Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
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What lipids are associated with Platelet activating factor?
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mencia-Huerta JM | Possible role of the T-cell-factor-dependent mast cell subclass in the generation of leukotrienes from lung. | 1985 Sep-Oct | Ann. Inst. Pasteur Immunol. | pmid:3878684 |
| Ozaki Y et al. | A comparative study on the effects of inhibitors of the lipoxygenase pathway on neutrophil function. Inhibitory effects on neutrophil function may not be attributed to inhibition of the lipoxygenase pathway. | 1986 | Biochem. Pharmacol. | pmid:3021173 |
| Okamoto M et al. | FR-900452, a specific antagonist of platelet activating factor (PAF) produced by Streptomyces phaeofaciens. I. Taxonomy, fermentation, isolation, and physico-chemical and biological characteristics. | 1986 | J. Antibiot. | pmid:3082838 |
| Huang C et al. | Polymorphic phase behavior of platelet-activating factor. | 1986 | Biophys. J. | pmid:3697472 |
| Lad PM et al. | A step sensitive to pertussis toxin and phorbol ester in human neutrophils regulates chemotaxis and capping but not phagocytosis. | 1986 | FEBS Lett. | pmid:3699167 |
| Viero P et al. | Defective platelet aggregation induced by platelet activating factor in myeloproliferative disorders: deficiency of an aspirin-independent mechanism? | 1986 | Haemostasis | pmid:3699584 |
| Wallace JL and Whittle BJ | Picomole doses of platelet-activating factor predispose the gastric mucosa to damage by topical irritants. | 1986 | Prostaglandins | pmid:3726156 |
| Eche N et al. | Platelet aggregating and procoagulant activities of cultured human breast cancer cells (FAM). | 1986 | Thromb. Res. | pmid:3726808 |
| O'Flaherty JT et al. | Metabolism of 5-hydroxyicosatetraenoate by human neutrophils: production of a novel omega-oxidized derivative. | 1986 | J. Immunol. | pmid:3095426 |
| Buxton DB et al. | Specific antagonists of platelet activating factor-mediated vasoconstriction and glycogenolysis in the perfused rat liver. | 1986 | Biochem. Pharmacol. | pmid:3754140 |
| Toyofuku T et al. | Effects of ONO-6240, a platelet-activating factor antagonist, on endotoxin shock in unanesthetized sheep. | 1986 | Prostaglandins | pmid:3754344 |
| Touvay C et al. | Inhibition of antigen-induced lung anaphylaxis in the guinea-pig by BN 52021 a new specific paf-acether receptor antagonist isolated from Ginkgo biloba. | 1986 | Agents Actions | pmid:3754380 |
| Sugatani J and Hanahan DJ | Characterization of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (AGEPC)-induced protein phosphorylation in rabbit platelets: inhibitory effects of AGEPC analogs. | 1986 | Arch. Biochem. Biophys. | pmid:3754710 |
| Hsueh W et al. | Platelet activating factor-induced ischemic bowel necrosis: the effect of PAF antagonists. | 1986 | Eur. J. Pharmacol. | pmid:3754817 |
| Roubin R et al. | Biosynthesis of paf-acether: VIII: Impairment of paf-acether production in activated macrophages does not depend upon acetyltransferase activity. | 1986 | J. Immunol. | pmid:3950403 |
| Adnot S et al. | Interference of the PAF-acether antagonist BN 52021 with endotoxin-induced hypotension in the guinea-pig. | 1986 | Prostaglandins | pmid:3562865 |
| Piéroni G and Hanahan DJ | Effect of acetylglyceryl ether phosphocholine (platelet-activating factor) and thrombin on acylation of exogenous lysophosphoglycerides in rabbit platelets. | 1986 | Biochim. Biophys. Acta | pmid:3719000 |
| Porcellini G | [Platelet-activating factor: a new biochemical and pharmacologic frontier]. | 1986 | Clin Ter | pmid:3720244 |
| Wallace JL and Whittle BJ | Prevention of endotoxin-induced gastrointestinal damage by CV-3988, an antagonist of platelet-activating factor. | 1986 | Eur. J. Pharmacol. | pmid:3720841 |
| Oh-ishi S et al. | Suppression of phorbol myristate acetate-induced pleurisy by CV-3988, an antagonist of platelet-activating factor. | 1986 | Chem. Pharm. Bull. | pmid:3829203 |
| D'Humières S et al. | PAF-acether-induced synthesis of prostacyclin by human endothelial cells. | 1986 | Eur. J. Pharmacol. | pmid:3102256 |
| Chung KF et al. | Airway hyperresponsiveness induced by platelet-activating factor: role of thromboxane generation. | 1986 | J. Pharmacol. Exp. Ther. | pmid:3005546 |
