Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Am. J. Physiol., Cell Physiol. (2)
- Arterioscler. Thromb. Vasc. Biol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hynes AC et al. | The phosphatidylinositol signalling system in elongating bovine blastocysts; formation of phosphoinositides, inositol phosphates and stimulation by growth factors. | 2002 | Reprod. Fertil. Dev. | pmid:12617797 |
| Pike IL et al. | Actions of platelet activating factor (PAF) on gametes and embryos: clinical aspects. | 1992 | Reprod. Fertil. Dev. | pmid:1461991 |
| O'Neill C | Embryo-derived platelet activating factor. | 1992 | Reprod. Fertil. Dev. | pmid:1438959 |
| Kojima T et al. | Production and secretion of progesterone in vitro and presence of platelet activating factor (PAF) in early pregnancy of the marsupial, Macropus eugenii. | 1993 | Reprod. Fertil. Dev. | pmid:8234890 |
| Dusting GJ and Stewart AG | Overview of eicosanoid metabolism and relationship to platelet-activating factor. | 1990 | Reprod. Fertil. Dev. | pmid:2075239 |
| O'Neill C et al. | Embryo-derived platelet activating factor: interactions with the arachidonic acid cascade and the establishment and maintenance of pregnancy. | 1990 | Reprod. Fertil. Dev. | pmid:2075241 |
| Bragado MJ et al. | Platelet-activating factor in Iberian pig spermatozoa: receptor expression and role as enhancer of the calcium-induced acrosome reaction. | 2011 | Reprod. Domest. Anim. | pmid:22023717 |
| Schäfer-Somi S et al. | Vascular endothelial (VEGF) and epithelial growth factor (EGF) as well as platelet-activating factor (PAF) and receptors are expressed in the early pregnant canine uterus. | 2013 | Reprod. Domest. Anim. | pmid:22458960 |
| Tiemann U | The role of platelet-activating factor in the mammalian female reproductive tract. | 2008 | Reprod. Domest. Anim. | pmid:18363604 |
| Ali A et al. | Essential role of platelet-activating factor in male reproduction: a review. | 2007 | Reprod. Biomed. Online | pmid:17298732 |
| Jin XL and O'Neill C | Systematic analysis of the factors that adversely affect the rate of cell accumulation in mouse embryos during their culture in vitro. | 2014 | Reprod. Biol. Endocrinol. | pmid:24885989 |
| Seyffarth G et al. | Lipopolysaccharide induces nitric oxide synthase expression and platelet-activating factor increases nitric oxide production in human fetal membranes in culture. | 2004 | Reprod. Biol. Endocrinol. | pmid:15191613 |
| Neerhof MG et al. | The significance of endothelin in platelet-activating factor-induced fetal growth restriction. | 2012 | Reprod Sci | pmid:22534337 |
| Grinyó JM et al. | The role of platelet-activating factor antagonists in the prophylaxis of posttransplant acute tubular necrosis. | 1996 | Ren Fail | pmid:8827990 |
| López-Novoa JM et al. | The role of platelet-activating factor and the effect of PAF blocking receptors on the outcome of ARF. | 1996 | Ren Fail | pmid:8827995 |
| Pirotzky E et al. | Platelet-activating factor antagonist, BN-52021 protects against cis-diamminedichloroplatinum nephrotoxicity in the rat. | 1990 | Ren Fail | pmid:2287769 |
| Tamaoki J et al. | A human bronchial epithelial cell line releases arginine vasopressin: involvement of Ca2+ -activated K+ channels. | 1998 | Regul. Pept. | pmid:9712168 |
| Wallace JL et al. | Protective effects of somatostatin against gastric damage induced by hemorrhagic shock, stress and PAF in the rat. | 1993 | Regul. Pept. | pmid:7901873 |
| Iwamoto I et al. | Role of leukotriene B4 in substance P-induced granulocyte infiltration in mouse skin. | 1993 | Regul. Pept. | pmid:7692497 |
| Resetkova E et al. | Effect of human thyroglobulin on the production of platelet activating factor from peripheral blood mononuclear cells from patients with autoimmune thyroid diseases. | 1992 Jul-Aug | Reg Immunol | pmid:1476872 |
| Ploppa A et al. | Local anesthetic effects on human neutrophil priming and activation. | 2010 Jan-Feb | Reg Anesth Pain Med | pmid:20048657 |
| Carlson SA et al. | Lack of constitutive activation or inactivation of the platelet-activating factor receptor by glutamate substitution of alanine 230. | 1996 | Recept Signal Transduct | pmid:9015866 |
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| Weintraub ST et al. | Electrospray ionization for analysis of platelet-activating factor. | 1991 | Rapid Commun. Mass Spectrom. | pmid:1841648 |
| Smith JC et al. | Identification of lysophosphatidylcholine (LPC) and platelet activating factor (PAF) from PC12 cells and mouse cortex using liquid chromatography/multi-stage mass spectrometry (LC/MS3). | 2008 | Rapid Commun. Mass Spectrom. | pmid:18937225 |
