Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
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What lipids are associated with Platelet activating factor?
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Page CP et al. | Platelets and asthma. | 1985 | Lancet | pmid:2857401 |
| Gresele P et al. | Platelets and asthma. | 1985 | Lancet | pmid:2857402 |
| Barnes JL and Venkatachalam MA | The role of platelets and polycationic mediators in glomerular vascular injury. | 1985 | Semin. Nephrol. | pmid:2957770 |
| Wasserman SI | Mast cell mediators in the blood of patients with asthma. | 1985 | Chest | pmid:3880526 |
| Halonen M et al. | Participation of platelets in the physiologic alterations of the AGEPC response and of IgE anaphylaxis in the rabbit. Effects of PGI2 inhibition of platelet function. | 1985 | Am. Rev. Respir. Dis. | pmid:3881060 |
| Malone B et al. | Inactivation of platelet activating factor by rabbit platelets. Lyso-platelet activating factor as a key intermediate with phosphatidylcholine as the source of arachidonic acid in its conversion to a tetraenoic acylated product. | 1985 | J. Biol. Chem. | pmid:3918041 |
| Juhan-Vague I et al. | Possible participation of adenosine 5'-diphosphate, arachidonic acid and paf-acether in the platelet pro-aggregating effect of uncontrolled insulin-dependent diabetic erythrocytes in vitro. | 1985 | Thromb. Res. | pmid:3923649 |
| Steiner M et al. | Biological activity of platelet activating factor-amidophosphonate (PAF-AP), a novel phosphonolipid selective inhibitor of platelet activating factor (PAF). | 1985 | Biochem. Biophys. Res. Commun. | pmid:3936503 |
| Valone FH and Johnson B | Modulation of cytoplasmic calcium in human platelets by the phospholipid platelet-activating factor 1-O-alkyl-2-acetyl-SN-glycero-3-phosphorylcholine. | 1985 | J. Immunol. | pmid:2578151 |
| Camussi G et al. | The role of platelet-activating factor in experimental immune complex pathology. | 1985 | Int J Tissue React | pmid:2932406 |
| Murer EH | The role of platelet calcium. | 1985 | Semin. Hematol. | pmid:3901271 |
| Davis JW et al. | Effects of tobacco and non-tobacco cigarette smoking on endothelium and platelets. | 1985 | Clin. Pharmacol. Ther. | pmid:3987176 |
| O'Neill C | Examination of the causes of early pregnancy-associated thrombocytopenia in mice. | 1985 | J. Reprod. Fertil. | pmid:3989801 |
| Benveniste J | Biosynthesis and function of PAF-acether (platelet-activating factor). | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936197 |
| Kertscher HP and Ostermann G | [Synthesis and biological activity of isomeric structural analogs of platelet activating factor]. | 1985 | Pharmazie | pmid:3991788 |
| Wal F et al. | PAF-acether may not mediate the third pathway of platelet aggregation since self-desensitization reduces the effects of low thrombin but enhances those of convulxin. | 1985 | Thromb. Haemost. | pmid:3992525 |
| Waku K et al. | Metabolism of 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine: a precursor of platelet-activating factor in macrophages. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936199 |
| Khan SN et al. | Response to platelet-activating factor of platelets from patients with multiple sclerosis. | 1985 | Acta Neurol. Scand. | pmid:3993327 |
| Saito K et al. | Determination of AGEPC generated from human neutrophils and rat skin and muscle tissues by a selected ion monitoring technique of GC/MS. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936200 |
| Archer CB et al. | Inflammatory cell accumulation in response to intracutaneous Paf-acether: a mediator of acute and persistent inflammation? | 1985 | Br. J. Dermatol. | pmid:4015978 |
| Morley J et al. | The role of circulating cells in skin reactions. | 1985 | Br. J. Dermatol. | pmid:4015983 |
| Pirotzky E et al. | A role for Paf-acether (platelet-activating factor) in acute skin inflammation? | 1985 | Br. J. Dermatol. | pmid:4015984 |
| Ohno M et al. | An enantioselective synthesis of platelet-activating factors, their enantiomers, and their analogues from D- and L-tartaric acids. | 1985 | Chem. Pharm. Bull. | pmid:4017109 |
| O'Neill C et al. | Maternal blood platelet physiology and luteal-phase endocrinology as a means of monitoring pre- and postimplantation embryo viability following in vitro fertilization. | 1985 | J In Vitro Fert Embryo Transf | pmid:4020241 |
