Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Satouchi K et al. | Application of selected ion monitoring to determination of platelet-activating factor. | 1983 | J. Biochem. | pmid:6423622 |
Hillmar I and Zöllner N | Saturated and unsaturated 1-0-alkyl-2-0-acetoyl-sn-glycero-3-phosphocholines and 2-lyso derivatives from ratfish liver oil. Effect on adenosine 3':5'-cyclic monophosphate concentration in hepatocyte suspensions. | 1983 | Res Exp Med (Berl) | pmid:6310713 |
Mauco G et al. | Platelet activating factor (PAF-acether) promotes an early degradation of phosphatidylinositol-4,5-biphosphate in rabbit platelets. | 1983 | FEBS Lett. | pmid:6311620 |
Camussi G et al. | Release of platelet activating factor in rabbits with antibody-mediated injury of the lung: the role of leukocytes and of pulmonary endothelial cells. | 1983 | J. Immunol. | pmid:6311899 |
Hwang SB et al. | Specific receptor sites for 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine (platelet activating factor) on rabbit platelet and guinea pig smooth muscle membranes. | 1983 | Biochemistry | pmid:6313047 |
Larsen GL and Henson PM | Mediators of inflammation. | 1983 | Annu. Rev. Immunol. | pmid:6399978 |
Albert DH and Snyder F | Biosynthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor) from 1-alkyl-2-acyl-sn-glycero-3-phosphocholine by rat alveolar macrophages. Phospholipase A2 and acetyltransferase activities during phagocytosis and ionophore stimulation. | 1983 | J. Biol. Chem. | pmid:6401298 |
McManus LM et al. | Thromboxane B2 (TxB2) release following acetyl glyceryl ether phosphorylcholine (AGEPC) infusion in the rabbit. | 1983 | Immunopharmacology | pmid:6832960 |
König W et al. | On the biological role of lipid chemotactic factors. | 1983 | Agents Actions Suppl. | pmid:6404145 |
Ninio E et al. | Biosynthesis of platelet-activating factor (PAF-acether). V. Enhancement of acetyltransferase activity in murine peritoneal cells by calcium ionophore A23187. | 1983 | Biochim. Biophys. Acta | pmid:6405792 |
Alam I et al. | Human and rabbit platelets form platelet-activating factor in response to calcium ionophore. | 1983 | Thromb. Res. | pmid:6407140 |
Ostermann G et al. | Studies on the stimulation of human blood platelets by semi-synthetic platelet-activating factor. | 1983 | Thromb. Res. | pmid:6408754 |
Drapier JC et al. | Lipid-mediator synthesis in peritoneal macrophages from mice injected with immunostimulants. | 1983 | Biochim. Biophys. Acta | pmid:6131693 |
Otsuka A et al. | alpha-Adrenergic blocking action of 1-O-hexadecyl-2-O-acetyl-sn-glycero-3-phosphocholine in rats. | 1983 | Clin Exp Hypertens A | pmid:6133661 |
Jouvin-Marche E et al. | Effect of the Ca2+ antagonist nifedipine on the release of platelet-activating factor (PAF-acether), slow-reacting substance and beta-glucuronidase from human neutrophils. | 1983 | Eur. J. Pharmacol. | pmid:6134631 |
Hopkins NK et al. | Evidence for mediation of acetyl glyceryl ether phosphorylcholine stimulation of adenosine 3',5'-(cyclic)monophosphate levels in human polymorphonuclear leukocytes by leukotriene B4. | 1983 | Biochim. Biophys. Acta | pmid:6313071 |
Mencia-Huerta JM et al. | Antigen-initiated release of platelet-activating factor (PAF-acether) from mouse bone marrow-derived mast cells sensitized with monoclonal IgE. | 1983 | J. Immunol. | pmid:6315819 |
Czarnetzki B | Increased monocyte chemotaxis towards leukotriene B4 and platelet activating factor in patients with inflammatory dermatoses. | 1983 | Clin. Exp. Immunol. | pmid:6317241 |
