Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Thomet OA et al. | Role of petasin in the potential anti-inflammatory activity of a plant extract of petasites hybridus. | 2001 | Biochem. Pharmacol. | pmid:11286996 |
Hayashi J et al. | Platelet-activating factor antagonist, SM-12502, attenuates experimental glomerular thrombosis in rats. | 2001 | Nephron | pmid:11287764 |
Choi JH et al. | Platelet-activating factor-induced early activation of NF-kappa B plays a crucial role for organ clearance of Candida albicans. | 2001 | J. Immunol. | pmid:11290796 |
Marathe GK et al. | Identification of platelet-activating factor as the inflammatory lipid mediator in CCl4-metabolizing rat liver. | 2001 | J. Lipid Res. | pmid:11290831 |
Min JH et al. | Platelet-activating factor acetylhydrolases: broad substrate specificity and lipoprotein binding does not modulate the catalytic properties of the plasma enzyme. | 2001 | Biochemistry | pmid:11294621 |
Richardson RM et al. | RGS4 inhibits platelet-activating factor receptor phosphorylation and cellular responses. | 2001 | Biochemistry | pmid:11297424 |
Kuijpers TW et al. | The impact of platelet-activating factor (PAF)-like mediators on the functional activity of neutrophils: anti-inflammatory effects of human PAF-acetylhydrolase. | 2001 | Clin. Exp. Immunol. | pmid:11298128 |
Teeling JL et al. | Intravenous immunoglobulin preparations induce mild activation of neutrophils in vivo via triggering of macrophages--studies in a rat model. | 2001 | Br. J. Haematol. | pmid:11298603 |
Teather LA et al. | Differential interaction of platelet-activating factor and NMDA receptor function in hippocampal and dorsal striatal memory processes. | 2001 | Neurobiol Learn Mem | pmid:11300737 |
Aiboshi J et al. | Blood transfusion and the two-insult model of post-injury multiple organ failure. | 2001 | Shock | pmid:11303730 |
Ilveskero S et al. | Procoagulant activity on platelets adhered to collagen or plasma clot. | 2001 | Arterioscler. Thromb. Vasc. Biol. | pmid:11304482 |
Ishizuka S et al. | Acid exposure stimulates the adherence of Streptococcus pneumoniae to cultured human airway epithelial cells: effects on platelet-activating factor receptor expression. | 2001 | Am. J. Respir. Cell Mol. Biol. | pmid:11306440 |
Dery RE et al. | Inhibition of allergic inflammation by C-terminal peptides of the prohormone submandibular rat 1 (SMR-1). | 2001 Jan-Mar | Int. Arch. Allergy Immunol. | pmid:11306968 |
Lukashova V et al. | G-protein-independent activation of Tyk2 by the platelet-activating factor receptor. | 2001 | J. Biol. Chem. | pmid:11309383 |
Grassi S and Pettorossi VE | Synaptic plasticity in the medial vestibular nuclei: role of glutamate receptors and retrograde messengers in rat brainstem slices. | 2001 | Prog. Neurobiol. | pmid:11311461 |
Panayiotou A et al. | Lipid fractions with aggregatory and antiaggregatory activity toward platelets in fresh and fried cod (Gadus morhua): correlation with platelet-activating factor and atherogenesis. | 2000 | J. Agric. Food Chem. | pmid:11312810 |
Yildirim G et al. | Does the platelet-activating factor affect the antioxidant defense system? The possible role of hyperbaric oxygenation. | 2000 | Biol Trace Elem Res | pmid:11318001 |
Yan GT et al. | [Effect of calcium overload and platelet activating factor on calcitonin gene related peptide release from lung tissue]. | 1998 | Sheng Li Xue Bao | pmid:11324524 |
Alam N et al. | Additional bioactive Lyso-PAF congeners from the sponge Spirastrella abata. | 2001 | J. Nat. Prod. | pmid:11325244 |
