoprofen and phenylbutazone attenuation of PAF-induced lung inflammation in calves. | 1999 | Vet. J. | pmid:10030127 |
Michelotto PV et al. | Pulmonary inflammation due to exercise-induced pulmonary haemorrhage in Thoroughbred colts during race training. | 2011 | Vet. J. | pmid:22108190 |
da Silva MB et al. | Effect of ketoprofen on PAF-induced bovine platelet aggregation. | 1998 | Vet. J. | pmid:9564275 |
Alarcón P et al. | D-lactic acid interferes with the effects of platelet activating factor on bovine neutrophils. | 2011 | Vet. Immunol. Immunopathol. | pmid:21816488 |
Carretta MD et al. | Butyric acid stimulates bovine neutrophil functions and potentiates the effect of platelet activating factor. | 2016 | Vet. Immunol. Immunopathol. | pmid:27288853 |
Waller KP | Modulation of endotoxin-induced inflammation in the bovine teat using antagonists/inhibitors to leukotrienes, platelet activating factor and interleukin 1 beta. | 1997 | Vet. Immunol. Immunopathol. | pmid:9261962 |
Conejeros I et al. | 2-Aminoethoxydiphenyl borate (2-APB) reduces alkaline phosphatase release, CD63 expression, F-actin polymerization and chemotaxis without affecting the phagocytosis activity in bovine neutrophils. | 2012 | Vet. Immunol. Immunopathol. | pmid:22226550 |
Cook VL et al. | The effect of lidocaine on in vitro adhesion and migration of equine neutrophils. | 2009 | Vet. Immunol. Immunopathol. | pmid:19136156 |
Aktan I et al. | PKC isoenzymes in equine platelets and stimulus induced activation. | 2011 | Vet. Immunol. Immunopathol. | pmid:21513989 |
Topper EK et al. | Induction of tissue eosinophilia by platelet-activating factor in Merino sheep. | 1992 | Vet. Immunol. Immunopathol. | pmid:1604802 |
Foster AP et al. | Platelet activating factor mimics antigen-induced cutaneous inflammatory responses in sweet itch horses. | 1995 | Vet. Immunol. Immunopathol. | pmid:7747395 |
Brooks AC et al. | CXCL8 attenuates chemoattractant-induced equine neutrophil migration. | 2011 | Vet. Immunol. Immunopathol. | pmid:21040981 |
Corl CM et al. | Lipoxygenase metabolites modulate vascular-derived platelet activating factor production following endotoxin challenge. | 2010 | Vet. Immunol. Immunopathol. | pmid:20359754 |
Strøm H and Thomsen MK | Effects of proinflammatory mediators on canine neutrophil chemotaxis and aggregation. | 1990 | Vet. Immunol. Immunopathol. | pmid:2396362 |
Larrazabal CS et al. | Amiloride interferes with platelet- activating factor-induced respiratory burst and MMP-9 release in bovine neutrophils independent of Na/H exchanger 1. | 2017 | Vet. Immunol. Immunopathol. | pmid:28895869 |
Marr KA et al. | Agonist-induced adherence of equine neutrophils to fibronectin- and serum-coated plastic is CD18 dependent. | 1999 | Vet. Immunol. Immunopathol. | pmid:10532398 |
Leid RW and Potter KA | Inflammation and mediators of lung injury. | 1985 | Vet. Clin. North Am. Food Anim. Pract. | pmid:3907779 |
Moore RM et al. | Effect of platelet-activating factor antagonist L-691,880 on low-flow ischemia-reperfusion injury of the large colon in horses. | 1998 Jan-Feb | Vet Surg | pmid:9449176 |
Kulikov VI and Muzia GI | [Phospholipid thrombocyte activating factor, its analogs and antagonists: prospects of their use in medicine]. | 1991 | Vestn. Akad. Med. Nauk SSSR | pmid:1801455 |
Fedorov NA | [Physiological variants of functional and biochemical indicators of thrombocytes]. | 1991 | Vestn. Akad. Med. Nauk SSSR | pmid:1801458 |
Kaminskaia GO and Aladysheva ZhI | [Platelet activating factor and pulmonary tuberculosis]. | 1995 | Vestn. Akad. Med. Nauk SSSR | pmid:7670343 |
Strukova SM et al. | [Regulation of thrombocyte stimulating and other activities of thrombin by modulators of the recognition site]. | 1991 | Vestn. Akad. Med. Nauk SSSR | pmid:1724858 |
Shabanov VV | [Cytokines and other signal molecules in the pathogenesis of acute pancreatitis]. | 2003 | Vestn. Akad. Med. Nauk SSSR | pmid:14598737 |
Hemker HC and Béguin S | The generation of thrombin in whole plasma. Biochemical possibilities and physiological realities. | 1985 | Verh. K. Acad. Geneeskd. Belg. | pmid:4090648 |
Kim YH et al. | SIRT1 attenuates PAF-induced MMP-2 production via down-regulation of PAF receptor expression in vascular smooth muscle cells. | 2015 | Vascul. Pharmacol. | pmid:25967595 |
Marathe GK et al. | Activation of vascular cells by PAF-like lipids in oxidized LDL. | 2002 | Vascul. Pharmacol. | pmid:12449015 |
Rastogi P et al. | Urothelial cell platelet-activating factor production mediated by calcium-independent phospholipase A2γ. | 2011 | Urology | pmid:21094990 |
Baka S et al. | Treatment of sperm with platelet-activating factor does not improve intrauterine insemination outcome in unselected cases of mild male factor infertility: a prospective double-blind randomized crossover study. | 2009 | Urology | pmid:19716589 |