| MeSH term | MeSH ID | Detail |
|---|---|---|
| Liver Cirrhosis, Experimental | D008106 | 36 associated lipids |
| Fever | D005334 | 35 associated lipids |
| Glomerulonephritis | D005921 | 35 associated lipids |
| Anaphylaxis | D000707 | 35 associated lipids |
| Epilepsy | D004827 | 35 associated lipids |
| Infarction, Middle Cerebral Artery | D020244 | 35 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Acute Kidney Injury | D058186 | 34 associated lipids |
| Spinal Cord Injuries | D013119 | 34 associated lipids |
| Anemia, Sickle Cell | D000755 | 34 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Barnes PJ | Ceramide lances the lungs. | 2004 | Nat. Med. | pmid:14760419 |
| Rollin S et al. | VEGF-mediated endothelial P-selectin translocation: role of VEGF receptors and endogenous PAF synthesis. | 2004 | Blood | pmid:14764537 |
| Hidalgo MA et al. | Platelet-activating factor increases pH(i) in bovine neutrophils through the PI3K-ERK1/2 pathway. | 2004 | Br. J. Pharmacol. | pmid:14691048 |
| Gabrijelcic J et al. | Formoterol protects against platelet-activating factor-induced effects in asthma. | 2004 | Eur. Respir. J. | pmid:14738234 |
| Geiser T | The role of neutrophils and neutrophil products in pulmonary hemodynamics of endotoxin in oleic acid-induced lung injury. | 2004 | Anesth. Analg. | pmid:14742354 |
| Hill LL et al. | Neutrophils and neutrophil products do not mediate pulmonary hemodynamic effects of endotoxin on oleic acid-induced lung injury. | 2004 | Anesth. Analg. | pmid:14742386 |
| Tokiwano T et al. | Biosynthesis of phomactins: common intermediate phomactatriene and taxadiene. | 2004 | Chem. Commun. (Camb.) | pmid:15154058 |
| Poli G et al. | Oxidative stress and cell signalling. | 2004 | Curr. Med. Chem. | pmid:15134513 |
| Zhelev DV et al. | Controlled pseudopod extension of human neutrophils stimulated with different chemoattractants. | 2004 | Biophys. J. | pmid:15240502 |
| Gilroy DW et al. | A novel role for phospholipase A2 isoforms in the checkpoint control of acute inflammation. | 2004 | FASEB J. | pmid:15003994 |
| Jantan I et al. | Inhibitory effects of compounds from Zingiberaceae species on platelet activating factor receptor binding. | 2004 | Phytother Res | pmid:15742349 |
| Kondratskaya EL et al. | Inhibition of hippocampal LTP by ginkgolide B is mediated by its blocking action on PAF rather than glycine receptors. | 2004 | Neurochem. Int. | pmid:14568560 |
| Berdeli A et al. | Meconium enhances platelet-activating factor and tumor necrosis factor production by rat alveolar macrophages. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15301793 |
| Ma X et al. | [Corneal epithelial wound healing is delayed by platelet activating factor treatment]. | 2004 | Zhonghua Yan Ke Za Zhi | pmid:15307983 |
| Bossi F et al. | Platelet-activating factor and kinin-dependent vascular leakage as a novel functional activity of the soluble terminal complement complex. | 2004 | J. Immunol. | pmid:15557188 |
| Venkatesha RT et al. | Platelet-activating factor-induced chemokine gene expression requires NF-kappaB activation and Ca2+/calcineurin signaling pathways. Inhibition by receptor phosphorylation and beta-arrestin recruitment. | 2004 | J. Biol. Chem. | pmid:15308653 |
| Crawford SE et al. | Captopril suppresses post-transplantation angiogenic activity in rat allograft coronary vessels. | 2004 | J. Heart Lung Transplant. | pmid:15366425 |
| Seo KH et al. | Estrogen enhances angiogenesis through a pathway involving platelet-activating factor-mediated nuclear factor-kappaB activation. | 2004 | Cancer Res. | pmid:15374958 |