Sano K et al. | A role of calcium-activated phospholipid-dependent protein kinase in human platelet activation. Comparison of thrombin and collagen actions. | 1983 | J. Biol. Chem. | pmid:6218169 |
Vargaftig BB et al. | Synergized activation of human platelets by epinephrine and platelet-activating factor-acether is adenosine diphosphate and thromboxane A2-independent. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221558 |
Voelkel NF et al. | Platelet-activating factor causes pulmonary vasoconstriction and edema via platelet-independent leukotriene formation. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221590 |
Kloprogge E et al. | Properties of PAF-acether-induced platelet aggregation and secretion. Studies in gel-filtered human platelets. | 1983 | Thromb. Res. | pmid:6222507 |
Mueller HW et al. | 1-O-alkyl-linked phosphoglycerides of human platelets: distribution of arachidonate and other acyl residues in the ether-linked and diacyl species. | 1983 | Lipids | pmid:6419001 |
Heffner JE et al. | Acetyl glyceryl ether phosphorylcholine-stimulated human platelets cause pulmonary hypertension and edema in isolated rabbit lungs. Role of thromboxane A2. | 1983 | J. Clin. Invest. | pmid:6822668 |
Keraly CL et al. | Effect of structural analogues of PAF-acether on platelet desensitization. | 1983 | Br. J. Haematol. | pmid:6824590 |
Tence M et al. | The enantiomer and the positional isomer of platelet-activating factor. | 1983 | Biochim. Biophys. Acta | pmid:6824744 |
Camussi G et al. | Biosynthesis and release of platelet-activating factor from human monocytes. | 1983 | Int. Arch. Allergy Appl. Immunol. | pmid:6826235 |
Randolph AE et al. | Blood pressure and heart rate effects of alkyl ether phospholipids in conscious renal, spontaneously hypertensive, and normotensive rats. | 1983 | Clin Exp Hypertens A | pmid:6684006 |
Morley J et al. | Inflammatory actions of platelet activating factor (Pafacether) in guinea-pig skin. | 1983 | Br. J. Pharmacol. | pmid:6685552 |
Hornby EJ and Perry CR | 1-O-hexadecyl-2-acetyl-sn-3-glycerophosphorylcholine (PAF): some effects on the aggregation of human platelets by thrombin or collagen. | 1983 | Thromb. Haemost. | pmid:6636035 |
Ogihara T et al. | [Renomedullary hypotensive lipids and prostaglandins]. | 1983 | Horumon To Rinsho | pmid:6368051 |
Holt PG et al. | Platelet serotonin release by human polymorphonuclear leucocytes stimulated by cotton dust bacteria. | 1983 | Clin. Exp. Immunol. | pmid:6831770 |
McDonald TP and Kalmaz GD | Effects of thrombopoietin on the number and diameter of marrow megakaryocytes of mice. | 1983 | Exp. Hematol. | pmid:6832243 |
Lewis JC et al. | Platelet-activating factor effects on pulmonary ultrastructure in rabbits. | 1983 | Exp. Mol. Pathol. | pmid:6832335 |
Tanaka S et al. | Studies on the hypotensive effects of platelet activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine) in rats, guinea pigs, rabbits, and dogs. | 1983 | J. Pharmacobio-dyn. | pmid:6668545 |
Levy JV | Calmodulin antagonists inhibit aggregation of human, guniea pig and rabbit platelets induced with platelet activating factor. | 1983 | FEBS Lett. | pmid:6832368 |
Saeki S et al. | Hypotensive activity of 1-O-hexadecyl-2-O-acetyl-sn-glycero-3-phosphocholine in rats with various types of hypertension. | 1983 | Med J Osaka Univ | pmid:6669136 |
Touqui L et al. | Conversion of 3H-PAF acether by rabbit platelets is independent from aggregation: evidences for a novel metabolite. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6838557 |