Kato M et al. | Platelet activating factor degradation in tear fluid from guinea pigs with allergic conjunctivitis. | 2001 | J Ocul Pharmacol Ther | pmid:11327052 |
Caplan MS et al. | Effect of polyunsaturated fatty acid (PUFA) supplementation on intestinal inflammation and necrotizing enterocolitis (NEC) in a neonatal rat model. | 2001 | Pediatr. Res. | pmid:11328947 |
Sugano T et al. | Effects of platelet-activating factor on cytokine production by human uterine cervical fibroblasts. | 2001 | Mol. Hum. Reprod. | pmid:11331671 |
Taylor KE et al. | Could platelet activating factor play a role in developmental dyslexia? | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11334553 |
Vittimberga FJ et al. | Endotoxin fails to stimulate inositol triphosphate production in macrophages. | 1999 | Int. J. Surg. Investig. | pmid:11341611 |
Hattar K et al. | Cell density regulates neutrophil IL-8 synthesis: role of IL-1 receptor antagonist and soluble TNF receptors. | 2001 | J. Immunol. | pmid:11342652 |
Marcano H et al. | Effect of dopamine on platelet activating factor induced-pulmonary edema in isolated and perfused rabbit lungs. | 2001 | Respir Physiol | pmid:11348642 |
Wild MD and Roudebush WE | Platelet-activating factor improves intrauterine insemination outcome. | 2001 | Am. J. Obstet. Gynecol. | pmid:11349157 |
Wu C et al. | Evidence for the autocrine induction of capacitation of mammalian spermatozoa. | 2001 | J. Biol. Chem. | pmid:11350972 |
Taylor R et al. | Platelet-activating factor antagonism and streptokinase-induced hypotension in clinical acute myocardial infarction. | 2001 | Clin. Sci. | pmid:11352774 |
Ferland C et al. | Eotaxin promotes eosinophil transmigration via the activation of the plasminogen-plasmin system. | 2001 | J. Leukoc. Biol. | pmid:11358986 |
Lee T et al. | Differential regulation of three catalytic activities of platelet-activating factor (PAF)-dependent transacetylase. | 2001 | Arch. Biochem. Biophys. | pmid:11368182 |
Tu W et al. | [Influences of BN50739 on neutrophil elastase and phospholipase A2 in lung and tracheal mucosa of pigs with acute severe pancreatitis]. | 2000 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:11372382 |
Iwase M et al. | Cardiac functional and structural alterations induced by endotoxin in rats: importance of platelet-activating factor. | 2001 | Crit. Care Med. | pmid:11373429 |
Rosa MS et al. | Platelet-activating factor (PAF) modulates peritoneal mouse macrophage infection by Leishmania amazonensis. | 2001 | Curr. Microbiol. | pmid:11375661 |
Hirashima Y et al. | Effect of a platelet-activating factor receptor antagonist, E5880, on cerebral vasospasm after aneurysmal subarachnoid hemorrhage--open clinical trial to investigate efficacy and safety. | 2001 | Neurol. Med. Chir. (Tokyo) | pmid:11381675 |
Liu XH et al. | Platelet-activating factor antagonist BN 50730 attenuates hypoxic-ischemic brain injury in neonatal rats. | 2001 | Pediatr. Res. | pmid:11385142 |
Mi B and Maleczka RE | A Nozaki-Hiyama-Kishi Ni(II)/Cr(II) coupling approach to the phomactins. | 2001 | Org. Lett. | pmid:11388849 |
Roudebush WE and Diehl JR | Platelet-activating factor content in boar spermatozoa correlates with fertility. | 2001 | Theriogenology | pmid:11396471 |
Elzi DJ et al. | Ionomycin causes activation of p38 and p42/44 mitogen-activated protein kinases in human neutrophils. | 2001 | Am. J. Physiol., Cell Physiol. | pmid:11401859 |
Tiemann U et al. | Platelet-activating factor (PAF)-like activity, localization of PAF receptor (PAF-R) and PAF-acetylhydrolase (PAF-AH) activity in bovine endometrium at different stages of the estrous cycle and early pregnancy. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11403499 |