| Ma X et al. | Platelet-activating factor (PAF) induces corneal neovascularization and upregulates VEGF expression in endothelial cells. | 2004 | Invest. Ophthalmol. Vis. Sci. | pmid:15326102 |
| Wright CS et al. | Evidence for lipid packaging in the crystal structure of the GM2-activator complex with platelet activating factor. | 2004 | J. Mol. Biol. | pmid:15327957 |
| Thanou PG and Tsoukatos DC | Non-enzymatic platelet-activating factor formation by acetylated proteins. | 2004 | FEBS Lett. | pmid:15327967 |
| Smalling WE et al. | Protective effect of pentoxifylline on volume-induced lung injury in newborn piglets. | 2004 | Biol. Neonate | pmid:14981352 |
| Slomiany BL and Slomiany A | Platelet-activating factor mediates Porphyromonas gingivalis lipopolysaccharide interference with salivary mucin synthesis via phosphatidylinositol 3-kinase-dependent constitutive nitric-oxide synthase activation. | 2004 | J. Physiol. Pharmacol. | pmid:15082869 |
| Yang YM et al. | Creation of reversed phase high-performance liquid chromatographic technique to assay platelet-activating factor. | 2004 | J. Zhejiang Univ. Sci. | pmid:15101112 |
| Brown GE et al. | Distinct ligand-dependent roles for p38 MAPK in priming and activation of the neutrophil NADPH oxidase. | 2004 | J. Biol. Chem. | pmid:15102856 |
| Balestrieri ML et al. | Lycopene in association with alpha-tocopherol or tomato lipophilic extracts enhances acyl-platelet-activating factor biosynthesis in endothelial cells during oxidative stress. | 2004 | Free Radic. Biol. Med. | pmid:15059646 |
| Burgos RA et al. | Determination of specific receptor sites for platelet activating factor in bovine neutrophils. | 2004 | Am. J. Vet. Res. | pmid:15141884 |
| Wang J et al. | [Effect of Radix notoginseng saponins on platelet activating molecule expression and aggregation in patients with blood hyperviscosity syndrome]. | 2004 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:15143716 |
| Fu H et al. | The mechanism for activation of the neutrophil NADPH-oxidase by the peptides formyl-Met-Leu-Phe and Trp-Lys-Tyr-Met-Val-Met differs from that for interleukin-8. | 2004 | Immunology | pmid:15147563 |
| Beaudeux JL et al. | Activation of PAF receptor by oxidised LDL in human monocytes stimulates chemokine releases but not urokinase-type plasminogen activator expression. | 2004 | Clin. Chim. Acta | pmid:15149885 |
| Yang Y et al. | Increased hepatic platelet activating factor (PAF) and PAF receptors in carbon tetrachloride induced liver cirrhosis. | 2004 | Gut | pmid:15138217 |
| McDonagh PF et al. | Chronic expression of platelet adhesion proteins is associated with severe ischemic heart disease in type 2 diabetic patients: Chronic platelet activation in diabetic heart patients. | 2003 Sep-Oct | J. Diabetes Complicat. | pmid:12954156 |
| Kerek M et al. | Effects of recombinant platelet activating factor acetylhydrolase in obstructive jaundice. | 2003 Jul-Aug | Hepatogastroenterology | pmid:12845989 |
| Baltás E et al. | Platelet-activating factor antagonist WEB 2086 inhibits ultraviolet-B radiation-induced dermatitis in the human skin. | 2003 Jul-Aug | Skin Pharmacol. Appl. Skin Physiol. | pmid:12784066 |
| Hsueh W et al. | Neonatal necrotizing enterocolitis: clinical considerations and pathogenetic concepts. | 2003 Jan-Feb | Pediatr. Dev. Pathol. | pmid:12424605 |
| Diez-Fraile A et al. | Analysis of selective mobilization of L-selectin and Mac-1 reservoirs in bovine neutrophils and eosinophils. | 2003 Jan-Feb | Vet. Res. | pmid:12588684 |
| Shigematsu S et al. | Resveratrol, a red wine constituent polyphenol, prevents superoxide-dependent inflammatory responses induced by ischemia/reperfusion, platelet-activating factor, or oxidants. | 2003 | Free Radic. Biol. Med. | pmid:12654468 |
