| MeSH term | MeSH ID | Detail |
|---|---|---|
| Asphyxia Neonatorum | D001238 | 4 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Brain Diseases | D001927 | 27 associated lipids |
| Cardiovascular Diseases | D002318 | 24 associated lipids |
| Hypersensitivity, Delayed | D006968 | 43 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Staphylococcal Infections | D013203 | 15 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yamakawa Y et al. | Interaction of platelet activating factor, reactive oxygen species generated by xanthine oxidase, and leukocytes in the generation of hepatic injury after shock/resuscitation. | 2000 | Ann. Surg. | pmid:10714632 |
| McClenahan DJ et al. | Role of platelet-activating factor in alveolar septal injury associated with experimentally induced pneumonic pasteurellosis in calves. | 2000 | Am. J. Vet. Res. | pmid:10714514 |
| Maruoka S et al. | PAF-induced RANTES production by human airway smooth muscle cells requires both p38 MAP kinase and Erk. | 2000 | Am. J. Respir. Crit. Care Med. | pmid:10712344 |
| Turner PJ et al. | Involvement of kinins in hyperresponsiveness induced by platelet activating factor in the human nasal airway. | 2000 | Br. J. Pharmacol. | pmid:10711351 |
| Nikbakht-Sangari M et al. | The role of inflammatory mediators in the mechanism of the host immune response induced by ischemia-reperfusion injury. | 2000 | Immunol. Invest. | pmid:10709843 |
| Neuberger Y et al. | A lyso-platelet activating factor phospholipase C, originally suggested to be a neutral-sphingomyelinase, is located in the endoplasmic reticulum. | 2000 | FEBS Lett. | pmid:10708753 |
| Fukuda Y et al. | Effect of human plasma-type platelet-activating factor acetylhydrolase in two anaphylactic shock models. | 2000 | Eur. J. Pharmacol. | pmid:10708725 |
| Henderson WR et al. | Recombinant human platelet-activating factor-acetylhydrolase inhibits airway inflammation and hyperreactivity in mouse asthma model. | 2000 | J. Immunol. | pmid:10706731 |
| Hidi R et al. | Phosphodiesterase and cyclic adenosine monophosphate-dependent inhibition of T-lymphocyte chemotaxis. | 2000 | Eur. Respir. J. | pmid:10706503 |
| Tremblay G | BN 52021 decreases alveolar macrophage-mediated lung injury in experimental extrinsic allergic alveolitis. | 1999 | Mediators Inflamm. | pmid:10704058 |
| Zouki C et al. | The anti-inflammatory peptides, antiflammins, regulate the expression of adhesion molecules on human leukocytes and prevent neutrophil adhesion to endothelial cells. | 2000 | FASEB J. | pmid:10698973 |
| Emingil G et al. | Levels of leukotriene B4 and platelet activating factor in gingival crevicular fluid in renal transplant patients receiving cyclosporine A. | 2000 | J. Periodontol. | pmid:10695938 |
| De Plaen IG et al. | Lipopolysaccharide activates nuclear factor kappaB in rat intestine: role of endogenous platelet-activating factor and tumour necrosis factor. | 2000 | Br. J. Pharmacol. | pmid:10694237 |
| Nilsson G et al. | Demonstration that platelet-activating factor is capable of activating mast cells and inducing a chemotactic response. | 2000 | Immunology | pmid:10692052 |
| Weintraub ST et al. | Mass spectrometric analysis of platelet-activating factor after isolation by solid-phase extraction and direct derivatization with pentafluorobenzoic anhydride. | 2000 | J. Am. Soc. Mass Spectrom. | pmid:10689672 |
| Bleeker WK et al. | Vasoactive side effects of intravenous immunoglobulin preparations in a rat model and their treatment with recombinant platelet-activating factor acetylhydrolase. | 2000 | Blood | pmid:10688848 |
| Werr J et al. | Integrin alpha(2)beta(1) (VLA-2) is a principal receptor used by neutrophils for locomotion in extravascular tissue. | 2000 | Blood | pmid:10688841 |
| Sugano T et al. | Platelet-activating factor induces an imbalance between matrix metalloproteinase-1 and tissue inhibitor of metalloproteinases-1 expression in human uterine cervical fibroblasts. | 2000 | Biol. Reprod. | pmid:10684793 |
| Fujimura M et al. | No involvement of lipid mediators in a guinea pig model of ultrasonically nebulized distilled water-induced bronchoconstriction. | 2000 | Prostaglandins Other Lipid Mediat. | pmid:10680775 |
| Ishihara Y et al. | Regulation of immunoglobulin G2 production by prostaglandin E(2) and platelet-activating factor. | 2000 | Infect. Immun. | pmid:10678975 |
| Orozco AS et al. | Mechanisms of the proinflammatory response of endothelial cells to Candida albicans infection. | 2000 | Infect. Immun. | pmid:10678917 |
| Kimura I et al. | Release of endothelins and platelet-activating factor by a rat pleural mesothelial cell line. | 2000 | Eur. Respir. J. | pmid:10678641 |
| Fu Y and Hu YM | Prophylactic effects of tetramethyl pyrazine on mice with endotoxemia and its relationship with platelet-activating factor. | 1999 | Zhongguo Yao Li Xue Bao | pmid:10678147 |