Tong N et al. | Activation of glycogen synthase kinase 3 beta (GSK-3beta) by platelet activating factor mediates migration and cell death in cerebellar granule neurons. | 2001 | Eur. J. Neurosci. | pmid:11403684 |
Roudebush WE | Role of platelet-activating factor in reproduction: sperm function. | 2001 | Asian J. Androl. | pmid:11404790 |
Burke JR et al. | BMS-229724 is a tight-binding inhibitor of cytosolic phospholipase A2 that acts at the lipid/water interface and possesses anti-inflammatory activity in skin inflammation models. | 2001 | J. Pharmacol. Exp. Ther. | pmid:11408565 |
Briton-Jones C et al. | The effects of follicular fluid and platelet-activating factor on motion characteristics of poor-quality cryopreserved human sperm. | 2001 | J. Assist. Reprod. Genet. | pmid:11411433 |
Mizuno S et al. | Role of PAF in acute liver injury after extended hepatectomy: overexpression of PAF receptor mRNA in Kupffer cells. | 2001 | Dig. Dis. Sci. | pmid:11414308 |
Jehle R et al. | Platelet-activating factor (PAF)-acetylhydrolase and PAF-like compounds in the lung: effects of hyperoxia. | 2001 | Biochim. Biophys. Acta | pmid:11420174 |
Kulikov VI and Muzya GI | Inhibition of human platelet aggregation by amides and ester of salicylic acid with platelet-activating factor analogs. | 2001 | Biochemistry Mosc. | pmid:11421815 |
Virchow JC et al. | Effect of a specific cysteinyl leukotriene-receptor 1-antagonist (montelukast) on the transmigration of eosinophils across human umbilical vein endothelial cells. | 2001 | Clin. Exp. Allergy | pmid:11422147 |
Wang H et al. | Platelet-activating factor and endotoxin activate CCAAT/enhancer binding protein in rat small intestine. | 2001 | Br. J. Pharmacol. | pmid:11429396 |
Tsoukatos DC et al. | Platelet-activating factor acetylhydrolase and transacetylase activities in human plasma low-density lipoprotein. | 2001 | Biochem. J. | pmid:11439095 |
Miguel BG et al. | Increase of phosphoinositide hydrolysis and diacylglycerol production by PAF in isolated rat liver nuclei. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11444588 |
Thom SR et al. | Roles for platelet-activating factor and *NO-derived oxidants causing neutrophil adherence after CO poisoning. | 2001 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11454599 |
Grosman N | Similar effects of ether phospholipids, PAF and lyso-PAF on the Ca(2+)-ATPase activity of rat brain synaptosomes and leukocyte membranes. | 2001 | Int. Immunopharmacol. | pmid:11460312 |
Raggers RJ et al. | Multidrug-resistance P-glycoprotein (MDR1) secretes platelet-activating factor. | 2001 | Biochem. J. | pmid:11463358 |
Hollmann MW et al. | Local anesthetic effects on priming and activation of human neutrophils. | 2001 | Anesthesiology | pmid:11465548 |
Lane JS et al. | Platelet activating factor antagonism reduces the systemic inflammatory response in a murine model of acute pancreatitis. | 2001 | J. Surg. Res. | pmid:11469912 |
Velasquez LA et al. | PAF receptor and PAF acetylhydrolase expression in the endosalpinx of the human Fallopian tube: possible role of embryo-derived PAF in the control of embryo transport to the uterus. | 2001 | Hum. Reprod. | pmid:11473946 |
Akisu M et al. | The role of recombinant human erythropoietin in lipid peroxidation and platelet-activating factor generation in a rat model of necrotizing enterocolitis. | 2001 | Eur J Pediatr Surg | pmid:11475112 |