| Collado MP et al. | Endothelin-1 decreases ethanolamine plasmalogen levels and evokes PAF production in brain microvessels. | 2003 | Microvasc. Res. | pmid:14609525 |
| Odeh AI et al. | Effect of platelet-activating factor (PAF) on stallion sperm motility, capacitation and the acrosome reaction. | 2003 | Reproduction | pmid:14611633 |
| Sugimoto Y et al. | Inhibitory effects of glucocorticoids on rat eosinophil superoxide generation and chemotaxis. | 2003 | Int. Immunopharmacol. | pmid:12781701 |
| Biffl WL et al. | Clinically relevant hypertonicity prevents stored blood- and lipid-mediated delayed neutrophil apoptosis independent of p38 MAPK or caspase-3 activation. | 2003 | Surgery | pmid:12874587 |
| Akisu M et al. | Selective head cooling with hypothermia suppresses the generation of platelet-activating factor in cerebrospinal fluid of newborn infants with perinatal asphyxia. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12878450 |
| Møller CH and Steinbrüchel DA | Platelet function after coronary artery bypass grafting: is there a procoagulant activity after off-pump compared with on-pump surgery? | 2003 | Scand. Cardiovasc. J. | pmid:12881156 |
| Guarino MP et al. | PAF-like lipids- and PAF-induced gallbladder muscle contraction is mediated by different pathways in guinea pigs. | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12936911 |
| Curry FE et al. | Thrombin increases permeability only in venules exposed to inflammatory conditions. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12893636 |
| Mayer K et al. | Omega-3 vs. omega-6 lipid emulsions exert differential influence on neutrophils in septic shock patients: impact on plasma fatty acids and lipid mediator generation. | 2003 | Intensive Care Med | pmid:12897994 |
| Shen Z et al. | Effects of plumbagin on platelet aggregation and platelet-neutrophil interactions. | 2003 | Planta Med. | pmid:12898414 |
| de Assis EF et al. | Synergism between platelet-activating factor-like phospholipids and peroxisome proliferator-activated receptor gamma agonists generated during low density lipoprotein oxidation that induces lipid body formation in leukocytes. | 2003 | J. Immunol. | pmid:12902515 |
| Hu H et al. | Glycoprotein IIb/IIIa inhibition attenuates platelet-activating factor-induced platelet activation by reducing protein kinase C activity. | 2003 | J. Thromb. Haemost. | pmid:12911597 |
| Kalia N and Bardhan KD | Of blood and guts: association between Helicobacter pylori and the gastric microcirculation. | 2003 | J. Gastroenterol. Hepatol. | pmid:12911655 |
| Casillan AJ et al. | Mesenteric microvascular inflammatory responses to systemic hypoxia are mediated by PAF and LTB4. | 2003 | J. Appl. Physiol. | pmid:12598480 |
| Rios-Santos F et al. | A critical role of leukotriene B4 in neutrophil migration to infectious focus in cecal ligaton and puncture sepsis. | 2003 | Shock | pmid:12558146 |
| Mano T et al. | Novel imidazole compounds as a new series of potent, orally active inhibitors of 5-lipoxygenase. | 2003 | Bioorg. Med. Chem. | pmid:12927848 |
| Talvani A et al. | Experimental Trypanosoma cruzi infection in platelet-activating factor receptor-deficient mice. | 2003 | Microbes Infect. | pmid:12850205 |
| Triggiani M et al. | Secretory phospholipases A2 activate selective functions in human eosinophils. | 2003 | J. Immunol. | pmid:12626587 |
| Strait RT et al. | IL-4 exacerbates anaphylaxis. | 2003 | J. Immunol. | pmid:12646651 |
| Al-Darmaki S et al. | Differential expression of platelet-activating factor acetylhydrolase in macrophages and monocyte-derived dendritic cells. | 2003 | J. Immunol. | pmid:12496397 |
