| MeSH term | MeSH ID | Detail |
|---|---|---|
| Uveitis, Anterior | D014606 | 11 associated lipids |
| Migraine Disorders | D008881 | 11 associated lipids |
| Shock | D012769 | 11 associated lipids |
| Meningioma | D008579 | 11 associated lipids |
| Pregnancy Complications, Hematologic | D011250 | 11 associated lipids |
| Pregnancy Complications, Cardiovascular | D011249 | 11 associated lipids |
| Hepatitis C, Chronic | D019698 | 12 associated lipids |
| Blood Platelet Disorders | D001791 | 12 associated lipids |
| Amnesia | D000647 | 12 associated lipids |
| Hypertension, Portal | D006975 | 12 associated lipids |
| Duodenal Ulcer | D004381 | 12 associated lipids |
| Fetal Weight | D020567 | 12 associated lipids |
| Death, Sudden | D003645 | 12 associated lipids |
| Arterial Occlusive Diseases | D001157 | 12 associated lipids |
| Vitamin D Deficiency | D014808 | 13 associated lipids |
| Multiple Sclerosis | D009103 | 13 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
| Heart Arrest | D006323 | 13 associated lipids |
| Osteoarthritis, Knee | D020370 | 13 associated lipids |
| Polycythemia Vera | D011087 | 13 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chen LW et al. | Differential regulation of Ca2+ influx by fMLP and PAF in human neutrophils: possible involvement of store-operated Ca2+ channel. | 2000 | Shock | pmid:10718373 |
| Bar-Or D et al. | Copper stimulates the synthesis and release of interleukin-8 in human endothelial cells: a possible early role in systemic inflammatory responses. | 2003 | Shock | pmid:12865660 |
| Ruggiero V et al. | Beneficial effects of a novel platelet-activating factor receptor antagonist, ST 899, on endotoxin-induced shock in mice. | 1994 | Shock | pmid:7757521 |
| Froon AM et al. | Treatment with the platelet-activating factor antagonist TCV-309 in patients with severe systemic inflammatory response syndrome: a prospective, multi-center, double-blind, randomized phase II trial. | 1996 | Shock | pmid:9156785 |
| Buripakdi D and Karlstad MD | The role of platelet-activating factor in alterations of system A amino acid transport in rat soleus and extensor digitorum longus muscles during endotoxic shock. | 1994 | Shock | pmid:7735984 |
| Childs EW et al. | In vivo visualization of reactive oxidants and leukocyte-endothelial adherence following hemorrhagic shock. | 2002 | Shock | pmid:12412620 |
| Gomes RN et al. | Exogenous platelet-activating factor acetylhydrolase reduces mortality in mice with systemic inflammatory response syndrome and sepsis. | 2006 | Shock | pmid:16783197 |
| Chen LW et al. | Thermal injury-induced priming effect of neutrophil is TNF-alpha and P38 dependent. | 2006 | Shock | pmid:16783201 |
| Klabunde RE and Calvello C | Inhibition of endotoxin-induced microvascular leakage by a platelet-activating factor antagonist and 5-lipoxygenase inhibitor. | 1995 | Shock | pmid:8595525 |
| Cureton EL et al. | Endothelin 1 and prostacyclin attenuate increases in hydraulic permeability caused by platelet-activating factor in rats. | 2010 | Shock | pmid:19940814 |
| Zallen G et al. | Postinjury suppression of human neutrophil cytokine production results from the stabilization of inhibitory kappaB. | 1999 | Shock | pmid:10030791 |
| Granger J and Remick D | Acute pancreatitis: models, markers, and mediators. | 2005 | Shock | pmid:16374372 |
| Bulger EM et al. | The macrophage response to endotoxin requires platelet activating factor. | 2002 | Shock | pmid:11900334 |
| Mitsuoka H et al. | Protease inhibition in the intestinal lumen: attenuation of systemic inflammation and early indicators of multiple organ failure in shock. | 2002 | Shock | pmid:11900339 |
| Park EJ et al. | Dietary ganglioside inhibits acute inflammatory signals in intestinal mucosa and blood induced by systemic inflammation of Escherichia coli lipopolysaccharide. | 2007 | Shock | pmid:17510604 |
| Aiboshi J et al. | Blood transfusion and the two-insult model of post-injury multiple organ failure. | 2001 | Shock | pmid:11303730 |
| Jin Y et al. | [The effect of autocrine factors on development of early embryos of mouse]. | 2001 | Shi Yan Sheng Wu Xue Bao | pmid:12549014 |
| Hu DH and Ma CT | [Effect of platelet activating factor on TxA2, PGI2 and Ca(2+)-ATPase activity in the intra-pulmonary artery smooth muscle cells]. | 1996 | Sheng Li Xue Bao | pmid:9389196 |
| Zheng HL et al. | [Role of platelet-activating factor in progesterone synthesis and vascular endothelial growth factor expression in rat luteal cells]. | 2008 | Sheng Li Xue Bao | pmid:18425318 |