| Burgermeister E et al. | Inhibition of cytosolic phospholipase A(2) attenuates activation of mitogen-activated protein kinases in human monocytic cells. | 2000 | Eur. J. Pharmacol. | pmid:10675727 |
| Cowling RT and Birnboim HC | Expression of serum- and glucocorticoid-regulated kinase (sgk) mRNA is up-regulated by GM-CSF and other proinflammatory mediators in human granulocytes. | 2000 | J. Leukoc. Biol. | pmid:10670586 |
| Partrick DA et al. | Maximal human neutrophil priming for superoxide production and elastase release requires p38 mitogen-activated protein kinase activation. | 2000 | Arch Surg | pmid:10668885 |
| Gelbard HA | Neuroprotective strategies for HIV-1-associated neurologic disease. | 1999 | Ann. N. Y. Acad. Sci. | pmid:10668436 |
| Yu R et al. | Studies on the callus cultures of Ginkgo biloba and its metabolites-ginkgolides. | 1999 | Chin. J. Biotechnol. | pmid:10668135 |
| Goldman R et al. | Lipid mediators stimulate reactive oxygen species formation in immortalized human keratinocytes. | 1999 | Adv. Exp. Med. Biol. | pmid:10667361 |
| Kato K | Modulation of long-term potentiation in the CA1 area of rat hippocampus by platelet-activating factor. | 1999 | Adv. Exp. Med. Biol. | pmid:10667334 |
| Marshall LA et al. | Respective roles of the 14 kDa and 85 kDa phospholipase A2 enzymes in human monocyte eicosanoid formation. | 1999 | Adv. Exp. Med. Biol. | pmid:10667333 |
| Grimminger F et al. | PAF-induced synthesis of tetraenoic and pentaenoic leukotrienes in the isolated rabbit lung. | 2000 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:10666110 |
| Modschiedler K et al. | Dapsone and colchicine inhibit adhesion of neutrophilic granulocytes to epidermal sections. | 2000 | Arch. Dermatol. Res. | pmid:10664013 |
| Ibe BO et al. | Platelet activating factor acetylhydrolase activity in lamb lungs is up-regulated in the immediate newborn period. | 2000 | Mol. Genet. Metab. | pmid:10655157 |
| Dichmann S et al. | Adenosine triphosphate-induced oxygen radical production and CD11b up-regulation: Ca(++) mobilization and actin reorganization in human eosinophils. | 2000 | Blood | pmid:10648411 |
| Miike S et al. | Platelet-activating factor activates mitogen-activated protein kinases through the activation of phosphatidylinositol 3-kinase and tyrosine kinase in human eosinophils. | 2000 | J. Leukoc. Biol. | pmid:10648006 |
| Michibayashi T | Interaction between platelet-aggregating response and vasoconstrictive response to platelet activating factor. | 1999 | J Smooth Muscle Res | pmid:10647808 |
| Munir I et al. | Mitogen-activated protein kinase activation and regulation of cyclooxygenase 2 expression by platelet-activating factor and hCG in human endometrial adenocarcinoma cell line HEC-1B. | 1999 | J. Reprod. Fertil. | pmid:10645245 |
| Owaki T et al. | Endothelial cells potentiate phagocytic killing by macrophages via platelet-activating factor release. | 2000 | Am. J. Physiol. Heart Circ. Physiol. | pmid:10644608 |
| Clavijo LC et al. | Platelet-activating factor and bacteremia-induced pulmonary hypertension. | 2000 | J. Surg. Res. | pmid:10644485 |
| Tong N et al. | Neuronal fractalkine expression in HIV-1 encephalitis: roles for macrophage recruitment and neuroprotection in the central nervous system. | 2000 | J. Immunol. | pmid:10640747 |
| Chlopicki S et al. | Biphasic response to lipopolysaccharide from E. coli in the isolated ventilated blood-perfused rat lung. | 1999 | J. Physiol. Pharmacol. | pmid:10639006 |
| Keularts IM et al. | alpha(2A)-adrenergic receptor stimulation potentiates calcium release in platelets by modulating cAMP levels. | 2000 | J. Biol. Chem. | pmid:10636873 |
| Atuma C et al. | Helicobacter pylori extracts reduce gastric mucosal blood flow by a nitric oxide-independent but mast cell- and platelet-activating factor receptor-dependent pathway in rats. | 1999 | Scand. J. Gastroenterol. | pmid:10636064 |
| Montrucchio G et al. | Platelet-activating factor enhances vascular endothelial growth factor-induced endothelial cell motility and neoangiogenesis in a murine matrigel model. | 2000 | Arterioscler. Thromb. Vasc. Biol. | pmid:10634803 |
| Haines DD et al. | Cardioprotective effects of the calcineurin inhibitor FK506 and the PAF receptor antagonist and free radical scavenger, EGb 761, in isolated ischemic/reperfused rat hearts. | 2000 | J. Cardiovasc. Pharmacol. | pmid:10630731 |
| Franke B et al. | Sequential regulation of the small GTPase Rap1 in human platelets. | 2000 | Mol. Cell. Biol. | pmid:10629034 |
| Kaul DK et al. | Monoclonal antibodies to alphaVbeta3 (7E3 and LM609) inhibit sickle red blood cell-endothelium interactions induced by platelet-activating factor. | 2000 | Blood | pmid:10627437 |
| Kim DD et al. | Platelet-activating factor modulates microvascular dynamics through phospholipase C in the hamster cheek pouch. | 2000 | Microvasc. Res. | pmid:10625566 |
| Fukuda S et al. | Mechanisms for regulation of fluid shear stress response in circulating leukocytes. | 2000 | Circ. Res. | pmid:10625314 |