| MeSH term | MeSH ID | Detail |
|---|---|---|
| Asphyxia Neonatorum | D001238 | 4 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Brain Diseases | D001927 | 27 associated lipids |
| Cardiovascular Diseases | D002318 | 24 associated lipids |
| Hypersensitivity, Delayed | D006968 | 43 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Staphylococcal Infections | D013203 | 15 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Am. J. Physiol., Cell Physiol. (2)
- Arterioscler. Thromb. Vasc. Biol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sibelius U et al. | Staphylococcal alpha-toxin provokes coronary vasoconstriction and loss in myocardial contractility in perfused rat hearts: role of thromboxane generation. | 2000 Jan 4-11 | Circulation | pmid:10618308 |
| Thurston G et al. | Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1. | 1999 | Science | pmid:10617467 |
| Sawai H et al. | Function of the cloned putative neutral sphingomyelinase as lyso-platelet activating factor-phospholipase C. | 1999 | J. Biol. Chem. | pmid:10608884 |
| Hashimoto S et al. | p38 MAP kinase regulates TNF alpha-, IL-1 alpha- and PAF-induced RANTES and GM-CSF production by human bronchial epithelial cells. | 2000 | Clin. Exp. Allergy | pmid:10606930 |
| Bosch RJ et al. | Effects of parathyroid hormone-related protein on human mesangial cells in culture. | 1999 | Am. J. Physiol. | pmid:10600786 |
| Wechsung E and Houvenaghel A | Influence of platelet activating factor on gastrointestinal electrical activity and some haematological and clinical parameters in the conscious miniature pig. | 1999 | J. Vet. Pharmacol. Ther. | pmid:10597537 |
| Arbabi S et al. | Priming interleukin 8 production: role of platelet-activating factor and p38. | 1999 | Arch Surg | pmid:10593333 |
| Burns AR et al. | Analysis of tight junctions during neutrophil transendothelial migration. | 2000 | J. Cell. Sci. | pmid:10591624 |
| Kitsiouli EI et al. | Differential determination of phospholipase A(2) and PAF-acetylhydrolase in biological fluids using fluorescent substrates. | 1999 | J. Lipid Res. | pmid:10588961 |
| Kafoury RM et al. | Induction of inflammatory mediators in human airway epithelial cells by lipid ozonation products. | 1999 | Am. J. Respir. Crit. Care Med. | pmid:10588609 |
| Byrum RS et al. | Determination of the contribution of cysteinyl leukotrienes and leukotriene B4 in acute inflammatory responses using 5-lipoxygenase- and leukotriene A4 hydrolase-deficient mice. | 1999 | J. Immunol. | pmid:10586081 |
| Hendrickson HS et al. | Intramolecularly quenched BODIPY-labeled phospholipid analogs in phospholipase A(2) and platelet-activating factor acetylhydrolase assays and in vivo fluorescence imaging. | 1999 | Anal. Biochem. | pmid:10585741 |
| Wu R et al. | Antibodies to platelet-activating factor are associated with borderline hypertension, early atherosclerosis and the metabolic syndrome. | 1999 | J. Intern. Med. | pmid:10583710 |
| Rodrigues CO et al. | Platelet-activating factor induction of secreted phosphatase activity in Trypanosoma cruzi. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10581161 |
| Shin BA et al. | Lyso-PAF analogues and lysophosphatidylcholines from the marine sponge Spirastrella abata as inhibitors of cholesterol biosynthesis. | 1999 | J. Nat. Prod. | pmid:10579872 |
| Mizuki M et al. | Inhibition of eosinophil activation in bronchoalveolar lavage fluid from atopic asthmatics by Y-24180, an antagonist to platelet-activating factor. | 1999 | Life Sci. | pmid:10579457 |
| Goldfarb R | Investigations into the polydeterminant nature of sepsis. | 1999 | Crit. Care Med. | pmid:10579296 |
| Quinn JV and Slotman GJ | Platelet-activating factor and arachidonic acid metabolites mediate tumor necrosis factor and eicosanoid kinetics and cardiopulmonary dysfunction during bacteremic shock. | 1999 | Crit. Care Med. | pmid:10579269 |
| Grassi S et al. | Platelet-activating factor and group I metabotropic glutamate receptors interact for full development and maintenance of long-term potentiation in the rat medial vestibular nuclei. | 1999 | Neuroscience | pmid:10579215 |
| Kuśnierz B and Naskalski JW | [Mediators of the inflammatory response in the course of acute pancreatitis]. | 1999 | Prz. Lek. | pmid:10575924 |
| Olszanecki R and Chłopicki S | Endotoxaemia in rats: role of NO, PAF and TXA2 in pulmonary neutrophil sequestration and hyperlactataemia. | 1999 | J. Physiol. Pharmacol. | pmid:10574473 |
| Tekgül H et al. | Lymphocyte subsets and inflammatory mediators in patients with subacute sclerosing panencephalitis. | 1999 | J. Child Neurol. | pmid:10573462 |
| Grutters JC et al. | Asthma therapy modulates priming-associated blood eosinophil responsiveness in allergic asthmatics. | 1999 | Eur. Respir. J. | pmid:10573242 |
| Bratt T et al. | Interactions between neutrophil gelatinase-associated lipocalin and natural lipophilic ligands. | 1999 | Biochim. Biophys. Acta | pmid:10572948 |