Worthen GS et al. | Platelet-activating factor causes neutrophil accumulation and edema in rabbit lungs. | 1983 | Chest | pmid:6839840 |
Heffner JE et al. | Platelet-induced pulmonary hypertension and edema. A mechanism involving acetyl glyceryl ether phosphorylcholine and thromboxane A2. | 1983 | Chest | pmid:6839854 |
Vargaftig BB | Phospholipids, particularly platelet-activating factor (PAF-acether), in experimental bronchoconstriction. | 1983 | Agents Actions Suppl. | pmid:6575594 |
Levy JV | Calmodulin antagonist W-7 inhibits aggregation of human platelets induced by platelet activating factor. | 1983 | Proc. Soc. Exp. Biol. Med. | pmid:6844347 |
Page CP et al. | PAF-acether: a putative mediator of asthma and inflammation. | 1983 | Agents Actions Suppl. | pmid:6575595 |
O'Flaherty JT et al. | Platelet-activating factor and analogues: comparative studies with human neutrophils and rabbit platelets. | 1983 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:6844746 |
Valone FH and Goetzl EJ | Specific binding by human polymorphonuclear leucocytes of the immunological mediator 1-O-hexadecyl/octadecyl-2-acetyl-sn-glycero-3-phosphorylcholine. | 1983 | Immunology | pmid:6848449 |
Chilton FH et al. | Metabolic fate of platelet-activating factor in neutrophils. | 1983 | J. Biol. Chem. | pmid:6853486 |
Hartung HP et al. | Platelet activating factor (PAF) induces the oxidative burst in macrophages. | 1983 | Int. J. Immunopharmacol. | pmid:6874164 |
1st International Symposium on Platelet-Activating Factor (PAF-ACETHER, AGEPC) and structurally related ether-lipids. Paris (France) June 26-29, 1983. Abstracts. | 1983 | J Pharmacol | pmid:6876807 | |
Cargill DI et al. | Aggregation, release and desensitization induced in platelets from five species by platelet activating factor (PAF). | 1983 | Thromb. Haemost. | pmid:6879508 |
Virella G et al. | Release of PAF by human polymorphonuclear leucocytes stimulated by immune complexes bound to Sepharose particles and human erythrocytes. | 1983 | Immunology | pmid:6885111 |
Camussi G et al. | Platelet-activating factor-mediated contraction of rabbit lung strips: pharmacologic modulation. | 1983 | Immunopharmacology | pmid:6885382 |
O'Flaherty JT and Wykle RL | Biology and biochemistry of platelet-activating factor. | 1983 | Clin Rev Allergy | pmid:6370406 |
Tiffany ML | Technical considerations for platelet aggregation and related problems. | 1983 | Crit Rev Clin Lab Sci | pmid:6370596 |
Vermylen J et al. | Normal mechanisms of platelet function. | 1983 | Clin Haematol | pmid:6301715 |
Pieroni G and Hanahan DJ | Metabolic behavior of acetyl glyceryl ether phosphorylcholine on interaction with rabbit platelets. | 1983 | Arch. Biochem. Biophys. | pmid:6870274 |
Pinckard RN | Platelet-activating factor. | 1983 | Hosp. Pract. (Off. Ed.) | pmid:6414941 |
Camussi G et al. | The release of platelet-activating factor from human endothelial cells in culture. | 1983 | J. Immunol. | pmid:6415166 |
Bonnet J et al. | Dependency of the Paf-acether induced bronchospasm on the lipoxygenase pathway in the guinea-pig. | 1983 | Prostaglandins | pmid:6419289 |
Lin AH et al. | Acetyl glyceryl ether phosphorylcholine stimulates leukotriene B4 synthesis in human polymorphonuclear leukocytes. | 1982 | J. Clin. Invest. | pmid:6290535 |
Vargaftig BB et al. | Adrenaline and PAF-acether synergize to trigger cyclooxygenase-independent activation of plasma-free human platelets. | 1982 | Thromb. Res. | pmid:7164036 |
