Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Botitsi E et al. | Metabolic fate of platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) and lyso-PAF (1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine) in FRTL5 cells. | 1998 | J. Lipid Res. | pmid:9643362 |
Jung KY et al. | Magnone A and B, novel anti-PAF tetrahydrofuran lignans from the flower buds of Magnolia fargesii. | 1998 | J. Nat. Prod. | pmid:9644071 |
Derewenda ZS and Derewenda U | The structure and function of platelet-activating factor acetylhydrolases. | 1998 | Cell. Mol. Life Sci. | pmid:9645224 |
Shouji K et al. | Platelet-activating factor is a key mediator of pulmonary vasoconstriction and bronchoconstriction after antigen challenge in the perfused sensitized rabbit lung. | 1998 | Shock | pmid:9645492 |
Qayumi AK et al. | The role of platelet-activating factor in regional myocardial ischemia-reperfusion injury. | 1998 | Ann. Thorac. Surg. | pmid:9647083 |
Watson F and Edwards SW | Stimulation of primed neutrophils by soluble immune complexes: priming leads to enhanced intracellular Ca2+ elevations, activation of phospholipase D, and activation of the NADPH oxidase. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9647777 |
Matsumoto K et al. | Proinflammatory cytokine-induced and chemical mediator-induced IL-8 expression in human bronchial epithelial cells through p38 mitogen-activated protein kinase-dependent pathway. | 1998 | J. Allergy Clin. Immunol. | pmid:9648711 |
Shindo K et al. | Platelet-activating factor increases leukotriene B4 release in stimulated alveolar macrophages from asthmatic patients. | 1998 | Eur. Respir. J. | pmid:9648962 |
Han BH et al. | In vitro platelet-activating factor receptor binding inhibitory activity of pinusolide derivatives: a structure-activity study. | 1998 | J. Med. Chem. | pmid:9651167 |
Minamiya Y et al. | Platelet-activating factor mediates intercellular adhesion molecule-1-dependent radical production in the nonhypoxic ischemia rat lung. | 1998 | Am. J. Respir. Cell Mol. Biol. | pmid:9651191 |
Perry SW et al. | Platelet-activating factor receptor activation. An initiator step in HIV-1 neuropathogenesis. | 1998 | J. Biol. Chem. | pmid:9651362 |
Roudebush WE and Mathur RS | Presence of platelet-activating factor in squirrel monkey (Saimiri boliviensis) spermatozoa: seasonal differences. | 1998 | Am. J. Primatol. | pmid:9651652 |
Küçükhüseyin C et al. | On the mechanisms of adenosine induced pulmonary vasoconstriction in rats. | 1997 | J Basic Clin Physiol Pharmacol | pmid:9651801 |
Ginkgo biloba for dementia. | 1998 | Med Lett Drugs Ther | pmid:9653424 | |
Itadani K et al. | Inhibition of Na+,K(+)-ATPase by platelet-activating factor in dog submandibular glands. | 1998 | Prostaglandins Other Lipid Mediat. | pmid:9653774 |
Loucks EB et al. | Platelet-activating factor antagonism: a new concept in the management of regional myocardial ischemia-reperfusion injury. | 1997 Nov-Dec | J Invest Surg | pmid:9654389 |
Schwartz JD et al. | Cardiopulmonary bypass primes polymorphonuclear leukocytes. | 1998 | J. Surg. Res. | pmid:9655092 |
Rainger GE et al. | Neutrophils rolling on immobilised platelets migrate into homotypic aggregates after activation. | 1998 | Thromb. Haemost. | pmid:9657445 |
Ahmed A et al. | Localization, quantification, and activation of platelet-activating factor receptor in human endometrium during the menstrual cycle: PAF stimulates NO, VEGF, and FAKpp125. | 1998 | FASEB J. | pmid:9657523 |
Akisü M et al. | Effect of dietary n-3 fatty acids on hypoxia-induced necrotizing enterocolitis in young mice. n-3 fatty acids alter platelet-activating factor and leukotriene B4 production in the intestine. | 1998 | Biol. Neonate | pmid:9657667 |
Manya H et al. | Switching of platelet-activating factor acetylhydrolase catalytic subunits in developing rat brain. | 1998 | J. Biol. Chem. | pmid:9660828 |
Tuder RM and Voelkel NF | Pulmonary hypertension and inflammation. | 1998 | J. Lab. Clin. Med. | pmid:9665367 |
Barber LA et al. | Expression of the platelet-activating factor receptor results in enhanced ultraviolet B radiation-induced apoptosis in a human epidermal cell line. | 1998 | J. Biol. Chem. | pmid:9668065 |
Peçanha EP et al. | Synthesis and pharmacological evaluation of a new class of bicyclic phospholipids, designed as platelet activating factor antagonists. | 1998 | Farmaco | pmid:9679282 |
