Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Lenshof A and Laurell T | Emerging clinical applications of microchip-based acoustophoresis. | 2011 | J Lab Autom | pmid:22093301 |
Michelotto PV et al. | Pulmonary inflammation due to exercise-induced pulmonary haemorrhage in Thoroughbred colts during race training. | 2011 | Vet. J. | pmid:22108190 |
Li XJ et al. | [Expression of platelet-activating factor in necrotizing enterocolitis and its clinical significance]. | 2011 | Zhonghua Bing Li Xue Za Zhi | pmid:21426810 |
Leistad L et al. | Multiple phospholipase A2 enzymes participate in the inflammatory process in osteoarthritic cartilage. | 2011 | Scand. J. Rheumatol. | pmid:21417548 |
Xu LF et al. | Disruption of the F-actin cytoskeleton and monolayer barrier integrity induced by PAF and the protective effect of ITF on intestinal epithelium. | 2011 | Arch. Pharm. Res. | pmid:21380808 |
Aktan I et al. | PKC isoenzymes in equine platelets and stimulus induced activation. | 2011 | Vet. Immunol. Immunopathol. | pmid:21513989 |
Jiang W et al. | [Effects and mechanisms of platelet-activating factor on the invasiveness of ovarian cancer cells in vitro]. | 2011 | Zhonghua Fu Chan Ke Za Zhi | pmid:22333285 |
Kang NI et al. | Protein kinase CK2/PTEN pathway plays a key role in platelet-activating factor-mediated murine anaphylactic shock. | 2011 | J. Immunol. | pmid:21531890 |
Tang WZ et al. | Dimeric prenylated C6-C3 compounds from the stem bark of Illicium oligandrum. | 2011 | J. Nat. Prod. | pmid:21524101 |
Ma SG et al. | Four new phenolic diglycosides from the roots of Illicium oligandrum. | 2011 | Carbohydr. Res. | pmid:21524732 |
Orlando RC et al. | Esophageal disease: updated information on inflammation. | 2011 | Ann. N. Y. Acad. Sci. | pmid:21950828 |
Frisardi V et al. | Glycerophospholipids and glycerophospholipid-derived lipid mediators: a complex meshwork in Alzheimer's disease pathology. | 2011 | Prog. Lipid Res. | pmid:21703303 |
Musto AE and Samii M | Platelet-activating factor receptor antagonism targets neuroinflammation in experimental epilepsy. | 2011 | Epilepsia | pmid:21204830 |
Liao HJ et al. | Two new ginkgolides from the leaves of Ginkgo biloba. | 2011 | Planta Med. | pmid:21614751 |
Penna C et al. | Platelet activating factor: the good and the bad in the ischemic/reperfused heart. | 2011 | Exp. Biol. Med. (Maywood) | pmid:21378031 |
Kim HA et al. | Mechanisms of platelet-activating factor-induced enhancement of VEGF expression. | 2011 | Cell. Physiol. Biochem. | pmid:21325822 |
Ha SW and Lee CS | Differential effect of platelet activating factor on 1-methyl-4-phenylpyridinium-induced cell death through regulation of apoptosis-related protein activation. | 2010 May-Jun | Neurochem. Int. | pmid:20304020 |
Michelotto PV et al. | Platelet-activating factor and evidence of oxidative stress in the bronchoalveolar fluid of Thoroughbred colts during race training. | 2010 Mar-Apr | J. Vet. Intern. Med. | pmid:20102491 |
Ploppa A et al. | Local anesthetic effects on human neutrophil priming and activation. | 2010 Jan-Feb | Reg Anesth Pain Med | pmid:20048657 |
Ciprandi G and Cirillo I | Rupatadine improves nasal symptoms, airflow and inflammation in patients with persistent allergic rhinitis: a pilot study. | 2010 Apr-Jun | J. Biol. Regul. Homeost. Agents | pmid:20487631 |
Chomyszyn-Gajewska M | [Evaluation of chosen salivary periodontal disease markers]. | 2010 | Prz. Lek. | pmid:20687387 |
Thiele T et al. | [Heparin-induced thrombocytopenia]. | 2010 | Internist (Berl) | pmid:20694716 |
Jiang P et al. | PMS-1077, a PAF antagonist, induced differentiation of HL-60 cells with its novel activity. | 2010 | Cell Biol. Int. | pmid:20812915 |
Renteria LS et al. | Prolonged hypoxia modulates platelet activating factor receptor-mediated responses by fetal ovine pulmonary vascular smooth muscle cells. | 2010 | Mol. Genet. Metab. | pmid:20813571 |
Church MK | Efficacy and tolerability of rupatadine at four times the recommended dose against histamine- and platelet-activating factor-induced flare responses and ex vivo platelet aggregation in healthy males. | 2010 | Br. J. Dermatol. | pmid:20819087 |
Lin S et al. | Abietane and C20-norabietane diterpenes from the stem bark of Fraxinus sieboldiana and their biological activities. | 2010 | J. Nat. Prod. | pmid:20961093 |