| Flower RJ | Background and discovery of lipocortins. | 1986 | Agents Actions | pmid:2938452 |
| Ramesha CS and Pickett WC | Measurement of sub-picogram quantities of platelet activating factor (AGEPC) by gas chromatography/negative ion chemical ionization mass spectrometry. | 1986 | Biomed. Environ. Mass Spectrom. | pmid:2938649 |
| Resink TJ et al. | The influence of activating hormones on human platelet membrane Ca2+-ATPase activity. | 1986 | Biochem. Biophys. Res. Commun. | pmid:2943273 |
| Bourgain RH et al. | Thrombus induction by endogenic paf-acether and its inhibition by Ginkgo Biloba extracts in the guinea pig. | 1986 | Prostaglandins | pmid:3763943 |
| Guinot P et al. | Inhibition of PAF-acether induced weal and flare reaction in man by a specific PAF antagonist. | 1986 | Prostaglandins | pmid:3763944 |
| Scherf H et al. | Hemodynamic effects of platelet activating factor in the dog kidney in vivo. | 1986 | Hypertension | pmid:3744467 |
| Hsueh W et al. | Platelet-activating factor-induced ischemic bowel necrosis. An investigation of secondary mediators in its pathogenesis. | 1986 | Am. J. Pathol. | pmid:3080895 |
| Darius H et al. | Role of platelet-activating factor-acether in mediating guinea pig anaphylaxis. | 1986 | Science | pmid:3082008 |
| Söling HD and Fest W | Synthesis of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor) in exocrine glands and its control by secretagogues. | 1986 | J. Biol. Chem. | pmid:3095313 |
| Kohayakawa M and Inoue K | Augmentation of 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine (PAF)-induced human platelet activation by C-reactive protein. | 1986 | Thromb. Res. | pmid:3083530 |
| Ostermann G et al. | The role of lipoproteins in the degradation of platelet-activating factor. | 1986 | Thromb. Res. | pmid:3798402 |
| Morley J et al. | Effects of ketotifen upon responses to platelet activating factor: a basis for asthma prophylaxis. | 1986 | Ann Allergy | pmid:3083731 |
| Montrucchio G et al. | Intravascular release of platelet-activating factor during atrial pacing. | 1986 | Lancet | pmid:2874319 |
| Hackenthal E and Taugner R | Hormonal signals and intracellular messengers for renin secretion. | 1986 | Mol. Cell. Endocrinol. | pmid:2875004 |
| Swingle KF and Reiter MJ | Inhibition of Paf-acether-induced edema of the rat's paw. | 1986 | Agents Actions | pmid:2875631 |
| Ghezzi E | Autacoids and some mediators in allergic and non allergic forms. | 1986 | Boll Ist Sieroter Milan | pmid:2877678 |
| Homburger HA | Diagnosis of allergy: in vitro testing. | 1986 | Crit Rev Clin Lab Sci | pmid:2426037 |
| Pécoud A and Frei PC | [Developmental trends in allergologic-immunologic research]. | 1986 | Internist (Berl) | pmid:2427469 |
| Raphael GD and Metcalfe DD | Mediators of airway inflammation. | 1986 | Eur J Respir Dis Suppl | pmid:2429857 |
| Kawaguchi H and Yasuda H | Effect of platelet-activating factor on arachidonic acid metabolism in renal epithelial cells. | 1986 | Biochim. Biophys. Acta | pmid:3081036 |
| Kawaguchi H and Yasuda H | Platelet-activating factor stimulates prostaglandin synthesis in cultured cells. | 1986 | Hypertension | pmid:3081442 |
| Godfroid JJ et al. | Synthesis of ether phospholipids. | 1986 | Pharmacol Res Commun | pmid:3774838 |
| PAF and leukotrienes '85. Proceedings of the meeting. Paris, September 27th 1985. | 1986 | Pharmacol Res Commun | pmid:3774839 | |
| Kester M et al. | Alkylacetylglycerophosphocholine stimulates Na+-Ca2+ exchange, protein phosphorylation and polyphosphoinositide turnover in rat ileal plasmalemmal vesicles. | 1986 | Biochim. Biophys. Acta | pmid:3019423 |
| Vilain B et al. | Pharmacological control of the in vivo passive anaphylactic shock by the PAF-acether antagonist compound BN 52021. | 1986 | Pharmacol Res Commun | pmid:3774840 |
| Bessin P | PAF-acether and leukotriene participation in acute circulatory shock. | 1986 | Pharmacol Res Commun | pmid:3774841 |
| Goldstein RE et al. | Coronary and pulmonary vascular effects of leukotrienes and PAF-acether. | 1986 | Pharmacol Res Commun | pmid:3774842 |
| Zimmerman GA et al. | Thrombin stimulates neutrophil adherence by an endothelial cell-dependent mechanism: characterization of the response and relationship to platelet-activating factor synthesis. | 1986 | Ann. N. Y. Acad. Sci. | pmid:3471149 |