Mencia-Huerta JM et al. | Biosynthesis of platelet-activating factor (PAF)acether). III. Formation of PAF-acether from synthetic substrates by stimulated murine macrophages. | 1982 | J. Immunol. | pmid:7086143 |
Humphrey DM et al. | Induction of leukocytic infiltrates in rabbit skin by acetyl glyceryl ether phosphorylcholine. | 1982 | Lab. Invest. | pmid:7109542 |
Karpatkin S et al. | Platelet aggregating material (PAM) of two virally-transformed tumors: SV3T3 mouse fibroblast and PW20 rat renal sarcoma. Role of cell surface sialylation. | 1982 | Prog. Clin. Biol. Res. | pmid:7111309 |
Voelkel NF et al. | Nonimmunological production of leukotrienes induced by platelet-activating factor. | 1982 | Science | pmid:7123233 |
Kelly GL and Eiseman B | Development of a new vascular prosthetic: lessons learned. | 1982 | Arch Surg | pmid:7125901 |
Sugiura T et al. | Ether phospholipids in guinea pig polymorphonuclear leukocytes and macrophages. Occurrence of high levels of 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine. | 1982 | Biochim. Biophys. Acta | pmid:7126622 |
Vargaftig BB et al. | Non-steroidal anti-inflammatory drugs if combined with anti-histamine and anti-serotonin agents interfere with the bronchial and platelet effects of "platelet-activating factor" (PAF-acether). | 1982 | Eur. J. Pharmacol. | pmid:7128682 |
Namm DH et al. | Species specificity of the platelet responses to 1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine. | 1982 | Thromb. Res. | pmid:7071810 |
Keraly CL and Benveniste J | Specific desensitization of rabbit platelets by platelet-activating factor (PAF-acether) and derivatives. | 1982 | Br. J. Haematol. | pmid:7082588 |
Wykle RL et al. | Platelet activating factor (1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine). Activity of analogs lacking oxygen at the 2-position. | 1982 | FEBS Lett. | pmid:7084476 |
Sánchez-Crespo M et al. | Vascular actions of synthetic PAF-acether (a synthetic platelet-activating factor) in the rat: evidence for a platelet independent mechanism. | 1982 | Immunopharmacology | pmid:7085259 |
Mueller HW et al. | Ether lipid content and fatty acid distribution in rabbit polymorphonuclear neutrophil phospholipids. | 1982 | Lipids | pmid:7087685 |
Haslam RJ and Vanderwel M | Inhibition of platelet adenylate cyclase by 1-O-alkyl-2-O-acetyl-sn-glyceryl-3-phosphorylcholine (platelet-activating factor). | 1982 | J. Biol. Chem. | pmid:6177688 |
Page CP et al. | Platelet activation in asthma. | 1982 | N. Engl. J. Med. | pmid:7088080 |
Vargaftig BB et al. | Degranulation of rabbit platelets with PAF-acether: a new procedure for unravelling the mode of action of platelet-activating substances. | 1982 | Thromb. Haemost. | pmid:7135345 |
Sancho J et al. | The effect of the injection of a synthetic platelet-activating factor (PAF-acether) on the fate of IgG aggregates in mice. | 1982 | Immunology | pmid:7141463 |
Roubin R et al. | Release of platelet-activating factor (PAF-acether) and leukotrienes C and D from inflammatory macrophages. | 1982 | Eur. J. Immunol. | pmid:6122581 |
O'Flaherty JT | Lipid mediators of inflammation and allergy. | 1982 | Lab. Invest. | pmid:6126615 |
Camussi G et al. | The release of platelet-activating factor during phagocytosis by polymorphonuclear neutrophils and monocytes. | 1982 | Adv. Exp. Med. Biol. | pmid:7090917 |
Alonso F et al. | Modulatory role of cyclic AMP in the release of platelet-activating factor from human polymorphonuclear leucocytes. | 1982 | Immunology | pmid:6277775 |
