Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Foegh ML et al. | Prolongation of cardiac allograft survival with BN 52021, a specific antagonist of platelet-activating factor. | 1986 | Transplantation | pmid:3523888 |
Freiche JC et al. | Prolonged survival of renal transplants in nonimmunized and hyperimmunized rats receiving a platelet-activating factor antagonist. | 1990 | Transplantation | pmid:2368154 |
Lanese DM et al. | Sequential agonist activation and site-specific mediation of acute cyclosporine constriction in rat renal arterioles. | 1994 | Transplantation | pmid:7809931 |
Makowka L et al. | Platelet-activating factor and hyperacute rejection. The effect of a platelet-activating factor antagonist, SRI 63-441, on rejection of xenografts and allografts in sensitized hosts. | 1990 | Transplantation | pmid:2402783 |
Biancone L et al. | Platelet-activating factor synthesis and response on pancreatic islet endothelial cells: relevance for islet transplantation. | 2006 | Transplantation | pmid:16495796 |
Gu M et al. | Pharmacologic graft protection without donor pretreatment in liver transplantation from non-heart-beating donors. | 2000 | Transplantation | pmid:11045637 |
Saumweber DM et al. | Hyperacute rejection in an ex vivo model of renal xenografting. Role of the mediator response and its pharmacologic manipulation by the specific platelet-activating factor antagonist WEB 2086BS. | 1994 | Transplantation | pmid:8108870 |
Yin M et al. | The PAF antagonist TCV-309 reduces graft PMN infiltration and enhances early function of 24-hour-preserved rat kidneys with long warm ischemia. | 1996 | Transplantation | pmid:8633367 |
Conte JV et al. | Long-term lung preservation with the PAF antagonist BN 52021. | 1991 | Transplantation | pmid:2048190 |
Watson CJ et al. | The platelet-activating factor antagonist WEB 2170. Its beneficial effect on dog renal allograft survival. | 1993 | Transplantation | pmid:8212192 |
Suzuki S et al. | The roles of platelet-activating factor and endothelin-1 in renal damage after total hepatic ischemia and reperfusion. | 2000 | Transplantation | pmid:10868624 |
Marathe GK et al. | Oxidized LDL contains inflammatory PAF-like phospholipids. | 2001 Apr-May | Trends Cardiovasc. Med. | pmid:11686003 |
Zimmerman GA and McIntyre TM | PAF, ceramide and pulmonary edema: alveolar flooding and a flood of questions. | 2004 | Trends Mol Med | pmid:15177186 |
Braquet P et al. | Is there a case for PAF antagonists in the treatment of ischemic states? | 1989 | Trends Pharmacol. Sci. | pmid:2688213 |
Izzo AA et al. | Recent findings on the mode of action of laxatives: the role of platelet activating factor and nitric oxide. | 1998 | Trends Pharmacol. Sci. | pmid:9803830 |
Page C and Abbott A | PAF: new antagonists, new roles in disease and a major role in reproductive biology. | 1989 | Trends Pharmacol. Sci. | pmid:2672467 |
GarcÃa-Sáinz JA | Intercellular communication within the liver has clinical implications. | 1989 | Trends Pharmacol. Sci. | pmid:2595791 |
O'Neill C | A physiological role for PAF in the stimulation of mammalian embryonic development. | 1991 | Trends Pharmacol. Sci. | pmid:2053190 |
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Harputluoglu MM et al. | The effects of Gingko biloba extract on acetic acid-induced colitis in rats. | 2006 | Turk J Gastroenterol | pmid:16941250 |
Kabasakal C et al. | The role of PAF and leukotrienes in bioincompatibility of cuprophane membranes in hemodialysis. | 1998 Jul-Sep | Turk. J. Pediatr. | pmid:9763906 |
Hansen JF and Hansen BF | [Unstable angina pectoris, acute myocardial infarct, sudden heart death. Patho-anatomy and pathophysiology]. | 1987 | Ugeskr. Laeg. | pmid:3324429 |
Vavilova GL et al. | [The role of the thrombocyte-activating factor in inhibiting Na+,K(+)-ATPase in different tissues after ischemia and reperfusion of the small intestine]. | 1996 Mar-Apr | Ukr. Biokhim. Zh. | pmid:9005660 |
Yildirim G et al. | Effects of platelet-activating factor and hyperbaric oxygenation on antioxidant defense and duodenal contractility. | 2000 | Undersea Hyperb Med | pmid:11191161 |
Mehta A and Sigman M | Identification and preparation of sperm for ART. | 2014 | Urol. Clin. North Am. | pmid:24286775 |
