Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Wykle RL et al. | Platelet activating factor (1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine). Activity of analogs lacking oxygen at the 2-position. | 1982 | FEBS Lett. | pmid:7084476 |
Sánchez-Crespo M et al. | Vascular actions of synthetic PAF-acether (a synthetic platelet-activating factor) in the rat: evidence for a platelet independent mechanism. | 1982 | Immunopharmacology | pmid:7085259 |
Mueller HW et al. | Ether lipid content and fatty acid distribution in rabbit polymorphonuclear neutrophil phospholipids. | 1982 | Lipids | pmid:7087685 |
Page CP et al. | Platelet activation in asthma. | 1982 | N. Engl. J. Med. | pmid:7088080 |
Vargaftig BB et al. | Degranulation of rabbit platelets with PAF-acether: a new procedure for unravelling the mode of action of platelet-activating substances. | 1982 | Thromb. Haemost. | pmid:7135345 |
Sancho J et al. | The effect of the injection of a synthetic platelet-activating factor (PAF-acether) on the fate of IgG aggregates in mice. | 1982 | Immunology | pmid:7141463 |
Lüscher EF | The role of blood cells and of the vessel wall in the induction of intravascular coagulation. | 1982 | Klin. Wochenschr. | pmid:6750223 |
Shaw JO and Lyons RM | Requirements for different Ca2+ pools in the activation of rabbit platelets. I. release reaction and protein phosphorylation. | 1982 | Biochim. Biophys. Acta | pmid:6800409 |
Aderka D et al. | Morphological platelet anomalies in thrombotic thrombocytopenic purpura. | 1982 | Acta Haematol. | pmid:6801893 |
Hartung HP et al. | Stimulation of the oxidative burst in macrophages with platelet activating factor (PAF-acether). | 1982 | Agents Actions Suppl. | pmid:6960648 |