| Tu Q and Zhang QX | [Stimulation of megakaryocyte maturation and thrombopoiesis in vitro by thrombocytopoiesis-stimulating factor]. | 1990 | Sheng Li Xue Bao | pmid:2263959 |
| Ma CT | [Variation of plasma platelet activating factor during development and reversal of hypoxic pulmonary hypertension in conscious sheep]. | 1994 | Sheng Li Xue Bao | pmid:7973831 |
| Du YM et al. | Effects of platelet activating factor on action potentials and potassium channels in guinea-pig ventricular myocytes. | 2004 | Sheng Li Xue Bao | pmid:15224138 |
| Yan GT et al. | [Effect of calcium overload and platelet activating factor on calcitonin gene related peptide release from lung tissue]. | 1998 | Sheng Li Xue Bao | pmid:11324524 |
| Fu JM | [Effects of platelet activating factor on blood platelets]. | 1989 | Sheng Li Ke Xue Jin Zhan | pmid:2549618 |
| Yu SQ | [Effects of platelet-activating factor (PAF) and its antagonists on the male reproduction]. | 1995 | Sheng Li Ke Xue Jin Zhan | pmid:7604226 |
| Wang YY and Li CL | [Platelet-activating factor antagonists and asthma]. | 1992 | Sheng Li Ke Xue Jin Zhan | pmid:1329195 |
| Yin M and Fang ZY | [Platelet-activating factor]. | 1989 | Sheng Li Ke Xue Jin Zhan | pmid:2692167 |
| Liu Y and Kang GF | [Lipid mediators and liver injury]. | 1995 | Sheng Li Ke Xue Jin Zhan | pmid:8745570 |
| Wu QX | [Amplification and desensitization in platelet activation]. | 1992 | Sheng Li Ke Xue Jin Zhan | pmid:1299958 |
| Li SQ | [Platelet activating factor and cerebral ischemia]. | 1991 | Sheng Li Ke Xue Jin Zhan | pmid:1796263 |
| Shen YZ and Li CL | [The pathophysiological role of the platelet activating factor]. | 1991 | Sheng Li Ke Xue Jin Zhan | pmid:1796277 |
| Zeng NX | [Platelet activating factor and gastrointestinal mucosa injuries]. | 1991 | Sheng Li Ke Xue Jin Zhan | pmid:1947987 |
| Chen DC | [Phosphoinositide metabolism and platelet activation]. | 1987 | Sheng Li Ke Xue Jin Zhan | pmid:2838899 |
| Hu GL and Guo HS | [Progress in platelet-activating factor receptor research]. | 1997 | Sheng Li Ke Xue Jin Zhan | pmid:10921090 |
| Roudebush WE | Seminal platelet-activating factor. | 2007 | Semin. Thromb. Hemost. | pmid:17253192 |
| Carveth HJ et al. | Regulation of platelet-activating factor (PAF) synthesis and PAF-mediated neutrophil adhesion to endothelial cells activated by thrombin. | 1992 | Semin. Thromb. Hemost. | pmid:1315452 |
| Whatley RE et al. | Production of platelet-activating factor by endothelial cells. | 1987 | Semin. Thromb. Hemost. | pmid:3321437 |
| Silvestro L et al. | Platelet-activating factor-induced endothelial cell expression of adhesion molecules and modulation of surface glycocalyx, evaluated by electron spectroscopy chemical analysis. | 1994 | Semin. Thromb. Hemost. | pmid:7527938 |
| Braquet P et al. | Effect of platelet-activating factor on platelets and vascular endothelium. | 1989 | Semin. Thromb. Hemost. | pmid:2546255 |
| Frost BL et al. | The importance of pro-inflammatory signaling in neonatal necrotizing enterocolitis. | 2008 | Semin. Perinatol. | pmid:18346533 |
| Caplan MS et al. | The role of PAF, TLR, and the inflammatory response in neonatal necrotizing enterocolitis. | 2005 | Semin. Pediatr. Surg. | pmid:16084401 |
| Frost BL and Caplan MS | Necrotizing enterocolitis: pathophysiology, platelet-activating factor, and probiotics. | 2013 | Semin. Pediatr. Surg. | pmid:23611612 |
| Barnes JL and Venkatachalam MA | The role of platelets and polycationic mediators in glomerular vascular injury. | 1985 | Semin. Nephrol. | pmid:2957770 |
| Fischereder M et al. | Therapeutic strategies in the prevention of acute renal failure. | 1994 | Semin. Nephrol. | pmid:8140341 |
| Murer EH | The role of platelet calcium. | 1985 | Semin. Hematol. | pmid:3901271 |
| Lian EC | Pathogenesis of thrombotic thrombocytopenic purpura. | 1987 | Semin. Hematol. | pmid:3299722 |
| Lorant DE et al. | Platelet-activating factor mediates procoagulant activity on the surface of endothelial cells by promoting leukocyte adhesion. | 1995 | Semin. Cell Biol. | pmid:8562922 |
| Moore TL and Weiss TD | Mediators of inflammation. | 1985 | Semin. Arthritis Rheum. | pmid:3936177 |
| Felsen D et al. | Inflammatory mediators and interstitial cystitis. | 1991 | Semin Urol | pmid:1853005 |
| Moschos MM et al. | In Vitro Effects of Anti-Glaucomatous Eye Drops on Platelet-Activating Factor and its Metabolism. | 2017 | Semin Ophthalmol | pmid:26270771 |