Imagawa M et al. | Modulation of platelet-activating factor synthesis by recombinant interferon-alpha in human renal cell carcinoma. | 1996 | Urol. Int. | pmid:8840484 |
Rastogi P et al. | Urothelial cell platelet-activating factor production mediated by calcium-independent phospholipase A2γ. | 2011 | Urology | pmid:21094990 |
Baka S et al. | Treatment of sperm with platelet-activating factor does not improve intrauterine insemination outcome in unselected cases of mild male factor infertility: a prospective double-blind randomized crossover study. | 2009 | Urology | pmid:19716589 |
Kim YH et al. | SIRT1 attenuates PAF-induced MMP-2 production via down-regulation of PAF receptor expression in vascular smooth muscle cells. | 2015 | Vascul. Pharmacol. | pmid:25967595 |
Marathe GK et al. | Activation of vascular cells by PAF-like lipids in oxidized LDL. | 2002 | Vascul. Pharmacol. | pmid:12449015 |
Hemker HC and Béguin S | The generation of thrombin in whole plasma. Biochemical possibilities and physiological realities. | 1985 | Verh. K. Acad. Geneeskd. Belg. | pmid:4090648 |
Kulikov VI and Muzia GI | [Phospholipid thrombocyte activating factor, its analogs and antagonists: prospects of their use in medicine]. | 1991 | Vestn. Akad. Med. Nauk SSSR | pmid:1801455 |
Fedorov NA | [Physiological variants of functional and biochemical indicators of thrombocytes]. | 1991 | Vestn. Akad. Med. Nauk SSSR | pmid:1801458 |
Kaminskaia GO and Aladysheva ZhI | [Platelet activating factor and pulmonary tuberculosis]. | 1995 | Vestn. Akad. Med. Nauk SSSR | pmid:7670343 |
Strukova SM et al. | [Regulation of thrombocyte stimulating and other activities of thrombin by modulators of the recognition site]. | 1991 | Vestn. Akad. Med. Nauk SSSR | pmid:1724858 |
Shabanov VV | [Cytokines and other signal molecules in the pathogenesis of acute pancreatitis]. | 2003 | Vestn. Akad. Med. Nauk SSSR | pmid:14598737 |
Moore RM et al. | Effect of platelet-activating factor antagonist L-691,880 on low-flow ischemia-reperfusion injury of the large colon in horses. | 1998 Jan-Feb | Vet Surg | pmid:9449176 |
Leid RW and Potter KA | Inflammation and mediators of lung injury. | 1985 | Vet. Clin. North Am. Food Anim. Pract. | pmid:3907779 |
Alarcón P et al. | D-lactic acid interferes with the effects of platelet activating factor on bovine neutrophils. | 2011 | Vet. Immunol. Immunopathol. | pmid:21816488 |
Carretta MD et al. | Butyric acid stimulates bovine neutrophil functions and potentiates the effect of platelet activating factor. | 2016 | Vet. Immunol. Immunopathol. | pmid:27288853 |
Waller KP | Modulation of endotoxin-induced inflammation in the bovine teat using antagonists/inhibitors to leukotrienes, platelet activating factor and interleukin 1 beta. | 1997 | Vet. Immunol. Immunopathol. | pmid:9261962 |
Conejeros I et al. | 2-Aminoethoxydiphenyl borate (2-APB) reduces alkaline phosphatase release, CD63 expression, F-actin polymerization and chemotaxis without affecting the phagocytosis activity in bovine neutrophils. | 2012 | Vet. Immunol. Immunopathol. | pmid:22226550 |
Cook VL et al. | The effect of lidocaine on in vitro adhesion and migration of equine neutrophils. | 2009 | Vet. Immunol. Immunopathol. | pmid:19136156 |
Aktan I et al. | PKC isoenzymes in equine platelets and stimulus induced activation. | 2011 | Vet. Immunol. Immunopathol. | pmid:21513989 |
Topper EK et al. | Induction of tissue eosinophilia by platelet-activating factor in Merino sheep. | 1992 | Vet. Immunol. Immunopathol. | pmid:1604802 |
Foster AP et al. | Platelet activating factor mimics antigen-induced cutaneous inflammatory responses in sweet itch horses. | 1995 | Vet. Immunol. Immunopathol. | pmid:7747395 |
Brooks AC et al. | CXCL8 attenuates chemoattractant-induced equine neutrophil migration. | 2011 | Vet. Immunol. Immunopathol. | pmid:21040981 |
Corl CM et al. | Lipoxygenase metabolites modulate vascular-derived platelet activating factor production following endotoxin challenge. | 2010 | Vet. Immunol. Immunopathol. | pmid:20359754 |
Strøm H and Thomsen MK | Effects of proinflammatory mediators on canine neutrophil chemotaxis and aggregation. | 1990 | Vet. Immunol. Immunopathol. | pmid:2396362 |
Marr KA et al. | Agonist-induced adherence of equine neutrophils to fibronectin- and serum-coated plastic is CD18 dependent. | 1999 | Vet. Immunol. Immunopathol. | pmid:10532398 |