Zhang J et al. | [Experimental study on effect of Buyang Huanwu decoction on arterial blood platelet activating factor content pre- and post-arterial thrombosis of rats]. | 1998 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:11475720 |
Chang PY et al. | Oxidized low-density lipoprotein downregulates endothelial basic fibroblast growth factor through a pertussis toxin-sensitive G-protein pathway: mediator role of platelet-activating factor-like phospholipids. | 2001 | Circulation | pmid:11479258 |
Hermoso M et al. | Platelet activating factor increases ciliary activity in the hamster oviduct through epithelial production of prostaglandin E2. | 2001 | Pflugers Arch. | pmid:11484763 |
Sachais BS | Platelet-endothelial interactions in atherosclerosis. | 2001 | Curr Atheroscler Rep | pmid:11487452 |
Jantan I et al. | Inhibition of platelet-activating factor receptor binding by aporphine and phenanthrenoid alkaloids from Aromadendron elegans. | 2001 | Planta Med. | pmid:11488464 |
Coker A et al. | Is mannitol effective against platelet-activating factor (PAF)-induced liver damage in obstructive jaundice? | 2001 Jul-Aug | Hepatogastroenterology | pmid:11490817 |
Hu LH et al. | Synthesis and biological activity of amide derivatives of ginkgolide A. | 2001 | J Asian Nat Prod Res | pmid:11491398 |
Alvarez A and Sanz MJ | Reactive oxygen species mediate angiotensin II-induced leukocyte-endothelial cell interactions in vivo. | 2001 | J. Leukoc. Biol. | pmid:11493611 |
Liu Y et al. | [The role and significance of PAF in the early pulmonary injury following burns combined with endotoxemia in rats]. | 1999 | Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi | pmid:11501075 |
Hourton D et al. | Oxidized low density lipoproteins downregulate LPS-induced platelet-activating factor receptor expression in human monocyte-derived macrophages: implications for LPS-induced nuclear factor-kappaB binding activity. | 2001 | Eur. J. Biochem. | pmid:11502209 |
Stoddart NR et al. | Exogenous platelet-activating factor stimulates cell proliferation in mouse pre-implantation embryos prior to the fourth cell cycle and shows isoform-specific stimulatory effects. | 2001 | Zygote | pmid:11510473 |
Feldman C et al. | Vitamin E attenuates the injurious effects of bioactive phospholipids on human ciliated epithelium in vitro. | 2001 | Eur. Respir. J. | pmid:11510782 |
Mooren FC et al. | Decoupling of intracellular calcium signaling in granulocytes after exhaustive exercise. | 2001 | Int J Sports Med | pmid:11510867 |
Marathe GK et al. | Lysophosphatidylcholine and lyso-PAF display PAF-like activity derived from contaminating phospholipids. | 2001 | J. Lipid Res. | pmid:11518762 |
Smith DG et al. | Quinolinic acid is produced by macrophages stimulated by platelet activating factor, Nef and Tat. | 2001 | J. Neurovirol. | pmid:11519483 |
Hoenstein R et al. | Interleukin-2 activates human peripheral blood eosinophils. | 2001 | Cell. Immunol. | pmid:11520078 |
Carceller E et al. | Novel azo derivatives as prodrugs of 5-aminosalicylic acid and amino derivatives with potent platelet activating factor antagonist activity. | 2001 | J. Med. Chem. | pmid:11520209 |
Dubois MJ and Vincent JL | Clinically-oriented therapies in sepsis: a review. | 2000 | J. Endotoxin Res. | pmid:11521072 |
Bernatchez PN et al. | VEGF stimulation of endothelial cell PAF synthesis is mediated by group V 14 kDa secretory phospholipase A2. | 2001 | Br. J. Pharmacol. | pmid:11522612 |
Emingil G et al. | Levels of platelet-activating factor in gingival crevicular fluid and gingival tissue in specific periodontal diseases. | 2001 | J. Periodontol. | pmid:11525434 |