He J et al. | The induction of an angiogenic response in corneal myofibroblasts by platelet-activating factor (PAF). | 2010 | Curr. Eye Res. | pmid:20961214 |
Rechka A et al. | Identification of VEGF receptor-2 tyrosine phosphorylation sites involved in VEGF-mediated endothelial platelet-activating factor synthesis. | 2010 | Can. J. Physiol. Pharmacol. | pmid:20962896 |
Soliman A et al. | Platelet-activating factor induces TLR4 expression in intestinal epithelial cells: implication for the pathogenesis of necrotizing enterocolitis. | 2010 | PLoS ONE | pmid:20976181 |
Gao F et al. | [The levels of platelet-activating factor and nitric oxide synthase in bronchial asthma at high altitude]. | 2010 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:20979844 |
Zhu X et al. | Effects of ropivacaine on adhesion molecule CD11b expression and function in human neutrophils. | 2010 | Int. Immunopharmacol. | pmid:20348036 |
Zhao D et al. | PAF exerts a direct apoptotic effect on the rat H9c2 cardiomyocytes in Ca2+-dependent manner. | 2010 | Int. J. Cardiol. | pmid:19237210 |
Karantonis HC et al. | Platelet-activating factor involvement in thioacetamide-induced experimental liver fibrosis and cirrhosis. | 2010 | Dig. Dis. Sci. | pmid:19242794 |
Lefebvre JS et al. | Toll-like receptor ligands induce polymorphonuclear leukocyte migration: key roles for leukotriene B4 and platelet-activating factor. | 2010 | FASEB J. | pmid:19843712 |
Kida T et al. | Bepotastine besilate, a highly selective histamine H(1) receptor antagonist, suppresses vascular hyperpermeability and eosinophil recruitment in in vitro and in vivo experimental allergic conjunctivitis models. | 2010 | Exp. Eye Res. | pmid:20412793 |
Lorrain DS et al. | Pharmacology of AM803, a novel selective five-lipoxygenase-activating protein (FLAP) inhibitor in rodent models of acute inflammation. | 2010 | Eur. J. Pharmacol. | pmid:20519143 |
Salmon MD and Ahluwalia J | Discrimination between receptor- and store-operated Ca(2+) influx in human neutrophils. | 2010 | Cell. Immunol. | pmid:20716450 |
Ma J et al. | Signaling in TRPV1-induced platelet activating factor (PAF) in human esophageal epithelial cells. | 2010 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:19959817 |
Hasegawa S et al. | Role of PAF receptor in proinflammatory cytokine expression in the dorsal root ganglion and tactile allodynia in a rodent model of neuropathic pain. | 2010 | PLoS ONE | pmid:20454616 |
Yang L et al. | Chronic alcohol exposure increases circulating bioactive oxidized phospholipids. | 2010 | J. Biol. Chem. | pmid:20460374 |
Esquenazi S and Bazan HE | Role of platelet-activating factor in cell death signaling in the cornea: A review. | 2010 | Mol. Neurobiol. | pmid:20431963 |
Iyú D et al. | The role of prostanoid receptors in mediating the effects of PGE(2) on human platelet function. | 2010 | Platelets | pmid:20433310 |
Denizot Y | Platelet-activating factor and acute myelogenous leukemia. | 2010 | Exp. Hematol. | pmid:20303379 |
Rieder F et al. | Inflammatory mediators in gastroesophageal reflux disease: impact on esophageal motility, fibrosis, and carcinogenesis. | 2010 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:20299604 |
Zhou X and He P | Endothelial [Ca2+]i and caveolin-1 antagonistically regulate eNOS activity and microvessel permeability in rat venules. | 2010 | Cardiovasc. Res. | pmid:20080986 |
Kenchegowda S and Bazan HE | Significance of lipid mediators in corneal injury and repair. | 2010 | J. Lipid Res. | pmid:19965607 |
Jørgensen KM et al. | Platelet activating factor stimulates arachidonic acid release in differentiated keratinocytes via arachidonyl non-selective phospholipase A2. | 2010 | Arch. Dermatol. Res. | pmid:20041255 |
Coy Barrera ED and Cuca Suárez LE | In vitro inhibitory activities of Lauraceae aporphine alkaloids. | 2010 | Nat Prod Commun | pmid:20420312 |
Dyer KD et al. | Mouse and human eosinophils degranulate in response to platelet-activating factor (PAF) and lysoPAF via a PAF-receptor-independent mechanism: evidence for a novel receptor. | 2010 | J. Immunol. | pmid:20421642 |
Bate C et al. | Glycosylphosphatidylinositol anchor analogues sequester cholesterol and reduce prion formation. | 2010 | J. Biol. Chem. | pmid:20427265 |