Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Kim H et al. | Higher plasma platelet-activating factor levels are associated with increased risk of vertebral fracture and lower bone mineral density in postmenopausal women. | 2015 | J. Bone Miner. Metab. | pmid:25501698 |
Mullol J et al. | Update on rupatadine in the management of allergic disorders. | 2015 | Allergy | pmid:25491409 |
Zhao YM and Maimone TJ | Short, enantioselective total synthesis of chatancin. | 2015 | Angew. Chem. Int. Ed. Engl. | pmid:25470723 |
Kattan JD and Sicherer SH | Optimizing the diagnosis of food allergy. | 2015 | Immunol Allergy Clin North Am | pmid:25459577 |
Zelanis A et al. | Snake venom serine proteinases specificity mapping by proteomic identification of cleavage sites. | 2015 | J Proteomics | pmid:25452133 |
Vlachogianni IC et al. | Platelet Activating Factor (PAF) biosynthesis is inhibited by phenolic compounds in U-937 cells under inflammatory conditions. | 2015 | Prostaglandins Other Lipid Mediat. | pmid:26358846 |
Sato A et al. | Angiotensin peptides attenuate platelet-activating factor-induced inflammatory activity in rats. | 2015 | Peptides | pmid:26348270 |
Damiani E et al. | Platelet-Activating Factor Induces Epigenetic Modifications in Human Mast Cells. | 2015 | J. Invest. Dermatol. | pmid:26316070 |
Starossom SC et al. | Platelets Play Differential Role During the Initiation and Progression of Autoimmune Neuroinflammation. | 2015 | Circ. Res. | pmid:26294656 |
Morita K et al. | [Pain relieving effect of platelet-activating factor (PAF) antagonists in a bone cancer pain model]. | 2015 | Nippon Yakurigaku Zasshi | pmid:26256746 |