Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Shen ZQ et al. | Effect of protopine on cytosolic Ca2+ in rabbit platelets. | 1999 | Zhongguo Yao Li Xue Bao | pmid:10452120 |
Li SH et al. | Effects of platelet-activating factor on rat mesenteric microcirculation. | 1990 | Zhongguo Yao Li Xue Bao | pmid:2104488 |
Zeng GQ and Rui YC | [Inhibitory effect of dauricine on platelet activating factor released from calcimycin-induced mouse peritoneal macrophages]. | 1990 | Zhongguo Yao Li Xue Bao | pmid:2104489 |
Fu Y and Hu YM | Prophylactic effects of tetramethyl pyrazine on mice with endotoxemia and its relationship with platelet-activating factor. | 1999 | Zhongguo Yao Li Xue Bao | pmid:10678147 |
Li SH et al. | Pentoxifylline attenuates platelet activating factor-induced permeable edema in isolated perfused guinea pig lungs. | 1994 | Zhongguo Yao Li Xue Bao | pmid:7976374 |
Zhang M et al. | Effects of tetrandrine on rabbit platelet aggregation and platelet activating factor generation. | 1995 | Zhongguo Yao Li Xue Bao | pmid:7660812 |
Ju DW et al. | Inhibitory effects of triazolodiazepine on mouse splenocytes and peritoneal macrophages in vitro. | 1994 | Zhongguo Yao Li Xue Bao | pmid:8010089 |
Hong JL et al. | [Effects of tetrandrine on cytoplasmic free calcium in rat neutrophils]. | 1989 | Zhongguo Yao Li Xue Bao | pmid:2561935 |
Zeng S and Guo ZG | Mepyramine inhibits platelet activating factor-induced rabbit platelet aggregation: role of intracellular histamine. | 1997 | Zhongguo Yao Li Xue Bao | pmid:10072970 |
Zeng GQ et al. | Dauricine and anisodamine inhibited leukotrienes- and platelet activating factor-induced DNA synthesis and proliferation of bovine cerebral microvascular smooth muscle cells in culture. | 1993 | Zhongguo Yao Li Xue Bao | pmid:8249627 |