| MeSH term | MeSH ID | Detail |
|---|---|---|
| Coronary Thrombosis | D003328 | 7 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Cystitis | D003556 | 23 associated lipids |
| Death, Sudden | D003645 | 12 associated lipids |
| Dermatitis, Atopic | D003876 | 19 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetic Angiopathies | D003925 | 20 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Baker RR and Chang H | MgATP has different inhibitory effects on the use of 1-acyl-lysophosphatidylcholine and lyso platelet-activating factor acceptors by neuronal nuclear acetyltransferase activities. | 1998 | Biochim. Biophys. Acta | pmid:9630721 |
| De Plaen IG et al. | Intestinal NF-kappaB is activated, mainly as p50 homodimers, by platelet-activating factor. | 1998 | Biochim. Biophys. Acta | pmid:9630621 |
| Spapen H et al. | The platelet-activating factor antagonist BB-882 does not improve tissue oxygen extraction in endotoxic shock. | 1998 | J Crit Care | pmid:9627275 |
| Takada Y et al. | Prolonged hepatic warm ischemia in non-heart-beating donors: protective effects of FK506 and a platelet activating factor antagonist in porcine liver transplantation. | 1998 | Surgery | pmid:9626320 |
| Werr J et al. | beta1 integrins are critically involved in neutrophil locomotion in extravascular tissue In vivo. | 1998 | J. Exp. Med. | pmid:9625769 |
| Gómez FP et al. | Effect of a platelet-activating factor (PAF) antagonist, SR 27417A, on PAF-induced gas exchange abnormalities in mild asthma. | 1998 | Eur. Respir. J. | pmid:9623685 |
| Isumi H et al. | Expression of a 45K subunit of platelet-activating factor acetylhydrolase in the developing mouse cerebellum. | 1998 | Anat. Embryol. | pmid:9623676 |
| Lapchyns'ka II | [Platelet activating factor and its role in the pathogenesis of immune glomerulopathy]. | 1998 Jan-Feb | Lik. Sprava | pmid:9621619 |
| Lou YP et al. | Platelet-activating factor induces goblet cell hyperplasia and mucin gene expression in airways. | 1998 | Am. J. Respir. Crit. Care Med. | pmid:9620929 |
| Mollinedo F et al. | Physiological activation of human neutrophils down-regulates CD53 cell surface antigen. | 1998 | J. Leukoc. Biol. | pmid:9620662 |
| Shimada A et al. | In situ expression of platelet-activating factor (PAF)-receptor gene in rat skin and effects of PAF on proliferation and differentiation of cultured human keratinocytes. | 1998 | J. Invest. Dermatol. | pmid:9620295 |
| Tsuji F and Shirasawa E | The role of platelet-activating factor in cell infiltration in endotoxin-induced uveitis in guinea pigs. | 1998 | Curr. Eye Res. | pmid:9617545 |
| Nakos G et al. | Bronchoalveolar lavage fluid characteristics of early intermediate and late phases of ARDS. Alterations in leukocytes, proteins, PAF and surfactant components. | 1998 | Intensive Care Med | pmid:9609406 |
| Nguyen P et al. | [Modulators of leukocytic functions]. | 1998 | J Mal Vasc | pmid:9608925 |
| ZaÄtseva LG et al. | [The role of platelet activating factor in regulation of the phagocytic function of macrophages from different organs]. | 1998 | Biull Eksp Biol Med | pmid:9606554 |
| Kotelevets L et al. | Inhibition by platelet-activating factor of Src- and hepatocyte growth factor-dependent invasiveness of intestinal and kidney epithelial cells. Phosphatidylinositol 3'-kinase is a critical mediator of tumor invasion. | 1998 | J. Biol. Chem. | pmid:9603913 |
| O'Neill C | Autocrine mediators are required to act on the embryo by the 2-cell stage to promote normal development and survival of mouse preimplantation embryos in vitro. | 1998 | Biol. Reprod. | pmid:9603268 |
| Gómez FP et al. | The effects of 5-lipoxygenase inhibition by zileuton on platelet-activating-factor-induced pulmonary abnormalities in mild asthma. | 1998 | Am. J. Respir. Crit. Care Med. | pmid:9603138 |
| László F and Whittle BJ | Role of nitric oxide and platelet-activating factor in the initiation of indomethacin-provoked intestinal inflammation in rats. | 1998 | Eur. J. Pharmacol. | pmid:9600654 |
| Giménez R and Aguilar J | Effects of CDP-choline administration on brain striatum platelet-activating factor in aging rats. | 1998 | Eur. J. Pharmacol. | pmid:9600649 |