Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Burns D002056 34 associated lipids
Bronchopulmonary Sequestration D001998 3 associated lipids
Bronchopulmonary Dysplasia D001997 4 associated lipids
Bronchiectasis D001987 7 associated lipids
Bronchial Spasm D001986 18 associated lipids
Bronchial Diseases D001982 3 associated lipids
Brain Injuries D001930 4 associated lipids
Brain Edema D001929 20 associated lipids
Brain Diseases D001927 27 associated lipids
Bovine Virus Diarrhea-Mucosal Disease D001912 2 associated lipids
Body Weight D001835 333 associated lipids
Blood Platelet Disorders D001791 12 associated lipids
Blister D001768 16 associated lipids
Birth Weight D001724 23 associated lipids
Behcet Syndrome D001528 7 associated lipids
Pulmonary Atelectasis D001261 1 associated lipids
Asthma D001249 52 associated lipids
Asphyxia Neonatorum D001238 4 associated lipids
Ascites D001201 25 associated lipids
Arthus Reaction D001183 8 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Arthritis D001168 41 associated lipids
Arteriosclerosis Obliterans D001162 8 associated lipids
Arteriosclerosis D001161 86 associated lipids
Arterial Occlusive Diseases D001157 12 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Arenaviridae Infections D001117 1 associated lipids
Anthrax D000881 1 associated lipids
Hypoxia D000860 23 associated lipids
Angina, Unstable D000789 14 associated lipids
Angina Pectoris D000787 27 associated lipids
Anemia, Sickle Cell D000755 34 associated lipids
Anaphylaxis D000707 35 associated lipids
Amnesia D000647 12 associated lipids
Alzheimer Disease D000544 76 associated lipids
Albuminuria D000419 18 associated lipids
Agranulocytosis D000380 7 associated lipids
Adenocarcinoma D000230 166 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Yamauchi A et al. Systematic single cell analysis of migration and morphological changes of human neutrophils over stimulus concentration gradients. 2014 J. Immunol. Methods pmid:24370750
Flasiński M et al. Influence of platelet-activating factor, lyso-platelet-activating factor and edelfosine on Langmuir monolayers imitating plasma membranes of cell lines differing in susceptibility to anti-cancer treatment: the effect of plasmalogen level. 2014 J R Soc Interface pmid:24694892
Sato A et al. C-reactive protein specifically enhances platelet-activating factor-induced inflammatory activity in vivo. 2014 Eur. J. Pharmacol. pmid:25455842
Zebrowska A et al. Mediators of mast cells in bullous pemphigoid and dermatitis herpetiformis. 2014 Mediators Inflamm. pmid:25400334
Sahu RP et al. Chemotherapeutic agents subvert tumor immunity by generating agonists of platelet-activating factor. 2014 Cancer Res. pmid:25304264
Wu H et al. Lipoxin A4 and platelet activating factor are involved in E. coli or LPS-induced lung inflammation in CFTR-deficient mice. 2014 PLoS ONE pmid:24671173
Mitchell MJ et al. Fluid shear stress increases neutrophil activation via platelet-activating factor. 2014 Biophys. J. pmid:24853753
Carlioglu A et al. The platelet activating factor acetyl hydrolase, oxidized low-density lipoprotein, paraoxonase 1 and arylesterase levels in treated and untreated patients with polycystic ovary syndrome. 2014 Arch. Gynecol. Obstet. pmid:24840107
Yu Y et al. Epidermal growth factor induces platelet-activating factor production through receptors transactivation and cytosolic phospholipase A2 in ovarian cancer cells. 2014 J Ovarian Res pmid:24721622
Forkel S et al. Inositoylated platelet-activating factor (Ino-C2-PAF) modulates dynamic lymphocyte-endothelial cell interactions and alleviates psoriasis-like skin inflammation in two complementary mouse models. 2014 J. Invest. Dermatol. pmid:24714204
Kim SJ et al. Quantitative determination of major platelet activating factors from human plasma. 2014 Anal Bioanal Chem pmid:24682147
Kaplanis M et al. Re(I) tricarbonyl complex of 1,10-phenanthroline-5,6-dione: DNA binding, cytotoxicity, anti-inflammatory and anti-coagulant effects towards platelet activating factor. 2014 J. Inorg. Biochem. pmid:24632342
Mallet de Lima CD et al. Central role of PAFR signalling in ExoU-induced NF-κB activation. 2014 Cell. Microbiol. pmid:24612488
Moschos MM et al. In vitro effects of vitamin supplements on platelet-activating factor and its metabolism in age-related macular degeneration. 2014 Cutan Ocul Toxicol pmid:24147947
Abdulnour RE et al. Maresin 1 biosynthesis during platelet-neutrophil interactions is organ-protective. 2014 Proc. Natl. Acad. Sci. U.S.A. pmid:25369934
Chou YI et al. Correlations of platelet-derived microparticles with thromboxane B2, platelet-activating factor, endothelin-1, and neutrophil to lymphocyte ratio in patients with coronary intermediate lesions. 2014 Biomarkers pmid:25391885
Chérifi F et al. Isolation, functional characterization and proteomic identification of CC2-PLA₂ from Cerastes cerastes venom: a basic platelet-aggregation-inhibiting factor. 2014 Protein J. pmid:24384926
Rivera J et al. Platelet-activating factor contributes to Bacillus anthracis lethal toxin-associated damage. 2014 J. Biol. Chem. pmid:24478317
Kim KJ et al. Platelet-activating factor enhances tumour metastasis via the reactive oxygen species-dependent protein kinase casein kinase 2-mediated nuclear factor-κB activation. 2014 Immunology pmid:24628121
Tarui M et al. Selective inhibitors of a PAF biosynthetic enzyme lysophosphatidylcholine acyltransferase 2. 2014 J. Lipid Res. pmid:24850807