Rao GH et al. | Human platelet activation by an alkylacetyl analogue of phosphatidylcholine. | 1982 | Biochim. Biophys. Acta | pmid:6280777 |
Ingraham LM et al. | Metabolic, membrane, and functional responses of human polymorphonuclear leukocytes to platelet-activating factor. | 1982 | Blood | pmid:6282362 |
Valone FH et al. | Specific binding of phospholipid platelet-activating factor by human platelets. | 1982 | J. Immunol. | pmid:6286773 |
Lüscher EF | The role of blood cells and of the vessel wall in the induction of intravascular coagulation. | 1982 | Klin. Wochenschr. | pmid:6750223 |
Shaw JO and Lyons RM | Requirements for different Ca2+ pools in the activation of rabbit platelets. I. release reaction and protein phosphorylation. | 1982 | Biochim. Biophys. Acta | pmid:6800409 |
Aderka D et al. | Morphological platelet anomalies in thrombotic thrombocytopenic purpura. | 1982 | Acta Haematol. | pmid:6801893 |
Benveniste J et al. | Biosynthesis of platelet-activating factor (PAF-ACETHER). II. Involvement of phospholipase A2 in the formation of PAF-ACETHER and lyso-PAF-ACETHER from rabbit platelets. | 1982 | Thromb. Res. | pmid:6803388 |
Roubin R et al. | Biosynthesis of platelet-activating factor (PAF-acether). IV. Impairment of acetyl-transferase activity in thioglycollate-elicited mouse macrophages. | 1982 | J. Immunol. | pmid:6806384 |
Lee TC et al. | Activities of enzymes that metabolize platelet-activating factor (1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine) in neutrophils and eosinophils from humans and the effect of a calcium ionophore. | 1982 | Biochem. Biophys. Res. Commun. | pmid:6808993 |
Morgan WK et al. | Byssinosis: some unanswered questions. | 1982 | Am. Rev. Respir. Dis. | pmid:6808880 |
Myśliwiec M and Myśliwiec B | [Blood platelets, prostaglandin and complement interactions in inflammation]. | 1982 | Prz. Lek. | pmid:6753039 |
Miller OV et al. | Acetyl glycerylphosphorylcholine inhibition of prostaglandin I2-stimulated adenosine 3',5'-cyclic monophosphate levels in human platelets. Evidence for thromboxane A2 dependence. | 1982 | Biochim. Biophys. Acta | pmid:6285985 |
Miller CL | Infection in massively injured patients. | 1982 | Prog. Clin. Biol. Res. | pmid:6757964 |
Bruni A and Palatini P | Biological and pharmacological properties of phospholipids. | 1982 | Prog Med Chem | pmid:6758038 |
Chesney CM et al. | Effect of platelet-activating factor (PAF) on human platelets. | 1982 | Blood | pmid:7037068 |
Masugi F et al. | [Platelet-activating factor and antihypertensive polar renomedullary lipid: 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine]. | 1982 | Tanpakushitsu Kakusan Koso | pmid:6758041 |
Modiano A and Belisario A | [Recent information on PAF (Platelet Activating Factor) in hemocoagulative and immuno-allergic processes]. | 1982 | G Clin Med | pmid:6762313 |
Masugi F et al. | Potent hypotensive activity of 1-O-hexadecyl-2-O-acetyl-SN-glycero-3-phosphocholine in spontaneously hypertensive rat. | 1982 | Biochem. Biophys. Res. Commun. | pmid:7041899 |
Lapetina EG | Platelet-activating factor stimulates the phosphatidylinositol cycle. Appearance of phosphatidic acid is associated with the release of serotonin in horse platelets. | 1982 | J. Biol. Chem. | pmid:7045103 |
Hartung HP et al. | Stimulation of the oxidative burst in macrophages with platelet activating factor (PAF-acether). | 1982 | Agents Actions Suppl. | pmid:6960648 |