McManus LM et al. | Agonist-dependent failure of neutrophil function in diabetes correlates with extent of hyperglycemia. | 2001 | J. Leukoc. Biol. | pmid:11527989 |
Qian C et al. | Anti-inflammatory activities of LDP-392, a dual PAF receptor antagonist and 5-lipoxygenase inhibitor. | 2001 | Pharmacol. Res. | pmid:11529688 |
Thomet OA et al. | Differential inhibition of inflammatory effector functions by petasin, isopetasin and neopetasin in human eosinophils. | 2001 | Clin. Exp. Allergy | pmid:11529903 |
Watanabe S et al. | Suppression of platelet-activating factor generation and modulation of arachidonate metabolism by dietary enrichment with (n-9) eicosatrienoic acid or docosahexaenoic acid in mouse peritoneal cells. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11534547 |
Stafforini DM | PAF acetylhydrolase gene polymorphisms and asthma severity. | 2001 | Pharmacogenomics | pmid:11535107 |
Steer ML | Relationship between pancreatitis and lung diseases. | 2001 | Respir Physiol | pmid:11535257 |
Fazal N et al. | PAF receptor antagonist modulates neutrophil responses with thermal injury in vivo. | 2001 | Am. J. Physiol., Cell Physiol. | pmid:11546669 |
Tokutomi T et al. | Production of platelet-activating factor by neuronal cells in the rat brain with cold injury. | 2001 | Neurol. Res. | pmid:11547929 |
Denizot Y et al. | Is there a role of platelet-activating factor in human lung cancer? | 2001 Aug-Sep | Lung Cancer | pmid:11551414 |
Chemler SR et al. | Enantioselective synthesis of the oxadecalin core of phomactin A via a highly stereoselective Diels-Alder reaction. | 2001 | Org. Lett. | pmid:11554815 |
Kavakli K et al. | Intraleucocyte platelet-activating factor levels in desmopressin-treated patients with haemophilia A and von Willebrand disease. | 2001 | Haemophilia | pmid:11554936 |
Rozenfeld RA et al. | Role of gut flora on intestinal group II phospholipase A2 activity and intestinal injury in shock. | 2001 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11557516 |
Fukunaga K et al. | Single nucleotide polymorphism of human platelet-activating factor receptor impairs G-protein activation. | 2001 | J. Biol. Chem. | pmid:11560941 |
Tsai JJ and Wang TF | Different densities of human eosinophils respond differently to PAF and IL-5. | 1999 | J Microbiol Immunol Infect | pmid:11561566 |
Zhao L et al. | Effects of combining three different antiplatelet agents on platelets and leukocytes in whole blood in vitro. | 2001 | Br. J. Pharmacol. | pmid:11564653 |
McKenna DJ et al. | Efficacy, safety, and use of ginkgo biloba in clinical and preclinical applications. | 2001 Sep-Oct | Altern Ther Health Med | pmid:11565403 |
Bhatia M et al. | Inflammatory mediators as therapeutic targets in acute pancreatitis. | 2001 | Curr Opin Investig Drugs | pmid:11566005 |
Khoo C et al. | Inhibition of store-operated Ca(2+) influx by acidic extracellular pH in cultured human microglia. | 2001 | Glia | pmid:11571781 |
Mariano F et al. | Hemofiltration reduces the serum priming activity on neutrophil chemiluminescence in septic patients. | 2001 | Kidney Int. | pmid:11576379 |
Christie PE and Henderson WR | Lipid inflammatory mediators: leukotrienes, prostaglandins, platelet-activating factor. | 2002 | Clin Allergy Immunol | pmid:11577541 |
Jolly S et al. | Effect of intravenous platelet-activating factor on bovine pulmonary mast cells. | 2001 Aug-Oct | J. Comp. Pathol. | pmid:11578122 |
Sirolli V et al. | Platelet activation and platelet-erythrocyte aggregates in end-stage renal disease patients on hemodialysis. | 2001 | Thromb. Haemost. | pmid:11583316 |