| Heymans F et al. | Structure-activity relationship in PAF-acether. 2. rac-1-O-Octadecyl-2-O-acetyl-3-O-[gamma-(dimethylamino)propyl]glycerol . | 1985 | J. Med. Chem. | pmid:4020830 |
| Suemune H et al. | Synthetic studies on platelet-activating factor (PAF). | 1985 | Chem. Pharm. Bull. | pmid:4028291 |
| Parente L et al. | The release of lyso-PAF from guinea-pig lungs. | 1985 | Eur. J. Pharmacol. | pmid:4029263 |
| Sugiura T et al. | Transacylation of 1-O-alkyl-SN-glycero-3-phosphocholine (lyso platelet-activating factor) and 1-O-alkenyl-SN-glycero-3-phosphoethanolamine with docosahexaenoic acid (22:6 omega 3). | 1985 | Biochem. Biophys. Res. Commun. | pmid:2935146 |
| Valone FH and Johnson B | Decay of the activating signal after platelet stimulation with 1-0-alkyl-2-acetyl-SN-glycero-3-phosphorylcholine: changes in calcium permeability. | 1985 | Thromb. Res. | pmid:4082115 |
| Scherer GF | 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor) stimulates plant H+ transport in vitro and growth. | 1985 | Biochem. Biophys. Res. Commun. | pmid:4084306 |
| Handley DA et al. | Evidence for a direct effect on vascular permeability of platelet-activating factor induced hemoconcentration in the guinea pig. | 1985 | Thromb. Haemost. | pmid:4089809 |
| Hemker HC and Béguin S | The generation of thrombin in whole plasma. Biochemical possibilities and physiological realities. | 1985 | Verh. K. Acad. Geneeskd. Belg. | pmid:4090648 |
| Hallam TJ et al. | Relationship between cytoplasmic free calcium and myosin light chain phosphorylation in intact platelets. | 1985 | Biochem. J. | pmid:4091795 |
| Fouque F and Vargaftig BB | Adrenaline/PAF acether synergism on human platelets: involvement of Hydergine. | 1985 | J Pharmacol | pmid:4094442 |
| Vigo C | Effect of C-reactive protein on platelet-activating factor-induced platelet aggregation and membrane stabilization. | 1985 | J. Biol. Chem. | pmid:3919022 |
| Armstrong RA et al. | Mechanism of the inhibition of platelet aggregation produced by prostaglandin F2 alpha. | 1985 | Prostaglandins | pmid:2988022 |
| Sugiura T and Waku K | CoA-independent transfer of arachidonic acid from 1,2-diacyl-sn-glycero-3-phosphocholine to 1-O-alkyl-sn-glycero-3-phosphocholine (lyso platelet-activating factor) by macrophage microsomes. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3919727 |
| Dewald B and Baggiolini M | Activation of NADPH oxidase in human neutrophils. Synergism between fMLP and the neutrophil products PAF and LTB4. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2985075 |
| Wasserman SI | The mast cell and theophylline in asthma. | 1985 | Am. J. Med. | pmid:3002176 |
| Tou J | Platelet-activating factor promotes arachidonate incorporation into phosphatidylinositol and phosphatidylcholine in neutrophils. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3921017 |
| Avdonin PV and Altukhova IP | [Blocking with phorbol ester, a protein kinase C activator, of receptor-dependent platelet calcium channels]. | 1985 | Biokhimiia | pmid:2416359 |
| Lee TD et al. | Heterogeneity in mast cell populations. | 1985 | Clin Immunol Rev | pmid:2417770 |
| Leclercq M et al. | [Effects of Hymenoptera stings: physiopathology and immunology according to recent literature findings]. | 1985 | Rev Med Liege | pmid:2418479 |
| Pipili E | Platelet membrane potential: simultaneous measurement of diSC3(5) fluorescence and optical density. | 1985 | Thromb. Haemost. | pmid:2418525 |
| Snyder F | Chemical and biochemical aspects of platelet activating factor: a novel class of acetylated ether-linked choline-phospholipids. | 1985 Jan-Mar | Med Res Rev | pmid:2984489 |
| Kozubski W and Stańczyk L | [Platelet aggregation in patients with migraine during the pain attack and in the pain-free period]. | 1985 Jul-Aug | Neurol. Neurochir. Pol. | pmid:4094642 |
| Bette-Bobillo P et al. | Synthesis and characterization of a radioiodinated, photoreactive and physiologically active analogue of platelet activating factor. | 1985 Jun-Jul | Chem. Phys. Lipids | pmid:4042252 |
| Leprán I and Lefer AM | Ischemia aggravating effects of platelet-activating factor in acute myocardial ischemia. | 1985 Mar-Apr | Basic Res. Cardiol. | pmid:4039929 |