| Lukashova V et al. | Janus kinase 2 activation by the platelet-activating factor receptor (PAFR): roles of Tyk2 and PAFR C terminus. | 2003 | J. Immunol. | pmid:14500680 |
| Lie WJ et al. | Regulation and kinetics of platelet-activating factor and leukotriene C4 synthesis by activated human basophils. | 2003 | Clin. Exp. Allergy | pmid:12911788 |
| Fernandes LB and Goldie RG | The single mediator approach to asthma therapy: is it so unreasonable? | 2003 | Curr Opin Pharmacol | pmid:12810188 |
| Watanabe J et al. | Endotoxins stimulate neutrophil adhesion followed by synthesis and release of platelet-activating factor in microparticles. | 2003 | J. Biol. Chem. | pmid:12810708 |
| Toledo AA et al. | Fertilization potential of human sperm is correlated with endogenous platelet-activating factor content. | 2003 | J. Assist. Reprod. Genet. | pmid:12812462 |
| De Vriese AS and Bourgeois M | Pharmacologic treatment of acute renal failure in sepsis. | 2003 | Curr Opin Crit Care | pmid:14639066 |
| Souza DG et al. | Role of PAF receptors during intestinal ischemia and reperfusion injury. A comparative study between PAF receptor-deficient mice and PAF receptor antagonist treatment. | 2003 | Br. J. Pharmacol. | pmid:12812996 |
| Alviano DS et al. | Differentiation of Fonsecaea pedrosoi mycelial forms into sclerotic cells is induced by platelet-activating factor. | 2003 | Res. Microbiol. | pmid:14643407 |
| Brown RA et al. | Effects of heparin and related molecules upon neutrophil aggregation and elastase release in vitro. | 2003 | Br. J. Pharmacol. | pmid:12813008 |
| Chlopicki S et al. | Obligatory role of lipid mediators in platelet-neutrophil adhesion. | 2003 | Thromb. Res. | pmid:14592550 |
| Abu-Zidan FM | Comment on "Low-dose ethanol alters the cardiovascular, metabolic, and respiratory compensation for severe blood loss". | 2003 | J Trauma | pmid:12813357 |
| Montrucchio G et al. | Mechanisms of the priming effect of low doses of lipopoly-saccharides on leukocyte-dependent platelet aggregation in whole blood. | 2003 | Thromb. Haemost. | pmid:14597983 |
| Toledo DP et al. | Microvascular reactivity in experimental diabetes: responses of male and female rats. | 2003 | Inflamm. Res. | pmid:12813623 |
| Shabanov VV | [Cytokines and other signal molecules in the pathogenesis of acute pancreatitis]. | 2003 | Vestn. Akad. Med. Nauk SSSR | pmid:14598737 |
| Tonks AJ et al. | Regulation of platelet-activating factor synthesis in human monocytes by dipalmitoyl phosphatidylcholine. | 2003 | J. Leukoc. Biol. | pmid:12832447 |
| Estellés R et al. | Effect of two phenanthrene alkaloids on angiotensin II-induced leukocyte-endothelial cell interactions in vivo. | 2003 | Br. J. Pharmacol. | pmid:14559857 |
| Choi IW et al. | Platelet-activating factor-mediated NF-kappaB dependency of a late anaphylactic reaction. | 2003 | J. Exp. Med. | pmid:12835479 |
| Kell PJ et al. | Inhibition of platelet-activating factor (PAF) acetylhydrolase by methyl arachidonyl fluorophosphonate potentiates PAF synthesis in thrombin-stimulated human coronary artery endothelial cells. | 2003 | J. Pharmacol. Exp. Ther. | pmid:14560038 |
| Denizot Y et al. | Tissue concentrations of platelet-activating factor in colorectal carcinoma: inverse relationships with Dukes' stage of patients. | 2003 | Oncogene | pmid:14562051 |
| Ivanov AI et al. | Platelet-activating factor: a previously unrecognized mediator of fever. | 2003 | J. Physiol. (Lond.) | pmid:14565987 |
| Proudfoot JM et al. | Angiotensin II type 1 receptor antagonists inhibit basal as well as low-density lipoprotein and platelet-activating factor-stimulated human monocyte chemoattractant protein-1. | 2003 | J. Pharmacol. Exp. Ther. | pmid:12626661 |
