Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Pelvic Pain D017699 7 associated lipids
Carcinoma, Embryonal D018236 8 associated lipids
Respiratory Syncytial Virus Infections D018357 10 associated lipids
Leukocyte-Adhesion Deficiency Syndrome D018370 1 associated lipids
Pneumonia, Bacterial D018410 16 associated lipids
Encephalitis, Viral D018792 3 associated lipids
Leukostasis D018921 1 associated lipids
Postoperative Hemorrhage D019106 7 associated lipids
Pancreatitis, Acute Necrotizing D019283 18 associated lipids
Endotoxemia D019446 27 associated lipids
Capillary Leak Syndrome D019559 2 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Hepatitis B, Chronic D019694 4 associated lipids
Hepatitis C, Chronic D019698 12 associated lipids
Thrombophilia D019851 6 associated lipids
Brain Hemorrhage, Traumatic D020201 1 associated lipids
Optic Nerve Injuries D020221 4 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Venous Thrombosis D020246 11 associated lipids
Ventricular Remodeling D020257 28 associated lipids
Amnesia, Anterograde D020324 2 associated lipids
Migraine without Aura D020326 1 associated lipids
Enterocolitis, Necrotizing D020345 3 associated lipids
Osteoarthritis, Knee D020370 13 associated lipids
Stroke D020521 32 associated lipids
Fetal Weight D020567 12 associated lipids
Hypoxia-Ischemia, Brain D020925 22 associated lipids
Egg Hypersensitivity D021181 1 associated lipids
Peanut Hypersensitivity D021183 2 associated lipids
Coronary Stenosis D023921 6 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Hyperuricemia D033461 4 associated lipids
Jaundice, Obstructive D041781 2 associated lipids
Atherosclerosis D050197 85 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
Mucositis D052016 7 associated lipids
Acute Lung Injury D055371 33 associated lipids
Acute Kidney Injury D058186 34 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Song SQ and Hu YM Effects of tetrandrine, Fura 2-AM, and Bay k 8644 on platelet-activating factor release from rat peritoneal macrophages stimulated by lipopolysaccharides. 1996 Zhongguo Yao Li Xue Bao pmid:9812743
Chen SF et al. Three drugs inhibit phospholipase A2-induced high permeability of endothelial monolayers. 1994 Zhongguo Yao Li Xue Bao pmid:7801767
Shen ZQ et al. Effect of protopine on cytosolic Ca2+ in rabbit platelets. 1999 Zhongguo Yao Li Xue Bao pmid:10452120
Zeng S et al. Platelet activating factor-induced P-selectin expression in platelets and its related signal transduction. 1999 Zhongguo Yao Li Xue Bao pmid:11270998
Li SH et al. Effects of platelet-activating factor on rat mesenteric microcirculation. 1990 Zhongguo Yao Li Xue Bao pmid:2104488
Zeng GQ and Rui YC [Inhibitory effect of dauricine on platelet activating factor released from calcimycin-induced mouse peritoneal macrophages]. 1990 Zhongguo Yao Li Xue Bao pmid:2104489
Fu Y and Hu YM Prophylactic effects of tetramethyl pyrazine on mice with endotoxemia and its relationship with platelet-activating factor. 1999 Zhongguo Yao Li Xue Bao pmid:10678147
Wang XD and Bian RL [Effects of ketotifen on rabbit platelet aggregation and platelet activating factor formation from rat neutrophils]. 1990 Zhongguo Yao Li Xue Bao pmid:2130617
Yi FX and Guo ZG Platelet-released ADP stabilizes PAF-induced rabbit platelet aggregation by stabilizing intracellular calcium. 1998 Zhongguo Yao Li Xue Bao pmid:10375790
Li SH et al. Pentoxifylline attenuates platelet activating factor-induced permeable edema in isolated perfused guinea pig lungs. 1994 Zhongguo Yao Li Xue Bao pmid:7976374
Hu JH et al. Platelet adhesion to cultured bovine cerebral microvascular endothelial cells by stimulation of platelet activating factor and antagonism of drugs. 1995 Zhongguo Yao Li Xue Bao pmid:7668100
Zhang M et al. Effects of tetrandrine on rabbit platelet aggregation and platelet activating factor generation. 1995 Zhongguo Yao Li Xue Bao pmid:7660812
Ju DW et al. Inhibitory effects of triazolodiazepine on mouse splenocytes and peritoneal macrophages in vitro. 1994 Zhongguo Yao Li Xue Bao pmid:8010089
Hong JL et al. [Effects of tetrandrine on cytoplasmic free calcium in rat neutrophils]. 1989 Zhongguo Yao Li Xue Bao pmid:2561935
Zeng S and Guo ZG Mepyramine inhibits platelet activating factor-induced rabbit platelet aggregation: role of intracellular histamine. 1997 Zhongguo Yao Li Xue Bao pmid:10072970
Zeng GQ et al. Dauricine and anisodamine inhibited leukotrienes- and platelet activating factor-induced DNA synthesis and proliferation of bovine cerebral microvascular smooth muscle cells in culture. 1993 Zhongguo Yao Li Xue Bao pmid:8249627
Zhang B and Long K Effects of glaucocalyxin A on aggregation and cAMP levels of rabbit platelets in vitro. 1993 Zhongguo Yao Li Xue Bao pmid:8249632
Sun DX et al. Platelet activating factor production in bovine cerebral microvascular endothelial cells and its drug inhibition. 1993 Zhongguo Yao Li Xue Bao pmid:8503282
Shi B et al. [Influence of intensive insulin therapy on the intestinal microcirculatory dysfunction in rats with sepsis]. 2009 Zhongguo Wei Zhong Bing Ji Jiu Yi Xue pmid:19695175
Hao J et al. [Dynamic changes of platelet number in early multiple injury and it is effect on prognosis]. 2003 Zhongguo Wei Zhong Bing Ji Jiu Yi Xue pmid:14552687