| Feuerstein G et al. | Thyrotropin-releasing hormone blocks the hypotensive effects of platelet-activating factor in the unanesthetized guinea pig. | 1985 Mar-Apr | J. Cardiovasc. Pharmacol. | pmid:2581089 |
| Mencia-Huerta JM | Possible role of the T-cell-factor-dependent mast cell subclass in the generation of leukotrienes from lung. | 1985 Sep-Oct | Ann. Inst. Pasteur Immunol. | pmid:3878684 |
| Masugi F et al. | Role of acetyl glyceryl ether phosphorylcholine in blood pressure regulation in rats. | 1985 Sep-Oct | Hypertension | pmid:4030044 |
| Huang C et al. | Polymorphic phase behavior of platelet-activating factor. | 1986 | Biophys. J. | pmid:3697472 |
| Lad PM et al. | A step sensitive to pertussis toxin and phorbol ester in human neutrophils regulates chemotaxis and capping but not phagocytosis. | 1986 | FEBS Lett. | pmid:3699167 |
| Viero P et al. | Defective platelet aggregation induced by platelet activating factor in myeloproliferative disorders: deficiency of an aspirin-independent mechanism? | 1986 | Haemostasis | pmid:3699584 |
| Wallace JL and Whittle BJ | Picomole doses of platelet-activating factor predispose the gastric mucosa to damage by topical irritants. | 1986 | Prostaglandins | pmid:3726156 |
| Eche N et al. | Platelet aggregating and procoagulant activities of cultured human breast cancer cells (FAM). | 1986 | Thromb. Res. | pmid:3726808 |
| Handley DA et al. | Inhibition and reversal of endotoxin-, aggregated IgG- and paf-induced hypotension in the rat by SRI 63-072, a paf receptor antagonist. | 1986 | Immunopharmacology | pmid:3019921 |
| Hwang SB et al. | Specific binding of [3H]dihydrokadsurenone to rabbit platelet membranes and its inhibition by the receptor agonists and antagonists of platelet-activating factor. | 1986 | J. Biol. Chem. | pmid:3020044 |
| Biftu T et al. | Conformation and activity of tetrahydrofuran lignans and analogues as specific platelet activating factor antagonists. | 1986 | J. Med. Chem. | pmid:3020247 |
| Valone FH and Ruis NM | Platelet-activating factor binding to human platelet membranes. | 1986 | Biotechnol. Appl. Biochem. | pmid:3021183 |
| Desquand S et al. | Interference of BN 52021 (ginkgolide B) with the bronchopulmonary effects of PAF-acether in the guinea-pig. | 1986 | Eur. J. Pharmacol. | pmid:3019727 |
| Buxton DB et al. | Specific antagonists of platelet activating factor-mediated vasoconstriction and glycogenolysis in the perfused rat liver. | 1986 | Biochem. Pharmacol. | pmid:3754140 |
| Toyofuku T et al. | Effects of ONO-6240, a platelet-activating factor antagonist, on endotoxin shock in unanesthetized sheep. | 1986 | Prostaglandins | pmid:3754344 |
| Touvay C et al. | Inhibition of antigen-induced lung anaphylaxis in the guinea-pig by BN 52021 a new specific paf-acether receptor antagonist isolated from Ginkgo biloba. | 1986 | Agents Actions | pmid:3754380 |
| Sugatani J and Hanahan DJ | Characterization of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (AGEPC)-induced protein phosphorylation in rabbit platelets: inhibitory effects of AGEPC analogs. | 1986 | Arch. Biochem. Biophys. | pmid:3754710 |
| Hsueh W et al. | Platelet activating factor-induced ischemic bowel necrosis: the effect of PAF antagonists. | 1986 | Eur. J. Pharmacol. | pmid:3754817 |
| Daniel LW et al. | A novel mechanism of diglyceride formation. 12-O-tetradecanoylphorbol-13-acetate stimulates the cyclic breakdown and resynthesis of phosphatidylcholine. | 1986 | J. Biol. Chem. | pmid:3087989 |
| Kloprogge E et al. | Stimulus-aggregation coupling in platelets activated with PAF-acether. | 1986 | Biochim. Biophys. Acta | pmid:3089297 |
| Piéroni G and Hanahan DJ | Effect of acetylglyceryl ether phosphocholine (platelet-activating factor) and thrombin on acylation of exogenous lysophosphoglycerides in rabbit platelets. | 1986 | Biochim. Biophys. Acta | pmid:3719000 |
| Porcellini G | [Platelet-activating factor: a new biochemical and pharmacologic frontier]. | 1986 | Clin Ter | pmid:3720244 |
| Wallace JL and Whittle BJ | Prevention of endotoxin-induced gastrointestinal damage by CV-3988, an antagonist of platelet-activating factor. | 1986 | Eur. J. Pharmacol. | pmid:3720841 |
| Gillespie MN and Bowdy BD | Impact of platelet activating factor on vascular responsiveness in isolated rat lungs. | 1986 | J. Pharmacol. Exp. Ther. | pmid:3944767 |