| Fang HY et al. | Cyclooxygenase-2 in human non-small cell lung cancer. | 2003 | Eur J Surg Oncol | pmid:12633561 |
| Cole KP and Hsung RP | Intramolecular formal oxa-[3 + 3] cycloaddition approach to the ABD system of phomactin A. | 2003 | Org. Lett. | pmid:14653688 |
| Hao J et al. | [Dynamic changes of platelet number in early multiple injury and it is effect on prognosis]. | 2003 | Zhongguo Wei Zhong Bing Ji Jiu Yi Xue | pmid:14552687 |
| Benelli R et al. | Neutrophils and angiogenesis: potential initiators of the angiogenic cascade. | 2003 | Chem Immunol Allergy | pmid:12947984 |
| Wierzbicki T et al. | IL-4 primes human endothelial cells for secondary responses to histamine. | 2003 | J. Leukoc. Biol. | pmid:12949246 |
| Khanna A et al. | Beneficial effects of intraluminal nitroglycerin in intestinal ischemia-reperfusion injury in rats. | 2003 | J. Surg. Res. | pmid:13678693 |
| Bazan NG | Synaptic lipid signaling: significance of polyunsaturated fatty acids and platelet-activating factor. | 2003 | J. Lipid Res. | pmid:13130128 |
| Chatterjee SS et al. | Structure-activity studies with Ginkgo biloba extract constituents as receptor-gated chloride channel blockers and modulators. | 2003 | Pharmacopsychiatry | pmid:13130392 |
| Mahgoub AA | Thymoquinone protects against experimental colitis in rats. | 2003 | Toxicol. Lett. | pmid:12749817 |
| Mariano F et al. | Platelet-activating factor synthesis by neutrophils, monocytes, and endothelial cells is modulated by nitric oxide production. | 2003 | Shock | pmid:12688545 |
| Thaete LG et al. | Infusion of exogenous platelet-activating factor produces intrauterine growth restriction in the rat. | 2003 | J. Soc. Gynecol. Investig. | pmid:12699876 |
| Simon HU et al. | Interleukin-2 primes eosinophil degranulation in hypereosinophilia and Wells' syndrome. | 2003 | Eur. J. Immunol. | pmid:12672048 |
| Teather LA and Wurtman RJ | Cyclooxygenase-2 mediates platelet-activating factor-induced prostaglandin E2 release from rat primary astrocytes. | 2003 | Neurosci. Lett. | pmid:12672535 |
| Hou X et al. | Increased platelet-activating factor-induced periventricular brain microvascular constriction associated with immaturity. | 2003 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:12626359 |
| Vogensen SB et al. | Preparation of 7-substituted ginkgolide derivatives: potent platelet activating factor (PAF) receptor antagonists. | 2003 | J. Med. Chem. | pmid:12570381 |
| Gabbianelli R et al. | A new method to evaluate spontaneous platelet aggregation in type 2 diabetes by Cellfacts. | 2003 | Clin. Chim. Acta | pmid:12589971 |
| D'Andrea G et al. | Platelet aggregation profiles in cluster headache. | 2003 | Headache | pmid:12603647 |
| Gruska S et al. | Sodium/lithium countertransport and intracellular calcium concentration in patients with essential hypertension and coronary heart disease. | 2003 | Clin. Sci. | pmid:12605593 |
| Lu DP et al. | Ligand-activated signal transduction in the 2-cell embryo. | 2003 | Biol. Reprod. | pmid:12606379 |
| Hu G et al. | Neutrophils pretreated with volatile anesthetics lose ability to cause cardiac dysfunction. | 2003 | Anesthesiology | pmid:12606916 |
| Corl CM et al. | Oxidant stress enhances Lyso-PAF-AcT activity by modifying phospholipase D and phosphatidic acid in aortic endothelial cells. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12615078 |
| Chen L et al. | [Determination of platelet activating factor in middle ear effusion of patients with secretory oitits media]. | 2003 | Lin Chuang Er Bi Yan Hou Ke Za Zhi | pmid:14727433 |