da Silva MB et al. | Protective effects of WEB 2086 (PAF antagonist) and ketoprofen (NSAID) on PAF-induced changes in the morphological ultrastructure of blood platelets in calves. | 1998 | Vet. Res. Commun. | pmid:9686442 |
Bussolati B et al. | Platelet-activating factor synthesized by IL-12-stimulated polymorphonuclear neutrophils and NK cells mediates chemotaxis. | 1998 | J. Immunol. | pmid:9686616 |
Gozal D et al. | Platelet-activating factor modulates cardiorespiratory responses in the conscious rat. | 1998 | Am. J. Physiol. | pmid:9688699 |
Stolarek R et al. | Effect of various agonists on nitric oxide generation by human polymorphonuclear leukocytes. | 1998 | Int. J. Clin. Lab. Res. | pmid:9689552 |
Ribaldi E et al. | PAF levels in saliva are regulated by inflammatory cells. | 1998 | J. Periodont. Res. | pmid:9689619 |
Kaminskaia GO et al. | [Features of oxidative metabolism and level of platelet activating factor in pulmonary and circulating phagocytes of tuberculosis-resistant animals at stages of experimental infection]. | 1998 | Probl Tuberk | pmid:9691697 |
Li HP et al. | Effect of chinonin on acute hypoxic pulmonary vasoconstriction in Sprague-Dawley rats. | 1998 | Respirology | pmid:9692515 |
Moro F et al. | The beta and gamma subunits of the human platelet-activating factor acetyl hydrolase isoform Ib (PAFAH1B2 and PAFAH1B3) map to chromosome 11q23 and 19q13.1, respectively. | 1998 | Genomics | pmid:9693049 |
Napoli C | Familial hypercholesterolaemia and platelet-activating factor acetylhydrolase: difference between the homozygous and heterozygous form. | 1998 | Eur. J. Clin. Invest. | pmid:9693945 |
Karlsson H et al. | Heparin ameliorates pulmonary hypertension induced by platelet-activating factor in pigs. | 1998 | Thromb. Res. | pmid:9694244 |
Eakes AT and Olson MS | Regulation of endothelin synthesis in hepatic endothelial cells. | 1998 | Am. J. Physiol. | pmid:9696707 |
Cruzado JM et al. | Effect of a platelet-activating factor (PAF) receptor antagonist on hyperacute xenograft rejection; evaluation in a pig kidney-human blood xenoperfusion model. | 1998 | Clin. Exp. Immunol. | pmid:9697996 |
DeCoster MA et al. | Platelet-activating factor is a downstream messenger of kainate-induced activation of mitogen-activated protein kinases in primary hippocampal neurons. | 1998 | J. Neurosci. Res. | pmid:9698157 |
Alves AC et al. | Effect of selective phosphodiesterase inhibitors on the rat eosinophil chemotactic response in vitro. | 1997 | Mem. Inst. Oswaldo Cruz | pmid:9698934 |
Koyama S et al. | Human lung fibroblasts release chemokinetic activity for monocytes constitutively. | 1998 | Am. J. Physiol. | pmid:9700081 |
Andersson R et al. | Effect of a platelet-activating factor antagonist on pancreatitis-associated gut barrier dysfunction in rats. | 1998 | Pancreas | pmid:9700940 |
Pennings HJ et al. | Tumour necrosis factor-alpha induces hyperreactivity in tracheal smooth muscle of the guinea-pig in vitro. | 1998 | Eur. Respir. J. | pmid:9701413 |
Akisü M et al. | Platelet-activating factor levels in term and preterm human milk. | 1998 | Biol. Neonate | pmid:9701651 |
Thakur A and Willcox MD | Cytokine and lipid inflammatory mediator profile of human tears during contact lens associated inflammatory diseases. | 1998 | Exp. Eye Res. | pmid:9702174 |
Boulay F et al. | Phagocyte chemoattractant receptors. | 1997 | Ann. N. Y. Acad. Sci. | pmid:9704038 |
Pérez-Arellano JL et al. | BN 52021 (a platelet activating factor-receptor antagonist) decreases alveolar macrophage-mediated lung injury in experimental extrinsic allergic alveolitis. | 1998 | Mediators Inflamm. | pmid:9705608 |
Pei Y et al. | Activation of the epidermal platelet-activating factor receptor results in cytokine and cyclooxygenase-2 biosynthesis. | 1998 | J. Immunol. | pmid:9712066 |
Hilliquin P et al. | A double blind, placebo controlled study of a platelet activating factor antagonist in patients with rheumatoid arthritis. | 1998 | J. Rheumatol. | pmid:9712091 |
Tamaoki J et al. | A human bronchial epithelial cell line releases arginine vasopressin: involvement of Ca2+ -activated K+ channels. | 1998 | Regul. Pept. | pmid:9712168 |
Tsai IL et al. | Anti-platelet aggregation constituents from Formosan Toddalia asiatica. | 1998 | Phytochemistry | pmid:9720317 |
Karzai W et al. | [Current aspects of immunomodulatory therapy initiation for sepsis]. | 1998 | Dtsch. Med. Wochenschr. | pmid:9721572 |