| Flower RJ | Background and discovery of lipocortins. | 1986 | Agents Actions | pmid:2938452 |
| Viero P et al. | Thrombotic thrombocytopenic purpura and high-dose immunoglobulin treatment. | 1986 | Ann. Intern. Med. | pmid:3946966 |
| Ramesha CS and Pickett WC | Measurement of sub-picogram quantities of platelet activating factor (AGEPC) by gas chromatography/negative ion chemical ionization mass spectrometry. | 1986 | Biomed. Environ. Mass Spectrom. | pmid:2938649 |
| Siafaka-Kapadai A et al. | Biological activity of lipids of pine pollen on platelet aggregation in correlation with the platelet activating factor. | 1986 | Biochem. Int. | pmid:3947373 |
| Resink TJ et al. | The influence of activating hormones on human platelet membrane Ca2+-ATPase activity. | 1986 | Biochem. Biophys. Res. Commun. | pmid:2943273 |
| McManus LM | Pathobiology of platelet-activating factors. | 1986 | Pathol Immunopathol Res | pmid:3543915 |
| Davis RB and Johnson MF | Effects of bacterial endotoxin and platelet activating factor (PAF) on human platelet aggregation in native whole blood. | 1986 | Thromb. Res. | pmid:3544327 |
| Piper PJ and Stewart AG | Coronary vasoconstriction in the rat, isolated perfused heart induced by platelet-activating factor is mediated by leukotriene C4. | 1986 | Br. J. Pharmacol. | pmid:3091131 |
| Coëffier E et al. | Transient activation of the acetyltransferase necessary for paf-acether biosynthesis in thrombin-activated platelets. | 1986 | Br. J. Haematol. | pmid:3964558 |
| Raaijmakers JA et al. | Phospholipase A2 products induce pulmonary beta-adrenoceptor deviations. | 1986 | Eur. J. Pharmacol. | pmid:3019725 |
| Hsueh W et al. | Platelet-activating factor-induced ischemic bowel necrosis. An investigation of secondary mediators in its pathogenesis. | 1986 | Am. J. Pathol. | pmid:3080895 |
| Darius H et al. | Role of platelet-activating factor-acether in mediating guinea pig anaphylaxis. | 1986 | Science | pmid:3082008 |
| Kohayakawa M and Inoue K | Augmentation of 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine (PAF)-induced human platelet activation by C-reactive protein. | 1986 | Thromb. Res. | pmid:3083530 |
| Morley J et al. | Effects of ketotifen upon responses to platelet activating factor: a basis for asthma prophylaxis. | 1986 | Ann Allergy | pmid:3083731 |
| McKean ML et al. | Formation of diacyl- and alkylacylphosphatidylcholine by the membranes of human platelets. | 1986 | FEBS Lett. | pmid:3943622 |
| Montrucchio G et al. | Intravascular release of platelet-activating factor during atrial pacing. | 1986 | Lancet | pmid:2874319 |
| Hackenthal E and Taugner R | Hormonal signals and intracellular messengers for renin secretion. | 1986 | Mol. Cell. Endocrinol. | pmid:2875004 |
| Swingle KF and Reiter MJ | Inhibition of Paf-acether-induced edema of the rat's paw. | 1986 | Agents Actions | pmid:2875631 |
| Ghezzi E | Autacoids and some mediators in allergic and non allergic forms. | 1986 | Boll Ist Sieroter Milan | pmid:2877678 |
| Homburger HA | Diagnosis of allergy: in vitro testing. | 1986 | Crit Rev Clin Lab Sci | pmid:2426037 |
| Pécoud A and Frei PC | [Developmental trends in allergologic-immunologic research]. | 1986 | Internist (Berl) | pmid:2427469 |
| Raphael GD and Metcalfe DD | Mediators of airway inflammation. | 1986 | Eur J Respir Dis Suppl | pmid:2429857 |
| Godfroid JJ et al. | Synthesis of ether phospholipids. | 1986 | Pharmacol Res Commun | pmid:3774838 |
| PAF and leukotrienes '85. Proceedings of the meeting. Paris, September 27th 1985. | 1986 | Pharmacol Res Commun | pmid:3774839 | |
| Vilain B et al. | Pharmacological control of the in vivo passive anaphylactic shock by the PAF-acether antagonist compound BN 52021. | 1986 | Pharmacol Res Commun | pmid:3774840 |
| Hsueh W et al. | Release of leukotriene C4 by isolated, perfused rat small intestine in response to platelet-activating factor. | 1986 | J. Clin. Invest. | pmid:3459734 |
| Bessin P | PAF-acether and leukotriene participation in acute circulatory shock. | 1986 | Pharmacol Res Commun | pmid:3774841 |
| Goldstein RE et al. | Coronary and pulmonary vascular effects of leukotrienes and PAF-acether. | 1986 | Pharmacol Res Commun | pmid:3774842 |