| Torras J et al. | Long-term protective effect of UR-12670 after warm renal ischemia in uninephrectomized rats. | 1999 | Kidney Int. | pmid:10571788 |
| Ozaki N et al. | Mechanosensitive properties of gastric vagal afferent fibers in the rat. | 1999 | J. Neurophysiol. | pmid:10561400 |
| Fuentes E et al. | Lysophospholipids trigger calcium signals but not DNA synthesis in cortical astrocytes. | 1999 | Glia | pmid:10559786 |
| Lauener RW et al. | A role for phosphatidylinositol 3-kinase in platelet aggregation in response to low, but not high, concentrations of PAF or thrombin. | 1999 | Biochim. Biophys. Acta | pmid:10559473 |
| Falk S et al. | Quinolines attenuate PAF-induced pulmonary pressor responses and edema formation. | 1999 | Am. J. Respir. Crit. Care Med. | pmid:10556149 |
| Adunsky A et al. | Infarct volume, neurological severity and PAF binding to platelets of patients with acute cerebral ischemic stroke. | 1999 | Neurol. Res. | pmid:10555184 |
| Wang MM et al. | Stereoselective actions of hepoxilins A3 and B3 and their cyclopropane analogs (HxdeltaA3 and HxdeltaB3) on bradykinin and PAF-evoked potentiation of vascular leakage in rat skin. | 1999 | Gen. Pharmacol. | pmid:10553878 |
| Biancone L et al. | Motility induced by human immunodeficiency virus-1 Tat on Kaposi's sarcoma cells requires platelet-activating factor synthesis. | 1999 | Am. J. Pathol. | pmid:10550329 |
| Li S et al. | Experimental therapy of a platelet-activating factor antagonist (ginkgolide B) on photochemically induced thrombotic cerebral ischaemia in tree shrews. | 1999 | Clin. Exp. Pharmacol. Physiol. | pmid:10549411 |
| Uluoglu C and Timlioglu O | Endothelium-dependent vasodilation in the isolated rabbit kidney following in vivo and in vitro ischaemia and reperfusion: effects of antagonizing platelet activating factor (PAF). | 1999 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:10543435 |
| Gómez FP et al. | Gas exchange response to a PAF receptor antagonist, SR 27417A, in acute asthma: a pilot study. | 1999 | Eur. Respir. J. | pmid:10543285 |
| Echazarreta AL et al. | Effects of inhaled furosemide on platelet-activating factor challenge in mild asthma. | 1999 | Eur. Respir. J. | pmid:10543284 |
| Koyama S et al. | The potential of various lipopolysaccharides to release monocyte chemotactic activity from lung epithelial cells and fibroblasts. | 1999 | Eur. Respir. J. | pmid:10543273 |
| Manya H et al. | Biochemical characterization of various catalytic complexes of the brain platelet-activating factor acetylhydrolase. | 1999 | J. Biol. Chem. | pmid:10542206 |
| Ernest S and Bello-Reuss E | Secretion of platelet-activating factor is mediated by MDR1 P-glycoprotein in cultured human mesangial cells. | 1999 | J. Am. Soc. Nephrol. | pmid:10541289 |
| Tselepis AD et al. | Platelet aggregatory response to platelet activating factor (PAF), ex vivo, and PAF-acetylhydrolase activity in patients with unstable angina: effect of c7E3 Fab (abciximab) therapy. | 1999 | Cardiovasc. Res. | pmid:10536703 |
| McKenna CJ et al. | Familial dilated cardiomyopathy. | 1999 | Circulation | pmid:10534480 |
| Nicholson SC et al. | Echocardiographic and survival studies in mice undergoing endotoxic shock: effects of genetic ablation of inducible nitric oxide synthase and pharmacologic antagonism of platelet-activating factor. | 1999 | J. Surg. Res. | pmid:10534424 |
| Mustafa SB et al. | Suppression of lipopolysaccharide-induced nitric oxide synthase expression by platelet-activating factor receptor antagonists in the rat liver and cultured rat Kupffer cells. | 1999 | Hepatology | pmid:10534342 |
| Serou MJ et al. | Interleukin-1 beta activates expression of cyclooxygenase-2 and inducible nitric oxide synthase in primary hippocampal neuronal culture: platelet-activating factor as a preferential mediator of cyclooxygenase-2 expression. | 1999 | J. Neurosci. Res. | pmid:10533051 |
| Marr KA et al. | Agonist-induced adherence of equine neutrophils to fibronectin- and serum-coated plastic is CD18 dependent. | 1999 | Vet. Immunol. Immunopathol. | pmid:10532398 |
| Stammberger U et al. | Combined treatment with endothelin- and PAF-antagonists reduces posttransplant lung ischemia/reperfusion injury. | 1999 | J. Heart Lung Transplant. | pmid:10528748 |
| Vergnolle N | Proteinase-activated receptor-2-activating peptides induce leukocyte rolling, adhesion, and extravasation in vivo. | 1999 | J. Immunol. | pmid:10528212 |
| Sun Z et al. | Roles of platelet-activating factor, interleukin-1beta and interleukin-6 in intestinal barrier dysfunction induced by mesenteric arterial ischemia and reperfusion. | 1999 | J. Surg. Res. | pmid:10527709 |
| Kinlough-Rathbone RL et al. | Effects of cathepsin G pretreatment of platelets on their subsequent responses to aggregating agents. | 1999 | Thromb. Res. | pmid:10527409 |
| Wang X et al. | Platelet-activating factor induced Ca(2+) signaling in human microglia. | 1999 | Brain Res. | pmid:10526106 |