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| Templeton AG et al. | Effects of S-salbutamol on human isolated bronchus. | 1998 | Pulm Pharmacol Ther | pmid:9802957 |
| Webber SE et al. | PAF-induced secretory hyperresponsiveness in the ferret trachea to bradykinin and its pharmacological inhibition. | 1997 | Pulm Pharmacol Ther | pmid:9514626 |
| Manabe H et al. | The inhaled administration of KF19514, a phosphodiesterase 4 and 1 inhibitor, prevents antigen-induced lung inflammation in guinea pigs. | 2000 | Pulm Pharmacol Ther | pmid:10718985 |
| Touvay C et al. | Effect of long-term infusion of platelet-activating factor on pulmonary responsiveness and morphology in the guinea-pig. | 1991 | Pulm Pharmacol | pmid:1804494 |
| Salari H and Schellenberg RR | Stimulation of human airway epithelial cells by platelet activating factor (PAF) and arachidonic acid produces 15-hydroxyeicosatetraenoic acid (15-HETE) capable of contracting bronchial smooth muscle. | 1991 | Pulm Pharmacol | pmid:1804490 |
| Macquin-Mavier I et al. | Effects of platelet-activating factor on lung epithelial permeability in the guinea-pig. | 1991 | Pulm Pharmacol | pmid:1806136 |
| Underwood SL et al. | RP 58802B, a long-acting beta 2-adrenoceptor agonist: assessment of antiasthma activity in the guinea-pig in vivo. | 1992 | Pulm Pharmacol | pmid:1280178 |
| Lai CK and Holgate ST | Stimulation of human airway epithelial cells by platelet activating factor (PAF) and arachidonic acid produces 15-hydroxyeicosatetraenoic acid (15-HETE) capable of contracting bronchial smooth muscle. | 1992 | Pulm Pharmacol | pmid:1591466 |
| Spina D et al. | The role of platelet activating factor in allergic inflammation. | 1989 | Pulm Pharmacol | pmid:2520484 |
| Björck T and Dahlén SE | Leukotrienes and histamine mediate IgE-dependent contractions of human bronchi: pharmacological evidence obtained with tissues from asthmatic and non-asthmatic subjects. | 1993 | Pulm Pharmacol | pmid:8477156 |
| Teather LA et al. | Platelet-activating factor antagonists decrease the inflammatory nociceptive response in rats. | 2002 | Psychopharmacology (Berl.) | pmid:12373444 |
| Chomyszyn-Gajewska M | [Evaluation of chosen salivary periodontal disease markers]. | 2010 | Prz. Lek. | pmid:20687387 |
| Kuśnierz B and Naskalski JW | [Mediators of the inflammatory response in the course of acute pancreatitis]. | 1999 | Prz. Lek. | pmid:10575924 |
| Myśliwiec M and Myśliwiec B | [Blood platelets, prostaglandin and complement interactions in inflammation]. | 1982 | Prz. Lek. | pmid:6753039 |
| Gui C et al. | Understanding the regulation mechanisms of PAF receptor by agonists and antagonists: molecular modeling and molecular dynamics simulation studies. | 2007 | Proteins | pmid:17243151 |
| Aquino EN et al. | Proteomic Analysis of Neutrophil Priming by PAF. | 2016 | Protein Pept. Lett. | pmid:26631175 |
| Chérifi F et al. | Isolation, functional characterization and proteomic identification of CC2-PLA₂ from Cerastes cerastes venom: a basic platelet-aggregation-inhibiting factor. | 2014 | Protein J. | pmid:24384926 |
| Fonseca FV et al. | Characterization of a new platelet aggregating factor from crotoxin Crotalus durissus cascavella venom. | 2006 | Protein J. | pmid:16729248 |
| Ho YS et al. | Probing the substrate specificity of the intracellular brain platelet-activating factor acetylhydrolase. | 1999 | Protein Eng. | pmid:10469831 |
| Konger RL et al. | Oxidized glycerophosphocholines as biologically active mediators for ultraviolet radiation-mediated effects. | 2008 | Prostaglandins Other Lipid Mediat. | pmid:18555720 |
| Tiemann U et al. | Platelet-activating factor (PAF)-like activity, localization of PAF receptor (PAF-R) and PAF-acetylhydrolase (PAF-AH) activity in bovine endometrium at different stages of the estrous cycle and early pregnancy. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11403499 |
| Watanabe S et al. | Suppression of platelet-activating factor generation and modulation of arachidonate metabolism by dietary enrichment with (n-9) eicosatrienoic acid or docosahexaenoic acid in mouse peritoneal cells. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11534547 |
| Shibata K et al. | Mediation by platelet-activating factor of 12-hydroxyeicosatetraenoic acid-induced cytosolic free calcium concentration elevation in neutrophils. | 2000 | Prostaglandins Other Lipid Mediat. | pmid:11060901 |