Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Pelvic Pain D017699 7 associated lipids
Carcinoma, Embryonal D018236 8 associated lipids
Respiratory Syncytial Virus Infections D018357 10 associated lipids
Leukocyte-Adhesion Deficiency Syndrome D018370 1 associated lipids
Pneumonia, Bacterial D018410 16 associated lipids
Encephalitis, Viral D018792 3 associated lipids
Leukostasis D018921 1 associated lipids
Postoperative Hemorrhage D019106 7 associated lipids
Pancreatitis, Acute Necrotizing D019283 18 associated lipids
Endotoxemia D019446 27 associated lipids
Capillary Leak Syndrome D019559 2 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Hepatitis B, Chronic D019694 4 associated lipids
Hepatitis C, Chronic D019698 12 associated lipids
Thrombophilia D019851 6 associated lipids
Brain Hemorrhage, Traumatic D020201 1 associated lipids
Optic Nerve Injuries D020221 4 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Venous Thrombosis D020246 11 associated lipids
Ventricular Remodeling D020257 28 associated lipids
Amnesia, Anterograde D020324 2 associated lipids
Migraine without Aura D020326 1 associated lipids
Enterocolitis, Necrotizing D020345 3 associated lipids
Osteoarthritis, Knee D020370 13 associated lipids
Stroke D020521 32 associated lipids
Fetal Weight D020567 12 associated lipids
Hypoxia-Ischemia, Brain D020925 22 associated lipids
Egg Hypersensitivity D021181 1 associated lipids
Peanut Hypersensitivity D021183 2 associated lipids
Coronary Stenosis D023921 6 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Hyperuricemia D033461 4 associated lipids
Jaundice, Obstructive D041781 2 associated lipids
Atherosclerosis D050197 85 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
Mucositis D052016 7 associated lipids
Acute Lung Injury D055371 33 associated lipids
Acute Kidney Injury D058186 34 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Straube W [Early embryonal signals]. 1989 Zentralbl Gynakol pmid:2665388
Straube W [Which signals of early pregnancy are known currently, what cer- tainty have they and exactly how far are they applicable in practice?]. 1989 Zentralbl Gynakol pmid:2655355
Marzi I et al. [Involvement of platelet activating factors in pathologic leukocyte-endothelium interactions in the liver after hemorrhagic shock]. 1994 Zentralbl Chir pmid:7846961
Uhlmann D et al. Importance of microcirculatory disturbances in the pathogenesis of pancreatitis. 2001 Zentralbl Chir pmid:11753796
Becker BF et al. [Interaction of adenosine with leukocytes and thrombocytes]. 1996 Z Kardiol pmid:9064961
Krämer K et al. Studies on the metabolism of metallothionein and alkaline phosphatase of adult rat primary hepatocyte cultures: role of fetal calf serum and agonists of the phosphoinositide cascade. 1993 Z Ernahrungswiss pmid:8237077
Li SH et al. Effects of platelet-activating factor antagonist SRI 63-441 on endotoxin-induced changes in rat mesenteric microcirculation. 1991 Yao Xue Xue Bao pmid:1887797
Han GQ et al. [The isolation and identification of PAF inhibitors from Piper wallichii (Miq.) Hand-Mazz and P. hancei Maxim]. 1989 Yao Xue Xue Bao pmid:2609983
Han GQ et al. [Neolignans from Piper hancei Maxim]. 1986 Yao Xue Xue Bao pmid:3776545
Ju DW et al. [Leflunomide inhibits PAF induced DNA synthesis in rabbit synovial cells and PAF production from rat peritoneal macrophages]. 1994 Yao Xue Xue Bao pmid:8042517
Hu JH et al. [Effects of calcimycin on platelet adhesion to cultured bovine cerebral microvascular endothelial cells and its antagonism by drugs]. 1994 Yao Xue Xue Bao pmid:7976350
Ma Y et al. [PAF antagonistic benzofuran neolignans from Piper kadsura]. 1993 Yao Xue Xue Bao pmid:8237383
Ju DW et al. Effect of platelet activating factor antagonist WEB 2086 on the production of TNF from murine peritoneal macrophages. 1993 Yao Xue Xue Bao pmid:8009983
Zeng GQ et al. Effects of dauricine and tetrandrine on [3H] WEB 2086 specific binding to bovine anterior cerebral arterial smooth muscle cells in vitro. 1993 Yao Xue Xue Bao pmid:8285049
Ma Y et al. [Studies on PAF antagonistic bicyclo(3,2,1) octanoid neolignans from Piper kadsura]. 1993 Yao Xue Xue Bao pmid:8368081
Nie ZG and Wang WJ [Effect of ginkgolide B on platelet-activating factor induced activation of rat polymorphonuclear leukocytes]. 2003 Yao Xue Xue Bao pmid:12778742
Zhang LL et al. [Protective effect of rupatadine against oleic acid-induced acute lung injury in rabbits]. 2007 Yao Xue Xue Bao pmid:17520822
Nie ZG et al. [Effects of ginkgolide B on lipopolysaccharide-induced TNFalpha production in mouse peritoneal macrophages and NF-kappaB activation in rat pleural polymorphonuclear leukocytes]. 2004 Yao Xue Xue Bao pmid:15491096
Ou-Yang XY et al. [Inhibitory effect of ginkgolide B on angiogenesis in chronic inflammation]. 2005 Yao Xue Xue Bao pmid:16011257
Mao YJ et al. [Effect of ginkgolide B on the function of rat aorta smooth cells and U937 cells stimulated by oxLDL]. 2006 Yao Xue Xue Bao pmid:16683525