Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kattan JD and Sicherer SH | Optimizing the diagnosis of food allergy. | 2015 | Immunol Allergy Clin North Am | pmid:25459577 |
| Zelanis A et al. | Snake venom serine proteinases specificity mapping by proteomic identification of cleavage sites. | 2015 | J Proteomics | pmid:25452133 |
| Larkin EK et al. | New risk factors for adult-onset incident asthma. A nested case-control study of host antioxidant defense. | 2015 | Am. J. Respir. Crit. Care Med. | pmid:25408961 |
| Kooijman S et al. | Hematopoietic α7 nicotinic acetylcholine receptor deficiency increases inflammation and platelet activation status, but does not aggravate atherosclerosis. | 2015 | J. Thromb. Haemost. | pmid:25345495 |
| Detopoulou P et al. | The relation of diet with PAF and its metabolic enzymes in healthy volunteers. | 2015 | Eur J Nutr | pmid:24639073 |
| Damiani E et al. | Platelet-Activating Factor Induces Epigenetic Modifications in Human Mast Cells. | 2015 | J. Invest. Dermatol. | pmid:26316070 |
| Starossom SC et al. | Platelets Play Differential Role During the Initiation and Progression of Autoimmune Neuroinflammation. | 2015 | Circ. Res. | pmid:26294656 |
| Morita K et al. | [Pain relieving effect of platelet-activating factor (PAF) antagonists in a bone cancer pain model]. | 2015 | Nippon Yakurigaku Zasshi | pmid:26256746 |
| Plotkowski MC et al. | Contribution of the platelet activating factor signaling pathway to cerebral microcirculatory dysfunction during experimental sepsis by ExoU producing Pseudomonas aeruginosa. | 2015 | Pathog Dis | pmid:26187894 |
| Sato A et al. | Biotinylated heptapeptides substituted with a D-amino acid as platelet-activating factor inhibitors. | 2015 | Eur. J. Pharmacol. | pmid:26142829 |
| Sala-Cunill A and Cardona V | Biomarkers of anaphylaxis, beyond tryptase. | 2015 | Curr Opin Allergy Clin Immunol | pmid:26110683 |
| Gao L et al. | Steroid receptor coactivators 1 and 2 mediate fetal-to-maternal signaling that initiates parturition. | 2015 | J. Clin. Invest. | pmid:26098214 |
| Jiao D et al. | Macrophages are the dominant effector cells responsible for IgG-mediated passive systemic anaphylaxis challenged by natural protein antigen in BALB/c and C57BL/6 mice. | 2014 May-Jun | Cell. Immunol. | pmid:24751884 |
| Yamauchi A et al. | Systematic single cell analysis of migration and morphological changes of human neutrophils over stimulus concentration gradients. | 2014 | J. Immunol. Methods | pmid:24370750 |
| Sahu RP et al. | Chemotherapeutic agents subvert tumor immunity by generating agonists of platelet-activating factor. | 2014 | Cancer Res. | pmid:25304264 |
| Yu Y et al. | Transactivation of epidermal growth factor receptor through platelet-activating factor/receptor in ovarian cancer cells. | 2014 | J. Exp. Clin. Cancer Res. | pmid:25261977 |
| Agrawal V et al. | Platelet-activating factor: a role in preterm delivery and an essential interaction with Toll-like receptor signaling in mice. | 2014 | Biol. Reprod. | pmid:25253732 |
| Moschos MM et al. | In vitro effects of vitamin supplements on platelet-activating factor and its metabolism in age-related macular degeneration. | 2014 | Cutan Ocul Toxicol | pmid:24147947 |
| Chacón-Salinas R et al. | An essential role for platelet-activating factor in activating mast cell migration following ultraviolet irradiation. | 2014 | J. Leukoc. Biol. | pmid:24009177 |
| Semini G et al. | Glycosidated phospholipids - a promising group of anti-tumour lipids. | 2014 | Anticancer Agents Med Chem | pmid:24628240 |